Abstract:
:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated unchanged as unaltered antibiotic, primarily by renal excretion. In dogs, however, cefaclor is more labile to metabolism and only a portion of the administered antibiotic is eliminated unchanged via the kidney.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Sullivan HR,Due SL,Kau DL,Quay JF,Miller Wdoi
10.1128/aac.10.4.630subject
Has Abstractpub_date
1976-10-01 00:00:00pages
630-8issue
4eissn
0066-4804issn
1098-6596journal_volume
10pub_type
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