Abstract:
:Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study, the susceptibilities of 40 A. fumigatus clinical isolates were tested by using the CLSI method with amphotericin B, itraconazole, voriconazole, posaconazole, and the new triazole isavuconazole. Isavuconazole MICs were higher in strains with reduced susceptibilities to other triazoles, mirroring changes in voriconazole susceptibility. Isavuconazole MICs differed depending on the Cyp51A substitution.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Gregson L,Goodwin J,Johnson A,McEntee L,Moore CB,Richardson M,Hope WW,Howard SJdoi
10.1128/AAC.01141-13subject
Has Abstractpub_date
2013-11-01 00:00:00pages
5778-80issue
11eissn
0066-4804issn
1098-6596pii
AAC.01141-13journal_volume
57pub_type
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