Musculoskeletal safety outcomes of patients receiving daptomycin with HMG-CoA reductase inhibitors.

abstract：:Sixty-seven patients were treated with moxalactam in a noncomparative trial of hospitalized patients; 32 had endometritis or chorioamnionitis, 12 had skin and soft tissue infections, 5 had osteomyelitis, 5 had pneumonia, 5 had urinary tract infections, 4 had arthritis, 2 had sepsis from an unknown source, 1 had endoca...

journal_title：Antimicrobial agents and chemotherapy

authors： Marier RL,Faro S,Sanders CV,Williams W,Derks F,Janney A,Aldridge K

更新日期：1982-04-01 00:00:00

abstract：:In this paper we provide the first biochemical evidence of the existence of a family of structure-related antimicrobial peptides, the siderophore-microcins, in the Enterobacteriaceae family. We isolated and characterized two novel siderophore-microcins, MccM and MccH47, previously characterized through genetic studies...

journal_title：Antimicrobial agents and chemotherapy

authors： Vassiliadis G,Destoumieux-Garzón D,Lombard C,Rebuffat S,Peduzzi J

更新日期：2010-01-01 00:00:00

abstract：:PA-824 is a novel antibacterial agent that has shown in vitro activity against both drug-sensitive and drug-resistant Mycobacterium tuberculosis. The compound's MIC is between 0.015 and 0.25 microg/ml for drug-sensitive strains and between 0.03 and 0.53 microg/ml for drug-resistant strains. In addition, it is active a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ginsberg AM,Laurenzi MW,Rouse DJ,Whitney KD,Spigelman MK

更新日期：2009-09-01 00:00:00

abstract：:An Escherichia coli strain with a plasmidic amikacin resistance has been selected for which the evidence strongly indicates that resistance is mediated by aminoglycoside phosphotransferase [APH(3')-II]: (i) this resistance was coupled with resistance against kanamycin and neomycin; (ii) partially purified APH(3')-II[A...

journal_title：Antimicrobial agents and chemotherapy

authors： Bongaerts GP,Kaptijn GM

更新日期：1981-09-01 00:00:00

abstract：:The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined. Cefoperazone showed the highest antibacterial activity, followed by ceftezole, cefazolin, cefamandole, and cephalothin. There were two groups of resistant strains: one group (ca. 15%), of which B. fra...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Mitsuyama J,Hori R,Yasuda T,Saikawa I,Inoue M,Mitsuhashi S

更新日期：1988-12-01 00:00:00

abstract：:The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial n...

journal_title：Antimicrobial agents and chemotherapy

authors： Giacometti A,Cirioni O,Ghiselli R,Orlando F,D'Amato G,Kamysz W,Mocchegiani F,Sisti V,Silvestri C,Łukasiak J,Rocchi M,Saba V,Scalise G

更新日期：2004-08-01 00:00:00

abstract：:Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

journal_title：Antimicrobial agents and chemotherapy

authors： English BK,Maryniw EM,Talati AJ,Meals EA

更新日期：2006-06-01 00:00:00

abstract：:Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246, a small-molecule inhibitor of virus egress, has been shown to provide protection against severe disease and death induced by se...

journal_title：Antimicrobial agents and chemotherapy

authors： Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

更新日期：2009-12-01 00:00:00

abstract：:We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspofungin against Aspergillus and Fusarium. Caspofungin generated low MICs and MECs against Asperg...

journal_title：Antimicrobial agents and chemotherapy

authors： Arikan S,Lozano-Chiu M,Paetznick V,Rex JH

更新日期：2001-01-01 00:00:00

abstract：:The occurrence of resistance to last-resort antibiotics was evaluated among Enterobacteriaceae isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-amin...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Aires-de-Sousa M,Kudyba P,Kieffer N,Nordmann P

更新日期：2018-08-27 00:00:00

abstract：:We compared MICs and MBCs of various free- and liposome-incorporated antimicrobial agents against several patient isolates of Mycobacterium avium-M. intracellulare complex and certain American Type Culture Collection strains of M. avium, M. intracellulare, and Mycobacterium tuberculosis. Seven of 19 agents were select...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehta RT,Keyhani A,McQueen TJ,Rosenbaum B,Rolston KV,Tarrand JJ

更新日期：1993-12-01 00:00:00

abstract：:The effect of ethambutol (EMB) is primarily on polymerization steps in the biosynthesis of the arabinan component of cell wall arabinogalactan (AG) of Mycobacterium smegmatis. Inhibition of the synthesis of the arabinan of lipoarabinomannan (LAM) occurred later, and thus in the cases of AG and LAM, the polymerization ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mikusová K,Slayden RA,Besra GS,Brennan PJ

更新日期：1995-11-01 00:00:00

abstract：:It was previously found that certain nonnucleoside reverse transcriptase inhibitors (NNRTI) possess virucidal activity against human immunodeficiency virus type 1 (HIV-1), and it was suggested that the tight-binding mode of inhibition of reverse transcriptase might be important for this virucidal activity (Borkow et a...

journal_title：Antimicrobial agents and chemotherapy

authors： Motakis D,Parniak MA

更新日期：2002-06-01 00:00:00

abstract：:A total of 6,991 unique patient isolates of Streptococcus pneumoniae were collected from October 1997 to June 2002 from 25 medical centers in 9 of the 10 Canadian provinces. Among these isolates, 20.2% were penicillin nonsusceptible, with 14.6% being penicillin intermediate (MIC, 0.12 to 1 microg/ml) and 5.6% being pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Palatnick L,Nichol KA,Bellyou T,Low DE,Hoban DJ

更新日期：2003-06-01 00:00:00

abstract：:Many hospital antimicrobial stewardship programs restrict the availability of selected drugs by requiring prior approval. Carbapenems may be among the restricted drugs, but it is unclear if hospitals that restrict availability actually use fewer carbapenems than hospitals that do not restrict use. Nor is it clear if r...

journal_title：Antimicrobial agents and chemotherapy

authors： Pakyz AL,Oinonen M,Polk RE

更新日期：2009-05-01 00:00:00

abstract：:Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 stero...

journal_title：Antimicrobial agents and chemotherapy

authors： Urbina JA,Visbal G,Contreras LM,McLaughlin G,Docampo R

更新日期：1997-07-01 00:00:00

abstract：:The pathogenic yeast Candida albicans can exist in multiple morphological states, including budded, pseudohyphal, and true hyphal forms. The ability to convert between the budded and hyphal forms, termed the budded-to-hyphal-form transition, is important for virulence and is regulated by multiple environmental and cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Toenjes KA,Munsee SM,Ibrahim AS,Jeffrey R,Edwards JE Jr,Johnson DI

更新日期：2005-03-01 00:00:00

abstract：:Rationally designed synthetic inhibitors of retroviral proteases inhibit the processing of viral polyproteins in cultures of human immunodeficiency virus type 1 (HIV-1)-infected T lymphocytes and, as a result, inhibit the infectivity of HIV-1 for such cultures. The ability of HIV-1 protease inhibitors to suppress repl...

journal_title：Antimicrobial agents and chemotherapy

authors： Black PL,Downs MB,Lewis MG,Ussery MA,Dreyer GB,Petteway SR Jr,Lambert DM

更新日期：1993-01-01 00:00:00

abstract：:Telavancin displays potent in vitro and in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA), including strains with reduced susceptibility to vancomycin. We compared the efficacies of telavancin and vancomycin against MRSA strains with vancomycin MICs of ≥1 μg/ml in a neutropenic murine lung in...

journal_title：Antimicrobial agents and chemotherapy

authors： Crandon JL,Kuti JL,Nicolau DP

更新日期：2010-12-01 00:00:00

abstract：:The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human volunteers. Serum levels of tetracycline were uniformly reduced by approximately 50% by all test meals, whereas serum level...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Koch PA,Lau CC,Craig WA

更新日期：1977-03-01 00:00:00

abstract：:Macrolide antibiotics are used as anti-inflammatory agents, e.g., for prevention of exacerbations in chronic obstructive pulmonary disease and cystic fibrosis. Several studies have shown improved outcomes after the addition of macrolides to β-lactam antibiotics for treatment of severe community-acquired pneumonia. How...

journal_title：Antimicrobial agents and chemotherapy

authors： Kasetty G,Bhongir RKV,Papareddy P,Herwald H,Egesten A

更新日期：2017-08-24 00:00:00

abstract：:Thirty-nine adult patients with human immunodeficiency virus infection and oral candidiasis were randomly assigned to receive either one fluconazole capsule (100 mg) or five clotrimazole troches (10 mg each) daily for 14 days. Among 36 evaluable patients, clinical resolution rates were 100 and 65%, respectively (P = 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Koletar SL,Russell JA,Fass RJ,Plouffe JF

更新日期：1990-11-01 00:00:00

abstract：:Mefloquine was found to have bactericidal activity against methicillin- and fluoroquinolone-susceptible and -resistant strains of Staphylococcus aureus and Staphylococcus epidermidis and gentamicin- and vancomycin-resistant strains of Enterococcus faecalis and Enterococcus faecium. The MICs were 16 microg/ml, and the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kunin CM,Ellis WY

更新日期：2000-04-01 00:00:00

abstract：:Several classes of antibiotics exert antimalarial activity. The mechanisms of action of antibiotics against malaria parasites have been unclear, and prior studies have led to conflicting results, in part because they studied antibiotics at suprapharmacological concentrations. We examined the antimalarial effects of az...

journal_title：Antimicrobial agents and chemotherapy

authors： Dahl EL,Rosenthal PJ

更新日期：2007-10-01 00:00:00

abstract：:The bla(TLA-1) gene encoding an extended-spectrum beta-lactamase was identified in 11 enterobacterial isolates from Mexico City, Mexico. This gene was located on different plasmids and plasmid types with different sizes and incompatibility groups. It was associated with a novel insertion sequence, ISCR20, encoding a p...

journal_title：Antimicrobial agents and chemotherapy

authors： Berçot B,Poirel L,Silva-Sanchez J,Nordmann P

更新日期：2010-09-01 00:00:00

abstract：:Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol...

journal_title：Antimicrobial agents and chemotherapy

authors： Mayers M,Rush D,Madu A,Motyl M,Miller MH

更新日期：1991-09-01 00:00:00

abstract：:Bacteriolytic antibiotics cause the release of bacterial components that augment the host inflammatory response, which in turn contributes to the pathophysiology of brain injury in bacterial meningitis. In the present study, antibiotic therapy with nonbacteriolytic daptomycin was compared with that of bacteriolytic ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Grandgirard D,Schürch C,Cottagnoud P,Leib SL

更新日期：2007-06-01 00:00:00

abstract：:The ability of LM cells, thymidine kinase-deficient LM cells (LMTK-), and LMTK- cells transformed to the LMTK+ phenotype by herpes simplex virus type 1 genetic information (LH7 cells) to anabolize the acyclovir congener ganciclovir was examined. About 50-fold more ganciclovir triphosphate was produced by LH7 cells tha...

journal_title：Antimicrobial agents and chemotherapy

authors： St Clair MH,Lambe CU,Furman PA

更新日期：1987-06-01 00:00:00

abstract：:MICs of daptomycin, linezolid, and vancomycin against 212 isolates, including Listeria monocytogenes and Pediococcus, Leuconostoc, Rhodococcus, and Nocardia spp., were determined by the broth microdilution method; daptomycin MICs were also determined by the Etest. Except with those for Leuconostoc spp., daptomycin Ete...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang YT,Liao CH,Teng LJ,Hsueh PR

更新日期：2007-04-01 00:00:00

abstract：:For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrow...

journal_title：Antimicrobial agents and chemotherapy

authors： Rudin JE,Norden CW,Shinners EM

更新日期：1984-10-01 00:00:00