Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1.

abstract：:Mercury has a long history as an antimicrobial agent effective against eukaryotic and prokaryotic organisms. Despite its prolonged use, the basis for mercury toxicity in prokaryotes is not well understood. Archaea, like bacteria, are prokaryotes but they use a simplified version of the eukaryotic transcription apparat...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixit V,Bini E,Drozda M,Blum P

更新日期：2004-06-01 00:00:00

abstract：:The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobs MR,Abdelhamed AM,Good CE,Rhoads DD,Hujer KM,Hujer AM,Domitrovic TN,Rudin SD,Richter SS,van Duin D,Kreiswirth BN,Greco C,Fouts DE,Bonomo RA

更新日期：2018-12-21 00:00:00

abstract：:Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus (CMV) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusion and repeated every 8 h for 14 days. At the end of induction, 9 of 10 patients had stabilized...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson MA,O'Donnell JJ,Mills J

更新日期：1989-05-01 00:00:00

abstract：:In an open, randomized, six-period crossover study, the pharmacokinetics of ciprofloxacin, gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin were compared after a single oral dose in 12 healthy volunteers (6 men and 6 women). The volunteers received 250 mg of ciprofloxacin, 400 mg of gatifloxa...

journal_title：Antimicrobial agents and chemotherapy

authors： Lubasch A,Keller I,Borner K,Koeppe P,Lode H

更新日期：2000-10-01 00:00:00

abstract：:Many hospital antimicrobial stewardship programs restrict the availability of selected drugs by requiring prior approval. Carbapenems may be among the restricted drugs, but it is unclear if hospitals that restrict availability actually use fewer carbapenems than hospitals that do not restrict use. Nor is it clear if r...

journal_title：Antimicrobial agents and chemotherapy

authors： Pakyz AL,Oinonen M,Polk RE

更新日期：2009-05-01 00:00:00

abstract：:We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies nee...

journal_title：Antimicrobial agents and chemotherapy

authors： Cairns BJ,Payne RJ

更新日期：2008-12-01 00:00:00

abstract：:Selected cephalosporins, including cefamandole, cephaloridine, cephaloglycin, and cefoxitin, were examined for their ability to inhibit the enzymatic activity of and act as substrates for beta-lactamases produced by Enterobacter cloacae and Staphylococcus aureus. Enzyme inhibition was determined by Michaelis-Menten ki...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahoney DF,Koppel GA,Turner JR

更新日期：1976-09-01 00:00:00

abstract：:The in vitro activity of LY 146032, a cyclic lipopeptide antibiotic belonging to the class of agents designated A21978C, was compared with those of vancomycin, cefpirome, cefotaxime, and clindamycin against selected gram-positive bacteria. The new drug inhibited all staphylococcal isolates, including methicillin-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Eliopoulos GM,Willey S,Reiszner E,Spitzer PG,Caputo G,Moellering RC Jr

更新日期：1986-10-01 00:00:00

abstract：:A beta-lactam-sensitive strain (C152) of Shigella dysenteriae showed two major outer membrane proteins (OMPs) with M(r)s of 43,000 and 38,000, while the clinical isolate M2 lacked the 43,000-Mr OMP, which acted as a channel for beta-lactam antibiotics. Permeability of beta-lactams across the outer membrane (OM) of M2 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kar AK,Ghosh AS,Chauhan K,Ahamed J,Basu J,Chakrabarti P,Kundu M

更新日期：1997-10-01 00:00:00

abstract：:A PCR-based technique using new fluorescent probes, called molecular beacons, was developed to detect the antifolate resistance-associated S108N point mutation in Plasmodium falciparum. One hundred African clinical isolates were tested by the new method in comparison with the PCR-restriction fragment length polymorphi...

journal_title：Antimicrobial agents and chemotherapy

authors： Durand R,Eslahpazire J,Jafari S,Delabre JF,Marmorat-Khuong A,di Piazza JP,Le Bras J

更新日期：2000-12-01 00:00:00

abstract：:Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis that is characterized by hyphal bronchopneumonia, aerosol amphotericin B (aero-AmB; 1.6 mg/kg given 2 days before infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt HJ,Bernard EM,Häuser M,Armstrong D

更新日期：1988-11-01 00:00:00

abstract：:Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics techniques also co...

journal_title：Antimicrobial agents and chemotherapy

authors： Vincent IM,Ehmann DE,Mills SD,Perros M,Barrett MP

更新日期：2016-03-25 00:00:00

abstract：:Tigemonam, a new monobactam with excellent activity against gram-negative bacteria, was evaluated for in vivo efficacy and absorption after oral administration to laboratory animals. Tigemonam is absorbed when administered orally to mice and dogs. In a variety of gram-negative systemic infections in mice, orally admin...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark JM,Olsen SJ,Weinberg DS,Dalvi M,Whitney RR,Bonner DP,Sykes RB

更新日期：1987-02-01 00:00:00

abstract：:Because macrolide antibiotics are hypothesized to possess immunomodulatory activity independent of their antimicrobial activity, we evaluated the immunomodulatory effect of clarithromycin in a murine model of lung inflammation induced by either live or UV-killed Mycoplasma pneumoniae. BALB/c mice were intranasally ino...

journal_title：Antimicrobial agents and chemotherapy

authors： Hardy RD,Rios AM,Chavez-Bueno S,Jafri HS,Hatfield J,Rogers BB,McCracken GH,Ramilo O

更新日期：2003-05-01 00:00:00

abstract：:We used the Tn10-encoded Tet repressor, which has a highly specific binding capacity for tetracycline, to probe contacts between the drug and protein by chemical interference studies of the antibiotic. For that purpose, the equilibrium association constants of modified tetracyclines with the Tet repressor and Mg2+ cat...

journal_title：Antimicrobial agents and chemotherapy

authors： Degenkolb J,Takahashi M,Ellestad GA,Hillen W

更新日期：1991-08-01 00:00:00

abstract：:Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Slifer T,Araujo FG,Polzer RJ,Remington JS

更新日期：1997-05-01 00:00:00

abstract：:The pharmacokinetics of oral and intravenous ofloxacin (7.5 mg.kg of body weight-1 given over 30 min) were studied in an open crossover study of 17 Vietnamese children, aged between 5 and 14 years, with acute uncomplicated typhoid fever. Following oral administration, the median (95% confidence interval [CI]) time to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethell DB,Day NP,Dung NM,McMullin C,Loan HT,Tam DT,Minh LT,Linh NT,Dung NQ,Vinh H,MacGowan AP,White LO,White NJ

更新日期：1996-09-01 00:00:00

abstract：:Most surveys for class 1 integrons are at least partly predicated on PCR screening that targets integron conserved regions. However, class 1 integrons are structurally diverse, so dependence on conserved regions may lead to missing clinically relevant examples of class 1 integrons. Here, we surveyed a commensal popula...

journal_title：Antimicrobial agents and chemotherapy

authors： Betteridge T,Partridge SR,Iredell JR,Stokes HW

更新日期：2011-08-01 00:00:00

abstract：:Mannopeptimycins alpha, beta, gamma, delta, and epsilon are new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98. Mannopeptimycins gamma, delta, and epsilon, which have an isovaleryl substitution at various positions on the terminal mannose of the disaccharide moiety, demonstrated moderat...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Janso JE,Luckman SW,Lenoy EB,Bradford PA,Testa RT,Greenstein M

更新日期：2003-01-01 00:00:00

abstract：:A novel trait for transferable resistance to high concentrations of trimethoprim was found to dominate among enterobacteria collected from different parts of Sri Lanka. Drug resistance was a result of the production of dihydrofolate reductase with a decreased sensitivity to antifolates. By characterization of the part...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundström L,Vinayagamoorthy T,Sköld O

更新日期：1987-01-01 00:00:00

abstract：:A total of 104 carbapenemase (serine- and metallo-beta-lactamase [MbetaL])-producing strains of the Enterobacteriaceae family collected from 2000 to 2005 in medical centers distributed worldwide were tested against tigecycline and 25 comparators by reference broth microdilution methods. The most frequent carbapenemase...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Sader HS,Deshpande LM,Fritsche TR,Jones RN

更新日期：2008-02-01 00:00:00

abstract：:The DNA sequences of two plasmids carrying vanA, pVEF1 (39,626 bp) and pVEF2 (39,714 bp), were determined. Forty-three shared coding sequences were identified, and the only nucleotide difference was an 88-bp indel. A postsegregational killing system was identified. This system possibly explains the persistence of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sletvold H,Johnsen PJ,Simonsen GS,Aasnaes B,Sundsfjord A,Nielsen KM

更新日期：2007-02-01 00:00:00

abstract：:Dengue fever is a severe, widespread, and neglected disease with more than 2 million diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents a prime target for rational drug design. At the moment, there are no clinical PR inhibitors (PIs) available. We have identified diaryl (thio)ethers as c...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu H,Bock S,Snitko M,Berger T,Weidner T,Holloway S,Kanitz M,Diederich WE,Steuber H,Walter C,Hofmann D,Weißbrich B,Spannaus R,Acosta EG,Bartenschlager R,Engels B,Schirmeister T,Bodem J

更新日期：2015-02-01 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:Piperaquine (PQ) is an antimalarial drug whose high lipid solubility suggests that its absorption can be increased by a high-fat meal. We examined the pharmacokinetics of PQ phosphate (500 mg given orally) in the fasting state and after a high-fat meal in eight healthy Caucasian volunteers (randomized crossover). Plas...

journal_title：Antimicrobial agents and chemotherapy

authors： Sim IK,Davis TM,Ilett KF

更新日期：2005-06-01 00:00:00

abstract：:Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Muilwijk EW,Dekkers BGJ,Henriet SSV,Verweij PE,Witjes B,Lashof AMLO,Groeneveld GH,van der Hoeven J,Alffenaar JWC,Russel FGM,van de Veerdonk F,Brüggemann RJM

更新日期：2017-08-24 00:00:00

abstract：:This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In this observational study, serial blood samples were taken over several dosing intervals of intravenous fosfomycin treatment. Blood samples were analyzed using a validated liquid chromatography-tandem mass spectrometry tec...

journal_title：Antimicrobial agents and chemotherapy

authors： Parker SL,Frantzeskaki F,Wallis SC,Diakaki C,Giamarellou H,Koulenti D,Karaiskos I,Lipman J,Dimopoulos G,Roberts JA

更新日期：2015-10-01 00:00:00

abstract：:Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires. In contrast, five of six animals given ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shalit I,Barnea A,Shahar A

更新日期：1989-05-01 00:00:00

abstract：:The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

更新日期：1995-02-01 00:00:00

abstract：:The spread of extended-spectrum-beta-lactamase (ESBL)-producing organisms, particularly those harboring the CTX-M-type enzymes, both in the hospital and in the community, is difficult to discontinue due to the successful mobilization and evolution of the genetic elements harboring ESBL genes and coresistance rates in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Morosini MI,García-Castillo M,Coque TM,Valverde A,Novais A,Loza E,Baquero F,Cantón R

更新日期：2006-08-01 00:00:00