Antibacterial activity of niridazole against Salmonellae.

Abstract:

:Fifty-six strains, representing eight species of salmonellae of diverse geographic origin and possessing a variety of antimicrobial resistance profiles, were tested for susceptibility to niridazole by the agar dilution method. Calculated MICs for 50 and 90% of strains were 4.8 and 16.0 mg/liter, respectively, with a susceptibility range of 0.25 to 32 mg/liter. No obvious species differences were noted. Niridazole was found to be rapidly and powerfully bactericidal. No significant difference was detected between MICs and MBCs. Except for a strain-dependent effect with a subset of multiply resistant salmonella isolates, no inoculum effect was demonstrated.

authors

Bannatyne RM,Jackowski J,Grant RB

doi

10.1128/aac.29.5.923

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

923-4

issue

5

eissn

0066-4804

issn

1098-6596

journal_volume

29

pub_type

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