Pharmacokinetics of sparfloxacin and serum bactericidal activity against pneumococci.

abstract：:Establishing an effective empirical antifungal therapy requires that national surveillance studies be conducted. Herein, we report the clinical outcome of infections with and the microbiological features of Iranian isolates of Candidaglabrata derived from patients suffering from candidemia. C. glabrata isolates were r...

journal_title：Antimicrobial agents and chemotherapy

authors： Arastehfar A,Daneshnia F,Zomorodian K,Najafzadeh MJ,Khodavaisy S,Zarrinfar H,Hagen F,Zare Shahrabadi Z,Lackner M,Mirhendi H,Salehi M,Roudbary M,Pan W,Kostrzewa M,Boekhout T

更新日期：2019-06-24 00:00:00

abstract：:The in vivo activity of human immunoglobulin M monoclonal antibody IN-2A8, which is specific for flagellum type b of Pseudomonas aeruginosa, was evaluated in comparison to anti-O antigen (serotype B) MAb KO-2F2 and in combination with antibiotics. IN-2A8 showed stronger activity than KO-2F2 against subcutaneous infect...

journal_title：Antimicrobial agents and chemotherapy

authors： Uezumi I,Terashima M,Kohzuki T,Kato M,Irie K,Ochi H,Noguchi H

更新日期：1992-06-01 00:00:00

abstract：:Aminoglycoside acetyltransferase was detected in Mycobacterium kansasii and M. fortuitum but not in M. avium-M. intracellulare when they were screened by a radioassay. Aminoglycoside phosphotransferase and nucleotidyltransferase activities were absent from all three species tested. Acetyltransferases from both M. kans...

journal_title：Antimicrobial agents and chemotherapy

authors： Ho II,Chan CY,Cheng AF

更新日期：2000-01-01 00:00:00

abstract：:The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

journal_title：Antimicrobial agents and chemotherapy

authors： Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

更新日期：2012-06-01 00:00:00

abstract：:Aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (IA), a major cause of death among immunosuppressed patients. Echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for IA, but their activity is only fungistatic. Heat shock protein 90 (Hsp90) was previously shown ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Steinbach WJ

更新日期：2015-08-01 00:00:00

abstract：:Persistent infections with Chlamydia pneumoniae have been implicated in the development of chronic diseases, such as atherosclerosis and asthma. Although azithromycin, clarithromycin, and levofloxacin are frequently used for the treatment of respiratory C. pneumoniae infections, little is known about the dose and dura...

journal_title：Antimicrobial agents and chemotherapy

authors： Kutlin A,Roblin PM,Hammerschlag MR

更新日期：2002-02-01 00:00:00

abstract：:PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Fritsche TR,Kaniga K,Ge Y,Jones RN

更新日期：2005-08-01 00:00:00

abstract：:Serratia marcescens S-95, which displayed an unusually high degree of resistance to aminoglycosides, including kanamycins and gentamicins, was isolated in 2002 from a patient in Japan. The resistance was mediated by a large plasmid which was nonconjugative but transferable to an Escherichia coli recipient by transform...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Yokoyama K,Yamane K,Wachino J,Shibata N,Yagi T,Shibayama K,Kato H,Arakawa Y

更新日期：2004-02-01 00:00:00

abstract：:Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinf...

journal_title：Antimicrobial agents and chemotherapy

authors： Quiroga MP,Orman B,Errecalde L,Kaufman S,Centrón D

更新日期：2015-05-01 00:00:00

abstract：:There are currently few or no published data on the amount of cerebrospinal fluid (CSF) penetration of daptomycin in patients with suspected or documented neurosurgical infections. We conducted a prospective study, assessing the pharmacokinetics and CSF penetration of a single intravenous daptomycin dose administered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kullar R,Chin JN,Edwards DJ,Parker D,Coplin WM,Rybak MJ

更新日期：2011-07-01 00:00:00

abstract：:In the eubacterial cell, the peptidoglycan is perpetually hydrolyzed throughout the cell cycle by different enzymes such as lytic transglycosylases, endopeptidases, and amidases. In Escherichia coli, four N-acetylmuramoyl-l-alanine amidases, AmiA, -B, -C, and -D, are present in the periplasm. AmiA, -B, and -C are solu...

journal_title：Antimicrobial agents and chemotherapy

authors： Pennartz A,Généreux C,Parquet C,Mengin-Lecreulx D,Joris B

更新日期：2009-07-01 00:00:00

abstract：:Dengue virus (DENV) causes disease globally, with an estimated 25 to 100 million new infections per year. At present, no effective vaccine is available, and treatment is supportive. In this study, we identified BP2109, a potent and selective small-molecule inhibitor of the DENV NS2B/NS3 protease, by a high-throughput ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang CC,Hsieh YC,Lee SJ,Wu SH,Liao CL,Tsao CH,Chao YS,Chern JH,Wu CP,Yueh A

更新日期：2011-01-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:We evaluated the antituberculosis (anti-TB) activity of five β-lactams alone or in combination with β-lactamase inhibitors against 41 clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains. Of those, tebipenem, an oral carbapenem, showed the most potent an...

journal_title：Antimicrobial agents and chemotherapy

authors： Horita Y,Maeda S,Kazumi Y,Doi N

更新日期：2014-11-01 00:00:00

abstract：:In most experiments when aminoglycoside antibiotic (AG) tissue levels are measured, the AG is extracted into buffered media. The data from this study reveal that buffer extraction results in only partial recovery of AG from tissues and that total recovery can be obtained after NaOH or trichloroacetic acid treatment. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Fox KE

更新日期：1989-04-01 00:00:00

abstract：:The effect of antichagasic benznidazole (BZL; 100 mg/kg body weight/day, 3 consecutive days, intraperitoneally) on biotransformation systems and ABC transporters was evaluated in rats. Expression of cytochrome P-450 (CYP3A), UDP-glucuronosyltransferase (UGT1A), glutathione S-transferases (alpha glutathione S-transfera...

journal_title：Antimicrobial agents and chemotherapy

authors： Perdomo VG,Rigalli JP,Villanueva SS,Ruiz ML,Luquita MG,Echenique CG,Catania VA

更新日期：2013-10-01 00:00:00

abstract：:Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population...

journal_title：Antimicrobial agents and chemotherapy

authors： Francis J,Barnes KI,Workman L,Kredo T,Vestergaard LS,Hoglund RM,Byakika-Kibwika P,Lamorde M,Walimbwa SI,Chijioke-Nwauche I,Sutherland CJ,Merry C,Scarsi KK,Nyagonde N,Lemnge MM,Khoo SH,Bygbjerg IC,Parikh S,Aweeka FT,

更新日期：2020-04-21 00:00:00

abstract：:A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kashyap V,Sharma S,Singh V,Sharma SK,Saquib M,Srivastava R,Shaw AK

更新日期：2014-06-01 00:00:00

abstract：:There is concern about the rise of antifungal drug resistance, but little is known about comparative biological properties and pathogenicity of drug-resistant strains. We generated fluconazole (FLC; CO23 RFLC)- or micafungin (FK; CO23 RFK)-resistant strains of Candida albicans by treating a FLC- and FK-susceptible str...

journal_title：Antimicrobial agents and chemotherapy

authors： Angiolella L,Stringaro AR,De Bernardis F,Posteraro B,Bonito M,Toccacieli L,Torosantucci A,Colone M,Sanguinetti M,Cassone A,Palamara AT

更新日期：2008-03-01 00:00:00

abstract：:The comparative in vitro activity of SMT19969, a novel, narrow-spectrum, nonabsorbable agent, was studied against 50 ribotype-defined Clostridium difficile strains, 174 Gram-positive and 136 Gram-negative intestinal anaerobes, and 40 Gram-positive aerobes. SMT19969 was one dilution more active against C. difficile iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Tyrrell KL,Merriam CV

更新日期：2013-10-01 00:00:00

abstract：:Streptomyces bacteria are renowned for their ability to produce bioactive secondary metabolites. Recently, synthetic biology has enabled the production of intermediates and shunt products, which may have altered biological activities compared to the end products of the pathways. Here, we have evaluated the potential o...

journal_title：Antimicrobial agents and chemotherapy

authors： Oja T,San Martin Galindo P,Taguchi T,Manner S,Vuorela PM,Ichinose K,Metsä-Ketelä M,Fallarero A

更新日期：2015-10-01 00:00:00

abstract：:The pharmacokinetics of two prodrugs of zidovudine (AZT), 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester and isoleucinyl ester (DPAZT and IAZT, respectively), were investigated in a rabbit model to determine their potential utility as drugs against human immunodeficiency virus. Drugs were administered by intraven...

journal_title：Antimicrobial agents and chemotherapy

authors： Lupia RH,Ferencz N,Lertora JJ,Aggarwal SK,George WJ,Agrawal KC

更新日期：1993-04-01 00:00:00

abstract：:The potent antiretroviral pyrimidinediones IQP-0528 (PYD1) and IQP-0532 (PYD2) were formulated in polyurethane intravaginal rings (IVRs) as prophylactic drug delivery systems to prevent the sexual transmission of HIV-1. To aid in the selection of a pyrimidinedione candidate and the optimal loading of the drug in the I...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson TJ,Srinivasan P,Albright TH,Watson-Buckheit K,Rabe L,Martin A,Pau CP,Hendry RM,Otten R,McNicholl J,Buckheit R Jr,Smith J,Kiser PF

更新日期：2012-03-01 00:00:00

abstract：:A mouse model of cystitis caused by uropathogenic Escherichia coli was used to study the distribution of gallium in bladder tissue following oral administration of gallium maltolate during urinary tract infection. The median concentration of gallium in homogenized bladder tissue from infected mice was 1.93 μg/g after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ball KR,Sampieri F,Chirino M,Hamilton DL,Blyth RI,Sham TK,Dowling PM,Thompson J

更新日期：2013-11-01 00:00:00

abstract：:We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lennerstrand J,Stammers DK,Larder BA

更新日期：2001-07-01 00:00:00

abstract：:Seven bla(IMP-1)-harboring Acinetobacter sp. isolates and one Pseudomonas putida clinical isolate were recovered from hospitalized patients. All isolates possessed a class 1 integron, named In86, carrying the same cassette array [bla(IMP1), aac(6')-31, and aadA1], which was plasmid located in five of the isolates. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendes RE,Castanheira M,Toleman MA,Sader HS,Jones RN,Walsh TR

更新日期：2007-07-01 00:00:00

abstract：:A cytochrome P-450-deficient mutant of Candida albicans, strain D10, was employed to study the mode of action of imidazole antifungal agents. This mutant accumulates exclusively 14-alpha-methylsterols, resulting in a sterol profile which mimics that of azole-treated wild-type strains. Since the widely accepted primary...

journal_title：Antimicrobial agents and chemotherapy

authors： Lees ND,Broughton MC,Sanglard D,Bard M

更新日期：1990-05-01 00:00:00

abstract：:An oligonucleoside methylphosphonate (ONMP) complementary to the splice acceptor site of immediate-early (IE) pre-mRNAs 4 and 5 (IE4,5SA) inhibits herpes simplex virus type 1 (HSV-1) growth in vitro and in infected animals. The antiviral effect appears to be due to inhibition of IE pre-mRNA 4 and 5 splicing and/or IE4...

journal_title：Antimicrobial agents and chemotherapy

authors： Kulka M,Smith CC,Levis J,Fishelevich R,Hunter JC,Cushman CD,Miller PS,Ts'o PO,Aurelian L

更新日期：1994-04-01 00:00:00

abstract：:The penetration of cefonicid and cefazolin into cardiac tissue was compared after a single 30-mg/kg dose in 30 patients undergoing aortocoronary artery bypass graft surgery. Samples of the right atrial appendage, pericardial fluid, and serum were obtained at various times and assayed for drug content. The concentratio...

journal_title：Antimicrobial agents and chemotherapy

authors： Dudley MN,Nightingale CH,Drezner AD,Low HB,Quintiliani R

更新日期：1984-09-01 00:00:00

abstract：:Both recombinant alpha A interferon and azidothymidine inhibit the replication of human immunodeficiency virus in peripheral blood mononuclear cells. Combinations of recombinant alpha A interferon and azidothymidine at concentrations that are easily achievable in patients synergistically inhibit human immunodeficiency...

journal_title：Antimicrobial agents and chemotherapy

authors： Hartshorn KL,Vogt MW,Chou TC,Blumberg RS,Byington R,Schooley RT,Hirsch MS

更新日期：1987-02-01 00:00:00