Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.

abstract：:Antibacterial agents disrupt the ecological balance of the normal human microflora. Tigecycline, a member of a new class of antibiotics (glycylcyclines), has been shown to have a potent broad-spectrum activity against most gram-positive and gram-negative aerobic and anaerobic bacteria. The aim of the study was to inve...

journal_title：Antimicrobial agents and chemotherapy

authors： Nord CE,Sillerström E,Wahlund E

更新日期：2006-10-01 00:00:00

abstract：:Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role of β-lactamase in th...

journal_title：Antimicrobial agents and chemotherapy

authors： Hengzhuang W,Ciofu O,Yang L,Wu H,Song Z,Oliver A,Høiby N

更新日期：2013-01-01 00:00:00

abstract：:Intragastric inoculation of mice with Klebsiella pneumoniae can cause liver abscesses, necrosis of liver tissues, and bacteremia. A newly isolated phage (φNK5) with lytic activity for K. pneumoniae was used to treat K. pneumoniae infection in an intragastric model. Both intraperitoneal and intragastric administration ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hung CH,Kuo CF,Wang CH,Wu CM,Tsao N

更新日期：2011-04-01 00:00:00

abstract：:In light of the need for new antifungal regimens, we report that at noncandidacidal concentrations, the lactoferrin-derived peptide hLF(1-11), which is highly active against fluconazole-resistant Candida albicans, acts synergistically with fluconazole against this yeast and a fluconazole-sensitive C. albicans strain a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lupetti A,Paulusma-Annema A,Welling MM,Dogterom-Ballering H,Brouwer CP,Senesi S,Van Dissel JT,Nibbering PH

更新日期：2003-01-01 00:00:00

abstract：:The in vitro activities of two new carboxyquinolones, A-56619 (difloxacin) and A-56620, were compared with those of ciprofloxacin, norfloxacin, and ofloxacin against genital tract pathogens. All the quinolones were highly active against Neisseria gonorrhoeae. A-56619 had the lowest MICs against Chlamydia trachomatis (...

journal_title：Antimicrobial agents and chemotherapy

authors： Liebowitz LD,Saunders J,Fehler G,Ballard RC,Koornhof HJ

更新日期：1986-12-01 00:00:00

abstract：:We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

更新日期：2002-02-01 00:00:00

abstract：:Mechanism-based inactivators of beta-lactamases are used to overcome the resistance of clinical pathogens to beta-lactam antibiotics. This strategy can itself be overcome by mutations of the beta-lactamase that compromise the effectiveness of their inactivation. We used PCR mutagenesis of the TEM-1 beta-lactamase gene...

journal_title：Antimicrobial agents and chemotherapy

authors： Vakulenko SB,Geryk B,Kotra LP,Mobashery S,Lerner SA

更新日期：1998-07-01 00:00:00

abstract：:The indinavir dosage regimen currently used for human immunodeficiency virus (HIV)-infected children is not based on pharmacokinetic data obtained in the target patient population. The purpose of our study was to characterize indinavir pharmacokinetics and pharmacodynamics in HIV-infected children. Eleven children (ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Vigano' A,Sala N,Vella S,Bassetti M,Bassetti D,Principi N

更新日期：2000-03-01 00:00:00

abstract：:Gentamicin is a commonly used antibiotic for the treatment of gram-negative-bacterial infections. Bacterial endotoxin is liberated during antibiotic therapy, and we have shown that endotoxemic animals accumulate more aminoglycosides in their renal parenchyma than normal animals. Vasoactive mediators, such as prostagla...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron MG,Bergeron Y,Tardif M,Marchand S,Beauchamp D

更新日期：1989-08-01 00:00:00

abstract：:Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang TS,Liu YC,Sy CL,Chen YS,Tu HZ,Chen BC

更新日期：2008-06-01 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:Ribonucleic acid (RNA) synthesis in the sorbitol-dependent, fragile yeast mutant VY1160 (Venkov et al., 1974) is rapidly inhibited by rifampin. The growth of the mutant cells and protein synthesis are more slowly affected by the antibiotic, apparently as secondary phenomena. Lower doses of rifampin (50 to 100 mug/ml) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkov PV,Milchev GI,Hadjiolov AA

更新日期：1975-12-01 00:00:00

abstract：:A total of 4,226 Spanish clinical isolates of Candida spp. were analyzed to assess resistance to voriconazole according to breakpoints established by the European Committee for Antimicrobial Susceptibility Testing (where susceptibility [S] to voriconazole corresponds to a MIC of ≤ 0.12 mg/liter). Resistance was uncomm...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Gomez-Lopez A,Cuesta I,Zaragoza O,Mellado E,Rodriguez-Tudela JL,Antifungal Subcommittee of European Committee on Antimicrobial Susceptibility Testing.

更新日期：2011-04-01 00:00:00

abstract：:Many Pseudomonas aeruginosa isolates from the airways of patients with cystic fibrosis (CF) are sensitive to antibiotics in susceptibility testing, but eradication of the infection is difficult. The main reason is the biofilm formation in the airways of patients with CF. The pharmacokinetics (PKs) and pharmacodynamics...

journal_title：Antimicrobial agents and chemotherapy

authors： Hengzhuang W,Wu H,Ciofu O,Song Z,Høiby N

更新日期：2012-05-01 00:00:00

abstract：:aac(6')-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6')-Ib-cr gene cassette and found that it contribut...

journal_title：Antimicrobial agents and chemotherapy

authors： Raherison S,Jove T,Gaschet M,Pinault E,Tabesse A,Torres C,Ploy MC

更新日期：2017-04-24 00:00:00

abstract：:Cyclic phosphate derivative of DHPG, 2'-nor-cGMP [9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]-guani ne phosphate-oxide] was evaluated for activity against guinea pig cytomegalovirus (GPCMV) infection in cultured guinea pig embryo cells and in guinea pigs. By virus yield reduction and plaque reduction assays,...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang ZH,Lucia HL,Tolman RL,Colonno RJ,Hsiung GD

更新日期：1989-09-01 00:00:00

abstract：:The need for novel antibacterial strategies and the awareness of the importance of quorum sensing (QS) in bacterial infections have stimulated research aimed at identifying QS inhibitors (QSIs). However, clinical application of QSIs identified so far is still distant, likely due to their unsuitability for use in human...

journal_title：Antimicrobial agents and chemotherapy

authors： Imperi F,Massai F,Ramachandran Pillai C,Longo F,Zennaro E,Rampioni G,Visca P,Leoni L

更新日期：2013-02-01 00:00:00

abstract：:The effect of the cephalosporin precursors and amino acids of the aspartic acid family on antibiotic production by Streptomyces clavuligerus was investigated DL-meso-Diaminopimelate and L-lysine each stimulated specific antibiotic production by 75%. A fourfold increase in specific production was obtained by simultaneo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendelovitz S,Aharonowitz Y

更新日期：1982-01-01 00:00:00

abstract：:Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study, the susceptibilities of 40 A. fumigatus clinical isolates were tested by using the CLSI method with amphotericin B, itraconazo...

journal_title：Antimicrobial agents and chemotherapy

authors： Gregson L,Goodwin J,Johnson A,McEntee L,Moore CB,Richardson M,Hope WW,Howard SJ

更新日期：2013-11-01 00:00:00

abstract：:Thirty-five strains of Pasteurella multocida from humans and animals were tested for susceptibility to five cephalosporins by a broth dilution method. Cefcanel showed high activity against all isolates (MIC and MBC, less than or equal to 0.64 micrograms/ml). The corresponding figure for cefaclor and cefuroxime was 2.5...

journal_title：Antimicrobial agents and chemotherapy

authors： Holst E,Rollof J,Miörner H

更新日期：1989-12-01 00:00:00

abstract：:Piperacillin and vancomycin were used as initial empirical therapy for 211 febrile episodes in cancer patients. The response rate in 95 episodes of documented infection was 72%. The response of bacteremias, soft tissue infections, and pneumonias was 78, 71, and 38%, respectively. The response in infections caused by g...

journal_title：Antimicrobial agents and chemotherapy

authors： Jadeja L,Bolivar R,Fainstein V,Keating M,McCredie K,Hay M,Bodey GP

更新日期：1984-09-01 00:00:00

abstract：:The nucleotide sequence of the constitutively produced beta-lactamase (Bla) gene from Enterococcus faecalis HH22 was shown to be identical to the published sequences of three of four staphylococcal type A beta-lactamase genes; more differences were seen with the genes for staphylococcal type C and D enzymes. One hundr...

journal_title：Antimicrobial agents and chemotherapy

authors： Zscheck KK,Murray BE

更新日期：1991-09-01 00:00:00

abstract：:Blastocystis is an enteric parasite with extensive global prevalence. Studies have linked infection with this protist with a variety of gastrointestinal disorders, including irritable bowel syndrome. Due to the polymorphic nature of Blastocystis, studies on the parasite could be complicated, as results can be easily m...

journal_title：Antimicrobial agents and chemotherapy

authors： Yason JA,Koh KARP,Tan KSW

更新日期：2018-07-27 00:00:00

abstract：:Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantim...

journal_title：Antimicrobial agents and chemotherapy

authors： Vennerstrom JL,Lovelace JK,Waits VB,Hanson WL,Klayman DL

更新日期：1990-05-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection does not generally cause problems in the immunocompetent adult but can result in severe clinical disease in the fetus, neonate, and immunocompromised host. Ganciclovir (GCV), the agent currently used to treat most HCMV infections, has resulted in much therapeutic success; however...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak RJ,Hartline CB,Qiu YL,Zemlicka J,Harden E,Marshall G,Sommadossi JP,Kern ER

更新日期：2000-06-01 00:00:00

abstract：:Microdialysis was applied to sample the unbound drug concentration in the extracellular fluid in brain and muscle of rats given zalcitabine (2',3'-dideoxycytidine; n = 4) or BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine; n = 4) (50 mg/kg of body weight given subcutaneously). Zalcitabine and BEA005 were analyzed by h...

journal_title：Antimicrobial agents and chemotherapy

authors： Borg N,Ståhle L

更新日期：1998-09-01 00:00:00

abstract：:Pseudomonas aeruginosa colonizes the sputum of most adult cystic fibrosis patients, forming difficult-to-eradicate biofilms in which bacteria are protected in their self-produced extracellular polymeric substance (EPS) matrices. EPS provide biofilms with viscoelastic properties, causing time-dependent relaxation after...

journal_title：Antimicrobial agents and chemotherapy

authors： Rozenbaum RT,van der Mei HC,Woudstra W,de Jong ED,Busscher HJ,Sharma PK

更新日期：2019-03-27 00:00:00

abstract：:Cefmenoxime, an investigational semisynthetic cephalosporin, was evaluated in 18 pediatric patients with a variety of infections. There were seven patients with urinary tract infections, two with wound infections, two with osteomyelitis, two with abscess infections, one with cervical adenitis, one with hidradenitis, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Tansino GF,Hammerschlag MR,Congeni BL,Cox PA,Doraiswamy B,duBouchet L

更新日期：1985-10-01 00:00:00

abstract：:The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of li...

journal_title：Antimicrobial agents and chemotherapy

authors： Gikas A,Spyridaki I,Scoulica E,Psaroulaki A,Tselentis Y

更新日期：2001-11-01 00:00:00

abstract：:Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to beta-lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC beta-lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% ident...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchese A,Arlet G,Schito GC,Lagrange PH,Philippon A

更新日期：1998-02-01 00:00:00