Use of a new mouse model of Acinetobacter baumannii pneumonia to evaluate the postantibiotic effect of imipenem.

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00

abstract：:Vancomycin pharmacokinetics were studied in four patients with peritonitis undergoing chronic intermittent peritoneal dialysis. Serum levels exceeding 4.0 micrograms/ml were maintained for 8 and 13 days after a single 1-g intravenous dose. Vancomycin serum concentrations measured before, during, and upon completion of...

journal_title：Antimicrobial agents and chemotherapy

authors： Magera BE,Arroyo JC,Rosansky SJ,Postic B

更新日期：1983-05-01 00:00:00

abstract：:The biosynthetic gene cluster of the aminocoumarin antibiotic coumermycin A(1) was cloned by screening of a cosmid library of Streptomyces rishiriensis DSM 40489 with heterologous probes from a dTDP-glucose 4,6-dehydratase gene, involved in deoxysugar biosynthesis, and from the aminocoumarin resistance gyrase gene gyr...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang ZX,Li SM,Heide L

更新日期：2000-11-01 00:00:00

abstract：:The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Koup JR,Lau AH,Brodsky B,Slaughter RL

更新日期：1979-05-01 00:00:00

abstract：:Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I...

journal_title：Antimicrobial agents and chemotherapy

authors： Osburne MS,Maiese WM,Greenstein M

更新日期：1990-07-01 00:00:00

abstract：:The pharmacokinetics, distribution, and plasma and renal clearance of a new aminoglycoside antibiotic, tobramycin, was studied in the treatment of 18 elderly male patients (average age, 69 years) with urinary tract infections. Ten of these patients had normal renal function and eight had impaired renal function of var...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Westenfelder SR,Madsen PO

更新日期：1973-04-01 00:00:00

abstract：:Minocycline and valproic acid are potential adjuvant therapies for the treatment of human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine whether minocycline alone or in combination with valproic acid affected atazanavir plasma concentrations. Twelve adult HIV-i...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson DR,Cruttenden K,Mariuz P,Rezk NL,Hochreiter J,Gelbard H,Schifitto G

更新日期：2008-09-01 00:00:00

abstract：:The activities of teicoplanin and vancomycin against 362 coagulase-negative staphylococci were determined by an agar dilution method. At the 4- and 32-micrograms/ml breakpoint levels of the National Committee for Clinical Laboratory Standards, 23.2% of the strains were intermediate and 1.7% were resistant to teicoplan...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein FW,Coutrot A,Sieffer A,Acar JF

更新日期：1990-05-01 00:00:00

abstract：:The effect of micafungin dose scheduling on the treatment of candidemia is unknown. Neutropenic mice with disseminated Candida glabrata infection were treated with single intraperitoneal micafungin doses of 0 to 100 mg/kg of body weight and sacrificed 7 days later. The maximal decline in kidney fungal burden was 5.8 l...

journal_title：Antimicrobial agents and chemotherapy

authors： Gumbo T,Drusano GL,Liu W,Kulawy RW,Fregeau C,Hsu V,Louie A

更新日期：2007-03-01 00:00:00

abstract：:Meropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant Enterobacteriaceae (CRE) infections. We describe the in vitro activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered Escherichia coli isolates harboring mutant blaKPC genes associated with ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson WR,Kline EG,Jones CE,Morder KT,Mettus RT,Doi Y,Nguyen MH,Clancy CJ,Shields RK

更新日期：2019-02-26 00:00:00

abstract：:Acinetobacter baumannii is a Gram-negative bacterium that causes nosocomial infections worldwide. This microbe's propensity to form biofilms allows it to persist and to survive on clinical abiotic surfaces for long periods. In fact, A. baumannii biofilm formation and its multidrug-resistant nature severely compromise ...

journal_title：Antimicrobial agents and chemotherapy

authors： Krishnamoorthy S,Shah BP,Lee HH,Martinez LR

更新日期：2015-10-12 00:00:00

abstract：:An association exists between respiratory viruses and bacterial infections. Prevention or treatment of the preceding viral infection is a logical goal for reducing this important cause of morbidity and mortality. The ability of the novel, selective parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Alymova IV,Portner A,Takimoto T,Boyd KL,Babu YS,McCullers JA

更新日期：2005-01-01 00:00:00

abstract：:Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Evron R,Guizie M,Zehavi U,Polacheck I

更新日期：1990-08-01 00:00:00

abstract：:Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the synthesis of both DHBV DNA and DHBV core antigen. Several nucleoside analogs which were previously shown to inhibit the replication of DNA viruses (i.e., herpesviruses) and retroviruses were examined for their inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Yokota T,Konno K,Chonan E,Mochizuki S,Kojima K,Shigeta S,de Clercq E

更新日期：1990-07-01 00:00:00

abstract：:An Escherichia coli strain with a plasmidic amikacin resistance has been selected for which the evidence strongly indicates that resistance is mediated by aminoglycoside phosphotransferase [APH(3')-II]: (i) this resistance was coupled with resistance against kanamycin and neomycin; (ii) partially purified APH(3')-II[A...

journal_title：Antimicrobial agents and chemotherapy

authors： Bongaerts GP,Kaptijn GM

更新日期：1981-09-01 00:00:00

abstract：:Itraconazole is used for the prevention and treatment of infections caused by Aspergillus fumigatus. An understanding of the pharmacodynamics of itraconazole against wild-type and triazole-resistant strains provides a basis for innovative therapeutic strategies for treatment of infections. An in vitro model of the hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Nakeeb Z,Sudan A,Jeans AR,Gregson L,Goodwin J,Warn PA,Felton TW,Howard SJ,Hope WW

更新日期：2012-08-01 00:00:00

abstract：:The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality, and economic hardship. Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options. We designed methyltriazenyl pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodenko B,Wanner MJ,Alkhaldi AA,Ebiloma GU,Barnes RL,Kaiser M,Brun R,McCulloch R,Koomen GJ,de Koning HP

更新日期：2015-11-01 00:00:00

abstract：:Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC-8; 53 kDa) followi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berdugo M,Larsen IV,Abadie C,Deloche C,Kowalczuk L,Touchard E,Dubielzig R,Brandt CR,Behar-Cohen F,Combette JM

更新日期：2012-03-01 00:00:00

abstract：:Enterococcus faecalis is an opportunistic pathogen and leading cause of health care-associated infections. Daily chlorhexidine gluconate (CHG) bathing of patients is generally regarded as an effective strategy to reduce the occurrence of health care-associated infections. It is likely that E. faecalis is frequently ex...

journal_title：Antimicrobial agents and chemotherapy

authors： Li FJ,Palmer KL

更新日期：2018-05-25 00:00:00

abstract：:The in vitro activities of a new quinolone, WIN 57273, and the combination of piperacillin and tazobactam, a beta-lactamase inhibitor, were compared with those of cefoxitin, ceftizoxime, chloramphenicol, clindamycin, imipenem, metronidazole, and piperacillin for 123 clinical anaerobic isolates. Ceftizoxime and cefoxit...

journal_title：Antimicrobial agents and chemotherapy

authors： Venezia RA,Yocum DM,Robbiano EM,Echols RM

更新日期：1990-09-01 00:00:00

abstract：:A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Pascual A,Garcia I,Perea EJ

更新日期：1989-05-01 00:00:00

abstract：:The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were determined, and the virulence-suppressing effects of AZM were compared with those of erythromycin (EM), roxithromycin (RXM)...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizukane R,Hirakata Y,Kaku M,Ishii Y,Furuya N,Ishida K,Koga H,Kohno S,Yamaguchi K

更新日期：1994-03-01 00:00:00

abstract：:Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses, only a restricted ...

journal_title：Antimicrobial agents and chemotherapy

authors： Keller P,Müller C,Engelhardt I,Hiller E,Lemuth K,Eickhoff H,Wiesmüller KH,Burger-Kentischer A,Bracher F,Rupp S

更新日期：2015-10-01 00:00:00

abstract：:Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium rel...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen WC,Chou DL,Feingold DS

更新日期：1978-06-01 00:00:00

abstract：:Amoxycillin was significantly more active than ampicillin in the treatment of intraperitoneal mouse infections when administered by oral and parenteral routes, although the causal bacteria were equally susceptible in vitro to the two penicillins. Amoxycillin produced higher antibiotic blood concentrations in mice than...

journal_title：Antimicrobial agents and chemotherapy

authors： Comber KR,Osborne CD,Sutherland R

更新日期：1975-02-01 00:00:00

abstract：:A hemoglobin-supplemented medium composed of Columbia agar base supplemented with 1% hemoglobin and 1% Polyvitex was used to investigate the in vitro activity of 29 antimicrobial agents against Capnocytophaga species. Clindamycin was the most active agent, with all strains being inhibited by 0.06 microgram/ml or less....

journal_title：Antimicrobial agents and chemotherapy

authors： Rummens JL,Gordts B,Van Landuyt HW

更新日期：1986-11-01 00:00:00

abstract：:Using measured free fraction and 50% inhibitory concentration (IC50) values for the human immunodeficiency virus protease inhibitors lopinavir (LPV) and ritonavir (RTV) in tissue culture media with various protein concentrations ranging from 5 to 50%, we estimated serum-free IC50 values for each drug. The range of ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Hickman D,Vasavanonda S,Nequist G,Colletti L,Kati WM,Bertz R,Hsu A,Kempf DJ

更新日期：2004-08-01 00:00:00

abstract：:A gentamicin resistance determinant of a conjugative plasmid from Enterobacter cloacae was cloned on a 3.2-kilobase fragment in the PstI site of pBR322. Substrate profiles for eight aminoglycosides at three concentrations showed that the resistance was due to aminoglycoside-(3)-N-acetyltransferase isoenzyme II. Insert...

journal_title：Antimicrobial agents and chemotherapy

authors： Vliegenthart JS,Ketelaar-van Gaalen PA,van de Klundert JA

更新日期：1989-08-01 00:00:00

abstract：:An in vitro investigation of the structure-activity profiles for a range of 9-anilinoacridines on drug-resistant Plasmodium falciparum is reported. C-3, 6-diamino substitution, low lipophilicity, and high pKa values substantially increased the activities of the 9-anilinoacridines tested. There appeared to be no correl...

journal_title：Antimicrobial agents and chemotherapy

authors： Chavalitshewinkoon P,Wilairat P,Gamage S,Denny W,Figgitt D,Ralph R

更新日期：1993-03-01 00:00:00

abstract：:The in vitro activities of LY146032 and seven comparative antimicrobial agents against 14 species of staphylococci, streptococci, and enterococci were studied. MICs of LY146032 were less than or equal to 0.5 microgram/ml for all staphylococci, including oxacillin-resistant strains; less than or equal to 0.25 microgram...

journal_title：Antimicrobial agents and chemotherapy

authors： Fass RJ,Helsel VL

更新日期：1986-11-01 00:00:00