Distribution of subclasses mefA and mefE of the mefA gene among clinical isolates of macrolide-resistant (M-phenotype) Streptococcus pneumoniae, viridans group streptococci, and Streptococcus pyogenes.

abstract：:The MIC of an antimalarial drug for a particular infection is the drug level associated with a net parasite multiplication rate of one per asexual cycle. To ensure the cure of malaria, the MIC must be exceeded until all parasites have been eliminated. The development of highly sensitive and accurate PCR quantitation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Hien TT,White NJ,Thuy-Nhien NT,Hoa NT,Thuan PD,Tarning J,Nosten F,Magnusson B,Jain JP,Hamed K

更新日期：2017-01-24 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:The activity of methacycline against microbial L-forms and their parent bacteria was compared with that of oxytetracycline, chlortetracycline, tetracycline, and demethylchlortetracycline, as well as with that of 22 other antibiotics which included examples of major groups of antibiotics. The L-forms and bacteria used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hubert EG,Kalmanson GM,Montgomerie JZ,Guze LB

更新日期：1972-10-01 00:00:00

abstract：:Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

更新日期：1996-03-01 00:00:00

abstract：:Using a new rabbit model of methicillin-susceptible Staphylococcus aureus knee prosthesis infection, we compared the efficacies of sparfloxacin (50 mg/kg of body weight subcutaneously, twice a day) and pefloxacin (50 mg/kg subcutaneously, twice a day). A partial knee replacement was performed with a silicone implant f...

journal_title：Antimicrobial agents and chemotherapy

authors： Crémieux AC,Mghir AS,Bleton R,Manteau M,Belmatoug N,Massias L,Garry L,Sales N,Mazière B,Carbon C

更新日期：1996-09-01 00:00:00

abstract：:OXA-48-like carbapenemases have only recently emerged in Europe. OXA-162 is a rare OXA-48 variant usually coexpressed with extended-spectrum β-lactamases. Here, we report the identification of the first OXA-162 carbapenemase-producing Klebsiella pneumoniae isolates, which coexpressed an AmpC cephalosporinase (DHA-1), ...

journal_title：Antimicrobial agents and chemotherapy

authors： Voulgari E,Poulou A,Dimitroulia E,Politi L,Ranellou K,Gennimata V,Markou F,Pournaras S,Tsakris A

更新日期：2015-12-14 00:00:00

abstract：:The penam nucleus can assume two conformations; these are designated open and closed. The synthetic (2,3)-alpha- and (2,3)-beta-methylenepenams can be regarded as analogs of the open and closed conformations, respectively. It has been shown that the beta-methylenepenams are essentially inactive, suggesting that the cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Christenson JG,Pruess DL,Talbot MK,Keith DD

更新日期：1988-07-01 00:00:00

abstract：:Atazanavir (Reyataz; ATV) is a well-tolerated protease inhibitor (PI) that is indicated as a once-daily treatment for HIV infections. These features of ATV, combined with its virologic potency, make it particularly desirable for the treatment of HIV-infected pediatric patients. The objective of this study was to use a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong Y,Kowalski KG,Zhang J,Zhu L,Horga M,Bertz R,Pfister M,Roy A

更新日期：2011-12-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:The intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime were studied in 68 volunteers who received single, oral doses of azithromycin (0.5 g), clarithormycin (0.5 g), ciprofloxacin (0.5 g), or cefuroxime (0.5 g). In subgroups of four subjects each, the subjects underwent bron...

journal_title：Antimicrobial agents and chemotherapy

authors： Conte JE Jr,Golden J,Duncan S,McKenna E,Lin E,Zurlinden E

更新日期：1996-07-01 00:00:00

abstract：:The aim of this study was to explore bactericidal activity of total and free serum simulated concentrations after the oral administration of cefditoren (400 mg, twice daily [bid]) versus the oral administration of amoxicillin-clavulanic acid extended release formulation (2,000/125 mg bid) against Haemophilus influenza...

journal_title：Antimicrobial agents and chemotherapy

authors： Torrico M,Aguilar L,González N,Giménez MJ,Echeverría O,Cafini F,Sevillano D,Alou L,Coronel P,Prieto J

更新日期：2007-10-01 00:00:00

abstract：:Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K

更新日期：2006-11-01 00:00:00

abstract：:Miconazole, a broad-spectrum antimycotic agent with some antibacterial activity, has recently become available for experimental parenteral use in the United States. Its efficacy as an anticandidal drug was tested in adult Wistar rats. A previously established infectious dose of 5 x 10(6)Candida albicans was intravenou...

journal_title：Antimicrobial agents and chemotherapy

authors： Balk MW,Crumrine MH,Fischer GW

更新日期：1978-02-01 00:00:00

abstract：:Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of Neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strain...

journal_title：Antimicrobial agents and chemotherapy

authors： Sackel SG,Alpert S,Rosner B,McCormack WM,Finland M

更新日期：1977-07-01 00:00:00

abstract：:CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested being less than or equal to 1 microgram/ml. The compound was from 10- to 100-fold more active than...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz T,Retsema J,Girard A,Hamanaka E,Anderson M,Sokolowski S

更新日期：1989-08-01 00:00:00

abstract：:The pharmacokinetics of intravenously administered levofloxacin and ciprofloxacin were studied in intensive care unit patients during continuous venovenous hemofiltration (CVVH; four patients received levofloxacin, and five received ciprofloxacin) or hemodiafiltration (CVVHDF; six patients received levofloxacin, and f...

journal_title：Antimicrobial agents and chemotherapy

authors： Malone RS,Fish DN,Abraham E,Teitelbaum I

更新日期：2001-10-01 00:00:00

abstract：:5-episisomicin (Sch 22591) is a novel semisynthetic aminoglycoside with a spectrum and potency similar to gentamicin in its activity against susceptible bacterial strains, but with increased potency against Pseudomonas, Providencia, and Proteus rettgeri. It is also more active than tobramycin and amikacin against thes...

journal_title：Antimicrobial agents and chemotherapy

authors： Waitz JA,Miller GH,Moss E Jr,Chiu PJ

更新日期：1978-01-01 00:00:00

abstract：:The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except against Corynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity against Corynebacterium spp., being more active than 14- and 16-membered macrolides, azithromycin, or clindamyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Martínez L,Pascual A,Suárez AI,Perea EJ

更新日期：1998-12-01 00:00:00

abstract：:IncK plasmids encoding CTX-M-14 extended-spectrum β-lactamase (ESBL) and highly related to plasmid pCT were detected in 13 of 67 (19%) human clinical isolates of Escherichia coli with a group 9 CTX-M-type ESBL from the United Kingdom and in 2 quality assurance isolates. None of these E. coli strains was related to the...

journal_title：Antimicrobial agents and chemotherapy

authors： Dhanji H,Khan P,Cottell JL,Piddock LJ,Zhang J,Livermore DM,Woodford N

更新日期：2012-06-01 00:00:00

abstract：:The effect of the cephalosporin precursors and amino acids of the aspartic acid family on antibiotic production by Streptomyces clavuligerus was investigated DL-meso-Diaminopimelate and L-lysine each stimulated specific antibiotic production by 75%. A fourfold increase in specific production was obtained by simultaneo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendelovitz S,Aharonowitz Y

更新日期：1982-01-01 00:00:00

abstract：:Antifungal azoles are widely used for controlling fungal infections. Fungi are able to change the expression of many genes when they adapt to azole stress, and increased expression of some of these genes can elevate resistance to azoles. However, the regulatory mechanisms behind transcriptional adaption to azoles in f...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun X,Wang K,Yu X,Liu J,Zhang H,Zhou F,Xie B,Li S

更新日期：2014-01-01 00:00:00

abstract：:The present study was designed to determine the temporal changes in tobramycin nephrotoxicity during the dark and the light periods of the day and to look for the mechanisms of such changes. Female Sprague-Dawley rats (9 to 11 weeks old) were housed in a 14-h-light-10-h-dark cycle (lights on 0600 to 2000 h). A bolus o...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin L,Grenier L,Bergeron Y,Simard M,Bergeron MG,Labrecque G,Beauchamp D

更新日期：1994-01-01 00:00:00

abstract：:Staphylococcal biofilms are a major cause of therapeutic failure, especially when caused by multiresistant strains. Oral fusidic acid is currently being redeveloped in the United States for skin, skin structure, and orthopedic infections, in which biofilms play a major role. The aim of this study was to examine the ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Siala W,Rodriguez-Villalobos H,Fernandes P,Tulkens PM,Van Bambeke F

更新日期：2018-06-26 00:00:00

abstract：:The activity of four antifungal agents against 15 systemic (blood and vascular catheter) and 10 superficial (skin) Malassezia furfur isolates was evaluated. MIC ranges were similar for the two groups of organisms: amphotericin B, 0.3 to 2.5 micrograms/ml; flucytosine, greater than 100 micrograms/ml; miconazole, 0.4 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Marcon MJ,Durrell DE,Powell DA,Buesching WJ

更新日期：1987-06-01 00:00:00

abstract：:Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patie...

journal_title：Antimicrobial agents and chemotherapy

authors： Ogwang S,Good CE,Okware B,Nsereko M,Jacobs MR,Boom WH,Bark CM

更新日期：2015-09-01 00:00:00

abstract：:Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distin...

journal_title：Antimicrobial agents and chemotherapy

authors： Marwaha S,Uvell H,Salin O,Lindgren AE,Silver J,Elofsson M,Gylfe A

更新日期：2014-05-01 00:00:00

abstract：:Previous studies on tetracycline transport into Staphylococcus aureus identified a high-affinity, saturable uptake system for the antibiotic (Km, 4.76 microM) (B.L. Hutchings, Biochim. Biophys. Acta 174:734-738, 1969). However, the earlier results could not be confirmed using conditions that permitted energy-dependent...

journal_title：Antimicrobial agents and chemotherapy

authors： Chopra I,Ismail S,Oliva B

更新日期：1991-12-01 00:00:00

abstract：:Mycobacterium abscessus has emerged as an important pathogen in people with chronic inflammatory lung diseases such as cystic fibrosis, and recent reports suggest that it may be transmissible by fomites. M. abscessus exhibits two major colony morphology variants: a smooth morphotype (MaSm ) and a rough morphotype (MaR...

journal_title：Antimicrobial agents and chemotherapy

authors： Clary G,Sasindran SJ,Nesbitt N,Mason L,Cole S,Azad A,McCoy K,Schlesinger LS,Hall-Stoodley L

更新日期：2018-02-23 00:00:00

abstract：:Sixteen weeks of treatment with clarithromycin (CLARI) alone displayed significant bactericidal activity against Mycobacterium avium complex infection in beige mice. Only two combined regimens, CLARI combined with an initial 4 or 8 weeks of amikacin (AMIKA), displayed activity greater than that displayed by CLARI alon...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Ji B,Truffot-Pernot C,Grosset J

更新日期：1995-03-01 00:00:00

abstract：:Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34 Madurella mycetomatis strains ...

journal_title：Antimicrobial agents and chemotherapy

authors： van Belkum A,Fahal AH,van de Sande WW

更新日期：2011-04-01 00:00:00