Pharmacokinetic interpretation of cephradine levels in serum after intravenous and extravascular administration in humans.

abstract：:We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at positi...

journal_title：Antimicrobial agents and chemotherapy

authors： Welsh KJ,Barlow M,Tenover FC,Biddle JW,Rasheed JK,Clark LA,McGowan JE Jr

更新日期：2005-03-01 00:00:00

abstract：:Isavuconazole, the active moiety of the prodrug isavuconazonium sulfate, has potent activity against a wide spectrum of fungal pathogens and is approved for the treatment of invasive aspergillosis, yet little is known about the tissue penetration of isavuconazole at the target sites of infection. Here, we explored the...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee A,Prideaux B,Lee MH,Zimmerman M,Dolgov E,Perlin DS,Zhao Y

更新日期：2019-05-24 00:00:00

abstract：:Time-kill studies examined the activities of telithromycin (HMR 3647), erythromycin A, azithromycin, clarithromycin, roxithromycin, clindamycin, pristinamycin, amoxicillin-clavulanate, and metronidazole against 11 gram-positive and gram-negative anaerobic bacteria. Time-kill studies were carried out with the addition ...

journal_title：Antimicrobial agents and chemotherapy

authors： Credito KL,Ednie LM,Jacobs MR,Appelbaum PC

更新日期：1999-08-01 00:00:00

abstract：:The efficacy of intravenous peramivir against influenza A (H1N1) 2009 virus infection was evaluated in mice in which the immune system was suppressed by cyclophosphamide (CP) treatment. The mortality rate of the vehicle control group was 100%, and the mice lost 20% of their body weight on average by day 13 postinfecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Kodama M,Itoh Y,Kanazu T,Kobayashi M,Yoshida R,Sato A

更新日期：2013-05-01 00:00:00

abstract：:As an obligate aerobe, Mycobacterium tuberculosis uses its electron transport chain (ETC) to produce energy via oxidative phosphorylation. This pathway has recently garnered a lot of attention and is a target for several new antimycobacterials. We tested the respiratory adaptation of M. tuberculosis to phenoxyalkylben...

journal_title：Antimicrobial agents and chemotherapy

authors： Berube BJ,Parish T

更新日期：2017-12-21 00:00:00

abstract：:The most widely used drug for treatment of candidiasis is fluconazole (FCZ). Recently, a new derivative of 1,4-benzothiazine, compound FS5, was developed. FS5 had an appreciable protective effect against murine candidiasis. The present study was designed to dissect the antifungal mechanisms triggered by FS5 and to est...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitzurra L,Fringuelli R,Perito S,Schiaffella F,Barluzzi R,Bistoni F,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:This work investigated the molecular events driving the evolution of the CTX-M-type β-lactamases by the use of DNA shuffling of fragments of the blaCTX-M-14 and blaCTX-M-15 genes. Analysis of a total of 51 hybrid enzymes showed that enzymatic activity could be maintained in most cases, yet hybrids that were active pos...

journal_title：Antimicrobial agents and chemotherapy

authors： Po KHL,Chan EWC,Chen S

更新日期：2017-11-22 00:00:00

abstract：:We conducted this double-blind, parallel-group, placebo-controlled, randomized, multiple-ascending-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of GS-9851 (formerly PSI-7851) in treatment-naïve patients infected with hepatitis C virus (HCV) genotype 1. Thirty-two patients recei...

journal_title：Antimicrobial agents and chemotherapy

authors： Lawitz E,Rodriguez-Torres M,Denning JM,Albanis E,Cornpropst M,Berrey MM,Symonds WT

更新日期：2013-03-01 00:00:00

abstract：:We conducted time-kill studies to evaluate the inhibitory activities of either cefotaxime or minocycline alone and the two drugs in combination against a clinical strain of Vibrio vulnificus. The MICs of cefotaxime and minocycline were 0.03 and 0.06 microg/ml, respectively. When approximately 5 x 10(5) CFU of V. vulni...

journal_title：Antimicrobial agents and chemotherapy

authors： Chuang YC,Liu JW,Ko WC,Lin KY,Wu JJ,Huang KY

更新日期：1997-10-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:Seven clinical isolates of Shigella sonnei with reduced susceptibilities to fluoroquinolones (sparfloxacin, ciprofloxacin, and ofloxacin) were obtained. The MICs of fluoroquinolones against these S. sonnei strains were 16 to 32 times higher than those obtained against typical strains that are highly susceptible to the...

journal_title：Antimicrobial agents and chemotherapy

authors： Horiuchi S,Inagaki Y,Yamamoto N,Okamura N,Imagawa Y,Nakaya R

更新日期：1993-11-01 00:00:00

abstract：:We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B....

journal_title：Antimicrobial agents and chemotherapy

authors： Kontoyiannis DP,Lewis RE,Sagar N,May G,Prince RA,Rolston KV

更新日期：2000-10-01 00:00:00

abstract：:Two group F vibrio organisms have been identified among a collection of vibrio strains isolated from the aquatic environment in Bangladesh. Neither group F strain produced a cholera-like enterotoxin. One of the isolates, BV12, contained an R plasmid conferring resistance to streptomycin and chloramphenicol. ...

journal_title：Antimicrobial agents and chemotherapy

authors： McNicol LA,Kaper JB,Lockman HA,Remmers EF,Spira WM,Colwell RR

更新日期：1980-03-01 00:00:00

abstract：:Ribavirin was inactive against the rotavirus of murine gastroenteritis; this may be due to the presence of guanosine inhibitors in the gut. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Schoub BD,Prozesky OW

更新日期：1977-10-01 00:00:00

abstract：:A gentamicin resistance determinant of a conjugative plasmid from Enterobacter cloacae was cloned on a 3.2-kilobase fragment in the PstI site of pBR322. Substrate profiles for eight aminoglycosides at three concentrations showed that the resistance was due to aminoglycoside-(3)-N-acetyltransferase isoenzyme II. Insert...

journal_title：Antimicrobial agents and chemotherapy

authors： Vliegenthart JS,Ketelaar-van Gaalen PA,van de Klundert JA

更新日期：1989-08-01 00:00:00

abstract：:Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the synthesis of both DHBV DNA and DHBV core antigen. Several nucleoside analogs which were previously shown to inhibit the replication of DNA viruses (i.e., herpesviruses) and retroviruses were examined for their inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Yokota T,Konno K,Chonan E,Mochizuki S,Kojima K,Shigeta S,de Clercq E

更新日期：1990-07-01 00:00:00

abstract：:Activity against the coccidial pathogen Eimeria tenella in chickens has been discovered among alpha 2 adrenergic agonists. The clonidine analog 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine was active in feed at 7.5 ppm, a concentration similar to the use levels of potent commercial agents, e.g., maduramicin. A...

journal_title：Antimicrobial agents and chemotherapy

authors： McFarland JW,Ricketts AP,Newcomb DM,Shively JE,Glazer EA

更新日期：1992-02-01 00:00:00

abstract：:The in vitro inhibitory effects of quinolones on the bacterial DNA gyrase of Escherichia coli KL-16 and topoisomerase II of fetal calf thymus were compared. All the quinolones tested required higher concentrations to inhibit the topoisomerase II than to inhibit the DNA gyrase, and no correlation existed among their in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoshino K,Sato K,Une T,Osada Y

更新日期：1989-10-01 00:00:00

abstract：:In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based assay which uses Alamar blue reagent for determination of growth was evaluated. MICs of 30 antimicrobial agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis H37Ra, and Mycobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins L,Franzblau SG

更新日期：1997-05-01 00:00:00

abstract：:Caspofungin (CAS) is approved for second-line management of proven or probable invasive aspergillosis at a dose of 50 mg once daily (QD). Preclinical and limited clinical data support the concept of the dose-dependent antifungal efficacy of CAS with preservation of its favorable safety profile. Little is known, howeve...

journal_title：Antimicrobial agents and chemotherapy

authors： Würthwein G,Cornely OA,Trame MN,Vehreschild JJ,Vehreschild MJ,Farowski F,Müller C,Boos J,Hempel G,Hallek M,Groll AH

更新日期：2013-04-01 00:00:00

abstract：:We have conducted experiments to determine if one daily injection of netilmicin (NET) would be synergistic with the broad-spectrum cephalosporin ceftriaxone (CRO) in the treatment of experimentally induced endocarditis. Rats with catheter-induced aortic vegetations were infected intravenously with 3 x 10(7) CFU of a b...

journal_title：Antimicrobial agents and chemotherapy

authors： Francioli PB,Glauser MP

更新日期：1993-02-01 00:00:00

abstract：:Propolis, a resinous bee product, has been shown to inhibit the growth of oral microorganisms and the activity of bacterium-derived glucosyltransferases (GTFs). Several compounds, mainly polyphenolics, have been identified in this natural product. The present study evaluated the effects of distinct chemical groups fou...

journal_title：Antimicrobial agents and chemotherapy

authors： Koo H,Rosalen PL,Cury JA,Park YK,Bowen WH

更新日期：2002-05-01 00:00:00

abstract：:Hand-foot-and-mouth disease (HFMD), caused by enterovirus, is a threat to public health worldwide. To date, enterovirus 71 (EV71) has been one of the major causative agents of HFMD in the Pacific-Asia region, and outbreaks with EV71 cause millions of infections. However, no drug is currently available for clinical the...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang Y,Cao L,Zhai Y,Yin Z,Sun Y,Shang L

更新日期：2017-06-27 00:00:00

abstract：:The integrase inhibitor raltegravir (RAL) is currently used for the treatment of both treatment-naïve and treatment-experienced HIV-1-infected patients. Elvitegravir (EVG) is in late phases of clinical development. Since significant cross-resistance between RAL and EVG is observed, there is a need for second-generatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Wesenbeeck L,Rondelez E,Feyaerts M,Verheyen A,Van der Borght K,Smits V,Cleybergh C,De Wolf H,Van Baelen K,Stuyver LJ

更新日期：2011-01-01 00:00:00

abstract：:The in vitro activities of CG400549, a novel FabI inhibitor, were compared to those of linezolid and commonly used antimicrobials against recent bacterial isolates. CG400549 had an MIC(90) of 0.5 microg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yum JH,Kim CK,Yong D,Lee K,Chong Y,Kim CM,Kim JM,Ro S,Cho JM

更新日期：2007-07-01 00:00:00

abstract：:Antiviral drugs do not currently exist for the treatment of enterovirus infections, which are often severe and potentially life-threatening. We conducted high-throughput molecular screening and identified a structurally diverse set of compounds that inhibit the replication of coxsackievirus B3, a commonly encountered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zuo J,Kye S,Quinn KK,Cooper P,Damoiseaux R,Krogstad P

更新日期：2015-12-28 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:The rate of occurrence of the extended-spectrum beta-lactamase (ESBL)-producing phenotype among Escherichia coli isolates in Tel Aviv is 12% (22). The aim of this study was to understand the molecular epidemiology of E. coli ESBL producers and to identify the ESBL genes carried by them. We studied 20 single-patient ES...

journal_title：Antimicrobial agents and chemotherapy

authors： Chmelnitsky I,Carmeli Y,Leavitt A,Schwaber MJ,Navon-Venezia S

更新日期：2005-11-01 00:00:00

abstract：:Twelve straight-chain esters, C(5) to C(14), C(16), and C(18), of p-hydroxybenzoic acid were prepared, and their melting points, solubilities in water at 25 degrees C, infrared spectra, dissociation constants (pK(a)), and activities against Clostridium botulinum were determined. These studies also included four commer...

journal_title：Antimicrobial agents and chemotherapy

authors： Dymicky M,Huhtanen CN

更新日期：1979-06-01 00:00:00

abstract：:Bacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue is trans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes in the absence of suff...

journal_title：Antimicrobial agents and chemotherapy

authors： Goralski TD,Dewan KK,Alumasa JN,Avanzato V,Place DE,Markley RL,Katkere B,Rabadi SM,Bakshi CS,Keiler KC,Kirimanjeswara GS

更新日期：2016-05-23 00:00:00