Treatment of bacterial meningitis with ceftizoxime.

abstract：:A clinical isolate of Pseudomonas aeruginosa, PAe191, was found to be highly resistant to all anti-Pseudomonas beta-lactam antibiotics (except imipenem) and resistant also to aminoglycosides. It produced a beta-lactamase (with an apparent pI of 7.6) which was not inhibited by clavulanic acid. Cloning and characterizat...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugnier P,Casin I,Bouthors AT,Collatz E

更新日期：1998-12-01 00:00:00

abstract：:In 2002, the first two clinical isolates of vancomycin-resistant Staphylococcus aureus (VRSA) containing vanA were recovered in Michigan and Pennsylvania. Tn1546, a mobile genetic element that encodes high-level vancomycin resistance in enterococci, was present in both isolates. With PCR and DNA sequence analysis, we ...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark NC,Weigel LM,Patel JB,Tenover FC

更新日期：2005-01-01 00:00:00

abstract：:Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Induci...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis KA,Crawford SA,Fiebelkorn KR,Jorgensen JH

更新日期：2005-07-01 00:00:00

abstract：:Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency against nonreplicating bacteria both in vitro and in vivo. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Vocat A,Hartkoorn RC,Lechartier B,Zhang M,Dhar N,Cole ST,Sala C

更新日期：2015-07-01 00:00:00

abstract：:Suboptimal doses of amphotericin B in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated Aspergillus fumigatus infection in mice. Despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradi...

journal_title：Antimicrobial agents and chemotherapy

authors： Arroyo J,Medoff G,Kobayashi GS

更新日期：1977-01-01 00:00:00

abstract：:Spider venoms are vast natural pharmacopoeias selected by evolution. The venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. We tested six of them (latarcins 1, 2a, 3a, 4b, 5, and cytoinsectotoxin 1a) for their ability to suppress Chlamydia trachomatis infection. HEK293 cells...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazarev VN,Polina NF,Shkarupeta MM,Kostrjukova ES,Vassilevski AA,Kozlov SA,Grishin EV,Govorun VM

更新日期：2011-11-01 00:00:00

abstract：:Aminoglycoside resistance in Campylobacter has been routinely monitored in the United States in clinical isolates since 1996 and in retail meats since 2002. Gentamicin resistance first appeared in a single human isolate of Campylobacter coli in 2000 and in a single chicken meat isolate in 2007, after which it increase...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen Y,Mukherjee S,Hoffmann M,Kotewicz ML,Young S,Abbott J,Luo Y,Davidson MK,Allard M,McDermott P,Zhao S

更新日期：2013-11-01 00:00:00

abstract：:Acyclovir, known as an antiherpetic agent, showed an inhibitory effect on the propagation of pseudorabies virus in BHK-21 cells. The antiviral effect of acyclovir was observed by plaque reduction, as well as by the inhibition of the virus-stimulated uptake of thymidine by BHK-21 cells. Amphotericin B potentiated the a...

journal_title：Antimicrobial agents and chemotherapy

authors： Malewicz B,Momsen M,Jenkin HM

更新日期：1983-01-01 00:00:00

abstract：:Antiviral therapeutics are currently unavailable for treatment of coxsackievirus B3, which can cause life-threatening myocarditis. A modified small interfering RNA (siRNA) containing 5'-triphosphate, 3p-siRNA, was shown to induce RNA interference and interferon activation. We aimed to develop a potent antiviral treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahn J,Ko A,Jun EJ,Won M,Kim YK,Ju ES,Jeon ES,Lee H

更新日期：2012-07-01 00:00:00

abstract：:Prophylactic administration of a nontoxic dose of 9-[[2-benzyloxyl-1-(benzyloxymethyl)ethoxy]methyl]-6-chlo roguanine (BIOLF-70) to mice reduced the number of myocarditic lesions induced by coxsackievirus B3 (CVB3). BIOLF-70 exhibited minimal antiviral activity against CVB3 in HeLa cells and murine neonatal skin fibro...

journal_title：Antimicrobial agents and chemotherapy

authors： Gauntt CJ,Arizpe HM,Kung JT,Ogilvie KK,Cheriyan UO

更新日期：1985-02-01 00:00:00

abstract：:The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul AS,Moreira CK,Elsworth B,Allred DR,Duraisingh MT

更新日期：2016-07-22 00:00:00

abstract：:We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaco...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández-Silva F,Capilla J,Mayayo E,Sutton DA,Hernández P,Guarro J

更新日期：2013-12-01 00:00:00

abstract：:TEM-24 remains one of the most widespread TEM-type extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae. To analyze the reasons influencing its spread and persistence, a multilevel population genetics study was carried out on 28 representative TEM-24 producers from Belgium, France, Portugal, and Spain (1...

journal_title：Antimicrobial agents and chemotherapy

authors： Novais A,Baquero F,Machado E,Cantón R,Peixe L,Coque TM

更新日期：2010-02-01 00:00:00

abstract：:Plasmid-mediated resistance to polymyxins mediated by the MCR-1/2 determinants has been reported in Enterobacteriaceae worldwide. Using PCR-based and cloning strategies, a series of Moraxella spp. were screened for mcr-like genes. Moraxella spp. that are mainly animal pathogens but may also be human pathogens were ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Kieffer N,Nordmann P,Poirel L

更新日期：2017-05-24 00:00:00

abstract：:Eleven patients about to undergo pulmonary surgery received a bolus injection of 1 g of cefoxitin. The concentrations of cefoxitin in the serum 1 and 2 h after dosage were 38.5 +/- 1.89 and 23.7 +/- 2.56 mug/ml; the lung concentrations at the respective times were 12.6 +/- 0.7 and 10.06 +/- 0.43 mug/ml. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Perea EJ,Garcia-Iglesias MC,Ayarra J,Loscertales J

更新日期：1983-02-01 00:00:00

abstract：:Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic fungi such as Candida albicans, its effect on Aspergillus fumigatus is less well understood. We used the fluorescent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowman JC,Hicks PS,Kurtz MB,Rosen H,Schmatz DM,Liberator PA,Douglas CM

更新日期：2002-09-01 00:00:00

abstract：:VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray crystallography studies provide support for the idea that VX-787 occupies the 7-methyl GTP (m(7)GTP) cap-binding site of PB2. VX-787 binds the cap-bi...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrn RA,Jones SM,Bennett HB,Bral C,Clark MP,Jacobs MD,Kwong AD,Ledeboer MW,Leeman JR,McNeil CF,Murcko MA,Nezami A,Perola E,Rijnbrand R,Saxena K,Tsai AW,Zhou Y,Charifson PS

更新日期：2015-03-01 00:00:00

abstract：:Campylobacter jejuni is a major zoonotic pathogen transmitted to humans via the food chain and is prevalent in chickens, a natural reservoir for this pathogenic organism. Due to the importance of macrolide antibiotics in clinical therapy of human campylobacteriosis, development of macrolide resistance in Campylobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Luangtongkum T,Shen Z,Seng VW,Sahin O,Jeon B,Liu P,Zhang Q

更新日期：2012-03-01 00:00:00

abstract：:The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Esc...

journal_title：Antimicrobial agents and chemotherapy

authors： Iizaka Y,Higashi N,Ishida M,Oiwa R,Ichikawa Y,Takeda M,Anzai Y,Kato F

更新日期：2013-03-01 00:00:00

abstract：:Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with missense mutations in the rpsL gene, which encodes ribosomal protei...

journal_title：Antimicrobial agents and chemotherapy

authors： Honoré N,Cole ST

更新日期：1994-02-01 00:00:00

abstract：:In order to probe the structure and function of the mycobacterial catalase-peroxidase enzyme (KatG), we employed a genetic approach using dominant-negative analysis of katG merodiploids. Transformation of Mycobacterium bovis BCG with various katG point mutants (expressed from low-copy-number plasmids) resulted in redu...

journal_title：Antimicrobial agents and chemotherapy

authors： DeVito JA,Morris S

更新日期：2003-01-01 00:00:00

abstract：:The susceptibility of Saccharomyces cerevisiae JG436 multidrug transporter deletion mutant, Deltapdr5, to several antifungal agents was compared to that of JG436-derived JGCDR1 and JGCaMDR1 transformants, harboring the CDR1 and CaMDR1 genes, encoding the main drug-extruding membrane proteins of Candida albicans. The J...

journal_title：Antimicrobial agents and chemotherapy

authors： Milewski S,Mignini F,Prasad R,Borowski E

更新日期：2001-01-01 00:00:00

abstract：:Hard-tick-borne relapsing fever (HTBRF) is an emerging infectious disease throughout the temperate zone caused by the relapsing-fever spirochete Borrelia miyamotoi Antibiotic treatment of HTBRF is empirically based on the treatment of Lyme borreliosis; however, the antibiotic susceptibility of B. miyamotoi has not bee...

journal_title：Antimicrobial agents and chemotherapy

authors： Koetsveld J,Draga ROP,Wagemakers A,Manger A,Oei A,Visser CE,Hovius JW

更新日期：2017-08-24 00:00:00

abstract：:We asked whether beta-lactamase inhibitors (BLIs) increased the activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA), the peptide antibiotic colistin (COL) against the emerging Gram-negative nosocomial pathogen Acinetobacter baumannii, and the human host defense peptide cathelicidin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sakoulas G,Rose W,Berti A,Olson J,Munguia J,Nonejuie P,Sakoulas E,Rybak MJ,Pogliano J,Nizet V

更新日期：2017-01-24 00:00:00

abstract：:A strain of Staphylococcus aureus was planted on filter membranes placed on Trypticase soy agar (BBL). After incubation, the membranes with growing staphylococci were transferred to Trypticase soy agar containing a subinhibitory concentration of penicillin (one-third minimal inhibitory concentration) and again incubat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lorian V

更新日期：1975-06-01 00:00:00

abstract：:The motility of viable Trichomonas vaginalis organisms is readily demonstrable in a clinical wet mount or cultured specimens. We attempted to determine whether migration is a dynamic process such that the organisms move to avoid exposure to toxic antimicrobial agents. With the use of axenic cultures of T. vaginalis th...

journal_title：Antimicrobial agents and chemotherapy

authors： Sugarman B,Mummaw N

更新日期：1988-09-01 00:00:00

abstract：:The effect of N-alkyl derivatives of saturated heterocyclic amine oxides on the growth and metabolism of microorganisms has been studied. 4-Dodecylmorpholine-N-oxide inhibited the differentiation and growth of Bacillus cereus, of different species of filamentous fungi, and of the yeast Saccharomyces cerevisiae. For ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Subík J,Takácsová G,Psenák M,Devínsky F

更新日期：1977-08-01 00:00:00

abstract：:The in vitro activities of two new beta-lactam antibiotics, moxalactam disodium (LY 127935) and cefotaxime (HR-756), were compared with cefoxitin, cefamandole, cefuroxime, cephalothin, and, in some instances, carbenicillin, gentamicin, and amikacin against aerobic gram-negative bacilli. Test isolates included normally...

journal_title：Antimicrobial agents and chemotherapy

authors： Jorgensen JH,Crawford SA,Alexander GA

更新日期：1980-06-01 00:00:00

abstract：:Community-associated infections due to Escherichia coli producing CTX-M-type extended-spectrum β-lactamases are increasingly recognized in the United States. The bla(CTX-M) genes are frequently carried on IncF group plasmids. In this study, bla(CTX-M-15)-harboring plasmids pCA14 (sequence type 131 [ST131]) and pCA28 (...

journal_title：Antimicrobial agents and chemotherapy

authors： Li JJ,Spychala CN,Hu F,Sheng JF,Doi Y

更新日期：2015-01-01 00:00:00

abstract：:Our aim was to assess the effect of miconazole oral gel on the pharmacokinetics of oral oxycodone. In an open crossover study with two phases, 12 healthy volunteers took a single oral dose of 10 mg of immediate-release oxycodone with or without thrice-daily 85-mg miconazole oral gel treatment. The plasma concentration...

journal_title：Antimicrobial agents and chemotherapy

authors： Grönlund J,Saari TI,Hagelberg N,Neuvonen PJ,Olkkola KT,Laine K

更新日期：2011-03-01 00:00:00