Abstract:
:Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2'-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin, moxifloxacin, and oxacillin. While the protective effect of 2,2'-bipyridyl plus thiourea varied among strains and compounds, the data support the hypothesis that hydroxyl radical enhances antimicrobial lethality.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Liu Y,Liu X,Qu Y,Wang X,Li L,Zhao Xdoi
10.1128/AAC.00754-12subject
Has Abstractpub_date
2012-11-01 00:00:00pages
6048-50issue
11eissn
0066-4804issn
1098-6596pii
AAC.00754-12journal_volume
56pub_type
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