N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.

abstract：:Levels of roxithromycin in serum and tissue were investigated in 29 subjects undergoing tonsillectomy. A total of 13 subjects received a single oral dose of 300 mg, and 16 received four oral doses 12 h apart as follows: a 300-mg loading dose followed by three 150-mg doses. Measurable levels of roxithromycin were prese...

journal_title：Antimicrobial agents and chemotherapy

authors： Galioto GB,Ortisi G,Mevio E,Sassella D,Bartucci F,Privitera G

更新日期：1988-09-01 00:00:00

abstract：:In this study, the genetic organization of three novel genomic antibiotic resistance islands (AbaRs) in Acinetobacter baumannii isolates belonging to group of European clone II (EC II) comM integrated sequences of 18-, 21-, and 23-kb resistance islands were determined. These resistance islands carry the backbone of Ab...

journal_title：Antimicrobial agents and chemotherapy

authors： Seputiene V,Povilonis J,Suziedeliene E

更新日期：2012-04-01 00:00:00

abstract：:Twenty-one adult patients hospitalized with lower respiratory tract infections due to Branhamella catarrhalis or Haemophilus influenzae or both were treated with the combination of oral amoxicillin and potassium clavulanate (Augmentin) in an open, noncomparative clinical trial. Diseases included pneumonia, empyema, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallace RJ Jr,Steele LC,Brooks DL,Luman JI,Wilson RW,McLarty JW

更新日期：1985-06-01 00:00:00

abstract：:The pharmacodynamic effects of metronidazole on Trichomonas vaginalis have been poorly characterized. The present in vitro study was performed to characterize the relationship between killing of trichomonads and metronidazole exposure (metronidazole concentration and time of exposure). Five laboratory strains and five...

journal_title：Antimicrobial agents and chemotherapy

authors： Nix DE,Tyrrell R,Müller M

更新日期：1995-08-01 00:00:00

abstract：:Acanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Contact lens wearers are most at risk and account for some 95% of cases. Hydrogen peroxide is used for contact lens disinfection due to its broad antimicrobial activity. Lenses must be neutralized before use to avoid pronounce...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes R,Kilvington S

更新日期：2001-07-01 00:00:00

abstract：:Preclinical animal models informing antimalarial drug development are scarce. We have used asexual erythrocytic Plasmodium cynomolgi infections of rhesus macaques to model Plasmodium vivax during preclinical development of compounds targeting parasite phospholipid synthesis. Using this malaria model, we accumulated da...

journal_title：Antimicrobial agents and chemotherapy

authors： Kocken CH,Remarque EJ,Dubbeld MA,Wein S,van der Wel A,Verburgh RJ,Vial HJ,Thomas AW

更新日期：2009-02-01 00:00:00

abstract：:Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds and has thus accelerated the process of drug discovery against H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Hosmillo M,Emmott E,Lu J,Goodfellow I

更新日期：2018-04-26 00:00:00

abstract：:Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants, young children, elderly persons, and severely immunocompromised patients. Effective postinfection treatments are not widely available, and currently there is no approved vaccine. TMC353121 is a potent RSV fusion ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rouan MC,Gevers T,Roymans D,de Zwart L,Nauwelaers D,De Meulder M,van Remoortere P,Vanstockem M,Koul A,Simmen K,Andries K

更新日期：2010-11-01 00:00:00

abstract：:By cloning studies and complementation experiments, the sulfonamide resistance gene of a serogroup B and serotype 15 (B:15) strain of Neisseria meningitidis was localized to a 1.2-kb chromosomal SspI fragment expressing a drug-resistant dihydropteroate synthase. The fragment hybridized to DNA from both resistant and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kristiansen BE,Rådström P,Jenkins A,Ask E,Facinelli B,Sköld O

更新日期：1990-11-01 00:00:00

abstract：:N-Formimidoyl thienamycin (MK0787) was active against beta-lactamase-producing strains and was an effective inhibitor of beta-lactamases extracted and purified from these strains except for plasmid-mediated penicillinase type IV. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Toda M,Sato K,Nakazawa H,Inoue M,Mitsuhashi S

更新日期：1980-11-01 00:00:00

abstract：:Mupirocin is a topical antibiotic used for the treatment of skin infections and the eradication of methicillin-resistant Staphylococcus aureus carriage. It inhibits bacterial protein synthesis by interfering with isoleucyl-tRNA synthetase activity. High-level mupirocin resistance (MIC of ≥ 512 μg/ml) is mediated by th...

journal_title：Antimicrobial agents and chemotherapy

authors： Seah C,Alexander DC,Louie L,Simor A,Low DE,Longtin J,Melano RG

更新日期：2012-04-01 00:00:00

abstract：:Plasmids determining resistance to arsenic, mercury, silver, and tellurium compounds in Escherichia coli and Pseudomonas aeruginosa were tested for resistance to 40 other metal compounds. Resistance to trivalent boron and hexavalent chromium compounds was a property of certain P. aeruginosa plasmids. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Summers AO,Jacoby GA

更新日期：1978-04-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were studied in 10 cystic fibrosis patients, ranging in age from 11 to 28 years. The patients received a 9- to 23-day course of 350 mg of azlocillin per kg in four or six divided daily doses in combination with am aminoglycoside. Blood and urine samples were collected at specified ti...

journal_title：Antimicrobial agents and chemotherapy

authors： Bosso JA,Saxon BA,Herbst JJ,Matsen JM

更新日期：1984-05-01 00:00:00

abstract：:Bactericidal activity in serum produced after administration of 1-g intravenous doses of cefoperazone, cefotaxime, ceftizoxime, and moxalactam was ascertained in six healthy subjects. The assay organisms were a strain of Staphylococcus aureus which was moderately susceptible to the drugs (MBC, 2 to 8 micrograms/ml) an...

journal_title：Antimicrobial agents and chemotherapy

authors： Barriere SL,Ozasa DC,Mordenti J

更新日期：1985-07-01 00:00:00

abstract：:Strains of Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger were tested for in vitro susceptibility to amphotericin B alone and in combination with fixed concentrations of tetracycline, doxycycline, or minocycline, using buffered minimal essential medium in microtiter plates. Enhanced inhibitory activi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes CE,Harris C,Peterson LR,Gerding DN

更新日期：1984-12-01 00:00:00

abstract：:Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resist...

journal_title：Antimicrobial agents and chemotherapy

authors： Theys K,Libin PJK,Van Laethem K,Abecasis AB

更新日期：2019-07-25 00:00:00

abstract：:Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive care units (ICUs) in central Greece, compared critically ill, mechanically ventilated patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsolaki V,Mantzarlis K,Mpakalis A,Malli E,Tsimpoukas F,Tsirogianni A,Papagiannitsis C,Zygoulis P,Papadonta ME,Petinaki E,Makris D,Zakynthinos E

更新日期：2020-02-21 00:00:00

abstract：:The in vitro susceptibility of 406 clinical isolates to BMY-28142, a new semisynthetic cephem, was evaluated and compared with cefpimizole, HR 810, ceftazidime, cefotaxime, moxalactam, and cefoperazone in a broth microdilution assay. On a weight basis, the activity of BMY-28142 against Escherichia coli, Proteus specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuji A,Maniatis A,Bertram MA,Young LS

更新日期：1985-04-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific lysin ClyJ comprising the binding doma...

journal_title：Antimicrobial agents and chemotherapy

authors： Luo D,Huang L,Gondil VS,Zhou W,Yang W,Jia M,Hu S,He J,Yang H,Wei H

更新日期：2020-11-17 00:00:00

abstract：:Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including c...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen B,Noller HF,Daubresse G,Oliva B,Misulovin Z,Rothstein DM,Ellestad GA,Gluzman Y,Tally FP,Chopra I

更新日期：1991-11-01 00:00:00

abstract：:In this study, we characterized two tigecycline-resistant Klebsiella pneumoniae isolates from dog urine samples. The isolates were genetically unrelated, belonging to sequence type 11 (ST11) and ST147, both classically related to human isolates. To the best of our knowledge, this is the first identification of tigecyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Ovejero CM,Escudero JA,Thomas-Lopez D,Hoefer A,Moyano G,Montero N,Martin-Espada C,Gonzalez-Zorn B

更新日期：2017-05-24 00:00:00

abstract：:Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in b...

journal_title：Antimicrobial agents and chemotherapy

authors： Keith KE,Oyston PC,Crossett B,Fairweather NF,Titball RW,Walsh TR,Brown KA

更新日期：2005-04-01 00:00:00

abstract：:Hemolytic-uremic syndrome (HUS) is a serious complication of infection by Shiga toxin-producing Escherichia coli. Shiga toxin type 2 (Stx2) is responsible for the renal toxicity that can follow intestinal infection and hemorrhagic colitis due to E. coli. A chimeric mouse-human antibody, designated c alpha Stx2, that h...

journal_title：Antimicrobial agents and chemotherapy

authors： Dowling TC,Chavaillaz PA,Young DG,Melton-Celsa A,O'Brien A,Thuning-Roberson C,Edelman R,Tacket CO

更新日期：2005-05-01 00:00:00

abstract：:Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Slifer T,Araujo FG,Polzer RJ,Remington JS

更新日期：1997-05-01 00:00:00

abstract：:Mammalian cathelicidins are a class of innate antimicrobial peptides isolated from leukocytes and epithelial cells that aid host defense against bacterial infections. Synthetic analogs of cathelicidins offer the promise of potent broad-spectrum antimicrobial efficacy. We developed a combined lung infection and ex vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Bartlett KH,McCray PB Jr,Thorne PS

更新日期：2003-12-01 00:00:00

abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

journal_title：Antimicrobial agents and chemotherapy

authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

更新日期：2007-04-01 00:00:00

abstract：:Staphylococci are the leading cause of hospital-acquired infections worldwide. Increasingly, they resist antibiotic treatment owing to the development of multiple antibiotic resistance mechanisms in most strains. Therefore, the activity and efficacy of recombinant lysostaphin as a drug against this pathogen have been ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hertlein T,Sturm V,Lorenz U,Sumathy K,Jakob P,Ohlsen K

更新日期：2014-01-01 00:00:00

abstract：:The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral do...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramon J,Dautrey S,Farinoti R,Carbon C,Rubinstein E

更新日期：1996-01-01 00:00:00

abstract：:Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

更新日期：2020-12-16 00:00:00

abstract：:Topical administration of live commensal bacteria to the vaginal tract holds significant potential as a cost-effective strategy for the treatment of sexually transmitted infections and the delivery of mucosal vaccines. Probiotic-releasing intravaginal rings (IVRs) embody significant theoretical advantages over traditi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunawardana M,Mullen M,Yoo J,Webster P,Moss JA,Baum MM

更新日期：2014-01-01 00:00:00