In vitro synergistic activities of aminoglycosides and new beta-lactams against multiresistant Pseudomonas aeruginosa.

abstract：:Extended-infusion ceftolozane-tazobactam treatment at 1.5 g every 8 h was used to treat multidrug-resistant Pseudomonas aeruginosa in a critically ill patient on continuous venovenous hemofiltration. Serum drug concentrations were measured at 1, 4, 5, 6, and 8 h after the start of infusion. Prefilter levels of ceftolo...

journal_title：Antimicrobial agents and chemotherapy

authors： Oliver WD,Heil EL,Gonzales JP,Mehrotra S,Robinett K,Saleeb P,Nicolau DP

更新日期：2015-12-28 00:00:00

abstract：:The objectives of this study were to investigate raltegravir transport across several blood-tissue barrier models and the potential interactions with drug efflux transporters. Raltegravir uptake, accumulation, and permeability were evaluated in vitro in (i) P-glycoprotein (P-gp), breast cancer resistance protein (BCRP...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoque MT,Kis O,De Rosa MF,Bendayan R

更新日期：2015-05-01 00:00:00

abstract：:The pharmacokinetics of meropenem and its ring-opened metabolite (ICI 213,689) were investigated with eight young (20- to 34-year-old) and eight elderly (67- to 80-year-old) healthy male volunteers given single 30-min intravenous infusions of 500 mg of meropenem. All subjects had normal age-correlated glomerular funct...

journal_title：Antimicrobial agents and chemotherapy

authors： Ljungberg B,Nilsson-Ehle I

更新日期：1992-07-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:Concomitant treatment of tuberculosis (TB) and HIV is recommended and improves outcomes. Bedaquiline is a novel drug for the treatment of multidrug-resistant (MDR) TB; combined use with antiretroviral drugs, nevirapine, or ritonavir-boosted lopinavir (LPV/r) is anticipated, but no clinical data from coinfected patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Svensson EM,Dooley KE,Karlsson MO

更新日期：2014-11-01 00:00:00

abstract：:Cystathionine gamma-lyase (EC 4.4.1.1) was purified from Streptomyces cattleya, an actinomycete which produces the unusual beta-lactam antibiotic thienamycin. The enzyme displays broad substrate specificity and is similar to gamma-lyases purified from other microorganisms. That the gamma-lyase functions in vivo to pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Williamson JM,Meyer R,Inamine E

更新日期：1985-10-01 00:00:00

abstract：:Gemifloxacin mesylate (SB 265805), a new fluoronaphthyridone, was tested against 359 recent clinical anaerobic isolates by the National Committee for Clinical Laboratory Standards reference agar dilution method with supplemented brucella blood agar and an inoculum of 10(5) CFU/spot. Comparative antimicrobials tested i...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Warren Y,Tyrrell K,Merriam CV

更新日期：1999-09-01 00:00:00

abstract：:Resistance of Mycobacterium tuberculosis to fluoroquinolones (FQ) results mostly from mutations in the gyrA gene. We developed a reverse hybridization-based line probe assay in which oligonucleotide probes carrying the wild-type gyrA sequence, a serine-to-threonine (S95T) polymorphism, and gyrA mutations (A90V, A90V-S...

journal_title：Antimicrobial agents and chemotherapy

authors： Giannoni F,Iona E,Sementilli F,Brunori L,Pardini M,Migliori GB,Orefici G,Fattorini L

更新日期：2005-07-01 00:00:00

abstract：:Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime....

journal_title：Antimicrobial agents and chemotherapy

authors： Nannini EC,Stryjewski ME,Singh KV,Rude TH,Corey GR,Fowler VG Jr,Murray BE

更新日期：2010-05-01 00:00:00

abstract：:The Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) offer different recommendations for carbapenem MIC susceptibility breakpoints for Acinetobacter species. In addition, the clinical efficacy of the intermediate category remains uncertain. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang YS,Wang YC,Kuo SC,Chen CT,Liu CP,Liu YM,Chen TL,Lee YT

更新日期：2017-08-24 00:00:00

abstract：:Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculosis strains from divers...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Stockbauer KE,Pan X,Kreiswirth BN,Moghazeh SL,Jacobs WR Jr,Telenti A,Musser JM

更新日期：1997-08-01 00:00:00

abstract：:According to the European AIDS Clinical Society, tenofovir disoproxil fumarate can be used in HIV-infected pregnant women if started prior to pregnancy, although no data are available on the pharmacokinetics of tenofovir (TFV) during pregnancy. The aim of this study was to describe TFV pharmacokinetics in HIV-infected...

journal_title：Antimicrobial agents and chemotherapy

authors： Benaboud S,Hirt D,Launay O,Pannier E,Firtion G,Rey E,Bouazza N,Foissac F,Chappuy H,Urien S,Tréluyer JM

更新日期：2012-02-01 00:00:00

abstract：:We analyzed the relationship between rifampin MICs and rpoB mutations of 40 clinical isolates of Mycobacterium tuberculosis. A point mutation in either codon 516, 526, or 531 was found in 13 strains requiring MICs of > or = 64 micrograms/ml, while 21 strains requiring MICs of < or = 1 microgram/ml showed no alteration...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohno H,Koga H,Kohno S,Tashiro T,Hara K

更新日期：1996-04-01 00:00:00

abstract：:The nucleoprotein (NP) binds the viral RNA genome and associates with the polymerase in a ribonucleoprotein complex (RNP) required for transcription and replication of influenza A virus. NP has no cellular counterpart, and the NP sequence is highly conserved, which led to considering NP a hot target in the search for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lejal N,Tarus B,Bouguyon E,Chenavas S,Bertho N,Delmas B,Ruigrok RW,Di Primo C,Slama-Schwok A

更新日期：2013-05-01 00:00:00

abstract：:Cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. Cefamandole had activity equivalent to cefazolin against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. Cefamandole was more active than cephalothin or cefazo...

journal_title：Antimicrobial agents and chemotherapy

authors： Shemonsky NK,Carrizosa J,Levison ME

更新日期：1975-12-01 00:00:00

abstract：:The activity of a new prototype carbapenem, L-695,256, against clinical isolates of gram-positive and gram-negative aerobes was studied in vitro by agar dilution. L-695,256 was highly active against methicillin-resistant and -susceptible isolates of staphylococci (MICs, 0.016 to 2 micrograms/ml) and against penicillin...

journal_title：Antimicrobial agents and chemotherapy

authors： Rylander M,Rollof J,Jacobsson K,Norrby SR

更新日期：1995-05-01 00:00:00

abstract：:We tested 32 Candida isolates recovered in the early 1990s from the bloodstreams of patients with candidemia for in vitro susceptibility to fluconazole and determined if MIC and/or the daily dose of fluconazole/MIC ratio correlated with the response to therapy. This is a unique data set since 87.5% (28/32) of patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Clancy CJ,Yu VL,Morris AJ,Snydman DR,Nguyen MH

更新日期：2005-08-01 00:00:00

abstract：:The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultraso...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins-Leite P,Gazzinelli G,Alves-Oliveira LF,Gazzinelli A,Malaquias LC,Correa-Oliveira R,Teixeira-Carvalho A,Silveira AM

更新日期：2008-08-01 00:00:00

abstract：:Determinants encoding resistance to antibiotics, except penicillin, of 5 of 21 Streptococcus anginosus clinical isolates that we examined transferred by conjugation into Enterococcus faecalis and into 1 to 5 streptococcal recipients at frequencies of 10(-6) to 10(-8) transconjugants per donor. No R plasmids were detec...

journal_title：Antimicrobial agents and chemotherapy

authors： Clermont D,Horaud T

更新日期：1990-09-01 00:00:00

abstract：:The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Morales G,Rodríguez-Avial I,Culebras E,Gómez M,López-Fabal F,Picazo JJ

更新日期：2010-05-01 00:00:00

abstract：:Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-dir...

journal_title：Antimicrobial agents and chemotherapy

authors： Krief S,Martin MT,Grellier P,Kasenene J,Sévenet T

更新日期：2004-08-01 00:00:00

abstract：:The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were determined, and the virulence-suppressing effects of AZM were compared with those of erythromycin (EM), roxithromycin (RXM)...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizukane R,Hirakata Y,Kaku M,Ishii Y,Furuya N,Ishida K,Koga H,Kohno S,Yamaguchi K

更新日期：1994-03-01 00:00:00

abstract：:The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicil...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Bedford KA

更新日期：1978-03-01 00:00:00

abstract：:Previous studies on tetracycline transport into Staphylococcus aureus identified a high-affinity, saturable uptake system for the antibiotic (Km, 4.76 microM) (B.L. Hutchings, Biochim. Biophys. Acta 174:734-738, 1969). However, the earlier results could not be confirmed using conditions that permitted energy-dependent...

journal_title：Antimicrobial agents and chemotherapy

authors： Chopra I,Ismail S,Oliva B

更新日期：1991-12-01 00:00:00

abstract：:The pharmacokinetics and metabolism of 3'-azido-3'-deoxythymidine (AZT) were investigated in rhesus monkeys after subcutaneous administration of 33.3 mg of AZT per kg of body weight alone or in the presence of 100 mg of probenecid per kg. In addition to unchanged drug, two catabolites, 5'-O-glucuronide (GAZT) and 3'-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Cretton EM,Schinazi RF,McClure HM,Anderson DC,Sommadossi JP

更新日期：1991-05-01 00:00:00

abstract：:Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin great...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Fuchs PC,Sommers HM,Gavan TL,Barry AL,Gerlach EH

更新日期：1980-04-01 00:00:00

abstract：:Sublethal doses of vincristine (VNC) and bacterial lipopolysaccharide (LPS) administered simultaneously to adult male mice resulted in markedly enhanced mortality. All of 10 strains of Pseudomonas aeruginosa tested, 4 of 7 strains of Bacteroides, and 6 of 10 strains of Listeria monocytogenes were able to substitute fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Munson AE,Drummond DC,Adams AC,Bradley SG

更新日期：1976-05-01 00:00:00

abstract：:Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2'-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu Y,Liu X,Qu Y,Wang X,Li L,Zhao X

更新日期：2012-11-01 00:00:00

abstract：:A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in D...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitzgibbon JE,John JF,Delucia JL,Dubin DT

更新日期：1998-08-01 00:00:00

abstract：:The effects of free amphotericin B (as Fungizone) and amphotericin B (AMB) incorporated into liposomes on the proliferation of lymphocytes were determined. Freshly obtained guinea pig and rat antigen-specific lymphocytes were compared with rat T-lymphocyte cell lines cultured for a long period of time. Incorporation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Boggs JM,Chang NH,Goundalkar A

更新日期：1991-05-01 00:00:00