Comparative in vitro studies of nalidixic acid, oxolinic acid, and a new analog with thieno (2,3-b) pyridine structure.

abstract：:Escherichia coli MRE 600 is a colicinogenic bacterium. Its colicinogenic activity may be ascribed mostly to colicin E1, although it produces a small amount of another, as yet unidentified, colicin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Salaj-Smic E

更新日期：1978-11-01 00:00:00

abstract：:Antiviral therapeutics are currently unavailable for treatment of coxsackievirus B3, which can cause life-threatening myocarditis. A modified small interfering RNA (siRNA) containing 5'-triphosphate, 3p-siRNA, was shown to induce RNA interference and interferon activation. We aimed to develop a potent antiviral treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahn J,Ko A,Jun EJ,Won M,Kim YK,Ju ES,Jeon ES,Lee H

更新日期：2012-07-01 00:00:00

abstract：:A global sample of group A streptococci (GAS) revealed > or =80 separate acquisitions of tetracycline resistance. Of 244 clones, 38 and 25% displayed resistance to tetracycline and erythromycin, respectively; a relatively high proportion (15%) were resistant to both classes of drugs. tet(M) displayed a highly signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Ayer V,Tewodros W,Manoharan A,Skariah S,Luo F,Bessen DE

更新日期：2007-05-01 00:00:00

abstract：:Development of resistance to the antipseudomonal penicillins and cephalosporins mediated by hyperproduction of the chromosomal cephalosporinase AmpC is a major threat to the successful treatment of Pseudomonas aeruginosa infections. Although ampD inactivation has been previously found to lead to a partially derepresse...

journal_title：Antimicrobial agents and chemotherapy

authors： Juan C,Moyá B,Pérez JL,Oliver A

更新日期：2006-05-01 00:00:00

abstract：:Linezolid was tested against 32 species of uncommonly isolated gram-positive organisms (3,251 strains) by reference MIC methods and found to be highly active (MIC50 range, 0.25 to 2 microg/ml; MIC90 range, 0.25 to 2 microg/ml). Only one isolate (viridans group streptococcus; 0.03% of tested strains) was resistant to l...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Stilwell MG,Hogan PA,Sheehan DJ

更新日期：2007-04-01 00:00:00

abstract：:In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine treatment (200 mg/day for 5 days) was associated with significant reductions in nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayden FG,Monto AS

更新日期：1986-02-01 00:00:00

abstract：:Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches in...

journal_title：Antimicrobial agents and chemotherapy

authors： Townsend EM,Sherry L,Kean R,Hansom D,Mackay WG,Williams C,Butcher J,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:Ritonavir-boosted darunavir with efavirenz may be considered a nucleoside-sparing regimen for treatment-naïve HIV-infected patients. However, the pharmacokinetics of this combination administered once daily have not been studied. We conducted a three-period interaction study with healthy volunteers. The subjects were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Soon GH,Shen P,Yong EL,Pham P,Flexner C,Lee L

更新日期：2010-07-01 00:00:00

abstract：:Exposure to isoniazid induced the expression of several secreted proteins in Mycobacterium tuberculosis H37Rv. Two-dimensional gel electrophoresis and immunoblot analyses indicated that two of the prominent isonicotinic acid hydrazide-inducible polypeptides were members of the antigen 85 complex, recently demonstrated...

journal_title：Antimicrobial agents and chemotherapy

authors： Garbe TR,Hibler NS,Deretic V

更新日期：1996-07-01 00:00:00

abstract：:Ceftizoxime was evaluated in the treatment of 18 patients (6 adults and 12 children) with bacterial meningitis. In seven patients Haemophilus influenzae was the causative agent, in three Neisseria meningitidis, in five Streptococcus pneumoniae, and in one each alpha-streptococcus and Escherichia coli; one case was cul...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Cable DC,Forthal DN,Shikuma C

更新日期：1984-02-01 00:00:00

abstract：:The pharmacokinetics of teicoplanin were determined after multiple 30-min intravenous infusions of 10 to 15 mg/kg every 12 to 24 h in 11 intravenous drug abuse (IVDA) patients being treated for bacterial endocarditis. Multiple serum samples were obtained over 7 to 14 days. Twenty-four-hour urine collections were obtai...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak MJ,Lerner SA,Levine DP,Albrecht LM,McNeil PL,Thompson GA,Kenny MT,Yuh L

更新日期：1991-04-01 00:00:00

abstract：:This randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (Augmentin XR) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sethi S,Breton J,Wynne B

更新日期：2005-01-01 00:00:00

abstract：:Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： Kiri N,Archer G,Climo MW

更新日期：2002-06-01 00:00:00

abstract：:We examined the correlation of mutations in the pyrazinamidase (PZase) gene (pncA) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis. 109:147-151, 1974), and the entire pncA nucleotide se...

journal_title：Antimicrobial agents and chemotherapy

authors： Morlock GP,Crawford JT,Butler WR,Brim SE,Sikes D,Mazurek GH,Woodley CL,Cooksey RC

更新日期：2000-09-01 00:00:00

abstract：:Therapy with nucleoside reverse transcriptase inhibitors (NRTIs) can be associated with mitochondrial toxicity. In vitro studies have been used to predict the predisposition for and characterize the mechanisms causing mitochondrial toxicity. Entecavir (ETV) is an approved deoxyguanosine nucleoside for the treatment of...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzucco CE,Hamatake RK,Colonno RJ,Tenney DJ

更新日期：2008-02-01 00:00:00

abstract：:Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the synthesis of both DHBV DNA and DHBV core antigen. Several nucleoside analogs which were previously shown to inhibit the replication of DNA viruses (i.e., herpesviruses) and retroviruses were examined for their inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Yokota T,Konno K,Chonan E,Mochizuki S,Kojima K,Shigeta S,de Clercq E

更新日期：1990-07-01 00:00:00

abstract：:The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral do...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramon J,Dautrey S,Farinoti R,Carbon C,Rubinstein E

更新日期：1996-01-01 00:00:00

abstract：:Morganocin 174-induced lethality was characterized by one-hit kinetics. Although it induced simultaneous inhibition of deoxyribonucleic acid, ribonucleic acid, and protein syntheses, the most striking effect of morganocin was a rapid reduction of intracellular adenosine 5'-triphosphate to less than 10% of the initial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams JA,Krizsanovich-Williams K

更新日期：1977-09-01 00:00:00

abstract：:Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine...

journal_title：Antimicrobial agents and chemotherapy

authors： Robert MG,Foguim Tsombeng F,Gendrot M,Mosnier J,Amalvict R,Benoit N,Torrentino-Madamet M,Pradines B,French National Reference Centre for Imported Malaria Study Group.

更新日期：2018-10-24 00:00:00

abstract：:We have developed a new recombinant retroviral system in which a library of infectious molecular clones of human immunodeficiency virus type 1 (HIV-1) is constructed with reverse transcriptase (RT) genes derived from viral RNA sequences in plasma. HIV-1 RT is amplified from plasma HIV-1 RNA by nested RT-PCR and cloned...

journal_title：Antimicrobial agents and chemotherapy

authors： Shi C,Mellors JW

更新日期：1997-12-01 00:00:00

abstract：:As an obligate aerobe, Mycobacterium tuberculosis uses its electron transport chain (ETC) to produce energy via oxidative phosphorylation. This pathway has recently garnered a lot of attention and is a target for several new antimycobacterials. We tested the respiratory adaptation of M. tuberculosis to phenoxyalkylben...

journal_title：Antimicrobial agents and chemotherapy

authors： Berube BJ,Parish T

更新日期：2017-12-21 00:00:00

abstract：:The antifungal activities of amphotericin B and two triazoles, Sch 39304 and fluconazole, were tested against Histoplasma capsulatum. In this study Sch 39304 compared favorably with amphotericin B in treating histoplasmosis in normal and leukopenic mice, whereas fluconazole was much less active. The differences in the...

journal_title：Antimicrobial agents and chemotherapy

authors： Kobayashi GS,Travis SJ,Rinaldi MG,Medoff G

更新日期：1990-04-01 00:00:00

abstract：:Tobramycin-resistant burn wound isolates of Klebsiella pneumoniae and Enterobacter cloacae, together with Escherichia coli K-12 transconjugants from these two strains, were examined for plasmid deoxyribonucleic acid (DNA). All the resistant strains contained a common, high-molecular-weight, covalently closed circular ...

journal_title：Antimicrobial agents and chemotherapy

authors： Elwell LP,Inamine JM,Minshew BH

更新日期：1978-02-01 00:00:00

abstract：:Biochemical variations accompanying the acquisition of ethambutol (EMB) resistance in a single-step mutant of Mycobacterium tuberculosis H37Ra were analyzed. Comparative analysis of phospholipids revealed a reduced content in the EMB-resistant strain, particularly in the cell membrane fraction. Significant alterations...

journal_title：Antimicrobial agents and chemotherapy

authors： Sareen M,Khuller GK

更新日期：1990-09-01 00:00:00

abstract：:A novel beta-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D beta-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA...

journal_title：Antimicrobial agents and chemotherapy

authors： Alfredson DA,Korolik V

更新日期：2005-06-01 00:00:00

abstract：:The aim of the present study was to characterize the pharmacokinetic-pharmacodynamic relationship of GV143253A, a novel trinem anti-methicillin-resistant Staphylococcus aureus (MRSA) agent active against gram-positive cocci, including multidrug-resistant clinical isolates. An in vitro pharmacodynamic study with methic...

journal_title：Antimicrobial agents and chemotherapy

authors： Ferrari L,Iavarone L,Braggio S,Di Modugno E

更新日期：2003-02-01 00:00:00

abstract：:The aminoglycoside-modifying enzymes present in the first 120 clinical isolates harboring extended-spectrum beta-lactamases isolated in Spain were studied. Most of these isolates (84%) were gentamicin resistant. The enzymes most frequently associated and cotransferred with SHV-2 or TEM-type beta-lactamases were AAC(3)...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandez-Rodriguez A,Canton R,Perez-Diaz JC,Martinez-Beltran J,Picazo JJ,Baquero F

更新日期：1992-11-01 00:00:00

abstract：:We showed in a previous study that associations of antimicrobial peptides (AMPs), which are key components of the innate immune systems of all living species, with the fluoroquinolone enrofloxacin can successfully cure HeLa cell cultures of Mycoplasma fermentans and M. hyorhinis contamination. In the present work, the...

journal_title：Antimicrobial agents and chemotherapy

authors： Fassi Fehri L,Wróblewski H,Blanchard A

更新日期：2007-02-01 00:00:00

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:Staphylococcus aureus bacteremia (SAB) causes high rates of morbidity and death. Several studies in academic health settings have demonstrated that consultations from infectious diseases specialists improve the quality of care and clinical outcomes for SAB. Few data that describe the impact in resource-limited setting...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Valcarlos E,Won R,Chang E,Schwartz J

更新日期：2016-09-23 00:00:00