Spider venom peptides for gene therapy of Chlamydia infection.

abstract：:The 13-residue dermaseptin S4 derivative K(4)S4(1-13)a (P) was previously shown to kill intraerythrocytic malaria parasites through the lysis of the host cells. In this study, we have sought peptides that will kill the parasite without lysing the erythrocyte. To produce such peptides, 26 compounds of variable structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Dagan A,Efron L,Gaidukov L,Mor A,Ginsburg H

更新日期：2002-04-01 00:00:00

abstract：:Antimicrobial lock solutions are important for prevention of microbial colonization and infection of long-term central venous catheters. We investigated the efficacy and safety of a novel antibiotic-free lock solution formed from gas plasma-activated disinfectant (PAD). Using a luminal biofilm model, viable cells of m...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhatt S,Mehta P,Chen C,Daines DA,Mermel LA,Chen HL,Kong MG

更新日期：2018-07-27 00:00:00

abstract：:Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation, and an increased risk of resistance emergence. We evaluated the impact of ciprofloxacin and meropenem as monotherapy and in combination in the d...

journal_title：Antimicrobial agents and chemotherapy

authors： Bilal H,Bergen PJ,Tait JR,Wallis SC,Peleg AY,Roberts JA,Oliver A,Nation RL,Landersdorfer CB

更新日期：2020-06-23 00:00:00

abstract：:Using the techniques of gap misrepair mutagenesis and site-directed mutagenesis, we have generated two novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein. DNA sequencing showed these mutations to be Ser-83----Ala and Gln-106----Arg. The mutant proteins were overproduced and purified, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Hallett P,Maxwell A

更新日期：1991-02-01 00:00:00

abstract：:Carbovir is a novel carbocyclic nucleoside which has been shown to have potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome. Sprague-Dawley male rats were used to investigate the pharmacokinetics and bioavailability of carbovir. Six rats received car...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeom YH,Remmel RP,Huang SH,Hua M,Vince R,Zimmerman CL

更新日期：1989-02-01 00:00:00

abstract：:We sought to determine whether there was an interaction between aminoglycoside use and shock in their effect on renal function among seriously ill patients suspected of having gram-negative sepsis. Serial serum creatinine determinations were used to estimate changes in creatinine clearance rates in 179 patients entere...

journal_title：Antimicrobial agents and chemotherapy

authors： Ambinder RF,Moore RD,Smith CR,Mellits ED,Lietman PS

更新日期：1985-02-01 00:00:00

abstract：:In a hospital-based, prospective cohort study, the effects of the three standard treatment regimens for mild Clostridium difficile infection (CDI), oral (p.o.) metronidazole at 500 mg three times/day, intravenous (i.v.) metronidazole at 500 mg three times/day, and oral (p.o.) vancomycin at 250 mg four times/day, were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wenisch JM,Schmid D,Kuo HW,Allerberger F,Michl V,Tesik P,Tucek G,Laferl H,Wenisch C

更新日期：2012-04-01 00:00:00

abstract：:Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rifkind D,Crowder ED,Hyland RN

更新日期：1974-12-01 00:00:00

abstract：:Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic fungi such as Candida albicans, its effect on Aspergillus fumigatus is less well understood. We used the fluorescent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowman JC,Hicks PS,Kurtz MB,Rosen H,Schmatz DM,Liberator PA,Douglas CM

更新日期：2002-09-01 00:00:00

abstract：:We undertook this study to investigate whether treatment with a higher dose of trimethoprim-sulfamethoxazole (TMP/SMX) led to greater clinical resolution in patients with skin and soft tissue infections (SSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA). A prospective, observational cohort with neste...

journal_title：Antimicrobial agents and chemotherapy

authors： Cadena J,Nair S,Henao-Martinez AF,Jorgensen JH,Patterson JE,Sreeramoju PV

更新日期：2011-12-01 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:A potential strategy that can be used to combat the worldwide AIDS epidemic is the development of a vaginal microbicide that prevents the sexual transmission of human immunodeficiency virus type 1 (HIV-1). Certain CC chemokines, including RANTES, MIP-1alpha, and MIP-1beta, might facilitate the development of such micr...

journal_title：Antimicrobial agents and chemotherapy

authors： Kish-Catalone TM,Lu W,Gallo RC,DeVico AL

更新日期：2006-04-01 00:00:00

abstract：:We used information available from routine clinic visits to characterize the pharmacokinetics of didanosine in 82 human immunodeficiency virus-infected patients. A total of 271 blood samples were collected for the measurement of didanosine concentrations in plasma (mean +/- standard deviation [SD], 3.30 +/- 2.21 sampl...

journal_title：Antimicrobial agents and chemotherapy

authors： Adams JM,Shelton MJ,Hewitt RG,Grasela TH,DeRemer M,Morse GD

更新日期：1998-04-01 00:00:00

abstract：:Mycobacterium smegmatis DSM43756 inactivates rifampin, and the inactivated antibiotic product recovered from culture medium was ribosylated on the 23-OH group. To study this process, the gene responsible for the inactivation was expressed at high levels by the lac promoter in Escherichia coli conferring resistance to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Quan S,Imai T,Mikami Y,Yazawa K,Dabbs ER,Morisaki N,Iwasaki S,Hashimoto Y,Furihata K

更新日期：1999-01-01 00:00:00

abstract：:Chloramphenicol acetyltransferases specified by fi(-) (F fertility-noninhibiting) R factors were compared with those specified by the fi(+) R factors R1, 222, and R6-S. Three classes of enzyme were distinguished: class I was determined by group N fi(-) R factors and was indistinguishable from the enzyme determined by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Foster TJ,Shaw WV

更新日期：1973-01-01 00:00:00

abstract：:The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodrigues M,McBride SW,Hullahalli K,Palmer KL,Duerkop BA

更新日期：2019-10-22 00:00:00

abstract：:Preclinical animal models of infection are employed to develop new agents but also to screen among molecules to rank them. There are often major differences between human pharmacokinetic (PK) profiles and those developed by animal models of infection, and these may lead to substantial differences in efficacy relative ...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Duncanson B,Scanga CA,Kim S,Schmidt S,Neely MN,Yamada WM,Vicchiarelli M,Peloquin CA,Louie A

更新日期：2020-11-17 00:00:00

abstract：:The present study investigated the effect of a model urease-binding polysaccharide in combination with a histamine H(2) receptor antagonist on Helicobacter pylori colonization in vivo. Euthymic hairless mice were treated daily with dextran sulfate via drinking water and/or famotidine via intragastric gavage starting a...

journal_title：Antimicrobial agents and chemotherapy

authors： Icatlo FC Jr,Kimura N,Goshima H,Kodama Y

更新日期：2000-09-01 00:00:00

abstract：:Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

更新日期：2018-11-26 00:00:00

abstract：:Sixty-seven patients were treated with moxalactam in a noncomparative trial of hospitalized patients; 32 had endometritis or chorioamnionitis, 12 had skin and soft tissue infections, 5 had osteomyelitis, 5 had pneumonia, 5 had urinary tract infections, 4 had arthritis, 2 had sepsis from an unknown source, 1 had endoca...

journal_title：Antimicrobial agents and chemotherapy

authors： Marier RL,Faro S,Sanders CV,Williams W,Derks F,Janney A,Aldridge K

更新日期：1982-04-01 00:00:00

abstract：:We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indi...

journal_title：Antimicrobial agents and chemotherapy

authors： Clarkson AB Jr,Turkel-Parrella D,Williams JH,Chen LC,Gordon T,Merali S

更新日期：2001-12-01 00:00:00

abstract：:One gram of ceftriaxone was given intravenously to 15 patients approximately 2 h before cardiopulmonary bypass surgery. Ceftriaxone levels in plasma (mean +/- standard deviation) were 60.4 +/- 18.8 micrograms/ml (range, 17.0 to 96.0 micrograms/ml) at the beginning of bypass, 44.2 +/- 16.6 micrograms/ml (range, 9.4 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryan CS,Morgan SL,Jordan AB,Smith CW,Sutton JP,Gangemi JD

更新日期：1984-01-01 00:00:00

abstract：:Posaconazole in oral suspension must be taken multiple times a day with food (preferably a high-fat meal) to ensure adequate exposure among patients. We evaluated the effect of food on the bioavailability of a new delayed-release tablet formulation of posaconazole at the proposed clinical dose of 300 mg once daily in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kersemaekers WM,Dogterom P,Xu J,Marcantonio EE,de Greef R,Waskin H,van Iersel ML

更新日期：2015-01-01 00:00:00

abstract：:Some Kelch mutations of the Plasmodium falciparum K13 protein confer increased survival to dihydroartemisinin (DHA)-treated ring-stage parasites. Here, we asked if K13 mutations affect a dormancy phenotype allowing parasites to survive DHA exposure and then sorbitol selection. Although recrudescence from dormancy diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Breglio KF,Rahman RS,Sá JM,Hott A,Roberts DJ,Wellems TE

更新日期：2018-04-26 00:00:00

abstract：:No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Downey AS,Chong CR,Graczyk TK,Sullivan DJ

更新日期：2008-09-01 00:00:00

abstract：:The long-term therapeutic and toxic effects of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated in simian immunodeficiency virus (SIV)-infected newborn rhesus macaques. Four untreated SIV-infected newborn macaques developed persistently high levels of viremia, and three of the four animals had rapidly fatal...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rompay KK,Cherrington JM,Marthas ML,Berardi CJ,Mulato AS,Spinner A,Tarara RP,Canfield DR,Telm S,Bischofberger N,Pedersen NC

更新日期：1996-11-01 00:00:00

abstract：:Ro 09-0179 (4',5-dihydroxy-3,3',7-trimethoxyflavone), isolated from a Chinese medicinal herb, was found to have potent antiviral activity. It selectively inhibited the replication of human picornaviruses, such as rhinoviruses and coxsackieviruses in tissue culture, but not other DNA and RNA viruses. Ro 09-0298 (4',5-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishitsuka H,Ohsawa C,Ohiwa T,Umeda I,Suhara Y

更新日期：1982-10-01 00:00:00

abstract：:A pyridodiazepine amine inhibitor of Helicobacter pylori glutamate racemase (MurI) was characterized. The compound was selectively active against H. pylori, and growth suppression was shown to be mediated through the inhibition of MurI by several methods. In killing kinetics experiments, the compound showed concentrat...

journal_title：Antimicrobial agents and chemotherapy

authors： de Jonge BL,Kutschke A,Newman JV,Rooney MT,Yang W,Cederberg C

更新日期：2015-04-01 00:00:00

abstract：:An automated fluorescence polarization immunoassay for the determination of vancomycin levels in serum was evaluated. The vancomycin assay is a homogeneous competitive inhibition immunoassay based on changes in fluorescence polarization that occur with antibody binding. This assay was compared with a liquid chromatogr...

journal_title：Antimicrobial agents and chemotherapy

authors： Filburn BH,Shull VH,Tempera YM,Dick JD

更新日期：1983-08-01 00:00:00

abstract：:Routine in vitro screening of a new synthetic series of 3,5-substituted 2-methylisoxazolidines revealed that three imidazole analogs (PR 967-248, PR 967-234, and PR 969-566) and, to a lesser extent, a triazole analog (PR 988-399) exerted rather potent antifungal activity against three systemic and four dermatophytic c...

journal_title：Antimicrobial agents and chemotherapy

authors： Palmer GC,Ordy MJ,Simmons RD,Strand JC,Radov LA,Mullen GB,Kinsolving CR,St Georgiev V,Mitchell JT,Allen SD

更新日期：1989-06-01 00:00:00