In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials.

abstract：:The emergence of resistance to last-resort antibiotics is a public health concern of global scale. Besides direct person-to-person propagation, environmental pathways might contribute to the dissemination of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Here, we describe the incidence of blaNDM...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantilla-Calderon D,Jumat MR,Wang T,Ganesan P,Al-Jassim N,Hong PY

更新日期：2016-08-22 00:00:00

abstract：:A spontaneous Escherichia coli mutant, named Q3, resistant to nalidixic acid was obtained from a previously described clinical isolate of E. coli, Q2, resistant to fluoroquinolones but susceptible to nalidixic acid (E. Cambau, F. Bordon, E. Collatz, and L. Gutmann, Antimicrob. Agents Chemother. 37:1247-1252, 1993). Q3...

journal_title：Antimicrobial agents and chemotherapy

authors： Truong QC,Nguyen Van JC,Shlaes D,Gutmann L,Moreau NJ

更新日期：1997-01-01 00:00:00

abstract：:Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (W...

journal_title：Antimicrobial agents and chemotherapy

authors： Yui Eto K,Firth N,Davis AM,Kwong SM,Krysiak M,Lee YT,O'Brien FG,Grubb WB,Coombs GW,Bond CS,Ramsay JP

更新日期：2019-10-22 00:00:00

abstract：:Analysis of the transport functions of individual Candida albicans plasma membrane drug efflux pumps is hampered by the multitude of endogenous transporters. We have stably expressed C. albicans Cdr1p, the major pump implicated in multiple-drug-resistance phenotypes, from the genomic PDR5 locus in a Saccharomyces cere...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura K,Niimi M,Niimi K,Holmes AR,Yates JE,Decottignies A,Monk BC,Goffeau A,Cannon RD

更新日期：2001-12-01 00:00:00

abstract：:We have conducted experiments to determine if one daily injection of netilmicin (NET) would be synergistic with the broad-spectrum cephalosporin ceftriaxone (CRO) in the treatment of experimentally induced endocarditis. Rats with catheter-induced aortic vegetations were infected intravenously with 3 x 10(7) CFU of a b...

journal_title：Antimicrobial agents and chemotherapy

authors： Francioli PB,Glauser MP

更新日期：1993-02-01 00:00:00

abstract：:The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycli...

journal_title：Antimicrobial agents and chemotherapy

authors： Shipley PL,Olsen RH

更新日期：1974-08-01 00:00:00

abstract：:Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors. However, it is unknown if the pathway to inhibition by β-lactamase inhibitors for CTX-M ESBLs is similar to TEM an...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethel CR,Taracila M,Shyr T,Thomson JM,Distler AM,Hujer KM,Hujer AM,Endimiani A,Papp-Wallace K,Bonnet R,Bonomo RA

更新日期：2011-07-01 00:00:00

abstract：:Pseudomonas putida is well known for its metabolic capabilities, but recently, it has been shown to exhibit resistance to a wide range of antibiotics. In P. putida DOT-T1E, the TtgABC efflux pump, which has a broad substrate specificity, extrudes antibiotics such as ampicillin, carbenicillin, tetracycline, nalidixic a...

journal_title：Antimicrobial agents and chemotherapy

authors： Terán W,Felipe A,Segura A,Rojas A,Ramos JL,Gallegos MT

更新日期：2003-10-01 00:00:00

abstract：:The radical-based theory proposes that three major classes of bactericidal antibiotics, i.e., β-lactams, quinolones, and aminoglycosides, have in common the downstream formation of lethal levels of reactive oxygen species (ROS) as part of the killing mechanism. If bactericidal antibiotics exhibit a common mechanism, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoeksema M,Brul S,Ter Kuile BH

更新日期：2018-05-25 00:00:00

abstract：:During the second quarter each of 1988, 1989, and 1990, a French collaborative study group, including 12 university hospital laboratories, surveyed the resistance to beta-lactams of clinical isolates from hospitalized patients: consecutively, 10,641, 10,692, and 9,382 isolates were tested. The distribution of bacteria...

journal_title：Antimicrobial agents and chemotherapy

authors： Sirot DL,Goldstein FW,Soussy CJ,Courtieu AL,Husson MO,Lemozy J,Meyran M,Morel C,Perez R,Quentin-Noury C

更新日期：1992-08-01 00:00:00

abstract：:Conventional therapy for human cytomegalovirus (CMV) relies on inhibition of the viral DNA polymerase. Ganciclovir (GCV) is the first-line therapy, but when GCV-resistant strains emerge, alternative therapies are extremely limited and are associated with significant toxicities. Combination of anti-CMV agents that act ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai H,Kapoor A,He R,Venkatadri R,Forman M,Posner GH,Arav-Boger R

更新日期：2014-01-01 00:00:00

abstract：:Neisseria meningitidis has been relatively slow to acquire resistance to penicillin. We previously reported an increase in the incidence of invasive meningococcal disease (IMD) strains with decreased susceptibility to penicillin (DSP) in Ontario. Our objectives were to evaluate trends in IMD with DSP, to identify case...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown EM,Fisman DN,Drews SJ,Dolman S,Rawte P,Brown S,Jamieson F

更新日期：2010-03-01 00:00:00

abstract：:Eighty-five patients with cystic fibrosis who were experiencing an acute infectious exacerbation of their disease were randomized in double-blind fashion to receive either 50 or 75 mg of ceftazidime per kg (body weight) per dose administered intravenously every 8 h for 14 days. Three patients were dropped from the stu...

journal_title：Antimicrobial agents and chemotherapy

authors： Reed MD,Stern RC,O'Brien CA,Crenshaw DA,Blumer JL

更新日期：1987-05-01 00:00:00

abstract：:Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium rel...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen WC,Chou DL,Feingold DS

更新日期：1978-06-01 00:00:00

abstract：:Subtherapeutic levels of oxytetracycline plus neomycin in animal feeds did not bring about increases in the quantity, prevalence, or shedding of Salmonella typhimurium in swine, calves, or chickens. In fact, the medication generally reduced the proportion of animals carrying S. typhimurium. The medicated groups were f...

journal_title：Antimicrobial agents and chemotherapy

authors： Girard AE,English AR,Evangelisti DG,Lynch JE,Solomons IA

更新日期：1976-07-01 00:00:00

abstract：:Arguably, one of the most common and consequential laboratory tests performed in the world is Mycobacterium tuberculosis susceptibility testing. M. tuberculosis resistance is defined by growth of > or =1% of a bacillary inoculum on the critical concentration of an antibiotic. The critical concentration was chosen base...

journal_title：Antimicrobial agents and chemotherapy

authors： Gumbo T

更新日期：2010-04-01 00:00:00

abstract：:GV129606 is a new parenteral trinem antibiotic belonging to the beta-lactam class. It combines broad-spectrum activity (against gram-negative and -positive bacteria, aerobes and anaerobes), with high potency and resistance to beta-lactamases. Comparative in vitro and in vivo antibacterial activities were determined fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Di Modugno E,Broggio R,Erbetti I,Lowther J

更新日期：1997-12-01 00:00:00

abstract：:PSI-352938 is a novel cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine 5'-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with other inhibitors of H...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam AM,Espiritu C,Murakami E,Zennou V,Bansal S,Micolochick Steuer HM,Niu C,Keilman M,Bao H,Bourne N,Veselenak RL,Reddy PG,Chang W,Du J,Nagarathnam D,Sofia MJ,Otto MJ,Furman PA

更新日期：2011-06-01 00:00:00

abstract：:A PCR-based technique using new fluorescent probes, called molecular beacons, was developed to detect the antifolate resistance-associated S108N point mutation in Plasmodium falciparum. One hundred African clinical isolates were tested by the new method in comparison with the PCR-restriction fragment length polymorphi...

journal_title：Antimicrobial agents and chemotherapy

authors： Durand R,Eslahpazire J,Jafari S,Delabre JF,Marmorat-Khuong A,di Piazza JP,Le Bras J

更新日期：2000-12-01 00:00:00

abstract：:Increased expression of chromosomal genes for resistance-nodulation-cell division (RND)-type efflux systems plays a major role in the multidrug resistance (MDR) of Acinetobacter baumannii. However, the relative contributions of the three most prevalent pumps, AdeABC, AdeFGH, and AdeIJK, have not been evaluated in clin...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoon EJ,Courvalin P,Grillot-Courvalin C

更新日期：2013-07-01 00:00:00

abstract：:Disk diffusion antibiotic susceptibility tests as performed by the hospital diagnostic microbiology laboratory were read at 4, 8, and 12 h of incubation and compared to the traditional 18-h readings. Both the zone size in millimeters and a judgement of susceptible or resistant were recorded by the investigator at each...

journal_title：Antimicrobial agents and chemotherapy

authors： Kluge RM

更新日期：1975-08-01 00:00:00

abstract：:Enterococcus gallinarum N04-0414 (MIC for vancomycin, 256 microg/ml) harbored a vanD-type vancomycin resistance operon as well as the intrinsic vanC1 operon. The D-Ala:D-Ala ligase 2 gene (ddl2) was not present in the strain, though it is found downstream of the vanS gene from the vanC operon in E. gallinarum ATCC 495...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd DA,Miller MA,Mulvey MR

更新日期：2006-03-01 00:00:00

abstract：:Seasonal and pandemic influenza causes 650,000 deaths annually in the world. The emergence of drug resistance to specific anti-influenza virus drugs such as oseltamivir and baloxavir marboxil highlights the urgency of novel anti-influenza chemical entity discovery. In this study, we report a series of novel thiazolide...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao L,Yan Y,Dai Q,Li X,Xu K,Zou G,Yang K,Li W,Guo X,Yang J,Li Y,Xia Q,Cao R,Zhong W

更新日期：2020-06-23 00:00:00

abstract：:The small-colony-variant (SCV) phenotype of Staphylococcus aureus has been associated with difficult-to-treat infections, reduced antimicrobial susceptibility, and intracellular persistence. This study represents a detailed intra- and extracellular investigation of a clinical wild-type (WT) S. aureus strain and its co...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandberg A,Lemaire S,Van Bambeke F,Tulkens PM,Hughes D,von Eiff C,Frimodt-Møller N

更新日期：2011-04-01 00:00:00

abstract：:Mutations in the rifampin resistance-determining (Rif) regions of the rpoB gene of Staphylococcus aureus mutants obtained during therapy or in vitro were analyzed by gene amplification and sequencing. Each of the resistant clinical isolates, including five nonrelated clones and two strains isolated from the same patie...

journal_title：Antimicrobial agents and chemotherapy

authors： Aubry-Damon H,Soussy CJ,Courvalin P

更新日期：1998-10-01 00:00:00

abstract：:The effects of an antacid containing magnesium and aluminum hydroxide on the pharmacokinetics of pefloxacin in 10 healthy volunteers were investigated. In a randomized crossover design, each subject received an oral dose of 400 mg of pefloxacin either with or without multiple doses of the antacid. The concentrations o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaehde U,Sörgel F,Stephan U,Schunack W

更新日期：1994-05-01 00:00:00

abstract：:Acquiring iron (Fe) is critical to the metabolism and growth of Mycobacterium tuberculosis. Disruption of Fe metabolism is a potential approach for novel antituberculous therapy. Gallium (Ga) has many similarities to Fe. Biological systems are often unable to distinguish Ga(3+) from Fe(3+). Unlike Fe(3+), Ga(3+) canno...

journal_title：Antimicrobial agents and chemotherapy

authors： Olakanmi O,Kesavalu B,Pasula R,Abdalla MY,Schlesinger LS,Britigan BE

更新日期：2013-12-01 00:00:00

abstract：:Various doses of amphotericin B encapsulated into unilamellar vesicles of 0.1 micron diameter (lip-AMB) (1.0 to 20.0 mg/kg of body weight) were compared with free amphotericin B (AMB) (0.5 to 2.0 mg/kg of body weight) in a murine model of disseminated candidiasis. CD2F1 mice injected intravenously with 3 x 10(5) Candi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gondal JA,Swartz RP,Rahman A

更新日期：1989-09-01 00:00:00

abstract：:BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

journal_title：Antimicrobial agents and chemotherapy

authors： Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

更新日期：2019-05-24 00:00:00

abstract：:Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic w...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryson D,Hettle AG,Boraston AB,Hobbs JK

更新日期：2020-02-21 00:00:00