ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.

abstract：:We have recently cloned a DNA fragment containing a gene cluster that is responsible for the biosynthesis of an antituberculosis antibiotic, D-cycloserine. The gene cluster is composed of 10 open reading frames, designated dcsA to dcsJ. Judging from the sequence similarity between each putative gene product and known ...

journal_title：Antimicrobial agents and chemotherapy

authors： Uda N,Matoba Y,Kumagai T,Oda K,Noda M,Sugiyama M

更新日期：2013-06-01 00:00:00

abstract：:Three structural analogs of 5-ethyl-1-benzyloxymethyl-6-(phenylthio)uracil (E-BPU) inhibited human immunodeficiency virus type 1 (HIV-1) replication without cytotoxicity in vitro and were more potent than azidothymidine and were as potent as E-BPU. The target of these compounds is HIV-1 reverse transcriptase. Reverse ...

journal_title：Antimicrobial agents and chemotherapy

authors： Piras G,Dutschman GE,Im GJ,Pan BC,Chu SH,Cheng YC

更新日期：1995-02-01 00:00:00

abstract：:The ribosome-targeting antimicrobial, spectinomycin (SPC), strongly induced the mexXY genes of the MexXY-OprM multidrug efflux system in Pseudomonas aeruginosa and increased susceptibility to the polycationic antimicrobials polymyxin B and polymyxin E, concomitant with a decrease in expression of the polymyxin resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Poole K,Lau CH,Gilmour C,Hao Y,Lam JS

更新日期：2015-12-01 00:00:00

abstract：:Kill curves were determined for five isolates of Bacteroides fragilis with clindamycin at concentrations equal to the MIC or to 4, 16, and 64 times the MIC. Examination of plots of log CFU per milliliter versus time revealed no association between the clindamycin concentration and the rate and extent of the bactericid...

journal_title：Antimicrobial agents and chemotherapy

authors： Klepser ME,Banevicius MA,Quintiliani R,Nightingale CH

更新日期：1996-08-01 00:00:00

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:We have developed a new recombinant retroviral system in which a library of infectious molecular clones of human immunodeficiency virus type 1 (HIV-1) is constructed with reverse transcriptase (RT) genes derived from viral RNA sequences in plasma. HIV-1 RT is amplified from plasma HIV-1 RNA by nested RT-PCR and cloned...

journal_title：Antimicrobial agents and chemotherapy

authors： Shi C,Mellors JW

更新日期：1997-12-01 00:00:00

abstract：:Foscarnet is widely used for the treatment of acyclovir-resistant herpesvirus infections, and foscarnet-resistant herpesvirus infections are a serious concern in immunocompromised patients. Twenty-seven single-plaque isolates of herpes simplex virus type 1 (HSV-1) resistant to foscarnet were selected from foscarnet- a...

journal_title：Antimicrobial agents and chemotherapy

authors： Saijo M,Suzutani T,Morikawa S,Kurane I

更新日期：2005-02-01 00:00:00

abstract：:Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： Kiri N,Archer G,Climo MW

更新日期：2002-06-01 00:00:00

abstract：:The antimicrobial activities of BMY-28142, cefbuperazone (BMY-25182; formerly T-1982), and cefpiramide (WY-44635; formerly SM-1652) were compared with those of cefmenoxime, cefoperazone, cefotaxime, ceftizoxime, and moxalactam. BMY-28142 was the most active cephalosporin against the majority of aerobic and facultative...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan NJ,Bihl JA,Schell RF,LeFrock JL,Weber SJ

更新日期：1984-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) genotype (GT) 2 represents approximately 9% of all viral infections globally. While treatment outcomes for GT2-infected patients have improved substantially with direct-acting antiviral agents (DAAs) compared to interferon-α, the presence of polymorphisms in NS5A can impact efficacy of NS5A inh...

journal_title：Antimicrobial agents and chemotherapy

authors： Asante-Appiah E,Ingravallo P,McMonagle P,Bystol K,Xia E,Curry S,Qiu P,Black S,Chase R,Liu R,Lahser F

更新日期：2019-09-16 00:00:00

abstract：:Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kine...

journal_title：Antimicrobial agents and chemotherapy

authors： Rattie ES,Bernardo PD,Ravin JJ

更新日期：1976-08-01 00:00:00

abstract：:Streptomyces bacteria are renowned for their ability to produce bioactive secondary metabolites. Recently, synthetic biology has enabled the production of intermediates and shunt products, which may have altered biological activities compared to the end products of the pathways. Here, we have evaluated the potential o...

journal_title：Antimicrobial agents and chemotherapy

authors： Oja T,San Martin Galindo P,Taguchi T,Manner S,Vuorela PM,Ichinose K,Metsä-Ketelä M,Fallarero A

更新日期：2015-10-01 00:00:00

abstract：:The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline solution for 1 month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Hodzic E,Feng S,Holden K,Freet KJ,Barthold SW

更新日期：2008-05-01 00:00:00

abstract：:GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, di...

journal_title：Antimicrobial agents and chemotherapy

authors： Delbrück H,Bogaerts P,Kupper MB,Rezende de Castro R,Bennink S,Glupczynski Y,Galleni M,Hoffmann KM,Bebrone C

更新日期：2012-11-01 00:00:00

abstract：:The metallo-β-lactamase VIM-4, mainly found in Pseudomonas aeruginosa or Acinetobacter baumannii, was produced in Escherichia coli and characterized by biochemical and X-ray techniques. A detailed kinetic study performed in the presence of Zn²+ at concentrations ranging from 0.4 to 100 μM showed that VIM-4 exhibits a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lassaux P,Traoré DA,Loisel E,Favier A,Docquier JD,Sohier JS,Laurent C,Bebrone C,Frère JM,Ferrer JL,Galleni M

更新日期：2011-03-01 00:00:00

abstract：:The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycli...

journal_title：Antimicrobial agents and chemotherapy

authors： Shipley PL,Olsen RH

更新日期：1974-08-01 00:00:00

abstract：:The antimicrobial activity of CS-940, a new trifluorinated quinolone drug, was tested against 761 clinical isolates. CS-940 activity against members of the family Enterobacteriaceae was most similar to that of ciprofloxacin and ofloxacin, with a large range of MICs inhibiting 90% of isolates tested (MIC90S) of 0.015 t...

journal_title：Antimicrobial agents and chemotherapy

authors： Biedenbach DJ,Sutton LD,Jones RN

更新日期：1995-10-01 00:00:00

abstract：:Among the 7 most common UL97 mutations encountered in ganciclovir-resistant clinical cytomegalovirus isolates, the associated cyclopropavir cross-resistance varies from insignificant (L595S) to substantial (M460I and H520Q) as determined by recombinant phenotyping. Mutations M460I and H520Q were preferentially selecte...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S,Bowlin TL

更新日期：2011-01-01 00:00:00

abstract：:We have recently reported an influenza virus neuraminidase inhibitor, RWJ-270201 (BCX-1812), a novel cyclopentane derivative discovered through structure-based drug design. In this paper, we compare the potency of three compounds, RWJ-270201, oseltamivir, and zanamivir, against neuraminidase enzymes from various subty...

journal_title：Antimicrobial agents and chemotherapy

authors： Bantia S,Parker CD,Ananth SL,Horn LL,Andries K,Chand P,Kotian PL,Dehghani A,El-Kattan Y,Lin T,Hutchison TL,Montgomery JA,Kellog DL,Babu YS

更新日期：2001-04-01 00:00:00

abstract：:Mycobacterium tuberculosis and the fast-growing species Mycobacterium abscessus are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug-resistant M. tuberculosis strains and the high level of intrinsic resistance of M....

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta R,Rodrigues Felix C,Akerman MP,Akerman KJ,Slabber CA,Wang W,Adams J,Shaw LN,Tse-Dinh YC,Munro OQ,Rohde KH

更新日期：2018-04-26 00:00:00

abstract：:Polymyxins are increasingly used as a last-resort class of antibiotics against extensively drug-resistant (XDR) Gram-negative bacteria. However, resistance to polymyxins can emerge with monotherapy. As nephrotoxicity is the major dose-limiting factor for polymyxin monotherapy, dose escalation to suppress the emergence...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin YW,Yu HH,Zhao J,Han ML,Zhu Y,Akter J,Wickremasinghe H,Walpola H,Wirth V,Rao GG,Forrest A,Velkov T,Li J

更新日期：2018-05-25 00:00:00

abstract：:In vitro surveys of antimicrobial resistance among clinically important anaerobes are an important source of information that can be used for clinical decisions in the choice of empiric antimicrobial therapy. This study surveyed the susceptibilities of 556 clinical anaerobic isolates from four large medical centers us...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft D,Cambre K,Pierson CL,Jenkins SG,Rosenblatt JE

更新日期：2001-04-01 00:00:00

abstract：:Doxycycline is an alternative antibiotic drug for the treatment of syphilis, but data on its efficacy, especially data on its efficacy against late latent syphilis, are limited. A retrospective study was conducted to evaluate the effectiveness of doxycycline for the treatment of patients with different stages of syphi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dai T,Qu R,Liu J,Zhou P,Wang Q

更新日期：2016-12-27 00:00:00

abstract：:Resistance of influenza viruses to antiviral drugs can emerge following medication or may result from natural variation. Two classes of anti-influenza virus drugs targeting either the M2 protein (amantadine and rimantadine) or neuraminidase (NA; oseltamivir and zanamivir) are currently licensed. These drugs are expect...

journal_title：Antimicrobial agents and chemotherapy

authors： Deyde VM,Nguyen T,Bright RA,Balish A,Shu B,Lindstrom S,Klimov AI,Gubareva LV

更新日期：2009-03-01 00:00:00

abstract：:The current voriconazole dosing recommendation in adolescents is based on limited efficacy and pharmacokinetic data. To confirm the appropriateness of dosing adolescents like adults, a pharmacokinetic study was conducted in 26 immunocompromised adolescents aged 12 to <17 years following intravenous (IV) voriconazole t...

journal_title：Antimicrobial agents and chemotherapy

authors： Driscoll TA,Frangoul H,Nemecek ER,Murphey DK,Yu LC,Blumer J,Krance RA,Baruch A,Liu P

更新日期：2011-12-01 00:00:00

abstract：:The in vitro activities of tigecycline and selected antimicrobials were evaluated against a variety of multiple-drug-resistant clinical isolates, including extended-spectrum beta-lactamase- and/or metallo-beta-lactamase-producing gram-negative strains, colistin-resistant strains, vancomycin- and/or linezolid-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Souli M,Kontopidou FV,Koratzanis E,Antoniadou A,Giannitsioti E,Evangelopoulou P,Kannavaki S,Giamarellou H

更新日期：2006-09-01 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:Two aminocyclitol-negative Micromonospora mutants representing two different species, M. purpurea and M. inyoensis, and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee BK,Nagabhushan TL,Condon RG,Cooper AB,Waitz JA

更新日期：1978-07-01 00:00:00

abstract：:The opportunistic Gram-negative pathogen Pseudomonas aeruginosa, known for its intrinsic and acquired antibiotic resistance, has a notorious ability to form biofilms, which often facilitate chronic infections. The evolutionary paths to antibiotic resistance have mainly been investigated in planktonic cultures and are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahmed MN,Porse A,Sommer MOA,Høiby N,Ciofu O

更新日期：2018-07-27 00:00:00

abstract：:The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Neal SW,Parekh MC,Rice RJ

更新日期：1995-04-01 00:00:00