Theaflavin-3,3'-digallate and lactic acid combinations reduce herpes simplex virus infectivity.

abstract：:A rapid method for the detection of methicillin resistance in staphylococci was developed. The method was based on the polymerase chain reaction (PCR) and primers that targeted the internal region of the coding frame of the mec gene. The amplification reaction was carried out with crude cell lysates as a source of tar...

journal_title：Antimicrobial agents and chemotherapy

authors： Predari SC,Ligozzi M,Fontana R

更新日期：1991-12-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) causes serious opportunistic infections in AIDS patients. Previous studies with MAC-infected beige mice have indicated that weekly administration of liposome-encapsulated streptomycin can reduce significantly the CFU in the liver and spleen. We examined whether streptomycin encapsulat...

journal_title：Antimicrobial agents and chemotherapy

authors： Gangadharam PR,Ashtekar DR,Flasher DL,Düzgüneş N

更新日期：1995-03-01 00:00:00

abstract：:The need for an accurate and rapid method of testing ampicillin susceptibility of Haemophilus influenzae, especially strains isolated from patients with meningitis and septicemia, is indisputable. Various methods have been employed for this purpose. Each has advantages and disadvantages. This report describes a modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Park CH,Lopez JS,Cook CB

更新日期：1978-02-01 00:00:00

abstract：:The clinical use of the neuraminidase inhibitor (NAI) oseltamivir is associated with the emergence of drug resistance resulting from subtype-specific neuraminidase (NA) mutations. The influenza A/Texas/12/2007 (H3N2) virus isolated from an oseltamivir-treated immunocompromised patient exhibited reduced susceptibility ...

journal_title：Antimicrobial agents and chemotherapy

authors： Okomo-Adhiambo M,Demmler-Harrison GJ,Deyde VM,Sheu TG,Xu X,Klimov AI,Gubareva LV

更新日期：2010-05-01 00:00:00

abstract：:Stenotrophomonas maltophilia is an opportunistic pathogen observed in nosocomial infections. Due to biofilm production and resistance to numerous antimicrobials, eradication is difficult. This study evaluated outcomes for monomicrobial S. maltophilia infections. Seventy-six patients were included, with 45 patients on ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nys C,Cherabuddi K,Venugopalan V,Klinker KP

更新日期：2019-10-22 00:00:00

abstract：:Implicated as a major mechanism of ethambutol (EMB) resistance in clinical studies of Mycobacterium tuberculosis, mutations in codon 306 of the embB gene (embB306) have also been detected in EMB-susceptible clinical isolates. Other studies have found strong associations between embB306 mutations and multidrug resistan...

journal_title：Antimicrobial agents and chemotherapy

authors： Safi H,Sayers B,Hazbón MH,Alland D

更新日期：2008-06-01 00:00:00

abstract：:Artemisinin and its derivatives are important new antimalarials which are now used widely in Southeast Asia. Clinically relevant artemisinin resistance has not yet been reported but is likely to occur. In order to understand how the malaria parasite might become resistant to this drug, we studied artemisinin resistanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Walker DJ,Pitsch JL,Peng MM,Robinson BL,Peters W,Bhisutthibhan J,Meshnick SR

更新日期：2000-02-01 00:00:00

abstract：:Antimicrobial photodynamic inactivation (PDI) was shown to be a promising treatment modality for microbial infections. This study explores the effect of chitosan, a polycationic biopolymer, in increasing the PDI efficacy against Gram-positive bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Strep...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsai T,Chien HF,Wang TH,Huang CT,Ker YB,Chen CT

更新日期：2011-05-01 00:00:00

abstract：:Isolates of Aspergillus fumigatus that demonstrate resistance to itraconazole (ITZ) have been described previously; however, the prevalence and clinical significance of ITZ resistance are not completely understood. In this study we assessed the ITZ susceptibilities of 128 A. fumigatus isolates that caused invasive inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Balajee SA,Weaver M,Imhof A,Gribskov J,Marr KA

更新日期：2004-04-01 00:00:00

abstract：:We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaco...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández-Silva F,Capilla J,Mayayo E,Sutton DA,Hernández P,Guarro J

更新日期：2013-12-01 00:00:00

abstract：:Durlobactam (DUR; also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii The safety and pharmacokinetics (PK) of DUR alone and with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lickliter JD,Lawrence K,O'Donnell J,Isaacs R

更新日期：2020-06-23 00:00:00

abstract：:Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family. The synthesis of a focused series of these analogs facilitated exp...

journal_title：Antimicrobial agents and chemotherapy

authors： Inoyama D,Paget SD,Russo R,Kandasamy S,Kumar P,Singleton E,Occi J,Tuckman M,Zimmerman MD,Ho HP,Perryman AL,Dartois V,Connell N,Freundlich JS

更新日期：2018-02-23 00:00:00

abstract：:Resistance of Streptococcus pneumoniae to fluoroquinolones is caused predominantly by amino acid substitutions at positions Ser79 of ParC and Ser81 of GyrA to either Phe or Tyr encoded in the quinolone resistance-determining regions of the parC topoisomerase IV and gyrA DNA gyrase genes. Analysis of highly resistant c...

journal_title：Antimicrobial agents and chemotherapy

authors： Korzheva N,Davies TA,Goldschmidt R

更新日期：2005-06-01 00:00:00

abstract：:We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microd...

journal_title：Antimicrobial agents and chemotherapy

authors： Akaniro JC,Vidaurre CE,Stutman HR,Marks MI

更新日期：1990-10-01 00:00:00

abstract：:Seventy-two (54.5%) out of 132 fecal samples from a group of yellow-legged gulls in Barcelona, Spain, were positive for Escherichia coli producing either extended-spectrum β-lactamases (ESBL) (51.5%), carbapenemase (1.5%), or cephamycinase (1.5%). The isolation of two carbapenemase-producing E. coli strains is a matte...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Pitart C,Montalvo T,Roca I,Sabaté S,Hurtado JC,Planell R,Marco F,Ramírez B,Peracho V,de Simón M,Vila J

更新日期：2017-01-24 00:00:00

abstract：:This study determined the phylogenetic groups and virulence factors of 37 Escherichia coli isolates producing types of CTX-M compared with those of 19 isolates producing different types of extended-spectrum beta-lactamases (ESBLs) in a well-defined North American population. Most CTX-M-14 producers (97%) were from phy...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitout JD,Laupland KB,Church DL,Menard ML,Johnson JR

更新日期：2005-11-01 00:00:00

abstract：:Hard-tick-borne relapsing fever (HTBRF) is an emerging infectious disease throughout the temperate zone caused by the relapsing-fever spirochete Borrelia miyamotoi Antibiotic treatment of HTBRF is empirically based on the treatment of Lyme borreliosis; however, the antibiotic susceptibility of B. miyamotoi has not bee...

journal_title：Antimicrobial agents and chemotherapy

authors： Koetsveld J,Draga ROP,Wagemakers A,Manger A,Oei A,Visser CE,Hovius JW

更新日期：2017-08-24 00:00:00

abstract：:We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobact...

journal_title：Antimicrobial agents and chemotherapy

authors： Barth N,Ribeiro VB,Zavascki AP

更新日期：2015-01-01 00:00:00

abstract：:A new class of pyridine oxide derivatives as inhibitors of human immunodeficiency virus type 1 (HIV-1) and/or HIV-2 replication in cell culture has been identified. The compounds, which specifically inhibit HIV-1, behave as typical nonnucleoside reverse transcriptase inhibitors (NNRTIs). The most active congener of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Stevens M,Pannecouque C,De Clercq E,Balzarini J

更新日期：2003-09-01 00:00:00

abstract：:Candida albicans, an opportunistic fungus, and Staphylococcus aureus, a bacterial pathogen, are two clinically relevant biofilm-forming microbes responsible for a majority of catheter-related infections, with such infections often resulting in catheter loss and removal. Not only do these pathogens cause a substantial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Peters BM,Ward RM,Rane HS,Lee SA,Noverr MC

更新日期：2013-01-01 00:00:00

abstract：:A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis (1), and osteomyelitis (1). The most common bacterial pathogen was Pseudomonas aeruginosa, accounting for eight infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Simon GL,Snydman DR,Tally FP,Gorbach SL

更新日期：1980-07-01 00:00:00

abstract：:Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in b...

journal_title：Antimicrobial agents and chemotherapy

authors： Keith KE,Oyston PC,Crossett B,Fairweather NF,Titball RW,Walsh TR,Brown KA

更新日期：2005-04-01 00:00:00

abstract：:Pharmacodynamic parameters have become increasingly important for the determination of the optimal dosing schedules of antibiotics. In this study, the postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA SMEs), and the sub-MIC effects (SMEs) of roxithromycin, clarithromycin, and azithromycin on refere...

journal_title：Antimicrobial agents and chemotherapy

authors： Odenholt-Tornqvist I,Löwdin E,Cars O

更新日期：1995-01-01 00:00:00

abstract：:The interaction between four fluoroquinolones (ciprofloxacin, norfloxacin, pefloxacin, and ofloxacin) and biofilms of Pseudomonas aeruginosa in wells of microtiter plates and on segments of vascular catheters were studied in an in vitro model of vascular catheter colonization. Subinhibitory concentrations (one-half, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Yassien M,Khardori N,Ahmedy A,Toama M

更新日期：1995-10-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children and other high-risk populations. RSV nucleoprotein (N) is essential for virus assembly and replication as part of the viral ribonucleoprotein (RNP) complex. RSV604 was a putative N inhibitor in phase 2 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Challa S,Scott AD,Yuzhakov O,Zhou Y,Tiong-Yip CL,Gao N,Thresher J,Yu Q

更新日期：2015-02-01 00:00:00

abstract：:Active efflux confers intrinsic resistance to multiple antibiotics in Pseudomonas aeruginosa, including old disused molecules. Beside resistance, intracellular survival is another reason for failure to eradicate bacteria with antibiotics. We evaluated the capacity of polyaminoisoprenyl potentiators (designed as efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang GW,Brunel JM,Bolla JM,Van Bambeke F

更新日期：2020-12-14 00:00:00

abstract：:We have analyzed the contribution of different efflux components to glutathione-mediated abrogation of ciprofloxacin's activity in Escherichia coli and the underlying potential mechanism(s) behind this phenomenon. The results indicated that glutathione increased the total active efflux, thereby partially contributing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goswami M,Subramanian M,Kumar R,Jass J,Jawali N

更新日期：2016-06-20 00:00:00

abstract：:Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix susceptibility. In C...

journal_title：Antimicrobial agents and chemotherapy

authors： Liston SD,Whitesell L,Kapoor M,Shaw KJ,Cowen LE

更新日期：2020-04-21 00:00:00

abstract：:Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Munita JM,Panesso D,Diaz L,Tran TT,Reyes J,Wanger A,Murray BE,Arias CA

更新日期：2012-08-01 00:00:00

abstract：:Leukocyte chemotaxis was inhibited 9.6% compared with control in the presence of 10 mug of gentamicin per ml and 10.5% when exposed to 20 mug of amikacin per ml. However, cells incubated with an injectable form of gentamicin, containing preservatives, were inhibited an additional 25.8% relative to cells incubated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodhart GL

更新日期：1977-10-01 00:00:00