Effect of peritoneal dialysis fluid and pH on bactericidal activity of ciprofloxacin.

abstract：:Hydrophilic albumin microspheres are proposed as a new delivery system for amphotericin B (AMB; AMB microspheres). The acute toxicity of AMB microspheres was lower than that of the AMB-deoxycholate (AMB-Doc) reference formulation in hamsters. Lethal doses in healthy and infected animals were improved at least eight ti...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez-Brunete JA,Dea MA,Rama S,Bolás F,Alunda JM,Raposo R,Méndez MT,Torrado-Santiago S,Torrado JJ

更新日期：2004-09-01 00:00:00

abstract：:Approximately 39% of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 239 (ST239)-like bloodstream isolates from Liverpool Hospital (obtained between 1997 and 2008) carry an arginine catabolic mobile element (ACME). Whole-genome sequencing revealed that an ACME II variant is located between orfX and SC...

journal_title：Antimicrobial agents and chemotherapy

authors： Espedido BA,Steen JA,Barbagiannakos T,Mercer J,Paterson DL,Grimmond SM,Cooper MA,Gosbell IB,van Hal SJ,Jensen SO

更新日期：2012-06-01 00:00:00

abstract：:The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodrigues M,McBride SW,Hullahalli K,Palmer KL,Duerkop BA

更新日期：2019-10-22 00:00:00

abstract：:A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rafiq Y,Jabeen K,Hasan R,Jafri S,Laiq R,Malik F,Mangi R,Channa A,Hasan Z

更新日期：2011-02-01 00:00:00

abstract：:We previously reported the development of a prototype antibiotic sensitivity assay to detect drug-resistant Mycobacterium tuberculosis using infection by mycobacteriophage to create a novel nucleic acid transcript, a surrogate marker of mycobacterial viability, detected by reverse transcriptase PCR (M. C. Mulvey et al...

journal_title：Antimicrobial agents and chemotherapy

authors： Mulvey MC,Lemmon M,Rotter S,Lees J,Einck L,Nacy CA

更新日期：2015-01-01 00:00:00

abstract：:Sporangiomycin and micrococcin inhibit the binding of aminoacyl-transfer ribonucleic acid into the ribosomal A site in intact bacterial protoplasts. They also prevent the assembly of [ribosome-elongation factor G-guanine nucleotide] complexes in vitro and compete with [(35)S]thiostrepton for ribosomal binding sites. W...

journal_title：Antimicrobial agents and chemotherapy

authors： Cundliffe E,Dixon PD

更新日期：1975-07-01 00:00:00

abstract：:Preliminary studies showed that roxithromycin possessed significant in vitro activity against a variety of atypical mycobacteria such as the Mycobacterium avium complex, M. scrofulaceum, M. szulgai, M. malmoense, M. xenopi, M. marinum, and M. kansasii and rare pathogens such as M. chelonae and M. fortuitum. In this in...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Goh KS,Bryskier A

更新日期：1994-06-01 00:00:00

abstract：:Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥ 0.064 μg/ml but not among isolates with MICs of ≤ 0.032 μg/ml. Experimental infection of cipr...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong E,Thulin Hedberg S,Abad R,Fazio C,Enríquez R,Deghmane AE,Jolley KA,Stefanelli P,Unemo M,Vazquez JA,Veyrier FJ,Taha MK

更新日期：2013-04-01 00:00:00

abstract：:Treatment of Mycobacterium abscessus infections is extremely challenging due to its intrinsic resistance to most antibiotics, and research of pathogenesis is limited due to a lack of a practical in vivo model of infection. The objective of this study was to establish a simple in vivo model for M. abscessus infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meir M,Grosfeld T,Barkan D

更新日期：2018-03-27 00:00:00

abstract：:The in vitro activity of tosufloxacin (A-61827; T-3262) against 15 clinical isolates of Chlamydia trachomatis and 31 recent clinical isolates of Neisseria gonorrhoeae, including 15 spectinomycin-resistant N. gonorrhoeae and 16 penicillinase-producing N. gonorrhoeae, was determined. Tosufloxacin was compared with doxyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Segreti J,Hirsch DJ,Harris AA,Kapell KS,Orbach H,Kessler HA

更新日期：1990-06-01 00:00:00

abstract：:Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds and has thus accelerated the process of drug discovery against H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Hosmillo M,Emmott E,Lu J,Goodfellow I

更新日期：2018-04-26 00:00:00

abstract：:In Pseudomonas aeruginosa, the quorum-sensing (QS) system is closely related to biofilm formation. We previously demonstrated that 14-alpha-lipoyl andrographolide (AL-1) has synergistic effects on antibiofilm and antivirulence factors (pyocyanin and exopolysaccharide) of P. aeruginosa when combined with conventional a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma L,Liu X,Liang H,Che Y,Chen C,Dai H,Yu K,Liu M,Ma L,Yang CH,Song F,Wang Y,Zhang L

更新日期：2012-12-01 00:00:00

abstract：:We assessed prophylactic or continuous therapy of isavuconazole, posaconazole, or voriconazole in treating pulmonary murine mucormycosis. In the prophylaxis studies, only isavuconazole treatment resulted in significantly improved survival and lowered tissue fungal burden of immunosuppressed mice infected with Rhizopus...

journal_title：Antimicrobial agents and chemotherapy

authors： Gebremariam T,Alkhazraji S,Baldin C,Kovanda L,Wiederhold NP,Ibrahim AS

更新日期：2017-04-24 00:00:00

abstract：:An in vitro tissue culture system consisting of reaggregated embryonic brain cells was used to evaluate the inhibition of herpes simplex type 1 (HSV-1) by several antiviral compounds. The efficacy of acyclovir, vidarabine, bromovinyldeoxyuridine, and 9-(1,3-dihydroxy-2-propoxymethyl) guanine in HSV-1-infected Vero cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Pulliam L,Panitch HS,Baringer JR,Dix RD

更新日期：1986-12-01 00:00:00

abstract：:Pairs of 11 antimicrobial agents were tested in vitro for their ability to act synergistically against three strains of Mycobacterium avium complex isolated from patients with acquired immune deficiency syndrome. From the combinations tested, four drugs (ethambutol, rifampin, ciprofloxacin, and erythromycin) were sele...

journal_title：Antimicrobial agents and chemotherapy

authors： Yajko DM,Kirihara J,Sanders C,Nassos P,Hadley WK

更新日期：1988-09-01 00:00:00

abstract：:A sensitive and specific high-pressure liquid chromatographic method is described for the determination of the antibacterial drug flumequine and a major metabolite, 7-hydroxyflumequine, in human plasma and urine. The assay was linear over a concentration range of 1 to 120 micrograms/ml for both compounds. This method ...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison LI,Schuppan D,Rohlfing SR,Hansen AR,Hansen CS,Funk ML,Collins SH,Ober RE

更新日期：1984-03-01 00:00:00

abstract：:The etiological treatment of Chagas disease remains neglected. The compounds available show several limitations, mainly during the chronic phase. Lychnopholide encapsulated in polymeric nanocapsules (LYC-NC) was efficacious in mice infected with Trypanosoma cruzi and treated by intravenous administration during the ac...

journal_title：Antimicrobial agents and chemotherapy

authors： de Mello CG,Branquinho RT,Oliveira MT,Milagre MM,Saúde-Guimarães DA,Mosqueira VC,Lana Md

更新日期：2016-08-22 00:00:00

abstract：:Helicobacter pylori is killed in vitro by polyoxyethylene acyl esters and ethers similar to simethicone emulsifiers in therapeutic antifoams. The MBC of these compounds for Helicobacter pylori was less than 20 micrograms/ml, while other gram-negative bacteria were unaffected by much higher concentrations of up to 50 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Kane AV,Plaut AG

更新日期：1996-02-01 00:00:00

abstract：:Various doses of amphotericin B encapsulated into unilamellar vesicles of 0.1 micron diameter (lip-AMB) (1.0 to 20.0 mg/kg of body weight) were compared with free amphotericin B (AMB) (0.5 to 2.0 mg/kg of body weight) in a murine model of disseminated candidiasis. CD2F1 mice injected intravenously with 3 x 10(5) Candi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gondal JA,Swartz RP,Rahman A

更新日期：1989-09-01 00:00:00

abstract：:We investigated the impact of low-level resistance to fluoroquinolones on the bactericidal activity of ciprofloxacin in a murine model of urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] of 0.008 microg/ml) was compared to its transconjugants harboring qnrA1 or qnrS1...

journal_title：Antimicrobial agents and chemotherapy

authors： Allou N,Cambau E,Massias L,Chau F,Fantin B

更新日期：2009-10-01 00:00:00

abstract：:Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of both NTPase isoforms (...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai T,Takeuchi T,Diffenderfer J,Sibley LD

更新日期：2002-08-01 00:00:00

abstract：:Current data indicate that once-daily aminoglycoside therapy is as efficacious as traditional multiple daily dosing and equally or less toxic. Our experience with once-daily gentamicin, 6 mg/kg of body weight led to a 10% (3 of 33 patients) occurrence of documented ototoxicity after prolonged aminoglycoside exposure. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Singer C,Smith C,Krieff D

更新日期：1996-09-01 00:00:00

abstract：:The pathogenic yeast Candida albicans displays at its cell surface beta-1,2 oligomannosides (beta-1,2-Mans). In contrast to the ubiquitous alpha-Mans, beta-1,2-Mans bind to galectin-3, a major endogenous lectin expressed on epithelial cells. The specific role of beta-1,2-Mans in colonization of the gut by C. albicans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dromer F,Chevalier R,Sendid B,Improvisi L,Jouault T,Robert R,Mallet JM,Poulain D

更新日期：2002-12-01 00:00:00

abstract：:The 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (CMV) challenge in weanling or neonatal mice when administered before virus challenge. This protection was dependent upon the dosage of pyrimidinone administered. Wean...

journal_title：Antimicrobial agents and chemotherapy

authors： Brideau RJ,Wolcott JA

更新日期：1985-10-01 00:00:00

abstract：:Acyclovir cream has been available for the treatment of herpes labialis in numerous countries outside the United States for over a decade. Evidence for its efficacy comes from a few small clinical trials conducted in the 1980s. To examine more comprehensively the efficacy and safety of this formulation, we conducted t...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Nett R,Marbury T,Wolff R,Johnson J,Spaulding T

更新日期：2002-07-01 00:00:00

abstract：:Twenty-four Staphylococcus species and their subspecies were examined for their susceptibilities to teicoplanin by disk diffusion (30-micrograms disk) and agar dilution for the determination of MICs. Moderately susceptible and resistant clinical strains were further tested for their susceptibilities to oxacillin and v...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannerman TL,Wadiak DL,Kloos WE

更新日期：1991-09-01 00:00:00

abstract：:The penetration of ciprofloxacin into heart tissue (valve and myocardium), mediastinal fat, and sternal bone marrow was the object of a prospective nonrandomized study involving 36 patients undergoing mitral and/or aortic valve replacement. Patients were divided into two groups of 18. Group 1 patients were administere...

journal_title：Antimicrobial agents and chemotherapy

authors： Mertes PM,Voiriot P,Dopff C,Scholl H,Clavey M,Villemot JP,Canton P,Dureux JB

更新日期：1990-03-01 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00

abstract：:Data for a total of 164 bloodstream infection cases due to carbapenem-resistant Enterobacteriaceae (CRE) from 2013 to 2017 were retrospectively collected from 36 tertiary hospitals in 19 provinces in China to evaluate the outcomes and risk factors for mortality by univariable and multivariable analysis. The most frequ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang X,Wang Q,Cao B,Sun S,Zhang Y,Gu B,Li B,Liao K,Zhao F,Jin L,Jin C,Yang C,Pei F,Zhang Z,Wang H

更新日期：2018-12-21 00:00:00

abstract：:A collection of 2,278 isolates belonging to 86 different fungal species was tested with micafungin and eight other drugs using the EUCAST procedures. Micafungin was active against species of Candida and Aspergillus (even azole-resistant species) as well as Penicillium spp., Scedosporium apiospermum, and Acremonium spp...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Gomez-Lopez A,Mellado E,Monzon A,Buitrago MJ,Rodriguez-Tudela JL

更新日期：2009-05-01 00:00:00