Artifactual depression of serum glutamic oxaloacetic transaminase by metronidazole.

abstract：:A structurally diverse library of 93 lipophilic di- and tricyclic diaminopyrimidine derivatives was tested for the ability to inhibit recombinant dihydrofolate reductase (DHFR) cloned from human and bovine isolates of Cryptosporidium parvum (J. R. Vásquez et al., Mol. Biochem. Parasitol. 79:153-165, 1996). In parallel...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson RG,Rosowsky A

更新日期：2001-12-01 00:00:00

abstract：:The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 micrograms/ml for 100% inclusion inhibition and 0.031 to 0.063 microgram/ml for 50% inclusion inhibition. With pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh M,Kappus EW,Quinn TC

更新日期：1987-05-01 00:00:00

abstract：:The candidacidal activity of nitric oxide (NO) as delivered by a class of compounds termed diazeniumdiolates has been investigated. Diazeniumdiolates are stable agents capable of releasing NO in a biologically usable form at a predicted rate, and three such compounds were examined for activity. One compound, (Z)-1-[N-...

journal_title：Antimicrobial agents and chemotherapy

authors： McElhaney-Feser GE,Raulli RE,Cihlar RL

更新日期：1998-09-01 00:00:00

abstract：:The intrinsic mechanisms of resistance to beta-lactam antibiotics in Serratia marcescens IFO 12648 were investigated, comparing the action of benzylpenicillin, apalcillin, cefazolin, and ceftizoxime. The minimal inhibitory concentrations for this strain were 1,600, 3.13, 6,400, and 0.05 microgram/ml, respectively. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Takata N,Suginaka H,Kotani S,Ogawa M,Kosaki G

更新日期：1981-03-01 00:00:00

abstract：:The effect of ethambutol (EMB) is primarily on polymerization steps in the biosynthesis of the arabinan component of cell wall arabinogalactan (AG) of Mycobacterium smegmatis. Inhibition of the synthesis of the arabinan of lipoarabinomannan (LAM) occurred later, and thus in the cases of AG and LAM, the polymerization ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mikusová K,Slayden RA,Besra GS,Brennan PJ

更新日期：1995-11-01 00:00:00

abstract：:TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms, including tetracycline-specific efflux and ribosomal protection. The mechanism of action of TP-434 was assessed using both cell-based and in vitro assays. In Escherichia coli cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Grossman TH,Starosta AL,Fyfe C,O'Brien W,Rothstein DM,Mikolajka A,Wilson DN,Sutcliffe JA

更新日期：2012-05-01 00:00:00

abstract：:High-level azole resistance in the Darlington strain of Candida albicans was investigated by gene replacement in C. albicans and expression in Saccharomyces cerevisiae. We sequenced the ERG11 gene, which encodes the sterol C(14)alpha-demethylase, from our copy of the Darlington strain. Both alleles contained the histi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kakeya H,Miyazaki Y,Miyazaki H,Nyswaner K,Grimberg B,Bennett JE

更新日期：2000-11-01 00:00:00

abstract：:It has recently become apparent that inflammatory reactions including nitric oxide (NO) release contribute to the outcome of pulmonary infections. To investigate the effect of N(G)-monomethyl-L-arginine (L-NMMA), a NO synthase inhibitor, on the pathogenesis of pneumococcal pneumonia, we inoculated CD(1) Swiss mice wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron Y,Ouellet N,Simard M,Olivier M,Bergeron MG

更新日期：1999-09-01 00:00:00

abstract：:Staphylococcus aureus bacteremia (SAB) causes high rates of morbidity and death. Several studies in academic health settings have demonstrated that consultations from infectious diseases specialists improve the quality of care and clinical outcomes for SAB. Few data that describe the impact in resource-limited setting...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Valcarlos E,Won R,Chang E,Schwartz J

更新日期：2016-09-23 00:00:00

abstract：:An in vitro tissue culture system consisting of reaggregated embryonic brain cells was used to evaluate the inhibition of herpes simplex type 1 (HSV-1) by several antiviral compounds. The efficacy of acyclovir, vidarabine, bromovinyldeoxyuridine, and 9-(1,3-dihydroxy-2-propoxymethyl) guanine in HSV-1-infected Vero cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Pulliam L,Panitch HS,Baringer JR,Dix RD

更新日期：1986-12-01 00:00:00

abstract：:A number of compounds, as exemplified by verapamil and desipramine, have been shown to enhance the susceptibility of resistant malaria parasites to chloroquine. The mechanism by which these agents reverse resistance is still controversial but is though to involve alterations in drug transport causing an increase in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Ndifor AM,Howells RE,Bray PG,Ngu JL,Ward SA

更新日期：1993-06-01 00:00:00

abstract：:Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with t...

journal_title：Antimicrobial agents and chemotherapy

authors： Markantonis SL,Markou N,Fousteri M,Sakellaridis N,Karatzas S,Alamanos I,Dimopoulou E,Baltopoulos G

更新日期：2009-11-01 00:00:00

abstract：:Although fluoroquinolone antibiotics such as ciprofloxacin are able to gain access to lung tissue and both pleural and bronchial secretions, the characteristics of transport and cellular uptake of ciprofloxacin in human epithelial lung tissue remain obscure. We have chosen human airway epithelial (Calu-3) cells, recon...

journal_title：Antimicrobial agents and chemotherapy

authors： Cavet ME,West M,Simmons NL

更新日期：1997-12-01 00:00:00

abstract：:A total of 91 multiply resistant bacterial strains, including Klebsiella pneumoniae (32 strains), Pseudomonas aeruginosa (16 strains), and Serratia marcescens (43 strains), were collected during hospital epidemics of nosocomial infection from 1975 to 1979. These strains were resistant to gentamicin, tobramycin, cephal...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ,Gerding DN

更新日期：1980-02-01 00:00:00

abstract：:The antifungal pentapeptide auristatin PHE was recently shown to interfere with microtubule dynamics and nuclear and cellular division in the opportunistic pathogen Cryptococcus neoformans. To gain a broader understanding of the cellular response of C. neoformans to auristatin PHE, mRNA differential display (DD) and r...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Berens ME,Hoelzinger DB,Pettit GR,Winkelmann G,Pettit RK

更新日期：2004-02-01 00:00:00

abstract：:The anti-hepatitis C virus nucleotide prodrug GS-6620 employs a double-prodrug approach, with l-alanine-isopropyl ester and phenol moieties attached to the 5'-phosphate that release the nucleoside monophosphate in hepatocytes and a 3'-isobutyryl ester added to improve permeability and oral bioavailability. Consistent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Murakami E,Wang T,Babusis D,Lepist EI,Sauer D,Park Y,Vela JE,Shih R,Birkus G,Stefanidis D,Kim CU,Cho A,Ray AS

更新日期：2014-01-01 00:00:00

abstract：:The need for daily parenteral administration is an important limitation in the clinical use of pentavalent antimonial drugs against leishmaniasis. In this study, amphiphilic antimony(V) complexes were prepared from alkylmethylglucamides (L8 and L10, with carbon chain lengths of 8 and 10, respectively), and their poten...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes FR,Ferreira WA,Campos MA,Ramos GS,Kato KC,Almeida GG,Corrêa JD Junior,Melo MN,Demicheli C,Frézard F

更新日期：2013-09-01 00:00:00

abstract：:Bacterial susceptibility to a new organic acid related to nalidixic acid and oxolinic acid was tested. The in vitro susceptibility pattern of the new compound was found to be very similar to that of nalidixic acid. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gilis PM,Haemers A,Pattyn SR

更新日期：1978-03-01 00:00:00

abstract：:Data comparing the treatment outcomes of the two most frequently recommended empirical antibiotic regimens for community-acquired pneumonia (CAP)--combination therapy with an extended-spectrum beta-lactam and a macrolide (BL+M) or fluoroquinolone (F) monotherapy--for patients with severe CAP are sparse. The purpose of...

journal_title：Antimicrobial agents and chemotherapy

authors： Lodise TP,Kwa A,Cosler L,Gupta R,Smith RP

更新日期：2007-11-01 00:00:00

abstract：:There are limited long-term data on the trends in incidence and characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) in intensive care units (ICUs) in which infection control measures have been adopted. We evaluated the trend of incidence and changes in characteristics of MRSA bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim H,Kim ES,Lee SC,Yang E,Kim HS,Sung H,Kim MN,Jung J,Kim MJ,Kim SH,Lee SO,Choi SH,Woo JH,Kim YS,Chong YP

更新日期：2020-09-21 00:00:00

abstract：:A membrane fraction from Pseudomonas aeruginosa KM 338 was shown to catalyze in vitro peptidoglycan synthesis from uridine 5'-diphosphate-N-acetylmuramyl-l-alanyl-d- glutamyl-meso-diaminopimelyl-d-alanyl-d-alanine and uridine 5'-diphosphate-N-acetylglucosamine. Synthesized peptidoglycan was partially cross-linked by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Suginaka H,Ichikawa A,Kotani S

更新日期：1974-12-01 00:00:00

abstract：:The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycli...

journal_title：Antimicrobial agents and chemotherapy

authors： Shipley PL,Olsen RH

更新日期：1974-08-01 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:beta-Lactamases from Aeromonas hydrophila and A. sobria were purified and characterized. Both species produced beta-lactamases that were inducible by either cefoxitin or imipenem. These species were resistant to ampicillin and cephalothin but not imipenem. Isoelectric focusing of sonic extracts revealed one band at pI...

journal_title：Antimicrobial agents and chemotherapy

authors： Iaconis JP,Sanders CC

更新日期：1990-01-01 00:00:00

abstract：:We have attempted to validate in Aspergillus flavus the main in vitro methodologies that have been used to detect resistance in Aspergillus fumigatus. We developed a murine model with two A. flavus isolates, one that was apparently resistant in vitro to amphotericin B (AFL5) and another that was resistant to itraconaz...

journal_title：Antimicrobial agents and chemotherapy

authors： Mosquera J,Warn PA,Morrissey J,Moore CB,Gil-Lamaignere C,Denning DW

更新日期：2001-05-01 00:00:00

abstract：:A multicenter susceptibility surveillance (the S.A.U.C.E. project) including 2,721 Streptococcus pneumoniae, 3,174 Streptococcus pyogenes, and 2,645 Haemophilus influenzae consecutive isolates was carried out in 25 hospitals all over Spain from November 2001 to October 2002 to evaluate the current epidemiology of resi...

journal_title：Antimicrobial agents and chemotherapy

authors： Pérez-Trallero E,García-de-la-Fuente C,García-Rey C,Baquero F,Aguilar L,Dal-Ré R,García-de-Lomas J,Spanish Surveillance Group for Respiratory Pathogens.

更新日期：2005-05-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites lack the enzymes to salvage preformed pyrimidines. For this reason, a combination of a thymidylate synthase inhibitor and the nucleoside thymidine should provide selective antimalarial activity even in the absence of any known active site differences between malarial and mamm...

journal_title：Antimicrobial agents and chemotherapy

authors： Rathod PK,Reshmi S

更新日期：1994-03-01 00:00:00

abstract：:This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzitko K,Paneth A,Plech T,Pawełczyk J,Węglińska L,Paneth P

更新日期：2014-12-01 00:00:00

abstract：:The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin, and sitamaquine was assessed in vitro and additionally for the first three combinations in vivo. In vitro interactions were indifferent for miltefosine combined with amphotericin B (mean sums of fractional inhibitory concentrations...

journal_title：Antimicrobial agents and chemotherapy

authors： Seifert K,Croft SL

更新日期：2006-01-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00