Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides.


:The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.


Giacometti A,Cirioni O,Ghiselli R,Orlando F,D'Amato G,Kamysz W,Mocchegiani F,Sisti V,Silvestri C,Łukasiak J,Rocchi M,Saba V,Scalise G




Has Abstract


2004-08-01 00:00:00














  • Comparison of ofloxacin and ceftriaxone for short-course treatment of enteric fever.

    abstract::An open, randomized comparison of ofloxacin (200 mg, every 12 h) given orally for 5 days and ceftriaxone (3 g, once daily) given intravenously for 3 days in the treatment of uncomplicated enteric fever was conducted in Ho Chi Minh City, Vietnam. Salmonella paratyphi type A was isolated from six patients. Salmonella ty...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Smith MD,Duong NM,Hoa NT,Wain J,Ha HD,Diep TS,Day NP,Hien TT,White NJ

    更新日期:1994-08-01 00:00:00

  • Upregulation of Apoptosis Pathway Genes in Peripheral Blood Mononuclear Cells of HIV-Infected Individuals with Antiretroviral Therapy-Associated Mitochondrial Toxicity.

    abstract::A case-control study of the effect of antiretroviral therapy (ART) on apoptosis pathway genes comprising 16 cases (HIV infected with mitochondrial toxicity) and 16 controls (HIV uninfected) was conducted. A total of 26 of 84 genes of the apoptosis pathway were differentially expressed. Two of the upregulated genes, DF...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Foli Y,Ghebremichael M,Li M,Paintsil E

    更新日期:2017-07-25 00:00:00

  • Evaluation of vancomycin for therapy of adult pneumococcal meningitis.

    abstract::The emergence of pneumococci resistant to penicillin and other agents prompted us to evaluate intravenous vancomycin for the therapy of pneumococcal meningitis, which has an overall mortality of 30%. Eleven consecutive adult patients with cerebrospinal fluid (CSF)-culture-proven pneumococcal meningitis and positive in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Viladrich PF,Gudiol F,Liñares J,Pallarés R,Sabaté I,Rufí G,Ariza J

    更新日期:1991-12-01 00:00:00

  • In Vitro Synergy and In Vivo Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis.

    abstract::The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

    更新日期:2019-09-23 00:00:00

  • In Vitro Assessment of Combined Polymyxin B and Minocycline Therapy against Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae.

    abstract::The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes with intravenous minocycline-based com...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Huang D,Yu B,Diep JK,Sharma R,Dudley M,Monteiro J,Kaye KS,Pogue JM,Abboud CS,Rao GG

    更新日期:2017-06-27 00:00:00

  • Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.

    abstract::Enterococcus gallinarum N04-0414 (MIC for vancomycin, 256 microg/ml) harbored a vanD-type vancomycin resistance operon as well as the intrinsic vanC1 operon. The D-Ala:D-Ala ligase 2 gene (ddl2) was not present in the strain, though it is found downstream of the vanS gene from the vanC operon in E. gallinarum ATCC 495...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Boyd DA,Miller MA,Mulvey MR

    更新日期:2006-03-01 00:00:00

  • In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source.

    abstract::Platelet microbicidal proteins (PMPs), small cationic peptides released at sites of endovascular damage, kill common bloodstream pathogens in vitro. Our group previously showed that in vitro resistance of clinical staphylococcal and viridans group streptococcal bacteremic strains to PMPs correlated with the diagnosis ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bayer AS,Cheng D,Yeaman MR,Corey GR,McClelland RS,Harrel LJ,Fowler VG Jr

    更新日期:1998-12-01 00:00:00

  • Safety, tolerance, and pharmacokinetics of amphotericin B lipid complex in children with hepatosplenic candidiasis.

    abstract::The safety, tolerance, and pharmacokinetics of amphotericin B lipid complex (ABLC) were studied in a cohort of pediatric cancer patients. Six children with hepatosplenic candidiasis (HSC) received 2.5 mg of ABLC/kg of body weight/day for 6 weeks for a total dosage of 105 mg/kg. Mean serum creatinine (0.85 +/- 0.12 mg/...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Walsh TJ,Whitcomb P,Piscitelli S,Figg WD,Hill S,Chanock SJ,Jarosinski P,Gupta R,Pizzo PA

    更新日期:1997-09-01 00:00:00

  • Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.

    abstract::The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

    更新日期:2013-06-01 00:00:00

  • Pharmacokinetics of sparfloxacin and serum bactericidal activity against pneumococci.

    abstract::Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

    更新日期:1996-03-01 00:00:00

  • Different doses of cefetamet pivoxil (Ro 15-8075) in the treatment of acute uncomplicated gonococcal urethritis in men.

    abstract::In an open, dose-finding study, a 100% cure rate was observed in patients suffering from uncomplicated gonococcal urethritis who were treated with a single oral dose of either 1.2 g (n = 10), 0.8 g (n = 11), or 0.4 g (n = 10) of cefetamet pivoxil. The MICs of cefetamet for all gonococcal strains ranged from 0.001 to 0...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tio TT,Sindhunata IR,Wagenvoort JH,Michel MF,Stolz E

    更新日期:1990-04-01 00:00:00

  • Rapid disk test for determining clindamycin serum levels.

    abstract::A disk bioassay for determining clindamycin serum levels is presented. This method is rapid (results available in 6.0 to 6.5 h), reliable, and simple to perform. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Liberman DF,Fitzgerald J,Robertson RG

    更新日期:1974-05-01 00:00:00

  • Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.

    abstract::A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Perilli M,Mugnaioli C,Luzzaro F,Fiore M,Stefani S,Rossolini GM,Amicosante G

    更新日期:2005-04-01 00:00:00

  • In vitro antifungal activity of nikkomycin Z in combination with fluconazole or itraconazole.

    abstract::Nikkomycins are nucleoside-peptide antibiotics produced by Streptomyces species with antifungal activities through the inhibition of chitin synthesis. We investigated the antifungal activities of nikkomycin Z alone and in combination with fluconazole and itraconazole. Checkerboard synergy studies were carried out by a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Li RK,Rinaldi MG

    更新日期:1999-06-01 00:00:00

  • Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection Model.

    abstract::Persistent infections with Chlamydia pneumoniae have been implicated in the development of chronic diseases, such as atherosclerosis and asthma. Although azithromycin, clarithromycin, and levofloxacin are frequently used for the treatment of respiratory C. pneumoniae infections, little is known about the dose and dura...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kutlin A,Roblin PM,Hammerschlag MR

    更新日期:2002-02-01 00:00:00

  • In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides.

    abstract::In vitro activities of erythromycin A, telithromycin, and two investigational ketolides, JNJ-17155437 and JNJ-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. Against 46 macrolide-susceptible and -resistant Streptococcus pneumoniae strains, the MIC(90)...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Abbanat D,Webb G,Foleno B,Li Y,Macielag M,Montenegro D,Wira E,Bush K

    更新日期:2005-01-01 00:00:00

  • Mode of action of a new type of UDP-glucose analog against herpesvirus replication.

    abstract::The mode of action of a new type of UDP-glucose analog against herpes simplex virus type 1 (HSV-1) replication was examined. The analog showed good selectivity and potent activity. At 10 micrograms/ml, P-536 inhibited the formation of infectious HSV-1 by more than 90%, whereas at 100 micrograms/ml it had no cytotoxic ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Alarcón B,González ME,Carrasco L,Méndez-Castrillón PP,García-López MT,de las Heras FG

    更新日期:1988-08-01 00:00:00

  • GES-18, a new carbapenem-hydrolyzing GES-Type β-lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues.

    abstract::A clinical isolate of Pseudomonas aeruginosa recovered from the lower respiratory tract of an 81-year-old patient hospitalized in Belgium was sent to the national reference center to determine its resistance mechanism. PCR sequencing identified a new GES variant, GES-18, which differs from the carbapenem-hydrolyzing e...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bebrone C,Bogaerts P,Delbrück H,Bennink S,Kupper MB,Rezende de Castro R,Glupczynski Y,Hoffmann KM

    更新日期:2013-01-01 00:00:00

  • Comparative analysis of the bactericidal activities of amphibian peptide analogues against multidrug-resistant nosocomial bacterial strains.

    abstract::Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

    更新日期:2008-01-01 00:00:00

  • Combination of Amino Acid Substitutions Leading to CTX-M-15-Mediated Resistance to the Ceftazidime-Avibactam Combination.

    abstract::Single amino acid substitutions in the Ω loop of KPC β-lactamases are known to lead to resistance to the ceftazidime-avibactam combination. Here, we investigate this mechanism of resistance in CTX-M enzymes, which are the most widely spread extended-spectrum β-lactamases worldwide. Nine single amino acid polymorphisms...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Compain F,Dorchène D,Arthur M

    更新日期:2018-08-27 00:00:00

  • Kinetics of gentamicin in plasma of nonpregnant, pregnant, and fetal guinea pigs and its distribution in fetal tissues.

    abstract::Nonpregnant and pregnant guinea pigs in the last third of gestation were injected intramuscularly with 4 mg of gentamicin per kg, and drug concentrations in plasma were determined by radioimmunoassay at several intervals after injection. The maximum gentamicin concentration was lower in pregnant than in nonpregnant an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lelievre-Pegorier M,Sakly R,Meulemans A,Merlet-Benichou C

    更新日期:1985-10-01 00:00:00

  • Pharmacokinetics of Penicillin G in Preterm and Term Neonates.

    abstract::Group B streptococci are common causative agents of early-onset neonatal sepsis (EOS). Pharmacokinetic (PK) data for penicillin G have been described for extremely preterm neonates but have been poorly described for late-preterm and term neonates. Thus, evidence-based dosing recommendations are lacking. We describe th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Padari H,Metsvaht T,Germovsek E,Barker CI,Kipper K,Herodes K,Standing JF,Oselin K,Tasa T,Soeorg H,Lutsar I

    更新日期:2018-04-26 00:00:00

  • Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study.

    abstract::Clostridium difficile causes antibiotic-associated diarrhea and is a major public health concern. Current therapies disrupt the protective intestinal flora, do not reliably prevent recurrent infections, and will be decreasingly effective should less susceptible strains emerge. CRS3123 is an oral agent that inhibits ba...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nayak SU,Griffiss JM,Blumer J,O'Riordan MA,Gray W,McKenzie R,Jurao RA,An AT,Le M,Bell SJ,Ochsner UA,Jarvis TC,Janjic N,Zenilman JM

    更新日期:2017-07-25 00:00:00

  • Antimicrobial Resistance of Escherichia coli Urinary Isolates in the Veterans Affairs Health Care System.

    abstract::We reviewed data for almost 300,000 clinical Escherichia coli urinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Cont...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Morrill HJ,Morton JB,Caffrey AR,Jiang L,Dosa D,Mermel LA,LaPlante KL

    更新日期:2017-04-24 00:00:00

  • Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.

    abstract::Isavuconazole is a novel, broad-spectrum, antifungal azole. In order to evaluate its interactions with known azole resistance mechanisms, isavuconazole susceptibility among different yeast models and clinical isolates expressing characterized azole resistance mechanisms was tested and compared to those of fluconazole,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sanglard D,Coste AT

    更新日期:2015-10-19 00:00:00

  • Topoisomerase mutations in trovafloxacin-resistant Staphylococcus aureus.

    abstract::A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in D...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fitzgibbon JE,John JF,Delucia JL,Dubin DT

    更新日期:1998-08-01 00:00:00

  • Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae.

    abstract::We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Szabó D,Silveira F,Hujer AM,Bonomo RA,Hujer KM,Marsh JW,Bethel CR,Doi Y,Deeley K,Paterson DL

    更新日期:2006-08-01 00:00:00

  • Microbiological assay for estimating concentrations of DL-alanosine in mouse tissue.

    abstract::A sensitive, precise microbiological assay was developed for the determination of tissue distribution of dl-alanosine, a new antitumor agent. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pittillo RF,Woolley C

    更新日期:1973-06-01 00:00:00

  • In vitro selection and characterization of Bacillus anthracis mutants with high-level resistance to ciprofloxacin.

    abstract::Mutants of attenuated Bacillus anthracis with high-level ciprofloxacin resistance were isolated using a three-step in vitro selection. Ciprofloxacin MICs were 0.5 micro g/ml for first-step mutants, which had one of two gyrA quinolone resistance-determining region (QRDR) mutations. Ciprofloxacin MICs were 8 and 16 micr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Price LB,Vogler A,Pearson T,Busch JD,Schupp JM,Keim P

    更新日期:2003-07-01 00:00:00

  • Synergistic effects and antibiofilm properties of chimeric peptides against multidrug-resistant Acinetobacter baumannii strains.

    abstract::The increasing prevalence of drug-resistant pathogens highlights the need to identify novel antibiotics. Here we investigated the efficacies of four new antimicrobial peptides (AMPs) for potential drug development. The antibacterial activities, synergistic effects, and antibiofilm properties of the four chimeric AMPs ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gopal R,Kim YG,Lee JH,Lee SK,Chae JD,Son BK,Seo CH,Park Y

    更新日期:2014-01-01 00:00:00