Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.

abstract：:Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in vivo. For three cyclosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Ptak RG,Gallay PA,Jochmans D,Halestrap AP,Ruegg UT,Pallansch LA,Bobardt MD,de Béthune MP,Neyts J,De Clercq E,Dumont JM,Scalfaro P,Besseghir K,Wenger RM,Rosenwirth B

更新日期：2008-04-01 00:00:00

abstract：:Foscarnet is widely used for the treatment of acyclovir-resistant herpesvirus infections, and foscarnet-resistant herpesvirus infections are a serious concern in immunocompromised patients. Twenty-seven single-plaque isolates of herpes simplex virus type 1 (HSV-1) resistant to foscarnet were selected from foscarnet- a...

journal_title：Antimicrobial agents and chemotherapy

authors： Saijo M,Suzutani T,Morikawa S,Kurane I

更新日期：2005-02-01 00:00:00

abstract：:Streptomycin binds to the bacterial ribosome and disrupts protein synthesis by promoting misreading of mRNA. Restrictive mutations on the ribosomal subunit protein S12 confer a streptomycin resistance (Strr) phenotype and concomitantly increase the accuracy of the decoding process and decrease the rate of translation....

journal_title：Antimicrobial agents and chemotherapy

authors： Chen C,Blumentritt CA,Curtis MM,Sperandio V,Torres AG,Dudley EG

更新日期：2013-09-01 00:00:00

abstract：:OPC-20011, a new parenteral 2-oxaisocephem antibiotic, has an oxygen atom at the 2- position of the cephalosporin frame. OPC-20011 had the best antibacterial activities against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, and penicillin-resistant Streptoc...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto M,Tamaoka H,Ishikawa H,Kikuchi M

更新日期：1998-11-01 00:00:00

abstract：:Sixty-seven patients were treated with moxalactam in a noncomparative trial of hospitalized patients; 32 had endometritis or chorioamnionitis, 12 had skin and soft tissue infections, 5 had osteomyelitis, 5 had pneumonia, 5 had urinary tract infections, 4 had arthritis, 2 had sepsis from an unknown source, 1 had endoca...

journal_title：Antimicrobial agents and chemotherapy

authors： Marier RL,Faro S,Sanders CV,Williams W,Derks F,Janney A,Aldridge K

更新日期：1982-04-01 00:00:00

abstract：:Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal drug concentrations....

journal_title：Antimicrobial agents and chemotherapy

authors： Sekaggya-Wiltshire C,Chirehwa M,Musaazi J,von Braun A,Buzibye A,Muller D,Gutteck U,Motta I,Calcagno A,Fehr JS,Kambugu A,Castelnuovo B,Lamorde M,Denti P

更新日期：2019-05-24 00:00:00

abstract：:A novel beta-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D beta-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA...

journal_title：Antimicrobial agents and chemotherapy

authors： Alfredson DA,Korolik V

更新日期：2005-06-01 00:00:00

abstract：:Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage in Candida-infe...

journal_title：Antimicrobial agents and chemotherapy

authors： Lionakis MS,Albert ND,Swamydas M,Lee CR,Loetscher P,Kontoyiannis DP

更新日期：2017-02-23 00:00:00

abstract：:In the course of surveying for the carbapenem-hydrolyzing metallo-beta-lactamase gene bla(IMP) in pathogenic bacteria by the PCR method, we detected a gene encoding a variant metallo-beta-lactamase, designated IMP-3, which differed from IMP-1 by having low hydrolyzing activity for penicillins and carbapenems. PCR prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Iyobe S,Kusadokoro H,Ozaki J,Matsumura N,Minami S,Haruta S,Sawai T,O'Hara K

更新日期：2000-08-01 00:00:00

abstract：:Nosocomial pneumonia and sepsis, as well as severe diffuse peritonitis, must be treated early in order to prevent complications such as septic shock and organ dysfunctions. With the availability of new broad-spectrum and highly bactericidal antibiotics, the need of combining beta-lactams with aminoglycosides for the t...

journal_title：Antimicrobial agents and chemotherapy

authors： Cometta A,Baumgartner JD,Lew D,Zimmerli W,Pittet D,Chopart P,Schaad U,Herter C,Eggimann P,Huber O

更新日期：1994-06-01 00:00:00

abstract：:The pharmacokinetics of two prodrugs of zidovudine (AZT), 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester and isoleucinyl ester (DPAZT and IAZT, respectively), were investigated in a rabbit model to determine their potential utility as drugs against human immunodeficiency virus. Drugs were administered by intraven...

journal_title：Antimicrobial agents and chemotherapy

authors： Lupia RH,Ferencz N,Lertora JJ,Aggarwal SK,George WJ,Agrawal KC

更新日期：1993-04-01 00:00:00

abstract：:A comparison of the daclatasvir (DCV [BMS-790052]) resistance barrier on authentic or hybrid replicons containing NS5A from hepatitis C virus (HCV) genotypes 1 to 6 (GT-1 to -6) was completed using a replicon elimination assay. The data indicated that genotype 1b (GT-1b) has the highest relative resistance barrier and...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang C,Jia L,O'Boyle DR 2nd,Sun JH,Rigat K,Valera L,Nower P,Huang X,Kienzle B,Roberts S,Gao M,Fridell RA

更新日期：2014-09-01 00:00:00

abstract：:This study investigates the role of active efflux system MexXY in the emergence of aminoglycoside (AG) resistance among cystic fibrosis (CF) isolates of Pseudomonas aeruginosa. Three genotypically related susceptible and resistant (S/R) bacterial pairs and three other AG-resistant CF strains were compared to four non-...

journal_title：Antimicrobial agents and chemotherapy

authors： Vogne C,Aires JR,Bailly C,Hocquet D,Plésiat P

更新日期：2004-05-01 00:00:00

abstract：:The in vitro activities of vancomycin and teicoplanin alone and in combination with gentamicin or tobramycin were studied by time-kill techniques with 11 strains of pathogenic diphtheroids (Corynebacterium group JK). The activities of vancomycin and teicoplanin were similar (MIC for 90% of strains tested [MIC90], 1 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Spitzer PG,Eliopoulos GM,Karchmer AW,Moellering RC Jr

更新日期：1988-04-01 00:00:00

abstract：:Past studies conducted in Australian and American families have demonstrated that alpha 2b interferon (IFN) is effective in preventing rhinovirus-associated illnesses in exposed family members. IFN had been used by intranasal application for 7 days after exposure (5 x 10(6) IU/day). We used the same approach but with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Monto AS,Schwartz SA,Albrecht JK

更新日期：1989-03-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically...

journal_title：Antimicrobial agents and chemotherapy

authors： Forrest A,Garonzik SM,Thamlikitkul V,Giamarellos-Bourboulis EJ,Paterson DL,Li J,Silveira FP,Nation RL

更新日期：2017-10-24 00:00:00

abstract：:The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

journal_title：Antimicrobial agents and chemotherapy

authors： Queener SF,Bartlett MS,Nasr M,Smith JW

更新日期：1993-10-01 00:00:00

abstract：:Aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. We describe a novel aminoglycoside 2″-phosphotransferase from the Gram-negative pathogen Campylobacter jejuni, which shares 78% amino acid sequence identity with the APH(2″)-Ia do...

journal_title：Antimicrobial agents and chemotherapy

authors： Toth M,Frase H,Antunes NT,Vakulenko SB

更新日期：2013-01-01 00:00:00

abstract：:The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity against both gram-positive and gram-negative bacteria. We studied the ability of several fragments of LL-37, exhibiting different antimicrobial activities, to interact with membranes whose compositions mimic the cytoplasmic memb...

journal_title：Antimicrobial agents and chemotherapy

authors： Epand RF,Wang G,Berno B,Epand RM

更新日期：2009-09-01 00:00:00

abstract：:Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hawser SP,Bouchillon SK,Hoban DJ,Badal RE,Hsueh PR,Paterson DL

更新日期：2009-08-01 00:00:00

abstract：:We investigated the occurrence of multidrug resistance in 44 Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Efflux was involved in resistance in E. aerogenes isolates more frequently than in K. pneumoniae isolates (100 versus 38% of isolates) and was associated with the expression of phenylalanine...

journal_title：Antimicrobial agents and chemotherapy

authors： Tran QT,Dupont M,Lavigne JP,Chevalier J,Pagès JM,Sotto A,Davin-Regli A

更新日期：2009-04-01 00:00:00

abstract：:In Portugal erythromycin resistance of 26.6% (n = 352) remained constant during 1998 to 2003, however in 1998 the MLS(B) phenotype dominated (85%), whereas in 2003 the M phenotype prevailed (77%). A decline in T12/emm22 MLS(B) isolates could partially explain the drop in this phenotype, but the rise of the M phenotype...

journal_title：Antimicrobial agents and chemotherapy

authors： Silva-Costa C,Ramirez M,Melo-Cristino J,Portuguese Surveillance Group for the Study of Respiratory Pathogens.

更新日期：2005-05-01 00:00:00

abstract：:The 747-bp cfiA gene, which encodes a metallo-beta-lactamase, and the regions flanking cfiA in six imipenem-resistant and four imipenem-susceptible Bacteroides fragilis strains isolated in Japan were analyzed by PCR and DNA sequencing. The nucleotide sequences of the cfiA genes (designated cfiA(1) to cfiA(10)) of all ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kato N,Yamazoe K,Han CG,Ohtsubo E

更新日期：2003-03-01 00:00:00

abstract：:Many of the nitroaromatic agents used in medicine function as prodrugs and must undergo activation before exerting their toxic effects. In most cases, this is catalyzed by flavin mononucleotide (FMN)-dependent type I nitroreductases (NTRs), a class of enzyme absent from higher eukaryotes but expressed by bacteria and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Seifert K,Helsby NA,Wilkinson SR

更新日期：2014-01-01 00:00:00

abstract：:5-episisomicin (Sch 22591) is a novel semisynthetic aminoglycoside with a spectrum and potency similar to gentamicin in its activity against susceptible bacterial strains, but with increased potency against Pseudomonas, Providencia, and Proteus rettgeri. It is also more active than tobramycin and amikacin against thes...

journal_title：Antimicrobial agents and chemotherapy

authors： Waitz JA,Miller GH,Moss E Jr,Chiu PJ

更新日期：1978-01-01 00:00:00

abstract：:The influence of inhibitors of P-glycoprotein (verapamil [VE], cyclosporine [CY], and GF120918 [GF]) on the cell handling of macrolides (erythromycin [ERY], clarithromycin [CLR], roxithromycin [ROX], azithromycin [AZM], and telithromycin [TEL]) was examined in J774 murine macrophages. The net influx rates of AZM and T...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Michot JM,Chanteux H,Mingeot-Leclercq MP,Tulkens PM,Van Bambeke F

更新日期：2003-03-01 00:00:00

abstract：:Bone concentrations of seven antimicrobial agents were determined after parenteral administration. Antibiotics were administered in large doses at customary intervals for 12 to 20 h before total hip or knee replacement; anticipated levels of each drug were achieved in the serum. Methicillin, carbenicillin, and clindam...

journal_title：Antimicrobial agents and chemotherapy

authors： Smilack JD,Flittie WH,Williams TW Jr

更新日期：1976-01-01 00:00:00

abstract：:The 72 Escherichia coli strains of the ECOR collection were examined for resistance to 10 different antimicrobial agents including ampicillin, tetracycline, mercury, trimethoprim, and sulfonamides. Eighteen strains were resistant to at least one of the antibiotics tested, and nearly 20% (14 of 72) were resistant to tw...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazel D,Dychinco B,Webb VA,Davies J

更新日期：2000-06-01 00:00:00

abstract：:The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated that Chlamydia is capable of FASII and this pathway is indispensable for Chlamydia growth. Previously, a high-conte...

journal_title：Antimicrobial agents and chemotherapy

authors： Mojica SA,Salin O,Bastidas RJ,Sunduru N,Hedenström M,Andersson CD,Núñez-Otero C,Engström P,Valdivia RH,Elofsson M,Gylfe Å

更新日期：2017-09-22 00:00:00

abstract：:Given that tedizolid exhibits substantial lung penetration, we hypothesize that it could achieve good efficacy against Streptococcus pneumoniae lung infections. We evaluated the pharmacodynamics of tedizolid for treatment of S. pneumoniae lung infections and compared the efficacies of tedizolid human-simulated epithel...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelraouf K,Nicolau DP

更新日期：2016-12-27 00:00:00