Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility.

abstract：:Herpes simplex virus (HSV) types 1 and 2 (two strains each) were inactivated at different rates in vitro by 40 muM AgNO(3). The inactivation of HSV type 1 strains was virtually complete in 10 to 15 min, whereas almost half of the infectivity of HSV type 2 strains survived this exposure. One strain of type 1 inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Coleman VR,Wilkie J,Levinson WE,Stevens T,Jawetz E

更新日期：1973-09-01 00:00:00

abstract：:Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizushima T,Matsuo M,Sekimizu K

更新日期：1997-01-01 00:00:00

abstract：:Drug exposure or pharmacodynamic breakpoints refer to a magnitude of drug exposure which separates a population into groups with high and low probabilities of attaining a desired outcome. We used a pharmacodynamic model of disseminated candidiasis to define an in vivo drug exposure breakpoint for flucytosine (5FC) aga...

journal_title：Antimicrobial agents and chemotherapy

authors： Hope WW,Warn PA,Sharp A,Howard S,Kasai M,Louie A,Walsh TJ,Drusano GL,Denning DW

更新日期：2006-11-01 00:00:00

abstract：:Guanylhydrazones are cationic heteroaromatic drugs similar to the diamidines which are effective in the treatment of African trypanosomiasis and pneumocystosis. On the basis of their antitrypanosomal activity, different guanylhydrazones were selected for evaluation in a rat model of Pneumocystis carinii pneumonia. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Walzer PD,Foy J,Runck J,Steele P,White M,Klein RS,Otter BA,Sundberg RJ

更新日期：1994-11-01 00:00:00

abstract：:The efficacy of ciprofloxacin for experimental aortic valve endocarditis in rabbits infected by either a methicillin-susceptible or a methicillin-resistant strain of Staphylococcus aureus was compared with standard therapy of nafcillin or vancomycin, respectively. After 4 days of therapy, ciprofloxacin reduced the cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Carpenter TC,Hackbarth CJ,Chambers HF,Sande MA

更新日期：1986-09-01 00:00:00

abstract：:Patients with severe coccidioidomycosis infections are often treated with either amphotericin B lipid complex (ABLC) or liposomal amphotericin B (L-AmB). Outcome data with these agents in severe coccidioidomycosis cases are currently lacking. The purpose of this study is to evaluate the efficacy and toxicity of ABLC a...

journal_title：Antimicrobial agents and chemotherapy

authors： Sidhu R,Lash DB,Heidari A,Natarajan P,Johnson RH

更新日期：2018-06-26 00:00:00

abstract：:Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both infections. Each of the constituent components of artemether-lumef...

journal_title：Antimicrobial agents and chemotherapy

authors： Chijioke-Nwauche I,van Wyk A,Nwauche C,Beshir KB,Kaur H,Sutherland CJ

更新日期：2013-09-01 00:00:00

abstract：:Seventy-one strains of 15 species of rapidly growing mycobacteria were studied for their susceptibilities to fatty acids with 2 to 20 carbons by the agar dilution method at pH 7.0. Most mycobacteria other than potential pathogens (Mycobacterium fortuitum and Mycobacterium chelonei) were resistant to saturated fatty ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Saito H,Tomioka H,Yoneyama T

更新日期：1984-08-01 00:00:00

abstract：:We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spre...

journal_title：Antimicrobial agents and chemotherapy

authors： Escudero JA,San Millan A,Catalan A,de la Campa AG,Rivero E,Lopez G,Dominguez L,Moreno MA,Gonzalez-Zorn B

更新日期：2007-02-01 00:00:00

abstract：:Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

更新日期：2008-01-01 00:00:00

abstract：:Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae. The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Reda A,Marchillo K,Van Hecker J,Craig WA,Andes D

更新日期：2014-10-01 00:00:00

abstract：:Isavuconazole, the active moiety of the prodrug isavuconazonium sulfate, has potent activity against a wide spectrum of fungal pathogens and is approved for the treatment of invasive aspergillosis, yet little is known about the tissue penetration of isavuconazole at the target sites of infection. Here, we explored the...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee A,Prideaux B,Lee MH,Zimmerman M,Dolgov E,Perlin DS,Zhao Y

更新日期：2019-05-24 00:00:00

abstract：:The aim of this study was to investigate the influence of hypovolemia on the distribution of imipenem in muscle extracellular fluid determined by microdialysis in awake rats. Microdialysis probes were inserted into the jugular vein and hind leg muscle. Imipenem recoveries in muscle and blood were determined in each ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchand S,Dahyot C,Lamarche I,Plan E,Mimoz O,Couet W

更新日期：2005-12-01 00:00:00

abstract：:The objective of the study was to measure antiretroviral exposures in four physiological compartments during pregnancy, delivery, and postpartum. This prospective, open-label, longitudinal study collected paired blood plasma (BP) and genital tract (GT) aspirates antepartum, at delivery, and up to 12 weeks postpartum. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeh RF,Rezk NL,Kashuba AD,Dumond JB,Tappouni HL,Tien HC,Chen YC,Vourvahis M,Horton AL,Fiscus SA,Patterson KB

更新日期：2009-06-01 00:00:00

abstract：:Treatment of Mycobacterium abscessus infections is extremely challenging due to its intrinsic resistance to most antibiotics, and research of pathogenesis is limited due to a lack of a practical in vivo model of infection. The objective of this study was to establish a simple in vivo model for M. abscessus infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meir M,Grosfeld T,Barkan D

更新日期：2018-03-27 00:00:00

abstract：:VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray crystallography studies provide support for the idea that VX-787 occupies the 7-methyl GTP (m(7)GTP) cap-binding site of PB2. VX-787 binds the cap-bi...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrn RA,Jones SM,Bennett HB,Bral C,Clark MP,Jacobs MD,Kwong AD,Ledeboer MW,Leeman JR,McNeil CF,Murcko MA,Nezami A,Perola E,Rijnbrand R,Saxena K,Tsai AW,Zhou Y,Charifson PS

更新日期：2015-03-01 00:00:00

abstract：:The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hennequin C,Benailly N,Silly C,Sorin M,Scheinmann P,Lenoir G,Gaillard JL,Berche P

更新日期：1997-09-01 00:00:00

abstract：:We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microd...

journal_title：Antimicrobial agents and chemotherapy

authors： Akaniro JC,Vidaurre CE,Stutman HR,Marks MI

更新日期：1990-10-01 00:00:00

abstract：:The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Fothergill AW,Arzeni D,Greganti G,Giannini D,Rinaldi MG,Scalise G

更新日期：2005-06-01 00:00:00

abstract：:We compared the activity of delavirdine (DLV) plus zidovudine (AZT) (n = 300) with that of AZT (n = 297) against human immunodeficiency virus type 1 in a randomized, double-blind, placebo-controlled trial. DLV exerted a transient antiviral effect, and mutations for resistance to DLV were found in more than 90% of subj...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly V,Moroni M,Concia E,Lazzarin A,Hirschel B,Jost J,Chiodo F,Bentwich Z,Love WC,Hawkins DA,Wilkins EG,Gatell AJ,Vetter N,Greenwald C,Freimuth WW,de Cian W

更新日期：2000-11-01 00:00:00

abstract：:A new rifampin resistance gene, arr-2, has been found in Pseudomonas aeruginosa. The ARR-2 protein shows 54% amino acid identity to the rifampin ADP-ribosylating transferase encoded by the arr gene from Mycobacterium smegmatis. This arr-2 gene is located on a gene cassette within a class I integron. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Fennewald M

更新日期：1999-04-01 00:00:00

abstract：:The intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime were studied in 68 volunteers who received single, oral doses of azithromycin (0.5 g), clarithormycin (0.5 g), ciprofloxacin (0.5 g), or cefuroxime (0.5 g). In subgroups of four subjects each, the subjects underwent bron...

journal_title：Antimicrobial agents and chemotherapy

authors： Conte JE Jr,Golden J,Duncan S,McKenna E,Lin E,Zurlinden E

更新日期：1996-07-01 00:00:00

abstract：:Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST...

journal_title：Antimicrobial agents and chemotherapy

authors： Li A,Yang Y,Miao M,Chavda KD,Mediavilla JR,Xie X,Feng P,Tang YW,Kreiswirth BN,Chen L,Du H

更新日期：2016-06-20 00:00:00

abstract：:Nocardia species are gram-positive environmental saprophytes, but some cause the infectious disease nocardiosis. The complete genomic sequence of Nocardia farcinica IFM 10152 has been determined, and analyses indicated the presence of two different RNA polymerase beta subunit genes, rpoB and rpoB2, in the genome (J. I...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishikawa J,Chiba K,Kurita H,Satoh H

更新日期：2006-04-01 00:00:00

abstract：:(E)-(S)-4-((S)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-pent-4-ynoylamino)-5-((S)-2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid ethyl ester (Compound 1) is a novel, irreversible inhibitor of human rhinovirus (HRV) 3C protease {inactivation rate constant (Kobs/[I]) of 223,000 M-1s-1}. In cell-base...

journal_title：Antimicrobial agents and chemotherapy

authors： Patick AK,Brothers MA,Maldonado F,Binford S,Maldonado O,Fuhrman S,Petersen A,Smith GJ 3rd,Zalman LS,Burns-Naas LA,Tran JQ

更新日期：2005-06-01 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats. VCM administered intr...

journal_title：Antimicrobial agents and chemotherapy

authors： Qu S,Dai C,Lang F,Hu L,Tang Q,Wang H,Zhang Y,Hao Z

更新日期：2018-12-21 00:00:00

abstract：:GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, di...

journal_title：Antimicrobial agents and chemotherapy

authors： Delbrück H,Bogaerts P,Kupper MB,Rezende de Castro R,Bennink S,Glupczynski Y,Galleni M,Hoffmann KM,Bebrone C

更新日期：2012-11-01 00:00:00

abstract：:We have studied the interference of roxithromycin with NADPH oxidase, the key enzymatic system for oxidant production by human neutrophils. Roxithromycin alters the reconstitution of an active enzyme and impairs the translocation to the outer membrane of the cytosolic components p47-phox and p67-phox. Interestingly, i...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelghaffar H,Babin-Chevaye C,Labro MT

更新日期：2005-07-01 00:00:00

abstract：:Mammalian serum amyloid A (SAA) is a major acute phase protein that shows a massive increase in plasma concentration during inflammation. In the present study, we demonstrate that the expression of mouse SAA1 in serum was increased when infected with Candida albicans, a major human fungal pathogen, in a systemic infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Gong J,Wu J,Ikeh M,Tao L,Zhang Y,Bing J,Nobile CJ,Huang G

更新日期：2019-12-20 00:00:00