Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.

abstract：:A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime...

journal_title：Antimicrobial agents and chemotherapy

authors： Schneider I,Queenan AM,Markovska R,Markova B,Keuleyan E,Bauernfeind A

更新日期：2009-10-01 00:00:00

abstract：:Mupirocin is a topical antimicrobial used to decolonize patients who carry methicillin-resistant Staphylococcus aureus (MRSA), and the topical agent retapamulin may be a potential alternative therapy. The goal of this study was to determine the in vitro activity of retapamulin as well as a panel of 15 antimicrobial ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrington AT,Black JA,Clarridge JE 3rd

更新日期：2015-12-14 00:00:00

abstract：:Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify the concentrations of both ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Rubio-Aparicio D,Nelson K,Dudley MN,Lomovskaya O

更新日期：2017-11-22 00:00:00

abstract：:Aggregatibacter actinomycetemcomitans, a periodontopathogen, has been associated with several systemic diseases. Herein, we report the protective effect of human lactoferrin (hLF) during A. actinomycetemcomitans bacteremia in lactoferrin knockout (LFKO(-/-)) mice. The prophylactic, concurrent, and therapeutic intraven...

journal_title：Antimicrobial agents and chemotherapy

authors： Velusamy SK,Poojary R,Ardeshna R,Alabdulmohsen W,Fine DH,Velliyagounder K

更新日期：2014-01-01 00:00:00

abstract：:MprF is responsible for the lysinylation of phosphatidylglycerol (PG) to synthesize the positively charged phospholipid (PL) species, lysyl-PG (L-PG). It has been proposed that the single-nucleotide polymorphisms (SNPs) within the mprF open reading frame (ORF) are associated with a gain-in-function phenotype in terms ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Mishra NN,Chen L,Kreiswirth BN,Rubio A,Yang SJ

更新日期：2015-08-01 00:00:00

abstract：:Acanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Contact lens wearers are most at risk and account for some 95% of cases. Hydrogen peroxide is used for contact lens disinfection due to its broad antimicrobial activity. Lenses must be neutralized before use to avoid pronounce...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes R,Kilvington S

更新日期：2001-07-01 00:00:00

abstract：:Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and...

journal_title：Antimicrobial agents and chemotherapy

authors： Leavitt A,Navon-Venezia S,Chmelnitsky I,Schwaber MJ,Carmeli Y

更新日期：2007-08-01 00:00:00

abstract：:A novel plasmid-mediated metallo-beta-lactamase (IMP-9) is described in seven isolates of Pseudomonas aeruginosa from Guangzhou, China, isolated in 2000. The gene was carried on a large (approximately 450-kb) IncP-2 conjugative plasmid. This is the first report of carriage of bla(IMP) genes on such large plasmids. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong J,Hynes MF,Ye H,Chen H,Yang Y,M'zali F,Hawkey PM

更新日期：2006-01-01 00:00:00

abstract：:Dogs were experimentally inoculated with Rickettsia rickettsii to determine if anti-inflammatory or immunosuppressive dosages of prednisolone, when administered in conjunction with an antirickettsial antibiotic (doxycycline), induced therapeutically relevant pathophysiological consequences that ultimately influence di...

journal_title：Antimicrobial agents and chemotherapy

authors： Breitschwerdt EB,Davidson MG,Hegarty BC,Papich MG,Grindem CB

更新日期：1997-01-01 00:00:00

abstract：:It was previously found that certain nonnucleoside reverse transcriptase inhibitors (NNRTI) possess virucidal activity against human immunodeficiency virus type 1 (HIV-1), and it was suggested that the tight-binding mode of inhibition of reverse transcriptase might be important for this virucidal activity (Borkow et a...

journal_title：Antimicrobial agents and chemotherapy

authors： Motakis D,Parniak MA

更新日期：2002-06-01 00:00:00

abstract：:A new recombinant phenotyping method was developed for the analysis of drug resistance mutations in human cytomegalovirus (CMV). CMV strain T2211 was derived from strain AD169 by inserting unique restriction sites and a secreted alkaline phosphatase (SEAP) reporter gene for rapid viral quantitation. Specific viral UL9...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S,Van Wechel LC,Lichy HM,Marousek GI

更新日期：2005-07-01 00:00:00

abstract：:A preliminary study was conducted with netilmicin, a new aminoglycoside antibiotic. Its effectiveness was evaluated in vitro against 546 strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from clinical material. Its effectiveness against gentamicin-susceptible strains was roughly similar to that of gent...

journal_title：Antimicrobial agents and chemotherapy

authors： Klastersky J,Meunier-Carpentier F,Coppens-Kahan L,Daneau D,Prevost JM

更新日期：1977-10-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:The 747-bp cfiA gene, which encodes a metallo-beta-lactamase, and the regions flanking cfiA in six imipenem-resistant and four imipenem-susceptible Bacteroides fragilis strains isolated in Japan were analyzed by PCR and DNA sequencing. The nucleotide sequences of the cfiA genes (designated cfiA(1) to cfiA(10)) of all ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kato N,Yamazoe K,Han CG,Ohtsubo E

更新日期：2003-03-01 00:00:00

abstract：:Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be available for quite some time. Clinicians will need to find more effective ways to utilize available agents. Colistin is an older but no...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson BW,Ibrahim KH,Hovde LB,Fromm TL,Reed MD,Rotschafer JC

更新日期：2003-03-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV), a paramyxovirus, is a major cause of acute upper and lower respiratory tract infections in infants, young children, and adults. RFI-641 is a novel anti-RSV agent with potent in vitro and in vivo activity. RFI-641 is active against both RSV type A and B strains. The viral specif...

journal_title：Antimicrobial agents and chemotherapy

authors： Huntley CC,Weiss WJ,Gazumyan A,Buklan A,Feld B,Hu W,Jones TR,Murphy T,Nikitenko AA,O'Hara B,Prince G,Quartuccio S,Raifeld YE,Wyde P,O'Connell JF

更新日期：2002-03-01 00:00:00

abstract：:The substituted benzimidazole omeprazole, used for the treatment of human peptic ulcer disease, inhibits the growth of the metronidazole-resistant bovine pathogen Tritrichomonas foetus in vitro (MIC at which the growth of parasite cultures is inhibited by 50%, 22 microg/ml [63 microM]). The antitrichomonad activity ap...

journal_title：Antimicrobial agents and chemotherapy

authors： Sutak R,Tachezy J,Kulda J,Hrdý I

更新日期：2004-06-01 00:00:00

abstract：:Seasonal and pandemic influenza causes 650,000 deaths annually in the world. The emergence of drug resistance to specific anti-influenza virus drugs such as oseltamivir and baloxavir marboxil highlights the urgency of novel anti-influenza chemical entity discovery. In this study, we report a series of novel thiazolide...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao L,Yan Y,Dai Q,Li X,Xu K,Zou G,Yang K,Li W,Guo X,Yang J,Li Y,Xia Q,Cao R,Zhong W

更新日期：2020-06-23 00:00:00

abstract：:The objective of this study was to determine the population pharmacokinetic parameters of levofloxacin, gatifloxacin, and moxifloxacin following multiple oral doses. Twenty-nine patients with tuberculosis at the University Hospital in Vitória, Brazil, participated. Subjects received multiple doses of one drug (levoflo...

journal_title：Antimicrobial agents and chemotherapy

authors： Peloquin CA,Hadad DJ,Molino LP,Palaci M,Boom WH,Dietze R,Johnson JL

更新日期：2008-03-01 00:00:00

abstract：:The influence of inhibitors of P-glycoprotein (verapamil [VE], cyclosporine [CY], and GF120918 [GF]) on the cell handling of macrolides (erythromycin [ERY], clarithromycin [CLR], roxithromycin [ROX], azithromycin [AZM], and telithromycin [TEL]) was examined in J774 murine macrophages. The net influx rates of AZM and T...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Michot JM,Chanteux H,Mingeot-Leclercq MP,Tulkens PM,Van Bambeke F

更新日期：2003-03-01 00:00:00

abstract：:Human cell culture-derived interferon was shown to inhibit human cytomegalovirus in vitro. A prototype strain, Davis, and six clinical isolates of cytomegalovirus were tested. All six isolates showed uniform susceptibility to interferon, exceeding that of the Davis strain by two- to fourfold. The latter virus was foun...

journal_title：Antimicrobial agents and chemotherapy

authors： Postic B,Dowling JN

更新日期：1977-04-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans and Capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. They are resistant to many antibiotics of microbial origin but are sensitive to the n...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

更新日期：1993-12-01 00:00:00

abstract：:Six strains of ampicillin-resistant Haemophilus influenzae type b were studied in vitro for synergy between ampicillin and nafcillin. The minimal inhibitory concentrations for these strains with 10(4) colony-forming units per ml were 6.25 to 12.5 microgram of ampicillin per ml and 6.25 to 25 microgram of nafcillin per...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Burkholder E,Davis AT

更新日期：1980-03-01 00:00:00

abstract：:A practical preclinical model for the hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors has been developed. Indinavir and atazanavir produced significant hyperbilirubinemia, whereas amprenavir, the negative control, was indistinguishable from the ritonavir booster dose. This model was use...

journal_title：Antimicrobial agents and chemotherapy

authors： Kempf DJ,Waring JF,Morfitt DC,Werner P,Ebert B,Mitten M,Nguyen B,Randolph JT,DeGoey DA,Klein LL,Marsh K

更新日期：2006-02-01 00:00:00

abstract：:Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of w...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Y,Creek D,Chollet J,Matile H,Charman SA,Wittlin S,Wood JK,Vennerstrom JL

更新日期：2007-08-01 00:00:00

abstract：:Histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the Americas. Amphotericin B (AMB) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but AMB is toxic, and the bioavailability of itraconazole is erratic. Therefore, it is...

journal_title：Antimicrobial agents and chemotherapy

authors： de Aguiar Cordeiro R,de Farias Marques FJ,de Aguiar Cordeiro R,da Silva MR,Donato Maia Malaquias A,Silva de Melo CV,Mafezoli J,Ferreira de Oliveira Mda C,Nogueira Brilhante RS,Gadelha Rocha MF,Pinheiro Gomes Bandeira Tde J,Costa Si

更新日期：2014-05-01 00:00:00

abstract：:The efficiencies of two dosage schedules of amikacin (2 x 10 mg/kg of body weight per 24 h and 1 x 20 mg/kg/24 h intramuscularly for 5 days) against Pseudomonas aeruginosa sepsis in rabbits were compared. Blood samples were drawn at various times after the first application, and amikacin concentrations in serum were a...

journal_title：Antimicrobial agents and chemotherapy

authors： Staneva M,Markova B,Atanasova I,Terziivanov D

更新日期：1994-05-01 00:00:00

abstract：:The long-term cumulative cytotoxicity of antiretrovirals (ARVs) is among the major causes of treatment failure in patients infected with human immunodeficiency virus (HIV) and patients with AIDS. This calls for the development of novel ARVs with less or no cytotoxicity. In the present study, we compared the cytotoxic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lopes de Campos WR,Coopusamy D,Morris L,Mayosi BM,Khati M

更新日期：2009-07-01 00:00:00

abstract：:Three mer transposons from the Murray collection of preantibiotic enterobacteria show >99% sequence identity to current isolates. Tn5073 is most closely related to Tn5036 and Tn1696, and Tn5074 is most closely related to Tn5053. Tn5075 is most closely related to Tn21 but lacks integron In2 and is flanked by insertion ...

journal_title：Antimicrobial agents and chemotherapy

authors： Essa AM,Julian DJ,Kidd SP,Brown NL,Hobman JL

更新日期：2003-03-01 00:00:00

abstract：:The penam nucleus can assume two conformations; these are designated open and closed. The synthetic (2,3)-alpha- and (2,3)-beta-methylenepenams can be regarded as analogs of the open and closed conformations, respectively. It has been shown that the beta-methylenepenams are essentially inactive, suggesting that the cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Christenson JG,Pruess DL,Talbot MK,Keith DD

更新日期：1988-07-01 00:00:00