Action of deferoxamine against Pneumocystis carinii.

abstract：:The assembly of hepatitis B virus (HBV) core protein (HBc) into capsids represents a critical step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it an attractive target for antiviral therapies. Capsid assembly modulators (CAMs) induce the formation of empty capsid or aberrant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lahlali T,Berke JM,Vergauwen K,Foca A,Vandyck K,Pauwels F,Zoulim F,Durantel D

更新日期：2018-09-24 00:00:00

abstract：:Due to the rise of antibiotic resistance and the small number of effective antiviral drugs, new approaches for treating infectious diseases are urgently needed. Identifying targets for host-based therapies represents an emerging strategy for drug discovery. The ubiquitin-proteasome system is a central mode of signalin...

journal_title：Antimicrobial agents and chemotherapy

authors： Passalacqua KD,Charbonneau ME,Donato NJ,Showalter HD,Sun D,Wen B,He M,Sun H,O'Riordan MX,Wobus CE

更新日期：2016-06-20 00:00:00

abstract：:This study evaluated the pulmonary disposition of eravacycline in 20 healthy adult volunteers receiving 1.0 mg of eravacycline/kg intravenously every 12 h for a total of seven doses over 4 days. Plasma samples were collected at 0, 1, 2, 4, 6, and 12 h on day 4, with each subject randomized to undergo a single bronchoa...

journal_title：Antimicrobial agents and chemotherapy

authors： Connors KP,Housman ST,Pope JS,Russomanno J,Salerno E,Shore E,Redican S,Nicolau DP

更新日期：2014-01-01 00:00:00

abstract：:This analysis was conducted to determine whether the hepatitis C virus (HCV) viral kinetics (VK) model can predict viral load (VL) decreases for nonnucleoside polymerase inhibitors (NNPolIs) and protease inhibitors (PIs) after 3-day monotherapy studies of patients infected with genotype 1 chronic HCV. This analysis in...

journal_title：Antimicrobial agents and chemotherapy

authors： Reddy MB,Morcos PN,Le Pogam S,Ou Y,Frank K,Lave T,Smith P

更新日期：2012-06-01 00:00:00

abstract：:PA-824 is a novel antibacterial agent that has shown in vitro activity against both drug-sensitive and drug-resistant Mycobacterium tuberculosis. The compound's MIC is between 0.015 and 0.25 microg/ml for drug-sensitive strains and between 0.03 and 0.53 microg/ml for drug-resistant strains. In addition, it is active a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ginsberg AM,Laurenzi MW,Rouse DJ,Whitney KD,Spigelman MK

更新日期：2009-09-01 00:00:00

abstract：:We conducted this double-blind, parallel-group, placebo-controlled, randomized, multiple-ascending-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of GS-9851 (formerly PSI-7851) in treatment-naïve patients infected with hepatitis C virus (HCV) genotype 1. Thirty-two patients recei...

journal_title：Antimicrobial agents and chemotherapy

authors： Lawitz E,Rodriguez-Torres M,Denning JM,Albanis E,Cornpropst M,Berrey MM,Symonds WT

更新日期：2013-03-01 00:00:00

abstract：:Azithromycin is an effective treatment for uncomplicated infections with Salmonella enterica serovar Typhi and serovar Paratyphi A (enteric fever), but there are no clinically validated MIC and disk zone size interpretative guidelines. We studied individual patient data from three randomized controlled trials (RCTs) o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parry CM,Thieu NT,Dolecek C,Karkey A,Gupta R,Turner P,Dance D,Maude RR,Ha V,Tran CN,Thi PL,Be BP,Phi LT,Ngoc RN,Ghose A,Dongol S,Campbell JI,Thanh DP,Thanh TH,Moore CE,Sona S,Gaind R,Deb M,Anh HV,Van SN,

更新日期：2015-05-01 00:00:00

abstract：:Fusidic acid (FA), which was approved in the 1960s in many European and Asian countries, has gained renewed interest due to its continued effectiveness against methicillin-resistant Staphylococcus aureus As rhabdomyolysis has been reported upon coadministration of FA with statins, we aimed to elucidate the underlying ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta A,Harris JJ,Lin J,Bulgarelli JP,Birmingham BK,Grimm SW

更新日期：2016-09-23 00:00:00

abstract：:Herpes simplex virus (HSV) types 1 and 2 (two strains each) were inactivated at different rates in vitro by 40 muM AgNO(3). The inactivation of HSV type 1 strains was virtually complete in 10 to 15 min, whereas almost half of the infectivity of HSV type 2 strains survived this exposure. One strain of type 1 inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Coleman VR,Wilkie J,Levinson WE,Stevens T,Jawetz E

更新日期：1973-09-01 00:00:00

abstract：:The in vitro and in vivo activities of azithromycin against chlamydia were investigated. The MIC of azithromycin for five standard strains of different species of chlamydia and six wild-type strains of Chlamydia pneumoniae was 0.125 microgram/ml, which was superior to that of erythromycin but inferior to those of clar...

journal_title：Antimicrobial agents and chemotherapy

authors： Niki Y,Kimura M,Miyashita N,Soejima R

更新日期：1994-10-01 00:00:00

abstract：:We tested 32 Candida isolates recovered in the early 1990s from the bloodstreams of patients with candidemia for in vitro susceptibility to fluconazole and determined if MIC and/or the daily dose of fluconazole/MIC ratio correlated with the response to therapy. This is a unique data set since 87.5% (28/32) of patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Clancy CJ,Yu VL,Morris AJ,Snydman DR,Nguyen MH

更新日期：2005-08-01 00:00:00

abstract：:We investigated whether cells derived from the fetal central nervous system can support productive infection by a human immunodeficiency virus type 1 (HIV-1) isolate termed UHC-1, produced by a cellular clone derived from HIV-1 strain HIV-IIIB chronically infected U-937 promonocytic cells, and what the effect of nucle...

journal_title：Antimicrobial agents and chemotherapy

authors： Geleziunas R,Arts EJ,Boulerice F,Goldman H,Wainberg MA

更新日期：1993-06-01 00:00:00

abstract：:Macrolide-resistant group A streptococci (MRGAS) have been recovered from many countries worldwide. However, the strain typing information that is available has been insufficient for estimating the total number of macrolide-resistant clones, their geographic distributions, and their evolutionary relationships. In this...

journal_title：Antimicrobial agents and chemotherapy

authors： Robinson DA,Sutcliffe JA,Tewodros W,Manoharan A,Bessen DE

更新日期：2006-09-01 00:00:00

abstract：:Prior investigations have suggested the use of a dosing weight correction factor of ideal body weight (IBW) plus 40% excess body weight (EBW, where EBW = total body weight [TBW] - IBW) to determine the weight to use for aminoglycoside dosing in morbidly obese (TBW/IBW ratio, > 2) patients. Little data are available to...

journal_title：Antimicrobial agents and chemotherapy

authors： Traynor AM,Nafziger AN,Bertino JS Jr

更新日期：1995-02-01 00:00:00

abstract：:We previously showed that the mouse inorganic phosphate transporter Npt1 operates in the hepatic sinusoidal membrane transport of anionic drugs such as benzylpenicillin and mevalonic acid. In the present study, the mechanism of renal secretion of penem antibiotics was examined by using a Xenopus oocyte expression syst...

journal_title：Antimicrobial agents and chemotherapy

authors： Uchino H,Tamai I,Yabuuchi H,China K,Miyamoto K,Takeda E,Tsuji A

更新日期：2000-03-01 00:00:00

abstract：:Ten strains each of 18 clinically important species of Clostridium were tested for susceptibility to clindamycin. Of the 180 strains tested, 56 (31%) were resistant to more than 1.6 mug/ml. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilkins TD,Thiel T

更新日期：1973-01-01 00:00:00

abstract：:Multilocus microsatellite polymorphisms in 27 clinical Candida albicans isolates were found to be clearly unrelated to in vitro paradoxical growth or trailing effect with caspofungin. These findings suggest that such in vitro phenotypes are either gained or lost too rapidly to be predicted by more stable genomic marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Khlif M,Bogreau H,Michel-Nguyen A,Ayadi A,Ranque S

更新日期：2010-03-01 00:00:00

abstract：:A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kashyap V,Sharma S,Singh V,Sharma SK,Saquib M,Srivastava R,Shaw AK

更新日期：2014-06-01 00:00:00

abstract：:Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 and Pdr11 in fluconazole susceptibility. Using biolistic transformatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang ML,Uhrig J,Vu K,Singapuri A,Dennis M,Gelli A,Thompson GR 3rd

更新日期：2015-12-07 00:00:00

abstract：:Metronidazole is now being used with increasing frequency for various infectious conditions in patients with renal failure. It is commonly administered to septic patients who have developed acute renal failure requiring hemodialysis. The hemodialysis clearances of metronidazole and its metabolites were evaluated in ni...

journal_title：Antimicrobial agents and chemotherapy

authors： Lau AH,Chang CW,Sabatini S

更新日期：1986-02-01 00:00:00

abstract：:Ninety-four patients with recurrences of genital herpes were randomized in a double-blind trial to receive topical therapy for 5 days with either alpha-2a interferon at 30 X 10(6) IU/ml or 10 X 10(6) IU/ml or placebo six times daily. No differences were noted between either interferon dose and placebo with respect to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eron LJ,Toy C,Salsitz B,Scheer RR,Wood DL,Nadler PI

更新日期：1987-07-01 00:00:00

abstract：:Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye KS,Cosgrove S,Harris A,Eliopoulos GM,Carmeli Y

更新日期：2001-09-01 00:00:00

abstract：:The pharmacokinetics of piperacillin were examined after single intravenous doses to three groups of male patients with creatinine clearances of greater than or equal to 60 (group I), greater than or equal to 20 but less than 60 (group II), and less than 20 (group III) ml/min per 1.73 m2. Each of 32 patients received ...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Craig WA,Bundtzen RW,Kwok FW,Gerber AU,Madsen PO

更新日期：1983-06-01 00:00:00

abstract：:The need for daily parenteral administration is an important limitation in the clinical use of pentavalent antimonial drugs against leishmaniasis. In this study, amphiphilic antimony(V) complexes were prepared from alkylmethylglucamides (L8 and L10, with carbon chain lengths of 8 and 10, respectively), and their poten...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes FR,Ferreira WA,Campos MA,Ramos GS,Kato KC,Almeida GG,Corrêa JD Junior,Melo MN,Demicheli C,Frézard F

更新日期：2013-09-01 00:00:00

abstract：:Caspofungin (CAS) is approved for second-line management of proven or probable invasive aspergillosis at a dose of 50 mg once daily (QD). Preclinical and limited clinical data support the concept of the dose-dependent antifungal efficacy of CAS with preservation of its favorable safety profile. Little is known, howeve...

journal_title：Antimicrobial agents and chemotherapy

authors： Würthwein G,Cornely OA,Trame MN,Vehreschild JJ,Vehreschild MJ,Farowski F,Müller C,Boos J,Hempel G,Hallek M,Groll AH

更新日期：2013-04-01 00:00:00

abstract：:An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments-oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)-on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Dheilly A,Le Devendec L,Mourand G,Bouder A,Jouy E,Kempf I

更新日期：2012-01-01 00:00:00

abstract：:The antibiotic susceptibilities of 62 strains of Salmonella enterica serovar Typhi and 37 strains of S. enterica serovar Paratyphi A were investigated with 18 antibiotics. Eighteen S. enterica serovar Typhi isolates and five S. enterica serovar Paratyphi A isolates were resistant to one or more antimicrobial agents, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirose K,Tamura K,Sagara H,Watanabe H

更新日期：2001-03-01 00:00:00

abstract：:7-[alpha-(1-Methyl-4-pyridiniothio)-acetamido] cephalosporanic acid, referred to herein as BL-S 217, is a new broad-spectrum semisynthetic cephalosporin that offers several advantages over cephalothin. A comparison of the activity in vitro of these antibiotics indicates that BL-S 217 is about eightfold more effective ...

journal_title：Antimicrobial agents and chemotherapy

authors： Buck RE,Leitner F,Price KE

更新日期：1972-01-01 00:00:00

abstract：:L-nucleoside analogs are a new class of antiviral and anticancer agents, several of which are currently used in the clinic. The phosphorylation of these agents to the triphosphate form is thought to be important for exertion of their pharmacological activities. 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylur...

journal_title：Antimicrobial agents and chemotherapy

authors： Hu R,Li L,Degrève B,Dutschman GE,Lam W,Cheng YC

更新日期：2005-05-01 00:00:00

abstract：:The efficacy of ciprofloxacin for experimental aortic valve endocarditis in rabbits infected by either a methicillin-susceptible or a methicillin-resistant strain of Staphylococcus aureus was compared with standard therapy of nafcillin or vancomycin, respectively. After 4 days of therapy, ciprofloxacin reduced the cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Carpenter TC,Hackbarth CJ,Chambers HF,Sande MA

更新日期：1986-09-01 00:00:00