Derivation of an in vivo drug exposure breakpoint for flucytosine against Candida albicans and Impact of the MIC, growth rate, and resistance genotype on the antifungal effect.

abstract：:Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduc...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Courvalin P,Lambert T

更新日期：2012-07-01 00:00:00

abstract：:Isavuconazole is a novel, broad-spectrum, antifungal azole. In order to evaluate its interactions with known azole resistance mechanisms, isavuconazole susceptibility among different yeast models and clinical isolates expressing characterized azole resistance mechanisms was tested and compared to those of fluconazole,...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanglard D,Coste AT

更新日期：2015-10-19 00:00:00

abstract：:Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (defA) is not. Actin...

journal_title：Antimicrobial agents and chemotherapy

authors： Margolis P,Hackbarth C,Lopez S,Maniar M,Wang W,Yuan Z,White R,Trias J

更新日期：2001-09-01 00:00:00

abstract：:Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

journal_title：Antimicrobial agents and chemotherapy

authors： English BK,Maryniw EM,Talati AJ,Meals EA

更新日期：2006-06-01 00:00:00

abstract：:An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-13...

journal_title：Antimicrobial agents and chemotherapy

authors： Prinarakis EE,Miriagou V,Tzelepi E,Gazouli M,Tzouvelekis LS

更新日期：1997-04-01 00:00:00

abstract：:Both ampicillin and cefuroxime therapy of neonates selected drug- and species-dependent beta-lactam resistance patterns in fecal strains of Escherichia coli and Klebsiella spp. This was in contrast to our previous findings that ampicillin, but not cefuroxime, contributed to the emergence of beta-lactam resistance also...

journal_title：Antimicrobial agents and chemotherapy

authors： Tullus K,Berglund B,Burman LG

更新日期：1990-02-01 00:00:00

abstract：:The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. Of 91 patients with significant bacteriuria, 61 (67%) were cured of their original infection; this was similar to the 54 to 79% cure rates reported in unselected po...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardenas J,Quinn EL,Rooker G,Bavinger J,Pohlod D

更新日期：1986-03-01 00:00:00

abstract：:With the emergence of multidrug-resistant mycobacterial strains, better therapeutic strategies are required for the successful treatment of the infection. Although antimicrobial peptides (AMPs) and silver nanoparticles (AgNPs) are becoming one of the popular antibacterial agents, their antimycobacterial potential is n...

journal_title：Antimicrobial agents and chemotherapy

authors： Mohanty S,Jena P,Mehta R,Pati R,Banerjee B,Patil S,Sonawane A

更新日期：2013-08-01 00:00:00

abstract：:Multidrug-resistant Enterobacteriaceae (MRE) colonize the intestine asymptomatically from where they can breach into the bloodstream and cause life-threatening infections, especially in heavily colonized patients. Despite the clinical relevance of MRE colonization levels, we know little about how they vary in hospital...

journal_title：Antimicrobial agents and chemotherapy

authors： Djukovic A,González-Barberá EM,Sanz J,Artacho A,Peñaranda I,Herrera B,Garzón MJ,Salavert M,López-Hontangas JL,Xavier KB,Kuster B,Debrauwer L,Rolain JM,Sanz MA,Xavier JB,Ubeda C

更新日期：2020-01-27 00:00:00

abstract：:The pathogenic yeast Candida albicans displays at its cell surface beta-1,2 oligomannosides (beta-1,2-Mans). In contrast to the ubiquitous alpha-Mans, beta-1,2-Mans bind to galectin-3, a major endogenous lectin expressed on epithelial cells. The specific role of beta-1,2-Mans in colonization of the gut by C. albicans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dromer F,Chevalier R,Sendid B,Improvisi L,Jouault T,Robert R,Mallet JM,Poulain D

更新日期：2002-12-01 00:00:00

abstract：:Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and the immunocompromised population. Although several anti-HCMV therapies are available, the development of new anti-HCMV agents is highly desired. There is growing interest in identifying compounds that might inhibit HCMV b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kapoor A,Cai H,Forman M,He R,Shamay M,Arav-Boger R

更新日期：2012-09-01 00:00:00

abstract：:The bioactivity of imipenem at 20 micrograms/ml in various agar and broth media which are commonly used in susceptibility test assays was measured at different storage temperatures over time. Imipenem was found to be more stable at 4 degrees C than at -20 degrees C and least stable in all media at 35 degrees C. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Baron EJ,Hindler JA

更新日期：1984-06-01 00:00:00

abstract：:The in vitro interactions between amikacin, netilmicin, tobramycin, gentamicin, and various antipseudomonal beta-lactams were studied by the agar dilution checkerboard technique against 30 Pseudomonas aeruginosa strains resistant to all tested antibiotics. Amikacin produced more frequent synergy both at the total and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellou H,Zissis NP,Tagari G,Bouzos J

更新日期：1984-04-01 00:00:00

abstract：:We describe the first IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19, which differed from IMP-2 by a single amino acid change (Arg to Ala at position 38). bla(IMP-19) was found within a class 1 integron located on a 35-kb plasmid. This is also the first description of an IMP producer in France. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Neuwirth C,Siebor E,Robin F,Bonnet R

更新日期：2007-12-01 00:00:00

abstract：:Spectinomycin resistance in clinical isolates of Neisseria meningitidis and Neisseria gonorrhoeae was found to be due to mutations G1064C and C1192U (Escherichia coli numbering) in 16S rRNA genes, respectively. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Gerbaud G,Courvalin P

更新日期：2000-05-01 00:00:00

abstract：:To date, there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with in vivo activity superior to that of praziquantel against both adult and juvenile Schistosoma ma...

journal_title：Antimicrobial agents and chemotherapy

authors： Panic G,Ruf MT,Keiser J

更新日期：2017-11-22 00:00:00

abstract：:PSI-352938 is a novel cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine 5'-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with other inhibitors of H...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam AM,Espiritu C,Murakami E,Zennou V,Bansal S,Micolochick Steuer HM,Niu C,Keilman M,Bao H,Bourne N,Veselenak RL,Reddy PG,Chang W,Du J,Nagarathnam D,Sofia MJ,Otto MJ,Furman PA

更新日期：2011-06-01 00:00:00

abstract：:Mycobacterium tuberculosis and the fast-growing species Mycobacterium abscessus are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug-resistant M. tuberculosis strains and the high level of intrinsic resistance of M....

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta R,Rodrigues Felix C,Akerman MP,Akerman KJ,Slabber CA,Wang W,Adams J,Shaw LN,Tse-Dinh YC,Munro OQ,Rohde KH

更新日期：2018-04-26 00:00:00

abstract：:Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008...

journal_title：Antimicrobial agents and chemotherapy

authors： Peel TN,Cheng AC,Buising KL,Choong PF

更新日期：2012-05-01 00:00:00

abstract：:This study investigates the role of active efflux system MexXY in the emergence of aminoglycoside (AG) resistance among cystic fibrosis (CF) isolates of Pseudomonas aeruginosa. Three genotypically related susceptible and resistant (S/R) bacterial pairs and three other AG-resistant CF strains were compared to four non-...

journal_title：Antimicrobial agents and chemotherapy

authors： Vogne C,Aires JR,Bailly C,Hocquet D,Plésiat P

更新日期：2004-05-01 00:00:00

abstract：:Many pathogenic and commensal organisms are multidrug resistant due to exposure to various antibiotics. Often, this antimicrobial resistance is encoded by integrons that occur on plasmids or that are integrated into the bacterial chromosome. Integrons are commonly associated with bacterial genera in the family Enterob...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein C,Lee MD,Sanchez S,Hudson C,Phillips B,Register B,Grady M,Liebert C,Summers AO,White DG,Maurer JJ

更新日期：2001-03-01 00:00:00

abstract：:There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have no...

journal_title：Antimicrobial agents and chemotherapy

authors： Sime FB,Johnson A,Whalley S,Santoyo-Castelazo A,Montgomery AB,Walters KA,Lipman J,Hope WW,Roberts JA

更新日期：2016-12-27 00:00:00

abstract：:The gene coding for aminoglycoside 2'-N-acetyltransferase Ia [AAC(2')-Ia] from Providencia stuartii was amplified by PCR and cloned. The resulting construct, pACKF2, was transferred into Escherichia coli for overexpression of AAC(2')-Ia as a fusion protein with an N-terminal hexa-His tag. The fusion protein was isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Franklin K,Clarke AJ

更新日期：2001-08-01 00:00:00

abstract：:Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Suzuki S,Yamazaki T,Narita M,Okazaki N,Suzuki I,Andoh T,Matsuoka M,Kenri T,Arakawa Y,Sasaki T

更新日期：2006-02-01 00:00:00

abstract：:Numerous studies have described a strong association between respiratory syncytial virus (RSV) infection in infancy and the development of recurrent wheezing and airway hyperresponsiveness. We evaluated the effect of an anti-RSV neutralizing monoclonal antibody (palivizumab) on different aspects of RSV disease by usin...

journal_title：Antimicrobial agents and chemotherapy

authors： Mejías A,Chávez-Bueno S,Ríos AM,Saavedra-Lozano J,Fonseca Aten M,Hatfield J,Kapur P,Gómez AM,Jafri HS,Ramilo O

更新日期：2004-05-01 00:00:00

abstract：:We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Lim TP,Ong RT,Hon PY,Hawkey J,Holt KE,Koh TH,Leong ML,Teo JQ,Tan TY,Ng MM,Hsu LY

更新日期：2015-12-01 00:00:00

abstract：:Mycobacterium kansasii is the second most common mycobacterial cause of lung disease. Standard treatment consists of rifampin, isoniazid, and ethambutol for at least 12 months after negative sputum. Thus, shorter-duration therapies are needed. Moxifloxacin has good MICs for M. kansasii. However, good preclinical model...

journal_title：Antimicrobial agents and chemotherapy

authors： Srivastava S,Pasipanodya J,Sherman CM,Meek C,Leff R,Gumbo T

更新日期：2015-04-01 00:00:00

abstract：:Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mitchell KF,Taff HT,Cuevas MA,Reinicke EL,Sanchez H,Andes DR

更新日期：2013-04-01 00:00:00

abstract：:With the rapid spread of antimicrobial resistance in Gram-negative pathogens, biofilm-associated infections are increasingly harder to treat and combination therapy with colistin has become one of the most efficient therapeutic strategies. Our study aimed to evaluate the potential for the synergy of colistin combined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan JH,Vidaillac C,Yam JKH,Chua SL,Givskov M,Yang L

更新日期：2017-06-27 00:00:00

abstract：:This work investigated the molecular events driving the evolution of the CTX-M-type β-lactamases by the use of DNA shuffling of fragments of the blaCTX-M-14 and blaCTX-M-15 genes. Analysis of a total of 51 hybrid enzymes showed that enzymatic activity could be maintained in most cases, yet hybrids that were active pos...

journal_title：Antimicrobial agents and chemotherapy

authors： Po KHL,Chan EWC,Chen S

更新日期：2017-11-22 00:00:00