Itraconazole-amphotericin B antagonism in Aspergillus fumigatus: an E-test-based strategy.

abstract：:The most appropriate vancomycin dosing strategy in pediatric patients weighing ≥70 kg (weight based versus non-weight based) to achieve an area under the concentration-time curve (AUC) of ≥400 mg·liter/h and a trough concentration of <20 mg/liter is not known. Population pharmacokinetic analysis determined that dosing...

journal_title：Antimicrobial agents and chemotherapy

authors： Moffett BS,Ivaturi V,Morris J,Akcan Arikan A,Dutta A

更新日期：2019-03-27 00:00:00

abstract：:The creation of new chemotherapeutic regimens that permit shortening the duration of treatment is a major priority for antituberculosis drug development. In this study, we used the murine model of experimental tuberculosis therapy to determine whether incorporation of the investigational new nitroimidazopyran PA-824 i...

journal_title：Antimicrobial agents and chemotherapy

authors： Nuermberger E,Rosenthal I,Tyagi S,Williams KN,Almeida D,Peloquin CA,Bishai WR,Grosset JH

更新日期：2006-08-01 00:00:00

abstract：:Patients (n = 409) with severe skin and soft tissue infections (SSTIs) were randomized to receive clinafloxacin or piperacillin-tazobactam (plus optional vancomycin for methicillin-resistant cocci), administered intravenously, with the option to switch to oral medication. Most patients had cellulitis, wound infections...

journal_title：Antimicrobial agents and chemotherapy

authors： Siami G,Christou N,Eiseman I,Tack KJ,Severe Skin and Soft Tissue Infections Study Group.

更新日期：2001-02-01 00:00:00

abstract：:Despite dose-limiting nephrotoxicity concerns, polymyxin B has resurged as the treatment of last resort for multidrug-resistant Gram-negative bacterial infections. However, the pharmacokinetic, pharmacodynamic, and nephrotoxic properties of polymyxin B still are not thoroughly understood. The objective of this study w...

journal_title：Antimicrobial agents and chemotherapy

authors： Manchandani P,Zhou J,Ledesma KR,Truong LD,Chow DS,Eriksen JL,Tam VH

更新日期：2015-12-07 00:00:00

abstract：:Many gram-negative bacteria are known to be remarkably resistant to hydrophobic noxious agents by virtue of their outer membranes (OM). We investigated, by using four different assay methods, the ability of sodium hexametaphosphate (HMP) to disrupt this OM barrier. (i) In the growth inhibition assay, HMP was found to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Jaakkola J

更新日期：1989-10-01 00:00:00

abstract：:Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Stockbauer KE,Williams DL,Kreiswirth BN,Musser JM

更新日期：1996-04-01 00:00:00

abstract：:Sporadic isolates of carbapenem-resistant KPC-2-producing Klebsiella pneumoniae were isolated in Tel Aviv Medical Center during 2005 and 2006, parallel to the emergence of the KPC-3-producing K. pneumoniae sequence type 258 (ST 258). We aimed to study the molecular epidemiology of these isolates and to characterize th...

journal_title：Antimicrobial agents and chemotherapy

authors： Leavitt A,Carmeli Y,Chmelnitsky I,Goren MG,Ofek I,Navon-Venezia S

更新日期：2010-07-01 00:00:00

abstract：:Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 microg/ml. These MICs were lower than those of other quinolones (< or = 0.008 to > 32 microg/ml). Beta-lactam MICs were between < or = 0.008 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kosowska-Shick K,Smith K,Bogdanovich T,Ednie LM,Jones RN,Appelbaum PC

更新日期：2006-12-01 00:00:00

abstract：:Preclinical animal models informing antimalarial drug development are scarce. We have used asexual erythrocytic Plasmodium cynomolgi infections of rhesus macaques to model Plasmodium vivax during preclinical development of compounds targeting parasite phospholipid synthesis. Using this malaria model, we accumulated da...

journal_title：Antimicrobial agents and chemotherapy

authors： Kocken CH,Remarque EJ,Dubbeld MA,Wein S,van der Wel A,Verburgh RJ,Vial HJ,Thomas AW

更新日期：2009-02-01 00:00:00

abstract：:Ethambutol (EMB) plays a pivotal role in the chemotherapy of drug-resistant tuberculosis (TB), including multidrug-resistant tuberculosis (MDR-TB). Resistance to EMB is considered to be caused by mutations in the embCAB operon (embC, embA, and embB). In this study, we analyzed the embCAB mutations among 139 MDR-TB iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao LL,Sun Q,Liu HC,Wu XC,Xiao TY,Zhao XQ,Li GL,Jiang Y,Zeng CY,Wan KL

更新日期：2015-04-01 00:00:00

abstract：:Biapenem, formerly LJC 10,627 or L-627, a carbapenem antibiotic, was studied in its interactions with 12 beta-lactamases belonging to the four molecular classes proposed by R. P. Ambler (Philos. Trans. R. Soc. Lond. Biol. Sci. 289:321-331, 1980). Kinetic parameters were determined. Biapenem was readily inactivated by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Felici A,Perilli M,Segatore B,Franceschini N,Setacci D,Oratore A,Stefani S,Galleni M,Amicosante G

更新日期：1995-06-01 00:00:00

abstract：:Monophenol monooxygenase (monophenol, dihydroxyphenylalanine:oxygen oxidoreductase EC 1.14.18.1) was studied in melanin-positive and melanin-negative mutants of Streptomyces lincolnensis NCIB 9413, varying in the lincomycin synthesizing ability. The activities of laccase and tyrosine phenol lyase (EC 4.1.99.2) are abs...

journal_title：Antimicrobial agents and chemotherapy

authors： Michalik J,Emilianowicz-Czerska W,Switalski L,Raczyńska-Bojanowska K

更新日期：1975-11-01 00:00:00

abstract：:A clinical isolate of Pseudomonas aeruginosa recovered from the lower respiratory tract of an 81-year-old patient hospitalized in Belgium was sent to the national reference center to determine its resistance mechanism. PCR sequencing identified a new GES variant, GES-18, which differs from the carbapenem-hydrolyzing e...

journal_title：Antimicrobial agents and chemotherapy

authors： Bebrone C,Bogaerts P,Delbrück H,Bennink S,Kupper MB,Rezende de Castro R,Glupczynski Y,Hoffmann KM

更新日期：2013-01-01 00:00:00

abstract：:To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had f...

journal_title：Antimicrobial agents and chemotherapy

authors： Larder BA,Bloor S,Kemp SD,Hertogs K,Desmet RL,Miller V,Sturmer M,Staszewski S,Ren J,Stammers DK,Stuart DI,Pauwels R

更新日期：1999-08-01 00:00:00

abstract：:Similar to Neisseria gonorrhoeae, tetracycline-resistant isolates of N. meningitidis, Kingella denitrificans, and Eikenella corrodens contained 25.2-megadalton plasmids carrying the TetM determinant. In contrast, tetracycline-resistant N. subflava biovar perflava-N. sicca and N. mucosa isolates carried the TetM determ...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Johnson SR,Zenilman JM,Roberts MC,Morse SA

更新日期：1988-05-01 00:00:00

abstract：:Gemifloxacin mesylate (SB 265805), a new fluoronaphthyridone, was tested against 359 recent clinical anaerobic isolates by the National Committee for Clinical Laboratory Standards reference agar dilution method with supplemented brucella blood agar and an inoculum of 10(5) CFU/spot. Comparative antimicrobials tested i...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Warren Y,Tyrrell K,Merriam CV

更新日期：1999-09-01 00:00:00

abstract：:The efficacy of ciprofloxacin for experimental aortic valve endocarditis in rabbits infected by either a methicillin-susceptible or a methicillin-resistant strain of Staphylococcus aureus was compared with standard therapy of nafcillin or vancomycin, respectively. After 4 days of therapy, ciprofloxacin reduced the cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Carpenter TC,Hackbarth CJ,Chambers HF,Sande MA

更新日期：1986-09-01 00:00:00

abstract：:Penetration of cefprozil into the middle ear fluid was investigated in patients with chronic otitis media. A total of 89 patients ranging from 7 months to 11 years old participated in the study. The middle ear fluid was removed by ventilation tubes inserted through the tympanic membrane at times ranging from 0.38 to 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Haddad J,Reilly J,Khan WN,Campbell DA,Tsai Y,Barbhaiya RH

更新日期：1994-09-01 00:00:00

abstract：:Killing by beta-lactams is well known to be reduced against a dense bacterial population, commonly known as the inoculum effect. However, the underlying mechanism of this phenomenon is not well understood. We proposed a semi-mechanistic mathematical model to account for the reduced in vitro killing observed. Time-kill...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhagunde P,Chang KT,Singh R,Singh V,Garey KW,Nikolaou M,Tam VH

更新日期：2010-11-01 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis (HVH) type 2 provides a model for disseminated herpesvirus infections of human newborn infants. Treatment of this experimental infection with polyinosinic-polycytidylic acid [poly(I:C)] significantly increased the mean survival time and markedly altered t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-06-01 00:00:00

abstract：:A total of 6,991 unique patient isolates of Streptococcus pneumoniae were collected from October 1997 to June 2002 from 25 medical centers in 9 of the 10 Canadian provinces. Among these isolates, 20.2% were penicillin nonsusceptible, with 14.6% being penicillin intermediate (MIC, 0.12 to 1 microg/ml) and 5.6% being pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Palatnick L,Nichol KA,Bellyou T,Low DE,Hoban DJ

更新日期：2003-06-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:We have conducted experiments to determine if one daily injection of netilmicin (NET) would be synergistic with the broad-spectrum cephalosporin ceftriaxone (CRO) in the treatment of experimentally induced endocarditis. Rats with catheter-induced aortic vegetations were infected intravenously with 3 x 10(7) CFU of a b...

journal_title：Antimicrobial agents and chemotherapy

authors： Francioli PB,Glauser MP

更新日期：1993-02-01 00:00:00

abstract：:A cytochrome P-450-deficient mutant of Candida albicans, strain D10, was employed to study the mode of action of imidazole antifungal agents. This mutant accumulates exclusively 14-alpha-methylsterols, resulting in a sterol profile which mimics that of azole-treated wild-type strains. Since the widely accepted primary...

journal_title：Antimicrobial agents and chemotherapy

authors： Lees ND,Broughton MC,Sanglard D,Bard M

更新日期：1990-05-01 00:00:00

abstract：:The in vitro interaction between triclosan and fluconazole against 24 azole-resistant clinical isolates of Candida albicans was evaluated by the microdilution checkerboard technique. The synergisms were verified by time-killing curves and agar diffusion tests in selected strains. Antagonistic activity was not detected...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu L,Ling G,Deng X,Jin J,Jin Q,Guo N

更新日期：2011-07-01 00:00:00

abstract：:Sulfide production has been proposed to be a universal defense mechanism against antibiotics in bacteria (K. Shatalin, E. Shatalina, A. Mironov, and E. Nudler, Science 334:986-990, 2011, doi:10.1126/science.1209855). To gain insight into the mechanism underlying sulfide protection, we systematically and comparatively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Weikum J,Ritzmann N,Jelden N,Klöckner A,Herkersdorf S,Josten M,Sahl HG,Grein F

更新日期：2018-09-24 00:00:00

abstract：:The pharmacokinetics of teicoplanin were determined after multiple 30-min intravenous infusions of 10 to 15 mg/kg every 12 to 24 h in 11 intravenous drug abuse (IVDA) patients being treated for bacterial endocarditis. Multiple serum samples were obtained over 7 to 14 days. Twenty-four-hour urine collections were obtai...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak MJ,Lerner SA,Levine DP,Albrecht LM,McNeil PL,Thompson GA,Kenny MT,Yuh L

更新日期：1991-04-01 00:00:00

abstract：:The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by eit...

journal_title：Antimicrobial agents and chemotherapy

authors： Mishin VP,Hayden FG,Gubareva LV

更新日期：2005-11-01 00:00:00

abstract：:Bacteriophages have been used for more than a century for (unconventional) therapy of bacterial infections, for half a century as tools in genetic research, for 2 decades as tools for discovery of specific target-binding proteins, and for nearly a decade as tools for vaccination or as gene delivery vehicles. Here we p...

journal_title：Antimicrobial agents and chemotherapy

authors： Yacoby I,Shamis M,Bar H,Shabat D,Benhar I

更新日期：2006-06-01 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Klein K,Grønnemose RB,Alm M,Brinch KS,Kolmos HJ,Andersen TE

更新日期：2017-06-27 00:00:00