Penetration of cefprozil into middle ear fluid of patients with otitis media.

abstract：:PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Fritsche TR,Kaniga K,Ge Y,Jones RN

更新日期：2005-08-01 00:00:00

abstract：:A vancomycin-resistant Staphylococcus aureus (VRSA) isolate was obtained from a patient in Pennsylvania in September 2002. Species identification was confirmed by standard biochemical tests and analysis of 16S ribosomal DNA, gyrA, and gyrB sequences; all of the results were consistent with the S. aureus identification...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenover FC,Weigel LM,Appelbaum PC,McDougal LK,Chaitram J,McAllister S,Clark N,Killgore G,O'Hara CM,Jevitt L,Patel JB,Bozdogan B

更新日期：2004-01-01 00:00:00

abstract：:The susceptibilities of 430 Campylobacter jejuni strains and 79 C. coli strains to six antimicrobial agents were tested and analyzed. The two sets of strains originated from retail market chicken and turkey samples and from humans, respectively, in Berlin, Germany. Two groups of isolates, one dating from 1991 and the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luber P,Wagner J,Hahn H,Bartelt E

更新日期：2003-12-01 00:00:00

abstract：:A biodegradable system of poly-D,L-dilactide releasing ciprofloxacin was assessed in a Pseudomonas aeruginosa osteomyelitis model after inoculation of the test pathogen into the left tibia of 76 New Zealand White rabbits; 31 were controls (group A), and 45 were implanted with the polymer at the infection site (group B...

journal_title：Antimicrobial agents and chemotherapy

authors： Kanellakopoulou K,Thivaios GC,Kolia M,Dontas I,Nakopoulou L,Dounis E,Giamarellos-Bourboulis EJ,Andreopoulos A,Karagiannakos P,Giamarellou H

更新日期：2008-07-01 00:00:00

abstract：:Suboptimal doses of amphotericin B in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated Aspergillus fumigatus infection in mice. Despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradi...

journal_title：Antimicrobial agents and chemotherapy

authors： Arroyo J,Medoff G,Kobayashi GS

更新日期：1977-01-01 00:00:00

abstract：:Inter- and intralaboratory reproducibility of susceptibility testing requires stable control strains. The Food and Drug Administration diffusion procedure recommends the Seattle strains of Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) for this purpose. It was of interest to determine the present...

journal_title：Antimicrobial agents and chemotherapy

authors： Coyle MB,Lampe MF,Aitken CL,Feigl P,Sherris JC

更新日期：1976-09-01 00:00:00

abstract：:The antimicrobial activity of cinoxacin, 1-ethyl-4(1H)-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid, previously reported as compound 64716, was determined and compared with other antimicrobial agents at a dosage of 12 mg/kg once daily in a descending pyelonephritis rat model with Escherichia coli and Proteus mir...

journal_title：Antimicrobial agents and chemotherapy

authors： Holmes DH,Ensminger PW,Gordee RS

更新日期：1974-10-01 00:00:00

abstract：:Tedizolid and linezolid in vitro activities against 3,032 Gram-positive pathogens collected in Asia-Pacific, Eastern European, and Latin American medical centers during 2014 were assessed. The isolates were tested for susceptibility by the current reference broth microdilution methods. Due to concern over the effect o...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

更新日期：2016-08-22 00:00:00

abstract：:Acyclovir-resistant clinical isolates of herpes simplex virus type 1 (HSV-1) were analyzed in vitro for their susceptibilities to essential oils of ginger, thyme, hyssop, and sandalwood. All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Schnitzler P,Koch C,Reichling J

更新日期：2007-05-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are effective antibiotic agents commonly found in plants, animals, and microorganisms, and they have been suggested as the future of antimicrobial chemotherapies. It is vital to understand the molecular details that define the mechanism of action of resistance to AMPs for a rational plann...

journal_title：Antimicrobial agents and chemotherapy

authors： Maria-Neto S,Cândido Ede S,Rodrigues DR,de Sousa DA,da Silva EM,de Moraes LM,Otero-Gonzalez Ade J,Magalhães BS,Dias SC,Franco OL

更新日期：2012-04-01 00:00:00

abstract：:The optimal approach for empirical antibiotic therapy in patients with severe sepsis and septic shock remains controversial. A retrospective cohort study was conducted in the intensive care units of a university hospital. The data from 760 patients with severe sepsis or septic shock associated with Gram-negative bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Micek ST,Welch EC,Khan J,Pervez M,Doherty JA,Reichley RM,Kollef MH

更新日期：2010-05-01 00:00:00

abstract：:In 24 patients with hepatitic C virus (HCV) infection who participated in a randomized trial with alpha 2B interferon, HCV RNA analysis by the polymerase chain reaction with two separate primer sets was performed at weeks 0, 4, and 24 and during a follow-up period of 6 to 9 months. Prior to therapy all patients were H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kleter GE,Brouwer JT,Heijtink RA,Schalm SW,Quint WG

更新日期：1993-03-01 00:00:00

abstract：:Sixteen clinical fungal isolates were tested for antibiotic susceptibility by using disks impregnated with growth medium and antibiotic. The procedure was easier to perform, less time consuming, and as reliable as other currently available methods. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyer JE

更新日期：1976-06-01 00:00:00

abstract：:Fragments (414 bp) of the gene-encoding ribosomal protein L16 from Enterococcus faecium and Enterococcus faecalis that were resistant and susceptible to the oligosaccharide antibiotics avilamycin and evernimicin (SCH 27899) were sequenced and compared. The susceptible E. faecalis and E. faecium isolates had sequences ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aarestrup FM,Jensen LB

更新日期：2000-12-01 00:00:00

abstract：:Pipemidic acid was absorbed well by the oral route. Its peak levels in plasma ranged from 4 to 12 mug/ml at an oral dose of about 50 mg/kg in mice, rats, dogs, monkeys, and men. The protein binding of pipemidic acid was about 20% in dog plasma and about 30% in human serum. Pipemidic acid was distributed to most of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu M,Nakamura S,Takase Y,Kurobe N

更新日期：1975-04-01 00:00:00

abstract：:Although antimicrobial agents are effective therapy for early Lyme disease, optimal treatment schedules have not been conclusively established. The efficacy of various dosages of eight antibiotics used for borreliosis treatment was evaluated for C3H/HeNCrIBR mice, which reproducibly develop persistent infection, arthr...

journal_title：Antimicrobial agents and chemotherapy

authors： Moody KD,Adams RL,Barthold SW

更新日期：1994-07-01 00:00:00

abstract：:Ethambutol (EMB) is a major component of the first-line therapy of tuberculosis. Mutations in codon 306 of embB (embB306) were suggested as a major resistance mechanism in clinical isolates. To directly analyze the impact of individual embB306 mutations on EMB resistance, we used allelic exchange experiments to genera...

journal_title：Antimicrobial agents and chemotherapy

authors： Plinke C,Walter K,Aly S,Ehlers S,Niemann S

更新日期：2011-06-01 00:00:00

abstract：:The aim of this study was to explore bactericidal activity of total and free serum simulated concentrations after the oral administration of cefditoren (400 mg, twice daily [bid]) versus the oral administration of amoxicillin-clavulanic acid extended release formulation (2,000/125 mg bid) against Haemophilus influenza...

journal_title：Antimicrobial agents and chemotherapy

authors： Torrico M,Aguilar L,González N,Giménez MJ,Echeverría O,Cafini F,Sevillano D,Alou L,Coronel P,Prieto J

更新日期：2007-10-01 00:00:00

abstract：:Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： Kiri N,Archer G,Climo MW

更新日期：2002-06-01 00:00:00

abstract：:We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of m...

journal_title：Antimicrobial agents and chemotherapy

authors： Spreghini E,Orlando F,Santinelli A,Pisa E,Loretelli C,Manso E,Milici ME,Scalise G,Barchiesi F

更新日期：2009-09-01 00:00:00

abstract：:We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total, were highly cefoxitin resistant and had minimum inhibitory concentrations of greater than or equal to 64 micrograms/ml. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuchural GJ Jr,Tally FP,Jacobus NV,Marsh PK,Mayhew JW

更新日期：1983-12-01 00:00:00

abstract：:The design of novel integrase (IN) inhibitors has been aided by recent crystal structures revealing the binding mode of these compounds with a full-length prototype foamy virus (PFV) IN and synthetic viral DNA ends. Earlier docking studies relied on incomplete structures and did not include the contribution of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson BC,Métifiot M,Pommier Y,Hughes SH

更新日期：2012-01-01 00:00:00

abstract：:Enterococcus faecalis is an opportunistic pathogen and leading cause of health care-associated infections. Daily chlorhexidine gluconate (CHG) bathing of patients is generally regarded as an effective strategy to reduce the occurrence of health care-associated infections. It is likely that E. faecalis is frequently ex...

journal_title：Antimicrobial agents and chemotherapy

authors： Li FJ,Palmer KL

更新日期：2018-05-25 00:00:00

abstract：:For the present report, a novel complex class 1 integron, In60, was characterized. Part of this integron includes the bla(CTX-M-9) gene and its downstream nucleotide sequence, which shares 81% and 78% nucleotide identity with those of kluA-1 beta-lactamase and orf3 of K. ascorbata, respectively. Furthermore, a new ins...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabaté M,Navarro F,Miró E,Campoy S,Mirelis B,Barbé J,Prats G

更新日期：2002-08-01 00:00:00

abstract：:The antibiotic tolerances of bacterial persisters have been attributed to transient dormancy. While persisters have been observed to be growth inhibited prior to antibiotic exposure, we sought to determine whether such a trait was essential to the phenotype. Furthermore, we sought to provide direct experimental eviden...

journal_title：Antimicrobial agents and chemotherapy

authors： Orman MA,Brynildsen MP

更新日期：2013-07-01 00:00:00

abstract：:A survey carried out in 2005 among members of a healthy population of children living in Bolivia and Peru revealed that fecal carriage of Escherichia coli strains resistant to expanded-spectrum cephalosporins was remarkably increased compared to that observed in the same settings in 2002 (1.7% in 2005 versus 0.1% in 2...

journal_title：Antimicrobial agents and chemotherapy

authors： Pallecchi L,Bartoloni A,Fiorelli C,Mantella A,Di Maggio T,Gamboa H,Gotuzzo E,Kronvall G,Paradisi F,Rossolini GM

更新日期：2007-08-01 00:00:00

abstract：:Antibiotic treatment of lung infections may lead to the emergence of resistance in the gut flora. Appropriate dosing regimens could mitigate this adverse effect. In gnotobiotic rats harboring intestinal Escherichia coli and Enterococcus faecium populations, a lung infection by Klebsiella pneumoniae was instigated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Kesteman AS,Perrin-Guyomard A,Laurentie M,Sanders P,Toutain PL,Bousquet-Mélou A

更新日期：2010-07-01 00:00:00

abstract：:Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hawser SP,Bouchillon SK,Hoban DJ,Badal RE,Hsueh PR,Paterson DL

更新日期：2009-08-01 00:00:00

abstract：:OPC-20011, a new parenteral 2-oxaisocephem antibiotic, has an oxygen atom at the 2- position of the cephalosporin frame. OPC-20011 had the best antibacterial activities against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, and penicillin-resistant Streptoc...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto M,Tamaoka H,Ishikawa H,Kikuchi M

更新日期：1998-11-01 00:00:00

abstract：:Peroxide antimalarials, including artemisinin, are important for the treatment of multidrug-resistant malaria. These peroxides are known to react with iron or heme to produce reactive intermediates that are thought to be responsible for their antimalarial activities. This study investigated the potential interaction o...

journal_title：Antimicrobial agents and chemotherapy

authors： Creek DJ,Ryan E,Charman WN,Chiu FC,Prankerd RJ,Vennerstrom JL,Charman SA

更新日期：2009-08-01 00:00:00