Characteristics and expression of tetracycline resistance in gram-negative bacteria carrying the Pseudomonas R factor RP1.

abstract：:CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested being less than or equal to 1 microgram/ml. The compound was from 10- to 100-fold more active than...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz T,Retsema J,Girard A,Hamanaka E,Anderson M,Sokolowski S

更新日期：1989-08-01 00:00:00

abstract：:Helicobacter pylori is a major etiological agent in gastroduodenal disorders. The adhesion of H. pylori to human gastric epithelial cells is the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in the prevention of H. pylori infection. Experiments were performed to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayashi S,Sugiyama T,Amano K,Isogai H,Isogai E,Aihara M,Kikuchi M,Asaka M,Yokota K,Oguma K,Fujii N,Hirai Y

更新日期：1998-08-01 00:00:00

abstract：:Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including c...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen B,Noller HF,Daubresse G,Oliva B,Misulovin Z,Rothstein DM,Ellestad GA,Gluzman Y,Tally FP,Chopra I

更新日期：1991-11-01 00:00:00

abstract：:Strains of Pseudomonas aeruginosa resistant to either gentamicin or carbenicillin have been noted since their introduction into clinical use. During a 6-month period, twice-weekly cultures were obtained from all patients treated with either gentamicin or carbenicillin and from all patients with a positive culture for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaman W,Cates C,Snelling CF,Lank B,Ronald AR

更新日期：1976-03-01 00:00:00

abstract：:The pharmacokinetics of teicoplanin were determined after multiple 30-min intravenous infusions of 10 to 15 mg/kg every 12 to 24 h in 11 intravenous drug abuse (IVDA) patients being treated for bacterial endocarditis. Multiple serum samples were obtained over 7 to 14 days. Twenty-four-hour urine collections were obtai...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak MJ,Lerner SA,Levine DP,Albrecht LM,McNeil PL,Thompson GA,Kenny MT,Yuh L

更新日期：1991-04-01 00:00:00

abstract：:The in vitro activities of extracts of Nigerian chewing sticks against Bacteroides gingivalis and B. melaninogenicus are presented. The greatest inhibitory action was produced by Serindeia werneckei, whereas Fagara zanthoxyloides produced no appreciable inhibitory effect. A generally good correlation was found between...

journal_title：Antimicrobial agents and chemotherapy

authors： Rotimi VO,Laughon BE,Bartlett JG,Mosadomi HA

更新日期：1988-04-01 00:00:00

abstract：:We describe the first IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19, which differed from IMP-2 by a single amino acid change (Arg to Ala at position 38). bla(IMP-19) was found within a class 1 integron located on a 35-kb plasmid. This is also the first description of an IMP producer in France. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Neuwirth C,Siebor E,Robin F,Bonnet R

更新日期：2007-12-01 00:00:00

abstract：:Ciprofloxacin is active in vitro against most bacteria that cause peritonitis associated with peritoneal dialysis. We compared the effects of pH (5.5 and 7.4) and medium (dialysis fluid) on the bactericidal activity of ciprofloxacin, tobramycin, vancomycin plus rifampin, and rifampin against Pseudomonas aeruginosa, Es...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormick EM,Echols RM

更新日期：1987-04-01 00:00:00

abstract：:New drugs are needed to shorten the duration of tuberculosis treatment. R207910, a diarylquinoline, is very active against Mycobacterium tuberculosis both in vitro and in mice. In healthy volunteers, the coadministration of R207910 and rifampin induced the increased metabolism of R207910, resulting in a 50% reduction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Gevers T,Van Den Berg J,Andries K

更新日期：2008-10-01 00:00:00

abstract：:The role of extracellular DNA in the maintenance of biofilms formed by gram-positive and gram-negative bacteria was studied. This study evaluated all the bacterial strains that were tested for the presence of extracellular DNA with an average size of 30 kb in the matrix. Our results indicate changes in community bioma...

journal_title：Antimicrobial agents and chemotherapy

authors： Tetz GV,Artemenko NK,Tetz VV

更新日期：2009-03-01 00:00:00

abstract：:Several antibiotics have disulfiram-like effects; we evaluated disulfiram for its antibiotic-like effects. Disulfiram inhibited the in vitro growth of methicillin-resistant Staphylococcus aureus, with an MIC of 1.33 micrograms/ml, but was not effective against members of the family Enterobacteriaceae or Pseudomonas sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Phillips M,Malloy G,Nedunchezian D,Lukrec A,Howard RG

更新日期：1991-04-01 00:00:00

abstract：:Oseltamivir is the most widely used anti-influenza drug. In the 2009 H1N1 pandemic, in which the influenza viruses were oseltamivir sensitive, obesity was identified as a risk factor for severe disease and unfavorable outcomes. The aim of this study was to investigate the pharmacokinetic properties of oseltamivir and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jittamala P,Pukrittayakamee S,Tarning J,Lindegardh N,Hanpithakpong W,Taylor WR,Lawpoolsri S,Charunwattana P,Panapipat S,White NJ,Day NP

更新日期：2014-01-01 00:00:00

abstract：:A prospective, randomized, and double-blind study comparing teicoplanin with vancomycin in the initial management of febrile neutropenic patients was conducted. Teicoplanin was administered at 6 mg per kg of body weight every 24 h (q24h) intravenously (i.v.) after initial loading at 6 mg/kg q12h for three doses. Vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Kureishi A,Jewesson PJ,Rubinger M,Cole CD,Reece DE,Phillips GL,Smith JA,Chow AW

更新日期：1991-11-01 00:00:00

abstract：:We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Bebrone C,Huang TD,Bouchahrouf W,Degheldre Y,Deplano A,Hoffmann K,Glupczynski Y

更新日期：2012-06-01 00:00:00

abstract：:The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effects of single nucleotide polymorphisms (SNPs) in cytochrome P450 isoenzyme genes (CYP, n...

journal_title：Antimicrobial agents and chemotherapy

authors： Staehli Hodel EM,Csajka C,Ariey F,Guidi M,Kabanywanyi AM,Duong S,Decosterd LA,Olliaro P,Beck HP,Genton B

更新日期：2013-02-01 00:00:00

abstract：:The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by eit...

journal_title：Antimicrobial agents and chemotherapy

authors： Mishin VP,Hayden FG,Gubareva LV

更新日期：2005-11-01 00:00:00

abstract：:A combination of 3 g of ticarcillin and 200 mg of clavulanic acid was administered intravenously to six healthy male volunteers, after which the concentrations of these agents in serum and blister fluid were measured. The ratio of the two drugs in serum varied from 15:1 (ticarcillin-clavulanic acid) at the time of adm...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett S,Wise R,Weston D,Dent J

更新日期：1983-06-01 00:00:00

abstract：:CTX-M-type extended-spectrum beta-lactamases (ESBLs) have become increasingly common worldwide, with the notable exception of the United States, where TEM- and SHV-type ESBLs have appeared to predominate. We have noted the emergence of ESBLs in our health care system (the University Health System in San Antonio, TX), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lewis JS 2nd,Herrera M,Wickes B,Patterson JE,Jorgensen JH

更新日期：2007-11-01 00:00:00

abstract：:The in vitro activities of tedizolid and 10 antistaphylococcal agents were compared against 111 methicillin-resistant Staphylococcus aureus (MRSA) strains from 14 epidemiologically characterized groups. Tedizolid, tigecycline, and daptomycin were the most potent agents, with tedizolid 4-fold more potent than linezolid...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson KS,Goering RV

更新日期：2013-06-01 00:00:00

abstract：:Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Cane PA,Cook P,Ratcliffe D,Mutimer D,Pillay D

更新日期：1999-07-01 00:00:00

abstract：:Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008...

journal_title：Antimicrobial agents and chemotherapy

authors： Peel TN,Cheng AC,Buising KL,Choong PF

更新日期：2012-05-01 00:00:00

abstract：:The purpose of this study was to compare the activity of HMR 1043 with those of daptomycin and teicoplanin against gram-positive isolates. Susceptibility tests were performed for 52 strains, 26 parental strains, including staphylococcal, streptococcal, enterococcal, and listerial strains, and 26 HMR 1043-resistant mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Bemer P,Juvin ME,Bryskier A,Drugeon H

更新日期：2003-09-01 00:00:00

abstract：:The MIC of an antimalarial drug for a particular infection is the drug level associated with a net parasite multiplication rate of one per asexual cycle. To ensure the cure of malaria, the MIC must be exceeded until all parasites have been eliminated. The development of highly sensitive and accurate PCR quantitation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Hien TT,White NJ,Thuy-Nhien NT,Hoa NT,Thuan PD,Tarning J,Nosten F,Magnusson B,Jain JP,Hamed K

更新日期：2017-01-24 00:00:00

abstract：:The antimicrobial activities of BMY-28142, cefbuperazone (BMY-25182; formerly T-1982), and cefpiramide (WY-44635; formerly SM-1652) were compared with those of cefmenoxime, cefoperazone, cefotaxime, ceftizoxime, and moxalactam. BMY-28142 was the most active cephalosporin against the majority of aerobic and facultative...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan NJ,Bihl JA,Schell RF,LeFrock JL,Weber SJ

更新日期：1984-10-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura N,Mitsuhashi S

更新日期：1995-09-01 00:00:00

abstract：:We adopted an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VAN), arbekacin (ABK), and gentamicin (GEN) alone or in combination. Using two strains of clinically isolated methicillin-resistant Staphylococcus aureus, one GEN susceptible (GS171) and one GEN resistant (GR153), fibrin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee DG,Chun HS,Yim DS,Choi SM,Choi JH,Yoo JH,Shin WS,Kang MW

更新日期：2003-12-01 00:00:00

abstract：:Ketoconazole, an oral antimycotic imidazole drug, blocked the transport of electrons in the respiratory chain of Candida albicans under aerobic conditions with different substrates, such as NADH and succinate. This effect was a nonspecific inhibition of NADH oxidases and succinate oxidases. The addition of ketoconazol...

journal_title：Antimicrobial agents and chemotherapy

authors： Shigematsu ML,Uno J,Arai T

更新日期：1982-06-01 00:00:00

abstract：:The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiner N,Williams N,Birch G,Ramachandran C,Shipman C Jr,Flynn G

更新日期：1989-08-01 00:00:00

abstract：:The susceptibilities of 87 periodontitis-associated strains of Actinobacillus actinomycetemcomitans to clarithromycin and erythromycin were determined by standard methodology recommended for Haemophilus influenzae. For clarithromycin the MIC at which 90% of the isolates were inhibited was

journal_title：Antimicrobial agents and chemotherapy

authors： Piccolomini R,Catamo G,Di Bonaventura G

更新日期：1998-11-01 00:00:00