New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria.

abstract：:Eighty-five patients with cystic fibrosis who were experiencing an acute infectious exacerbation of their disease were randomized in double-blind fashion to receive either 50 or 75 mg of ceftazidime per kg (body weight) per dose administered intravenously every 8 h for 14 days. Three patients were dropped from the stu...

journal_title：Antimicrobial agents and chemotherapy

authors： Reed MD,Stern RC,O'Brien CA,Crenshaw DA,Blumer JL

更新日期：1987-05-01 00:00:00

abstract：:Human cryptococcosis can occur as a primary or opportunistic infection and develops as an acute, subacute, or chronic systemic infection involving different organs of the host. Given the limited therapeutic options and the occasional resistance to fluconazole, there is a need to develop novel drugs for the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sá NP,Lima CM,Lino CI,Barbeira PJS,Baltazar LM,Santos DA,Oliveira RB,Mylonakis E,Fuchs BB,Johann S

更新日期：2017-07-25 00:00:00

abstract：:Fifty-six strains, representing eight species of salmonellae of diverse geographic origin and possessing a variety of antimicrobial resistance profiles, were tested for susceptibility to niridazole by the agar dilution method. Calculated MICs for 50 and 90% of strains were 4.8 and 16.0 mg/liter, respectively, with a s...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Jackowski J,Grant RB

更新日期：1986-05-01 00:00:00

abstract：:Eighteen patients developed abnormally low serum glutamic oxaloacetic transaminase values during metronidazole therapy. Metronidazole absorbs at 340 nm, simulating reduced nicotinamide adenine dinucleotide, which is the final colorimetric product of the serum glutamic oxaloacetic transaminase assay. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rissing JP,Newman C,Moore WL Jr

更新日期：1978-10-01 00:00:00

abstract：:Patterns of susceptibility of 45 Proteus penneri clinical isolates to 14 antimicrobial agents were evaluated by a macrobroth dilution method. All strains were highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, netilmicin, and, with few exceptions, to amikacin, piperacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuksa M,Krajden S,Lee A

更新日期：1984-09-01 00:00:00

abstract：:The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazzarini C,Esposto MC,Prigitano A,Cogliati M,De Lorenzis G,Tortorano AM

更新日期：2015-11-09 00:00:00

abstract：:A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Segatore B,De Massis MR,Franceschini N,Bianchi C,Rossolini GM,Amicosante G

更新日期：2002-03-01 00:00:00

abstract：:Two morphotypes of Hafnia alvei differed in their susceptibilities to beta-lactam antibiotics. Both produced an inducible Bush group 1 beta-lactamase. Hyperinducibility of this enzyme was associated with reduced susceptibility in one morphotype. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson KS,Sanders CC,Washington JA 2nd

更新日期：1993-06-01 00:00:00

abstract：:The mycobacterial phosphoglycosyltransferase WecA, which initiates arabinogalactan biosynthesis in Mycobacterium tuberculosis, has been proposed as a target of the caprazamycin derivative CPZEN-45, a preclinical drug candidate for the treatment of tuberculosis. In this report, we describe the functional characterizati...

journal_title：Antimicrobial agents and chemotherapy

authors： Huszár S,Singh V,Polčicová A,Baráth P,Barrio MB,Lagrange S,Leblanc V,Nacy CA,Mizrahi V,Mikušová K

更新日期：2017-10-24 00:00:00

abstract：:3-O-(3',3'-Dimethylsuccinyl) betulinic acid (DSB), also known as PA-457, bevirimat (BVM), or MPC-4326, is a novel HIV-1 maturation inhibitor. Unlike protease inhibitors, BVM blocks the cleavage of the Gag capsid precursor (CA-SP1) to mature capsid (CA) protein, resulting in the release of immature, noninfectious viral...

journal_title：Antimicrobial agents and chemotherapy

authors： Lu W,Salzwedel K,Wang D,Chakravarty S,Freed EO,Wild CT,Li F

更新日期：2011-07-01 00:00:00

abstract：:According to recommendations of the 6th WHO Advisory Committee on Buruli ulcer, directly observed treatment with the combination of rifampin and streptomycin, administered daily for 8 weeks, was recommended to 310 patients diagnosed with Buruli ulcer in Pobè, Bénin. Among the 224 (72%) eligible patients for whom treat...

journal_title：Antimicrobial agents and chemotherapy

authors： Chauty A,Ardant MF,Adeye A,Euverte H,Guédénon A,Johnson C,Aubry J,Nuermberger E,Grosset J

更新日期：2007-11-01 00:00:00

abstract：:Granulocytopenia is a complication of human immunodeficiency virus disease, as well as a toxic manifestation of zidovudine therapy. To evaluate pharmacokinetic and pharmacodynamic relationships, 11 AIDS-AIDS-related complex patients who had developed zidovudine-associated granulocytopenia (mean absolute neutrophil cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Hewitt RG,Morse GD,Lawrence WD,Maliszewski ML,Santora J,Bartos L,Bonnem E,Poiesz B

更新日期：1993-03-01 00:00:00

abstract：:The efficacy of a 5-day treatment with coumermycin A1 (hereafter referred to as coumermycin) (at three dosage regimens), with ciprofloxacin, or with coumermycin plus ciprofloxacin was tested in experimental aortic valve endocarditis induced in rats by a strain of methicillin-susceptible Staphylococcus aureus and was c...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne CM,Malinverni R,Glauser MP

更新日期：1987-04-01 00:00:00

abstract：:We have cloned a 4.9-kilobase (kb) HincII fragment which contains a tetracycline resistance determinant (tetM) from the chromosome of Ureaplasma urealyticum. The 4.9-kb HincII fragment contains DNA in addition to the structural gene, is closely related to the previously characterized 5.0-kb fragment from pJI3, and con...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown JT,Roberts MC

更新日期：1987-11-01 00:00:00

abstract：:The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were determined, and the virulence-suppressing effects of AZM were compared with those of erythromycin (EM), roxithromycin (RXM)...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizukane R,Hirakata Y,Kaku M,Ishii Y,Furuya N,Ishida K,Koga H,Kohno S,Yamaguchi K

更新日期：1994-03-01 00:00:00

abstract：:We reported previously that intraperitoneal administration of a bis(benzyl)polyamine analog, MDL 27,695, suppressed both pentavalent antimony (Sbv)-susceptible and -resistant Leishmania donovani in vivo. The present studies were performed to optimize parasite suppression by parenteral administration and to evaluate th...

journal_title：Antimicrobial agents and chemotherapy

authors： Baumann RJ,McCann PP,Bitonti AJ

更新日期：1991-07-01 00:00:00

abstract：:Artemisinin-derivative combination therapies (ACT) are highly efficacious against multidrug-resistant Plasmodium falciparum malaria. Few efficacy data, however, are available for vivax malaria. With high rates of chloroquine (CQ) resistance in both vivax and falciparum malaria in Papua Province, Indonesia, new combina...

journal_title：Antimicrobial agents and chemotherapy

authors： Tjitra E,Baker J,Suprianto S,Cheng Q,Anstey NM

更新日期：2002-12-01 00:00:00

abstract：:A novel beta-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D beta-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA...

journal_title：Antimicrobial agents and chemotherapy

authors： Alfredson DA,Korolik V

更新日期：2005-06-01 00:00:00

abstract：:BO-1341, a new antipseudomonal semisynthetic cephalosporin, was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime, cefotaxime, and cefoperazone. The in vitro activity of BO-1341 was generally superior or comparable to the activities of the reference antibiotics against clinical...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Sanada M,Matsuda K,Hashizume T,Asahi Y,Ushijima R,Ohtake N,Tanaka N

更新日期：1989-09-01 00:00:00

abstract：:The mecillinam resistance of Escherichia coli K-12 mutants deficient in the enzyme responsible for the synthesis of adenosine 3',5'-monophosphate, adenylate cyclase, has been investigated. The results suggest that resistance to this antibiotic may be a consequence of the slow growth rate of these mutants rather than a...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott NW,Harwood CR

更新日期：1981-04-01 00:00:00

abstract：:The in vitro activities of eight antifungal drugs against clinical isolates of Fonsecaea pedrosoi (n = 21), Fonsecaea monophora (n = 25), and Fonsecaea nubica (n = 9) were tested. The resulting MIC(90)s for all strains (n = 55) were as follows, in increasing order: posaconazole, 0.063 microg/ml; itraconazole, 0.125 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Najafzadeh MJ,Badali H,Illnait-Zaragozi MT,De Hoog GS,Meis JF

更新日期：2010-04-01 00:00:00

abstract：:A new class of pyridine oxide derivatives as inhibitors of human immunodeficiency virus type 1 (HIV-1) and/or HIV-2 replication in cell culture has been identified. The compounds, which specifically inhibit HIV-1, behave as typical nonnucleoside reverse transcriptase inhibitors (NNRTIs). The most active congener of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Stevens M,Pannecouque C,De Clercq E,Balzarini J

更新日期：2003-09-01 00:00:00

abstract：:We have evaluated the efficacy of posaconazole (PSC), voriconazole (VRC), and amphotericin B (AMB) in a murine model of systemic infection by Cryptococcus gattii using immunocompromised animals and three clinical strains of the fungus. AMB was the most effective drug in prolonging the survival of mice and also in redu...

journal_title：Antimicrobial agents and chemotherapy

authors： Calvo E,Pastor FJ,Rodríguez MM,Pujol I,Guarro J

更新日期：2010-10-01 00:00:00

abstract：:The in vitro activity of PD 127,391, a dihalogenated quinolone, was compared with those of ofloxacin, ciprofloxacin, nalidixic acid, gentamicin, and cefuroxime against 525 recent isolates and well-characterized antimicrobial agent-resistant strains. The MICs of PD 127,391 against 90% of members of the family Enterobac...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Ashby JP,Andrews JM

更新日期：1988-08-01 00:00:00

abstract：:Forty-nine clinical isolates of multidrug-resistant Acinetobacter baumannii were obtained from 12 hospitals in 7 prefectures throughout Japan. Molecular phylogenetic analysis revealed the clonal spread of A. baumannii sequence type 208 (ST208) and ST455 isolates harboring the armA gene and ST512 harboring the armA and...

journal_title：Antimicrobial agents and chemotherapy

authors： Tada T,Miyoshi-Akiyama T,Shimada K,Shimojima M,Kirikae T

更新日期：2014-05-01 00:00:00

abstract：:Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagenic agent, often a nucleotide analogue. One of its advantages is its broad spectrum nature that renders the strategy potentially effective against emergent...

journal_title：Antimicrobial agents and chemotherapy

authors： Gallego I,Soria ME,Gregori J,de Ávila AI,García-Crespo C,Moreno E,Gadea I,Esteban J,Fernández-Roblas R,Esteban JI,Gómez J,Quer J,Domingo E,Perales C

更新日期：2019-09-30 00:00:00

abstract：:A preliminary study was conducted with netilmicin, a new aminoglycoside antibiotic. Its effectiveness was evaluated in vitro against 546 strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from clinical material. Its effectiveness against gentamicin-susceptible strains was roughly similar to that of gent...

journal_title：Antimicrobial agents and chemotherapy

authors： Klastersky J,Meunier-Carpentier F,Coppens-Kahan L,Daneau D,Prevost JM

更新日期：1977-10-01 00:00:00

abstract：:The in vitro interactions between bismuth subcitrate and a variety of antimicrobial agents against 12 Campylobacter pyloridis (C. pylori) isolates were studied by the agar dilution checkerboard technique. The combination of bismuth subcitrate with the older quinolone, oxolinic acid, produced synergistic activity again...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Caekenberghe DL,Breyssens J

更新日期：1987-09-01 00:00:00

abstract：:Dialyzed extracts of the gentamicin producer Micromonospora purpurea catalyze reactions which represent transaminations proposed for 2-deoxystreptamine biosynthesis. To determine whether these transaminations were catalyzed by a single aminotransferase or by multiple enzymes, we purified and characterized an L-glutami...

journal_title：Antimicrobial agents and chemotherapy

authors： Lucher LA,Chen YM,Walker JB

更新日期：1989-04-01 00:00:00

abstract：:MICs, time-kills, and postantibiotic effects (PAEs) of ABT-773 (a new ketolide) and 10 other agents were determined against 226 pneumococci. Against 78 ermB- and 44 mefE-containing strains, ABT-773 MICs at which 50% of the isolates tested were inhibited (MIC(50)s) and MIC(90)s were 0.016 to 0.03 and 0.125 microgram/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Ednie LM,Hoellman DM,Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：2000-07-01 00:00:00