Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections.

abstract：:We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin an...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss BD,Weiss EC,Haggard WO,Evans RP,McLaren SG,Smeltzer MS

更新日期：2009-01-01 00:00:00

abstract：:We evaluated MEDI8852, a human IgG1 monoclonal antibody that binds a highly conserved influenza A hemagglutinin stalk epitope, in outpatients with uncomplicated influenza A infection. A total of 126 subjects aged 18 to 65 years were enrolled during the 2015 to 2016 Northern and 2016 Southern Hemisphere seasons. Subjec...

journal_title：Antimicrobial agents and chemotherapy

authors： Ali SO,Takas T,Nyborg A,Shoemaker K,Kallewaard NL,Chiong R,Dubovsky F,Mallory RM

更新日期：2018-10-24 00:00:00

abstract：:Hemicholinium 3, decamethonium, and decyltrimethylammonium previously have been demonstrated to be efficient inhibitors, with 50% inhibitory concentrations of 4 X 10(-6), 10(-6), and 7 X 10(-7) M, respectively. We show that lengthening of the alkyl chain of decyltrimethylammonium by successive additions of two carbon ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ancelin ML,Vial HJ

更新日期：1986-05-01 00:00:00

abstract：:The present study examined the efficacy of using multiple mechanisms as part of a topical microbicide to inactivate herpes simplex virus (HSV) by combining theaflavin-3,3'-digallate (TF-3) and lactic acid (LA) over the pH range of 4.0 to 5.7 to mimic conditions in the female reproductive tract. Six clinical isolates o...

journal_title：Antimicrobial agents and chemotherapy

authors： Isaacs CE,Xu W

更新日期：2013-08-01 00:00:00

abstract：:The in vitro interactions between bismuth subcitrate and a variety of antimicrobial agents against 12 Campylobacter pyloridis (C. pylori) isolates were studied by the agar dilution checkerboard technique. The combination of bismuth subcitrate with the older quinolone, oxolinic acid, produced synergistic activity again...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Caekenberghe DL,Breyssens J

更新日期：1987-09-01 00:00:00

abstract：:A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eshaghi A,Zittermann S,Bharat A,Mulvey MR,Allen VG,Patel SN

更新日期：2020-04-21 00:00:00

abstract：:The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes with intravenous minocycline-based com...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang D,Yu B,Diep JK,Sharma R,Dudley M,Monteiro J,Kaye KS,Pogue JM,Abboud CS,Rao GG

更新日期：2017-06-27 00:00:00

abstract：:Methionine gamma-lyase, the enzyme which catalyzes the single-step conversion of methionine to alpha-ketobutyrate, ammonia, and methanethiol, is highly active in many anaerobic pathogenic microorganisms but has no counterpart in mammals. This study tested the hypothesis that this pathogen-specific enzyme can be exploi...

journal_title：Antimicrobial agents and chemotherapy

authors： Coombs GH,Mottram JC

更新日期：2001-06-01 00:00:00

abstract：:A portion of the Mycobacterium tuberculosis gene encoding the beta subunit of RNA polymerase (rpoB) was amplified by PCR using degenerate oligonucleotides and used as a hybridization probe to isolate plasmid clones carrying the entire rpoB gene of M. tuberculosis H37Rv, a virulent, rifampin-susceptible strain. Sequenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller LP,Crawford JT,Shinnick TM

更新日期：1994-04-01 00:00:00

abstract：:We examined 741 urinary tract isolates of the Morganella-Proteus-Providencia group, including the recently defined species Proteus penneri, for susceptibilities to aminoglycosides, semisynthetic penicillins, and cephalosporins. The data emphasize the importance of identification to the species level on the basis of ma...

journal_title：Antimicrobial agents and chemotherapy

authors： Piccolomini R,Cellini L,Allocati N,Di Girolamo A,Ravagnan G

更新日期：1987-10-01 00:00:00

abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

更新日期：2015-11-01 00:00:00

abstract：:Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

journal_title：Antimicrobial agents and chemotherapy

authors： Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

更新日期：2003-12-01 00:00:00

abstract：:The present study demonstrates the in vitro effectiveness of the macrolide rokitamycin and the phenothiazine compound chlorpromazine against Acanthamoeba castellanii. Growth curve evaluations revealed that both drugs inhibit trophozoite growth in dose- and time-dependent ways. The effects of both drugs when they were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mattana A,Biancu G,Alberti L,Accardo A,Delogu G,Fiori PL,Cappuccinelli P

更新日期：2004-12-01 00:00:00

abstract：:A total of 104 carbapenemase (serine- and metallo-beta-lactamase [MbetaL])-producing strains of the Enterobacteriaceae family collected from 2000 to 2005 in medical centers distributed worldwide were tested against tigecycline and 25 comparators by reference broth microdilution methods. The most frequent carbapenemase...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Sader HS,Deshpande LM,Fritsche TR,Jones RN

更新日期：2008-02-01 00:00:00

abstract：:Treatment options are limited for implant-associated infections (IAI) that are mainly caused by biofilm-forming staphylococci. We report here on the activity of the serrulatane compound 8-hydroxyserrulat-14-en-19-oic acid (EN4), a diterpene isolated from the Australian plant Eremophila neglecta. EN4 elicited antimicro...

journal_title：Antimicrobial agents and chemotherapy

authors： Nowakowska J,Griesser HJ,Textor M,Landmann R,Khanna N

更新日期：2013-01-01 00:00:00

abstract：:The need for an accurate and rapid method of testing ampicillin susceptibility of Haemophilus influenzae, especially strains isolated from patients with meningitis and septicemia, is indisputable. Various methods have been employed for this purpose. Each has advantages and disadvantages. This report describes a modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Park CH,Lopez JS,Cook CB

更新日期：1978-02-01 00:00:00

abstract：:A case-control study of the effect of antiretroviral therapy (ART) on apoptosis pathway genes comprising 16 cases (HIV infected with mitochondrial toxicity) and 16 controls (HIV uninfected) was conducted. A total of 26 of 84 genes of the apoptosis pathway were differentially expressed. Two of the upregulated genes, DF...

journal_title：Antimicrobial agents and chemotherapy

authors： Foli Y,Ghebremichael M,Li M,Paintsil E

更新日期：2017-07-25 00:00:00

abstract：:The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the tre...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavaldà J,Torres C,Tenorio C,López P,Zaragoza M,Capdevila JA,Almirante B,Ruiz F,Borrell N,Gomis X,Pigrau C,Baquero F,Pahissa A

更新日期：1999-03-01 00:00:00

abstract：:We evaluated the activity of the novel spiropyrimidinetrione AZD0914 (DNA gyrase inhibitor) against clinical gonococcal isolates and international reference strains (n=250), including strains with diverse multidrug resistance and extensive drug resistance. The AZD0914 MICs were substantially lower than those of most o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobsson S,Golparian D,Alm RA,Huband M,Mueller J,Jensen JS,Ohnishi M,Unemo M

更新日期：2014-09-01 00:00:00

abstract：:The efficacy of a new liposomal formulation of amphotericin B was compared to that of amphotericin B deoxycholate (Fungizone) in a murine model of visceral leishmaniasis induced by Leishmania infantum. Median effective doses (ED50) were determined with two different strains: strain 1 was obtained from an untreated pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul M,Durand R,Fessi H,Rivollet D,Houin R,Astier A,Deniau M

更新日期：1997-08-01 00:00:00

abstract：:Chloramphenicol acetyltransferases specified by fi(-) (F fertility-noninhibiting) R factors were compared with those specified by the fi(+) R factors R1, 222, and R6-S. Three classes of enzyme were distinguished: class I was determined by group N fi(-) R factors and was indistinguishable from the enzyme determined by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Foster TJ,Shaw WV

更新日期：1973-01-01 00:00:00

abstract：:The pharmacokinetics, distribution, and plasma and renal clearance of a new aminoglycoside antibiotic, tobramycin, was studied in the treatment of 18 elderly male patients (average age, 69 years) with urinary tract infections. Ten of these patients had normal renal function and eight had impaired renal function of var...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Westenfelder SR,Madsen PO

更新日期：1973-04-01 00:00:00

abstract：:The role of Acinetobacter baumannii ATCC 17978 UmuDC homologs A1S_0636-A1S_0637, A1S_1174-A1S_1173, and A1S_1389 (UmuDAb) in antibiotic resistance acquired through UV-induced mutagenesis was evaluated. Neither the growth rate nor the UV-related survival of any of the three mutants was significantly different from that...

journal_title：Antimicrobial agents and chemotherapy

authors： Aranda J,López M,Leiva E,Magán A,Adler B,Bou G,Barbé J

更新日期：2014-01-01 00:00:00

abstract：:Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

更新日期：2014-01-01 00:00:00

abstract：:The in vitro susceptibilities of 266 isolates of Streptococcus agalactiae determined by the agar dilution method showed that 6% of isolates were nonsusceptible to penicillin and 46% was resistant to erythromycin. Of the erythromycin-resistant isolates, 86.3% had the macrolide-lincosamide-streptogramin (MLS) resistance...

journal_title：Antimicrobial agents and chemotherapy

authors： Hsueh PR,Teng LJ,Lee LN,Ho SW,Yang PC,Luh KT

更新日期：2001-11-01 00:00:00

abstract：:In enterobacteria, the ampG gene encodes a transmembrane protein (permease) that transports 1,6-GlcNAc-anhydro-MurNAc and the 1,6-GlcNAc-anhydro-MurNAc peptide from the periplasm to the cytoplasm, which serve as signal molecules for the induction of ampC β-lactamase. The role of AmpG as a transporter is also essential...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Bao Q,Gagnon LA,Huletsky A,Oliver A,Jin S,Langaee T

更新日期：2010-11-01 00:00:00

abstract：:The fluoroquinolone antimicrobial drug danofloxacin was administered to sheep intravenously (i.v.) and intramuscularly (i.m.) at a dose of 1.25 mg/kg of body weight in a two-period crossover study. The pharmacokinetic properties of danofloxacin in serum, inflamed tissue cage fluid (exudate), and noninflamed tissue cag...

journal_title：Antimicrobial agents and chemotherapy

authors： Aliabadi FS,Landoni MF,Lees P

更新日期：2003-02-01 00:00:00

abstract：:Oral Fusobacterium nucleatum populations from 20 young, healthy children were examined for beta-lactamase production. Ten children (50%) harbored, altogether, 25 beta-lactamase-positive F. nucleatum isolates that were identified as F. nucleatum subsp. polymorphum, F. nucleatum subsp. nucleatum, and F. nucleatum subsp....

journal_title：Antimicrobial agents and chemotherapy

authors： Könönen E,Kanervo A,Salminen K,Jousimies-Somer H

更新日期：1999-05-01 00:00:00

abstract：:A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity of this resistance at the farm level. Strains were examined for resistance against beta-lactam antibiotics and other antimicrobial...

journal_title：Antimicrobial agents and chemotherapy

authors： Smet A,Martel A,Persoons D,Dewulf J,Heyndrickx M,Catry B,Herman L,Haesebrouck F,Butaye P

更新日期：2008-04-01 00:00:00

abstract：:The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Pulse ME,Nguyen P,Peterson K,Silva J,Simecka JW,Valtierra D,Sabet M,Griffith DC

更新日期：2017-12-21 00:00:00