Antimicrobial resistance in Campylobacter jejuni and Campylobacter coli strains isolated in 1991 and 2001-2002 from poultry and humans in Berlin, Germany.

abstract：:A mouse model of cystitis caused by uropathogenic Escherichia coli was used to study the distribution of gallium in bladder tissue following oral administration of gallium maltolate during urinary tract infection. The median concentration of gallium in homogenized bladder tissue from infected mice was 1.93 μg/g after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ball KR,Sampieri F,Chirino M,Hamilton DL,Blyth RI,Sham TK,Dowling PM,Thompson J

更新日期：2013-11-01 00:00:00

abstract：:We report patient-to-patient transmission of Enterobacter hormaechei isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the Ω-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibac...

journal_title：Antimicrobial agents and chemotherapy

authors： Munoz-Price LS,Reeme AE,Buchan BW,Mettus RT,Mustapha MM,Van Tyne D,Shields RK,Doi Y

更新日期：2019-09-23 00:00:00

abstract：:Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter...

journal_title：Antimicrobial agents and chemotherapy

authors： Lartigue MF,Leflon-Guibout V,Poirel L,Nordmann P,Nicolas-Chanoine MH

更新日期：2002-12-01 00:00:00

abstract：:Surotomycin (formerly called CB-183,315) is a novel, orally administered cyclic lipopeptide antibacterial in development for the treatment of Clostridium difficile infection (CDI) that has potent activity against vancomycin-resistant enterococci (VRE) but limited activity against Gram-negative bacilli, including Bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Deshpande A,Hurless K,Cadnum JL,Chesnel L,Gao L,Chan L,Kundrapu S,Polinkovsky A,Donskey CJ

更新日期：2016-05-23 00:00:00

abstract：:Many Pseudomonas aeruginosa isolates from the airways of patients with cystic fibrosis (CF) are sensitive to antibiotics in susceptibility testing, but eradication of the infection is difficult. The main reason is the biofilm formation in the airways of patients with CF. The pharmacokinetics (PKs) and pharmacodynamics...

journal_title：Antimicrobial agents and chemotherapy

authors： Hengzhuang W,Wu H,Ciofu O,Song Z,Høiby N

更新日期：2012-05-01 00:00:00

abstract：:In a previous work, we described the possible relationship between a defect of purine-cytosine permease and the acquisition of a cross-resistance to the antifungal combination flucytosine (5FC) and fluconazole (FLC) in Candida lusitaniae (T. Noël, F. François, P. Paumard, C. Chastin, D. Brethes, and J. Villard, Antimi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chapeland-Leclerc F,Bouchoux J,Goumar A,Chastin C,Villard J,Noël T

更新日期：2005-08-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study was to characterize a novel extended-spectrum beta-lactamase that belongs to the TEM family, the TEM-149 enzyme, and that was isolated from the urine of two hospitalized patients from different hospitals in southern Italy. The peculiarity of this enzyme was the finding of a valine residue at posi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Celenza G,De Santis F,Pellegrini C,Forcella C,Rossolini GM,Stefani S,Amicosante G

更新日期：2008-03-01 00:00:00

abstract：:Given that tedizolid exhibits substantial lung penetration, we hypothesize that it could achieve good efficacy against Streptococcus pneumoniae lung infections. We evaluated the pharmacodynamics of tedizolid for treatment of S. pneumoniae lung infections and compared the efficacies of tedizolid human-simulated epithel...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelraouf K,Nicolau DP

更新日期：2016-12-27 00:00:00

abstract：:Gardimycin, a new antibiotic, at 100 mug/ml, specifically inhibited cell wall synthesis and induced accumulation of uridine 5'-diphosphate-N-acetylmur-amylpentapeptide in whole cells of Bacillus subtilis. The antibiotic was active in a particulate enzyme preparation from Bacillus stearothermophilus: 60 mug/ml caused 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Somma S,Merati W,Parenti F

更新日期：1977-03-01 00:00:00

abstract：:TEM-24 remains one of the most widespread TEM-type extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae. To analyze the reasons influencing its spread and persistence, a multilevel population genetics study was carried out on 28 representative TEM-24 producers from Belgium, France, Portugal, and Spain (1...

journal_title：Antimicrobial agents and chemotherapy

authors： Novais A,Baquero F,Machado E,Cantón R,Peixe L,Coque TM

更新日期：2010-02-01 00:00:00

abstract：:The current voriconazole dosing recommendation in adolescents is based on limited efficacy and pharmacokinetic data. To confirm the appropriateness of dosing adolescents like adults, a pharmacokinetic study was conducted in 26 immunocompromised adolescents aged 12 to <17 years following intravenous (IV) voriconazole t...

journal_title：Antimicrobial agents and chemotherapy

authors： Driscoll TA,Frangoul H,Nemecek ER,Murphey DK,Yu LC,Blumer J,Krance RA,Baruch A,Liu P

更新日期：2011-12-01 00:00:00

abstract：:Strains of Pseudomonas aeruginosa resistant to either gentamicin or carbenicillin have been noted since their introduction into clinical use. During a 6-month period, twice-weekly cultures were obtained from all patients treated with either gentamicin or carbenicillin and from all patients with a positive culture for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaman W,Cates C,Snelling CF,Lank B,Ronald AR

更新日期：1976-03-01 00:00:00

abstract：:Nitazoxanide (NTZ), a drug currently being tested in human clinical trials for efficacy against chronic cryptosporidiosis, was assessed in cell culture and in two animal models. The inhibitory activity of NTZ was compared with that of paromomycin (PRM), a drug that is partially effective against Cryptosporidium parvum...

journal_title：Antimicrobial agents and chemotherapy

authors： Theodos CM,Griffiths JK,D'Onfro J,Fairfield A,Tzipori S

更新日期：1998-08-01 00:00:00

abstract：:Methionine gamma-lyase, the enzyme which catalyzes the single-step conversion of methionine to alpha-ketobutyrate, ammonia, and methanethiol, is highly active in many anaerobic pathogenic microorganisms but has no counterpart in mammals. This study tested the hypothesis that this pathogen-specific enzyme can be exploi...

journal_title：Antimicrobial agents and chemotherapy

authors： Coombs GH,Mottram JC

更新日期：2001-06-01 00:00:00

abstract：:Interpretive agreements among the results of fluconazole broth microdilution tests, Etests, and disk diffusion tests were documented by evaluating 495 Candida spp. Microdilution reference test results were in agreement with 96% of the Etest results; most discrepancies were minor differences. Fluconazole resistance of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Pfaller MA,Rennie RP,Fuchs PC,Brown SD

更新日期：2002-06-01 00:00:00

abstract：:The activity of MK-0826, a new carbapenem, against 309 Bacteroides fragilis group strains was investigated and compared with that of 11 other beta-lactam and 5 non-beta-lactam agents. MK-0826 showed excellent activity (MICs ranged from < or =0.06 to 4 microg/ml). The new carbapenem may be useful in the treatment of mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Sánchez A,Palau ML,Gómez M,Picazo JJ

更新日期：2001-08-01 00:00:00

abstract：:The antimalarial drug quinine has been shown to impair human polymorphonuclear leukocyte (PMN) functions. To gain insight into the mechanism of this phenomenon, we investigated quinine uptake by PMN with a fluorometric assay based on the fluorescence properties of this drug. After 30 min of incubation at 37 degrees C ...

journal_title：Antimicrobial agents and chemotherapy

authors： el Benna J,Pasquier C,Labro MT

更新日期：1991-07-01 00:00:00

abstract：:There has been a marked increase in the resistance of Neisseria gonorrhoeae isolated in Korea to penicillin, ampicillin, and tetracycline. In contrast, there has been no increased resistance to spectinomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson C,Rose DL,Tramont EC

更新日期：1976-04-01 00:00:00

abstract：:Two of the most common causes of inflammatory enteritis are Campylobacter fetus subsp. jejuni and Shigella species. No single antimicrobial agent is recommended for treatment of both diseases. Erythromycin is used to treat C. fetus subsp. jejuni infections but has not been studied in shigellosis. For this reason, we d...

journal_title：Antimicrobial agents and chemotherapy

authors： Greenberg RN,Pearson RD,Innes DJ,Sauer KT,Halterman LD,Guerrant RL

更新日期：1982-02-01 00:00:00

abstract：:After inducing mutagenesis with nitrosoguanidine, we used vancomycin enrichment in isolating auxotrophic mutants of Mycobacterium smegmatis. Compared with cycloserine and penicillin G, which are also cell wall inhibitors, vancomycin, with 24 h of exposure, produced less cell lysis and a greater reduction in viable cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Woodley CL,Baldwin JN,Greenberg J

更新日期：1981-04-01 00:00:00

abstract：:Difloxacin, A-56620, cefazolin, cefotaxime, ceftizoxime, cephapirin, SK&F 88070, and spectinomycin were used to compare the in vitro susceptibilities of Mycobacterium avium-M. intracellular isolates from patients with acquired immunodeficiency syndrome (AIDS), patients without AIDS, and diseased animals. Against the i...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne SK,Geddes GL,Isaac-Renton JL,Black WA

更新日期：1990-07-01 00:00:00

abstract：:To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline a...

journal_title：Antimicrobial agents and chemotherapy

authors： Tang HJ,Chen CC,Cheng KC,Wu KY,Lin YC,Zhang CC,Weng TC,Yu WL,Chiu YH,Toh HS,Chiang SR,Su BA,Ko WC,Chuang YC

更新日期：2013-11-01 00:00:00

abstract：:Multilocus microsatellite polymorphisms in 27 clinical Candida albicans isolates were found to be clearly unrelated to in vitro paradoxical growth or trailing effect with caspofungin. These findings suggest that such in vitro phenotypes are either gained or lost too rapidly to be predicted by more stable genomic marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Khlif M,Bogreau H,Michel-Nguyen A,Ayadi A,Ranque S

更新日期：2010-03-01 00:00:00

abstract：:Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation. In vitro resistance in Aspergillus fumig...

journal_title：Antimicrobial agents and chemotherapy

authors： Denning DW,Venkateswarlu K,Oakley KL,Anderson MJ,Manning NJ,Stevens DA,Warnock DW,Kelly SL

更新日期：1997-06-01 00:00:00

abstract：:Group B beta-hemolytic streptococci (GB-BHS) frequently cause severe infection in newborns. Previous in vitro studies showed accelerated killing of GB-BHS by ampicillin plus gentamicin as compared with ampicillin alone. To extend the in vitro observations, mice were infected experimentally with GB-BHS and treated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Deveikis A,Schauf V,Mizen M,Riff L

更新日期：1977-05-01 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:Although antimicrobial agents are effective therapy for early Lyme disease, optimal treatment schedules have not been conclusively established. The efficacy of various dosages of eight antibiotics used for borreliosis treatment was evaluated for C3H/HeNCrIBR mice, which reproducibly develop persistent infection, arthr...

journal_title：Antimicrobial agents and chemotherapy

authors： Moody KD,Adams RL,Barthold SW

更新日期：1994-07-01 00:00:00

abstract：:By the time-kill curve method, the combination of N-formimidoyl thienamycin and gentamicin showed synergism against 47 of 48 strains of enterococci, whereas the combination of N-formimidoyl thienamycin and tobramycin was synergistic against 46 strains. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanakunakorn C,Tisone JC

更新日期：1982-12-01 00:00:00

abstract：:Effervescent lozenges containing 10 mg of zinc acetate were evaluated as a treatment of upper respiratory tract infections in a double-blind randomized trial by using a placebo which was indistinguishable to most observers in taste and appearance from the active material. Of the 70 treatment courses used by 55 individ...

journal_title：Antimicrobial agents and chemotherapy

authors： Douglas RM,Miles HB,Moore BW,Ryan P,Pinnock CB

更新日期：1987-08-01 00:00:00