In vivo evaluation of tigemonam, a novel oral monobactam.

abstract：:Thirty-four infants and children ranging in age from 2.5 to 180 months (mean, 40 months) were treated with parenteral moxalactam (150 mg/kg per day) for suspected or proved bacterial infections outside the central nervous system. Six patients infected with Haemophilus influenzae b, nine infected with Staphylococcus au...

journal_title：Antimicrobial agents and chemotherapy

authors： Keyserling H,Feldman WE,Moffitt S,Manning N,Hollins M

更新日期：1982-06-01 00:00:00

abstract：:Cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. Cefamandole had activity equivalent to cefazolin against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. Cefamandole was more active than cephalothin or cefazo...

journal_title：Antimicrobial agents and chemotherapy

authors： Shemonsky NK,Carrizosa J,Levison ME

更新日期：1975-12-01 00:00:00

abstract：:The pharmacokinetic disposition of 2 g of cefoxitin administered intravenously over 30 min was determined in six patients undergoing continuous ambulatory peritoneal dialysis for chronic renal failure. During the 6-h dialysate dwell time after the drug infusion, the mean apparent volume of distribution for cefoxitin w...

journal_title：Antimicrobial agents and chemotherapy

authors： Greaves WL,Kreeft JH,Ogilvie RI,Richards GK

更新日期：1981-02-01 00:00:00

abstract：:The comparative in vitro activity of SMT19969, a novel, narrow-spectrum, nonabsorbable agent, was studied against 50 ribotype-defined Clostridium difficile strains, 174 Gram-positive and 136 Gram-negative intestinal anaerobes, and 40 Gram-positive aerobes. SMT19969 was one dilution more active against C. difficile iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Tyrrell KL,Merriam CV

更新日期：2013-10-01 00:00:00

abstract：:CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested being less than or equal to 1 microgram/ml. The compound was from 10- to 100-fold more active than...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz T,Retsema J,Girard A,Hamanaka E,Anderson M,Sokolowski S

更新日期：1989-08-01 00:00:00

abstract：:We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto K,Yanagihara K,Sugahara K,Imamura Y,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Hirakata Y,Kamihira S,Kohno S

更新日期：2009-08-01 00:00:00

abstract：:The aims of this study were to describe the blood plasma (BP) and seminal plasma (SP) pharmacokinetics of tenofovir (TFV) in HIV-1-infected men, to assess the role of genetic polymorphism in the variability of TFV transfer into the male genital tract, and to evaluate the impact of TFV SP exposure on seminal plasma HIV...

journal_title：Antimicrobial agents and chemotherapy

authors： Valade E,Bouazza N,Lui G,Illamola SM,Benaboud S,Treluyer JM,Cobat A,Foissac F,De Sousa Mendes M,Chenevier-Gobeaux C,Suzan-Monti M,Rouzioux C,Assoumou L,Viard JP,Urien S,Ghosn J,Hirt D

更新日期：2017-02-23 00:00:00

abstract：:A total of 100 and 97% of Haemophilus influenzae type b strains from major infections were susceptible, respectively, to levels of rifampin and sulfisoxazole attainable in saliva. It is theoretically feasible to eliminate Haemophilus influenzae from the nasopharynx with these drugs. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Cheung R

更新日期：1978-06-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00

abstract：:There is significant interest in the development of mass spectrometry (MS) methods for antimicrobial resistance protein detection, given the ability of these methods to confirm protein expression. In this work, we studied the performance of a liquid chromatography, tandem MS multiple-reaction monitoring (LC-MS/MS MRM)...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Strich JR,Drake SK,Chen Y,Youn JH,Rosenberg AZ,Gucek M,Dekker JP,Suffredini AF

更新日期：2019-08-23 00:00:00

abstract：:Acinetobacter baumannii is responsible for severe nosocomial pneumonia. To evaluate new therapeutic regimens for infections due to multiresistant strains and to study the pharmacodynamic properties of various antibiotics, we developed an experimental mouse model of acute A. baumannii pneumonia. C3H/HeN mice rendered t...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly-Guillou ML,Wolff M,Pocidalo JJ,Walker F,Carbon C

更新日期：1997-02-01 00:00:00

abstract：:As a means of gaining information on the selectivity of quinolone antibacterial agents, we examined their effect on four topoisomerases, topoisomerases I and II purified from Escherichia coli and calf thymus. The inhibition of supercoiling and relaxation activities was monitored by using the classical gel electrophore...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreau NJ,Robaux H,Baron L,Tabary X

更新日期：1990-10-01 00:00:00

abstract：:The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of > or = 17 microM) and an indifferent interaction with chloroqu...

journal_title：Antimicrobial agents and chemotherapy

authors： Wong RP,Davis TM

更新日期：2009-05-01 00:00:00

abstract：:Echinocandins are a preferred therapy for invasive candidiasis due to their potency and broad spectrum. Resistance, especially in Candida glabrata, is an emerging threat to their use. Pharmacodynamic (PD) studies examining reduced susceptibility secondary to fks mutations in C. glabrata are lacking. The current study ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak A,Castanheira M,Diekema D,Pfaller M,Andes D

更新日期：2012-11-01 00:00:00

abstract：:Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including c...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen B,Noller HF,Daubresse G,Oliva B,Misulovin Z,Rothstein DM,Ellestad GA,Gluzman Y,Tally FP,Chopra I

更新日期：1991-11-01 00:00:00

abstract：:Since human cytomegalovirus (HCMV) does not infect or replicate in nonhuman cells and tissues, there are few animal models currently available for evaluation of antiviral therapies for these infections. In the present studies, we utilized two different models in which severe combined immunodeficient (SCID) mice were i...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Hartline CB,Rybak RJ,Drach JC,Townsend LB,Biron KK,Bidanset DJ

更新日期：2004-05-01 00:00:00

abstract：:Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be hi...

journal_title：Antimicrobial agents and chemotherapy

authors： Bechard DL,Hawkins SS,Dhruv R,Friedhoff LT

更新日期：1985-02-01 00:00:00

abstract：:Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

更新日期：2018-11-26 00:00:00

abstract：:Cycloheximide (up to 0.4 g/liter) was significantly more inhibitory to the growth of three isolates of Aspergillus fumigatus at 23 C than at 37 or 45 C. Preincubation of the media for 7 days at 45 C did not alter the inhibitory effect of the cycloheximide at 23 C. Neither mutation nor adaptation in the fungus seems to...

journal_title：Antimicrobial agents and chemotherapy

authors： Berger CL,Merz WG,Silva-Hutner M

更新日期：1973-10-01 00:00:00

abstract：:Group B streptococci are common causative agents of early-onset neonatal sepsis (EOS). Pharmacokinetic (PK) data for penicillin G have been described for extremely preterm neonates but have been poorly described for late-preterm and term neonates. Thus, evidence-based dosing recommendations are lacking. We describe th...

journal_title：Antimicrobial agents and chemotherapy

authors： Padari H,Metsvaht T,Germovsek E,Barker CI,Kipper K,Herodes K,Standing JF,Oselin K,Tasa T,Soeorg H,Lutsar I

更新日期：2018-04-26 00:00:00

abstract：:The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted significant scientific interest as models for targeting and management o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parisot J,Carey S,Breukink E,Chan WC,Narbad A,Bonev B

更新日期：2008-02-01 00:00:00

abstract：:We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be conside...

journal_title：Antimicrobial agents and chemotherapy

authors： Clavel-Osorio C,Cazassus F,Stegmann S,Huc-Anaïs P,Lecam D,Peytavin G

更新日期：2013-12-01 00:00:00

abstract：:Zika virus (ZIKV), a flavivirus transmitted by mosquitoes, was an almost neglected pathogen until its introduction in the Americas in 2015 and its subsequent explosive spread throughout the continent, where it has infected millions of people. The virus has caused social and sanitary alarm, mainly due to its associatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Saiz JC,Martín-Acebes MA

更新日期：2017-05-24 00:00:00

abstract：:The resistome of P. aeruginosa for three β-lactam antibiotics, namely, ceftazidime, imipenem, and meropenem, was deciphered by screening a comprehensive PA14 mutant library for mutants with increased or reduced susceptibility to these antimicrobials. Confirmation of the phenotypes of all selected mutants was performed...

journal_title：Antimicrobial agents and chemotherapy

authors： Alvarez-Ortega C,Wiegand I,Olivares J,Hancock RE,Martínez JL

更新日期：2010-10-01 00:00:00

abstract：:Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in b...

journal_title：Antimicrobial agents and chemotherapy

authors： Keith KE,Oyston PC,Crossett B,Fairweather NF,Titball RW,Walsh TR,Brown KA

更新日期：2005-04-01 00:00:00

abstract：:This study was directed at characterizing the genetic elements carrying the methylase gene erm(B), encoding ribosome modification-mediated resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics, in Streptococcus pyogenes. In this species, erm(B) is responsible for MLS resistance in constitutively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Brenciani A,Bacciaglia A,Vecchi M,Vitali LA,Varaldo PE,Giovanetti E

更新日期：2007-04-01 00:00:00

abstract：:The linkage between the macrolide efflux gene mef(I) and the chloramphenicol inactivation gene catQ was first described in Streptococcus pneumoniae (strain Spn529), where the two genes are located in a module designated IQ element. Subsequently, two different defective IQ elements were detected in Streptococcus pyogen...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Morroni G,Giovanetti E,Del Grosso M,Pantosti A,Varaldo PE

更新日期：2014-10-01 00:00:00

abstract：:Two Klebsiella pneumoniae isolates of the same strain, identified in Poland, produced either TEM-47 or TEM-68, which differed by the Arg275Leu substitution. They harbored a few virulence factors, including an iron-chelating factor and capsule overproduction, suggesting that these factors were sufficient to enhance the...

journal_title：Antimicrobial agents and chemotherapy

authors： Robin F,Hennequin C,Gniadkowski M,Beyrouthy R,Empel J,Gibold L,Bonnet R

更新日期：2012-02-01 00:00:00

abstract：:Plasmodium falciparum, the deadliest species of malaria parasites, is dependent on glycolysis for the generation of ATP during the pathogenic red blood cell stage. Hexokinase (HK) catalyzes the first step in glycolysis, transferring the γ-phosphoryl group of ATP to glucose to yield glucose-6-phosphate. Here, we descri...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis MI,Patrick SL,Blanding WM,Dwivedi V,Suryadi J,Golden JE,Coussens NP,Lee OW,Shen M,Boxer MB,Hall MD,Sharlow ER,Drew ME,Morris JC

更新日期：2016-09-23 00:00:00

abstract：:Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime....

journal_title：Antimicrobial agents and chemotherapy

authors： Nannini EC,Stryjewski ME,Singh KV,Rude TH,Corey GR,Fowler VG Jr,Murray BE

更新日期：2010-05-01 00:00:00