Multicenter Study of the Relationship between Carbapenem MIC Values and Clinical Outcome of Patients with Acinetobacter Bacteremia.

abstract：:A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorabl...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Baldassarri I,Marigliano A,Arzeni D,Giannini D,Scalise G

更新日期：2004-10-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:We report a microanalytical high-performance liquid chromatography method for quantitation of cefpirome (HR 810) from serum. The drug was extracted from 0.05 ml of serum with 0.2 ml of isopropanol containing beta-hydroxypropyltheophylline, the internal standard. Separations were performed on a C18 column at ambient te...

journal_title：Antimicrobial agents and chemotherapy

authors： Turley CP,Kearns GL,Jacobs RF

更新日期：1988-10-01 00:00:00

abstract：:In vitro susceptibility testing of 28 strains of Eikenella corrodens by the agar dilution technique showed that all strains were uniformly susceptible to penicillin, ticarcillin, cefoxitin, cefotaxime, N-formimidoyl thienamycin, and moxalactam and resistant to clindamycin and cefadroxil. Cefoperazone, piperacillin, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Gombert ME,Agyare EO

更新日期：1980-11-01 00:00:00

abstract：:In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinic...

journal_title：Antimicrobial agents and chemotherapy

authors： Rhee SY,Liu T,Ravela J,Gonzales MJ,Shafer RW

更新日期：2004-08-01 00:00:00

abstract：:There is increasing interest in the use of lipophilic copper (Cu)-containing complexes to combat bacterial infections. In this work, we showed that Cu complexes with bis(thiosemicarbazone) ligands [Cu(btsc)] exert antibacterial activity against a range of medically significant pathogens. Previous work using Neisseria ...

journal_title：Antimicrobial agents and chemotherapy

authors： Djoko KY,Goytia MM,Donnelly PS,Schembri MA,Shafer WM,McEwan AG

更新日期：2015-10-01 00:00:00

abstract：:lacZ fusion strains were constructed using the promoters of five cell wall stress stimulon genes: pbp2, tcaA, vraSR, sgtB, and lytR. All fusion strains were induced only in the presence of cell wall-active antibiotics, suggesting the potential of these strains for use in high-throughput screening for new cell wall-act...

journal_title：Antimicrobial agents and chemotherapy

authors： Steidl R,Pearson S,Stephenson RE,Ledala N,Sitthisak S,Wilkinson BJ,Jayaswal RK

更新日期：2008-08-01 00:00:00

abstract：:A47934, a peptide antibiotic produced by Streptomyces toyocaensis, belongs to the glycopeptide class of compounds which includes ristocetin and vancomycin. Incorporation studies with radioisotope-labeled substrates indicated that tyrosine, p-hydroxyphenylglycine, p-hydroxyphenylglyoxylate, acetate, and sulfate were ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Zmijewski MJ Jr,Briggs B,Logan R,Boeck LD

更新日期：1987-10-01 00:00:00

abstract：:Fifty clinical isolates of Streptococcus pneumoniae received by the Streptococcus Laboratory of the Center for Disease Control from August 1976 through March 1977 and 50 pneumococcal strains retrieved from 13- to 16-year storage (originally isolated October 1961 through December 1964) were tested for susceptibility to...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksey RC,Facklam RR,Thornsberry C

更新日期：1978-04-01 00:00:00

abstract：:Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a major threat to humans due to its possible use as a bioterrorism agent. For many years, the risk of disease reemergence was thought to solely be through deliberate misuse of VARV strains kept in clandestine laboratories. Howev...

journal_title：Antimicrobial agents and chemotherapy

authors： Delaune D,Iseni F

更新日期：2020-03-24 00:00:00

abstract：:The evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. In countries where the highly pathogenic H5N1 virus is endemic or causes regular epidemics, the surveillance of these changes is important fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Naughtin M,Dyason JC,Mardy S,Sorn S,von Itzstein M,Buchy P

更新日期：2011-05-01 00:00:00

abstract：:Although it is generally believed that bactericidal and bacteriostatic drugs should not be combined in vivo, in vitro experiments using the checkerboard dilution technique revealed no antagonism between penicillin/cephalothin and rolitetracycline but rather additive or synergistic activity of either drug combination i...

journal_title：Antimicrobial agents and chemotherapy

authors： Daschner FD

更新日期：1976-11-01 00:00:00

abstract：:Antimicrobial resistance (AMR) is an ever-growing public health problem worldwide. The low rate of antibiotic discovery coupled with the rapid spread of drug-resistant bacterial pathogens is causing a global health crisis. To facilitate the drug discovery processes, we present a large-scale study of reference antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Rourke A,Beyhan S,Choi Y,Morales P,Chan AP,Espinoza JL,Dupont CL,Meyer KJ,Spoering A,Lewis K,Nierman WC,Nelson KE

更新日期：2020-02-21 00:00:00

abstract：:A major concern of immunocompromised patients, in particular those with AIDS, is susceptibility to infection caused by opportunistic pathogens such as Pneumocystis jirovecii, which is a leading cause of pneumonia in immunocompromised patients. We report the first kinetic and structural data for 2,4-diamino-6-[(2',5'-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Cody V,Pace J,Queener SF,Adair OO,Gangjee A

更新日期：2013-06-01 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00

abstract：:Leukocyte chemotaxis was inhibited 9.6% compared with control in the presence of 10 mug of gentamicin per ml and 10.5% when exposed to 20 mug of amikacin per ml. However, cells incubated with an injectable form of gentamicin, containing preservatives, were inhibited an additional 25.8% relative to cells incubated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodhart GL

更新日期：1977-10-01 00:00:00

abstract：:Structure-function relationships in antimicrobial peptides have been extensively investigated in order to obtain improved analogs. Most of these studies have targeted either alpha-helical peptides or beta-sheet peptides with multiple disulfide bridges. Tigerinins are short, nonhelical antimicrobial peptides with a sin...

journal_title：Antimicrobial agents and chemotherapy

authors： Sitaram N,Sai KP,Singh S,Sankaran K,Nagaraj R

更新日期：2002-07-01 00:00:00

abstract：:This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relap...

journal_title：Antimicrobial agents and chemotherapy

authors： Grimaldi G Jr,Porrozzi R,Friedrich K,Teva A,Marchevsky RS,Vieira F,Miekeley N,Paumgartten FJ

更新日期：2010-01-01 00:00:00

abstract：:Five patients with chronic hepatitis B were treated with 8-day courses of leukocyte (alpha) interferon (5 X 10(6) U/day) and with 8-day courses of recombinant fibroblast (betaser) interferon at dosages of 5 X 10(6), 35 X 10(6), and 105 X 10(6) U/day. Inhibition of hepatitis B virus replication as evidenced by a decrea...

journal_title：Antimicrobial agents and chemotherapy

authors： Eisenberg M,Rosno S,Garcia G,Konrad MW,Gregory PB,Robinson WS,Merigan TC

更新日期：1986-01-01 00:00:00

abstract：:The in vitro activity of tosufloxacin (A-61827; T-3262) against 15 clinical isolates of Chlamydia trachomatis and 31 recent clinical isolates of Neisseria gonorrhoeae, including 15 spectinomycin-resistant N. gonorrhoeae and 16 penicillinase-producing N. gonorrhoeae, was determined. Tosufloxacin was compared with doxyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Segreti J,Hirsch DJ,Harris AA,Kapell KS,Orbach H,Kessler HA

更新日期：1990-06-01 00:00:00

abstract：:Mycobacterium ulcerans causes Buruli ulcer, a potentially disabling ulcerative skin disease. Only recently was antimicrobial therapy proven effective. Treatment for 2 months with rifampin plus streptomycin was first proposed after experiments in the mouse footpad model demonstrated bactericidal activity. This treatmen...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang T,Li SY,Converse PJ,Almeida DV,Grosset JH,Nuermberger EL

更新日期：2011-01-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis type 2 provides an experimental infection that closely resembles disseminated herpesvirus infection of human newborn infants. After inoculation of mice, the virus multiplies in the respiratory tract and is disseminated through the blood to the liver and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-05-01 00:00:00

abstract：:The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined. Cefoperazone showed the highest antibacterial activity, followed by ceftezole, cefazolin, cefamandole, and cephalothin. There were two groups of resistant strains: one group (ca. 15%), of which B. fra...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Mitsuyama J,Hori R,Yasuda T,Saikawa I,Inoue M,Mitsuhashi S

更新日期：1988-12-01 00:00:00

abstract：:In published studies, cohorts of patients with bacteremia due to vancomycin-resistant Enterococcus (VRE) have predominantly been infected with Enterococcus faecium. Little is known about the epidemiology and outcomes associated with bacteremia due to VR Enterococcus faecalis. A retrospective study of isolates obtained...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayakawa K,Marchaim D,Martin ET,Tiwari N,Yousuf A,Sunkara B,Pulluru H,Kotra H,Hasan A,Bheemreddy S,Sheth P,Lee DW,Kamatam S,Bathina P,Nanjireddy P,Chalana IK,Patel S,Kumar S,Vahia A,Ku K,Yee V,Swan J,Pogue JM

更新日期：2012-05-01 00:00:00

abstract：:Herpes simplex virus (HSV) types 1 and 2 (two strains each) were inactivated at different rates in vitro by 40 muM AgNO(3). The inactivation of HSV type 1 strains was virtually complete in 10 to 15 min, whereas almost half of the infectivity of HSV type 2 strains survived this exposure. One strain of type 1 inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Coleman VR,Wilkie J,Levinson WE,Stevens T,Jawetz E

更新日期：1973-09-01 00:00:00

abstract：:Pradimicin S (PRM-S) is a highly water-soluble, negatively charged derivative of the antibiotic pradimicin A (PRM-A) in which the terminal xylose moiety has been replaced by 3-sulfated glucose. PRM-S does not prevent human immunodeficiency virus (HIV) adsorption on CD4(+) T cells, but it blocks virus entry into its ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Balzarini J,François KO,Van Laethem K,Hoorelbeke B,Renders M,Auwerx J,Liekens S,Oki T,Igarashi Y,Schols D

更新日期：2010-04-01 00:00:00

abstract：:An agar dilution method was employed to test the susceptibility of 12 strains of Coccidioides immitis to polymyxin B (PB). After 3 days of incubation, eight strains were markedly inhibited by 5.0 mug of PB per ml and four strains did not grow. PB at 10 mug/ml inhibited the growth of all strains through 20 days of incu...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins MS,Pappagianis D

更新日期：1976-08-01 00:00:00

abstract：:Among the 7 most common UL97 mutations encountered in ganciclovir-resistant clinical cytomegalovirus isolates, the associated cyclopropavir cross-resistance varies from insignificant (L595S) to substantial (M460I and H520Q) as determined by recombinant phenotyping. Mutations M460I and H520Q were preferentially selecte...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S,Bowlin TL

更新日期：2011-01-01 00:00:00

abstract：:A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of...

journal_title：Antimicrobial agents and chemotherapy

authors： Espuelas S,Legrand P,Loiseau PM,Bories C,Barratt G,Irache JM

更新日期：2000-08-01 00:00:00