An Exposure-Response Perspective on the Clinical Dose of Pretomanid.

abstract：:Our mutagenesis study has investigated all amino acid mutations in the penicillin-binding domain of PBP 1A from Hungarian pneumococcal isolate 3191 to determine the importance of every mutation in the development of penicillin and cefotaxime resistance. Our data reveal that mutations at amino acid positions 574 to 577...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith AM,Klugman KP

更新日期：2003-01-01 00:00:00

abstract：:We determined the pharmacodynamic parameter and the magnitude of that parameter that was predictive of the efficacy of fluconazole in the treatment of disseminated candidiasis. We used a neutropenic murine model of disseminated Candida albicans infection to characterize the time course of activity of fluconazole. Quan...

journal_title：Antimicrobial agents and chemotherapy

authors： Andes D,van Ogtrop M

更新日期：1999-09-01 00:00:00

abstract：:Tedizolid and linezolid in vitro activities against 3,032 Gram-positive pathogens collected in Asia-Pacific, Eastern European, and Latin American medical centers during 2014 were assessed. The isolates were tested for susceptibility by the current reference broth microdilution methods. Due to concern over the effect o...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

更新日期：2016-08-22 00:00:00

abstract：:The in vivo and in vitro determination of significant intracellular stavudine (d4T) triphosphate (d4TTP) concentrations in human immunodeficiency virus (HIV)-infected subjects and NS-1 cells treated with zidovudine (ZDV) has recently been reported. This study was conducted to corroborate these findings with in vivo sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Meléndez M,Blanco R,Delgado W,García R,Santana J,García H,Rosario O,Rodríguez JF

更新日期：2006-03-01 00:00:00

abstract：:The consequences of VanD type glycopeptide resistance on the activity of vancomycin and teicoplanin were evaluated in vitro and in a rabbit model of aortic endocarditis with VanD type clinical isolate Enterococcus faecium BM4339 (MICs: vancomycin, 64 microg/ml; teicoplanin, 4 microg/ml) and its susceptible derivative ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lefort A,Garry L,Depardieu F,Courvalin P,Fantin B

更新日期：2003-11-01 00:00:00

abstract：:The susceptibilities of 430 Campylobacter jejuni strains and 79 C. coli strains to six antimicrobial agents were tested and analyzed. The two sets of strains originated from retail market chicken and turkey samples and from humans, respectively, in Berlin, Germany. Two groups of isolates, one dating from 1991 and the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luber P,Wagner J,Hahn H,Bartelt E

更新日期：2003-12-01 00:00:00

abstract：:To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1 (hMRP1 [ABCC1]) or hMRP2 (cMOAT, or ABCC2), MDCKII cells that overexpress either hMRP1 (MDCKII-MRP1) or hMRP2 (MDCKII-MRP2) were used to investigate saquinavir's cytotoxicity and transport in comparison w...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams GC,Liu A,Knipp G,Sinko PJ

更新日期：2002-11-01 00:00:00

abstract：:The antifolate activity and the transport characteristics of isoaminopterin (IA) in HeLa cells were studied and compared with those of methotrexate (MTX). Both IA and MTX inhibited the incorporation of [2-(14)C]deoxyuridine into HeLa cell DNA by 50% at a concentration of 0.09 muM by 8 h postaddition of the compounds. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosemond-Hornbeak H,Nair MG

更新日期：1979-05-01 00:00:00

abstract：:We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Back AF,Babst AF,Taylor D,Rice RJ

更新日期：1993-07-01 00:00:00

abstract：:Trypanosomiasis remains a significant disease across the sub-Saharan African continent, with 50,000 to 70,000 individuals infected. The utility of current therapies is limited by issues of toxicity and the need to administer compounds intravenously. We have begun a program to pursue lead optimization around MDL 73811,...

journal_title：Antimicrobial agents and chemotherapy

authors： Barker RH Jr,Liu H,Hirth B,Celatka CA,Fitzpatrick R,Xiang Y,Willert EK,Phillips MA,Kaiser M,Bacchi CJ,Rodriguez A,Yarlett N,Klinger JD,Sybertz E

更新日期：2009-05-01 00:00:00

abstract：:Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC-8; 53 kDa) followi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berdugo M,Larsen IV,Abadie C,Deloche C,Kowalczuk L,Touchard E,Dubielzig R,Brandt CR,Behar-Cohen F,Combette JM

更新日期：2012-03-01 00:00:00

abstract：:Acyclovir-resistant clinical isolates of herpes simplex virus type 1 (HSV-1) were analyzed in vitro for their susceptibilities to essential oils of ginger, thyme, hyssop, and sandalwood. All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Schnitzler P,Koch C,Reichling J

更新日期：2007-05-01 00:00:00

abstract：:Emtricitabine [(-)FTC] [(-)-beta-2', 3'-dideoxy-5-fluoro-3'-thiacytidine] has been shown to be an effective inhibitor of hepatitis B virus (HBV) in cell culture, with a potency and selectivity that are essentially identical to those of lamivudine. The antiviral activity of oral administration of (-)FTC against WHV rep...

journal_title：Antimicrobial agents and chemotherapy

authors： Korba BE,Schinazi RF,Cote P,Tennant BC,Gerin JL

更新日期：2000-06-01 00:00:00

abstract：:The distributions of tet(M) and conjugative transposons related to Tn1545 were studied by hybridization in 47 clinical isolates of Streptococcus pneumoniae resistant to tetracycline. Resistance to tetracycline was always associated with resistance to minocycline and was due to the presence of the tet(M) gene. Associat...

journal_title：Antimicrobial agents and chemotherapy

authors： Poyart-Salmeron C,Trieu-Cuot P,Carlier C,Courvalin P

更新日期：1991-08-01 00:00:00

abstract：:We have previously shown that genetic disruption of Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3) affects calcium ionophore-induced egress. We examined whether Plasmodium falciparum CDPK1 (PfCDPK1), the closest homolog of TgCDPK3 in the malaria parasite P. falciparum, could complement a TgCDPK3 mutant...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaji RY,Checkley L,Reese ML,Ferdig MT,Arrizabalaga G

更新日期：2014-05-01 00:00:00

abstract：:Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Ca...

journal_title：Antimicrobial agents and chemotherapy

authors： Bachmann SP,VandeWalle K,Ramage G,Patterson TF,Wickes BL,Graybill JR,López-Ribot JL

更新日期：2002-11-01 00:00:00

abstract：:A radioimmunoassay system has been developed for the measurement of two major metabolites of 9,3"-diacetylmidecamycin, Mb-6 and Mb-12. A radioimmunoassay for Mb-6 was performed by using anti-Mb-6 serum and a [125I]tyramined Mb-6 derivative as a radiolabeled antigen. The labeled antigen was prepared by the chloramine T...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Ueda T,Yokoshima T,Umemura K,Shomura T

更新日期：1982-12-01 00:00:00

abstract：:The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of li...

journal_title：Antimicrobial agents and chemotherapy

authors： Gikas A,Spyridaki I,Scoulica E,Psaroulaki A,Tselentis Y

更新日期：2001-11-01 00:00:00

abstract：:For six clinical isolates of Chlamydia trachomatis, in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C (Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populat...

journal_title：Antimicrobial agents and chemotherapy

authors： Misyurina OY,Chipitsyna EV,Finashutina YP,Lazarev VN,Akopian TA,Savicheva AM,Govorun VM

更新日期：2004-04-01 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovi...

journal_title：Antimicrobial agents and chemotherapy

authors： Tung PP,Summers WC

更新日期：1994-09-01 00:00:00

abstract：:Statins are inhibitors of cholesterol synthesis, but other biological properties, such as antimicrobial effects, have also been assigned to them, leading to their designation as pleiotropic agents. Our goal was to investigate the activity and selectivity of atorvastatin (AVA) against Trypanosoma cruzi by using in vitr...

journal_title：Antimicrobial agents and chemotherapy

authors： Araujo-Lima CF,Peres RB,Silva PB,Batista MM,Aiub CAF,Felzenszwalb I,Soeiro MNC

更新日期：2018-08-27 00:00:00

abstract：:We determined the antibiotic susceptibilities of 1,785 enterococcal bloodstream isolates collected over 25 years. Antibiotic resistance emerged at a greater rate in Enterococcus faecium than in other enterococcal species, and E. faecium isolates became proportionally more common over time. Our findings confirm the pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Murdoch DR,Mirrett S,Harrell LJ,Monahan JS,Reller LB

更新日期：2002-11-01 00:00:00

abstract：:Aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (IA), a major cause of death among immunosuppressed patients. Echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for IA, but their activity is only fungistatic. Heat shock protein 90 (Hsp90) was previously shown ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Steinbach WJ

更新日期：2015-08-01 00:00:00

abstract：:A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also r...

journal_title：Antimicrobial agents and chemotherapy

authors： McKellar RC,McKenzie CN,Kushner KJ

更新日期：1976-10-01 00:00:00

abstract：:We identified GRL-1388 and -1398, potent nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran (Tp-THF). GRL-1388 was as potent as darunavir (DRV) against various drug-resistant HIV-1 laboratory strains with 50% ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Ide K,Aoki M,Amano M,Koh Y,Yedidi RS,Das D,Leschenko S,Chapsal B,Ghosh AK,Mitsuya H

更新日期：2011-04-01 00:00:00

abstract：:MICs of daptomycin, linezolid, and vancomycin against 212 isolates, including Listeria monocytogenes and Pediococcus, Leuconostoc, Rhodococcus, and Nocardia spp., were determined by the broth microdilution method; daptomycin MICs were also determined by the Etest. Except with those for Leuconostoc spp., daptomycin Ete...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang YT,Liao CH,Teng LJ,Hsueh PR

更新日期：2007-04-01 00:00:00

abstract：:Cryomicrotomy has been used as a new technique for removing gastric mucosae from adult guinea pigs for the study of amoxicillin secretion across gastric mucosae. This method allowed a very regular thickness of the removed surface layer of mucosa to be obtained with good reproducibility. Gastric superficial mucosa conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozniewski A,Weber M,De Korwin JD,Conroy MC,Franck P,Floquet J,Le Faou A,Burdin JC

更新日期：1995-03-01 00:00:00

abstract：:Concentration-QTc modeling was applied to pretomanid, a new nitroimidazooxazine antituberculosis drug. Data came from eight phase 2 and phase 3 studies. Besides pretomanid alone, various combinations with bedaquiline, linezolid, moxifloxacin, and pyrazinamide were considered; special attention was given to the bedaqui...

journal_title：Antimicrobial agents and chemotherapy

authors： Li H,Salinger DH,Everitt D,Li M,Del Parigi A,Mendel C,Nedelman JR

更新日期：2019-09-23 00:00:00

abstract：:The in vitro activities of GAR-936, the 9-t-butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of

journal_title：Antimicrobial agents and chemotherapy

authors： Boucher HW,Wennersten CB,Eliopoulos GM

更新日期：2000-08-01 00:00:00