Ocular distribution, spectrum of activity, and in vivo viral neutralization of a fully humanized anti-herpes simplex virus IgG Fab fragment following topical application.

abstract：:A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hexA(+) isogenic ancestor was challenged with low cefotaxime concentrations. Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of the tested selecte...

journal_title：Antimicrobial agents and chemotherapy

authors： Negri MC,Morosini MI,Baquero MR,del Campo R,Blázquez J,Baquero F

更新日期：2002-02-01 00:00:00

abstract：:Ceftizoxime was evaluated in the treatment of 18 patients (6 adults and 12 children) with bacterial meningitis. In seven patients Haemophilus influenzae was the causative agent, in three Neisseria meningitidis, in five Streptococcus pneumoniae, and in one each alpha-streptococcus and Escherichia coli; one case was cul...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Cable DC,Forthal DN,Shikuma C

更新日期：1984-02-01 00:00:00

abstract：:Cats were experimentally inoculated parenterally with the ME49 strain of Toxoplasma gondii to characterize the efficacies of two different dosages of orally administered clindamycin hydrochloride in the treatment of ocular toxoplasmosis. Concentrations of clindamycin hydrochloride at levels previously suggested to be ...

journal_title：Antimicrobial agents and chemotherapy

authors： Davidson MG,Lappin MR,Rottman JR,Tompkins MB,English RV,Bruce AT,Jayawickrama J

更新日期：1996-06-01 00:00:00

abstract：:The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

journal_title：Antimicrobial agents and chemotherapy

authors： Queener SF,Bartlett MS,Nasr M,Smith JW

更新日期：1993-10-01 00:00:00

abstract：:Ciprofloxacin is active in vitro against most bacteria that cause peritonitis associated with peritoneal dialysis. We compared the effects of pH (5.5 and 7.4) and medium (dialysis fluid) on the bactericidal activity of ciprofloxacin, tobramycin, vancomycin plus rifampin, and rifampin against Pseudomonas aeruginosa, Es...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormick EM,Echols RM

更新日期：1987-04-01 00:00:00

abstract：:The antimicrobial efflux system encoded by the operon mef(E)-mel on the mobile genetic element MEGA in Streptococcus pneumoniae and other Gram-positive bacteria is inducible by macrolide antibiotics and antimicrobial peptides. Induction may affect the clinical response to the use of macrolides. We developed mef(E) rep...

journal_title：Antimicrobial agents and chemotherapy

authors： Chancey ST,Zhou X,Zähner D,Stephens DS

更新日期：2011-07-01 00:00:00

abstract：:We conducted this double-blind, parallel-group, placebo-controlled, randomized, multiple-ascending-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of GS-9851 (formerly PSI-7851) in treatment-naïve patients infected with hepatitis C virus (HCV) genotype 1. Thirty-two patients recei...

journal_title：Antimicrobial agents and chemotherapy

authors： Lawitz E,Rodriguez-Torres M,Denning JM,Albanis E,Cornpropst M,Berrey MM,Symonds WT

更新日期：2013-03-01 00:00:00

abstract：:Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency against nonreplicating bacteria both in vitro and in vivo. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Vocat A,Hartkoorn RC,Lechartier B,Zhang M,Dhar N,Cole ST,Sala C

更新日期：2015-07-01 00:00:00

abstract：:In this study, we tested the antimicrobial activity of three metal nanoparticles (NPs), ZnO, MgO, and CaO NPs, against Salmonella enterica serovar Enteritidis in liquid medium and on solid surfaces. Out of the three tested metal NPs, ZnO NPs exhibited the most significant antimicrobial effect both in liquid medium and...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidovic S,Elder J,Medihala P,Lawrence JR,Predicala B,Zhang H,Korber DR

更新日期：2015-01-01 00:00:00

abstract：:Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic fungi such as Candida albicans, its effect on Aspergillus fumigatus is less well understood. We used the fluorescent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowman JC,Hicks PS,Kurtz MB,Rosen H,Schmatz DM,Liberator PA,Douglas CM

更新日期：2002-09-01 00:00:00

abstract：:Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significan...

journal_title：Antimicrobial agents and chemotherapy

authors： Vieira JLF,Rivera JGB,de Sena LWP,Ferreira MVD

更新日期：2020-02-21 00:00:00

abstract：:The increasing use of carbapenems for treating multidrug-resistant (MDR) Gram-negative bacterial infections has contributed to the global dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Serine and metallo-β-lactamases (MBLs) that hydrolyze carbapenems have become prevalent and endemic in some countries...

journal_title：Antimicrobial agents and chemotherapy

authors： Bradford PA,Kazmierczak KM,Biedenbach DJ,Wise MG,Hackel M,Sahm DF

更新日期：2015-12-14 00:00:00

abstract：:Sulfobutylether-beta-cyclodextrin (SBECD), a large cyclic oligosaccharide that is used to solubilize voriconazole (VRC) for intravenous administration, is eliminated mainly by renal excretion. The pharmacokinetics of SBECD and voriconazole in patients undergoing extracorporeal renal replacement therapies are not well ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hafner V,Czock D,Burhenne J,Riedel KD,Bommer J,Mikus G,Machleidt C,Weinreich T,Haefeli WE

更新日期：2010-06-01 00:00:00

abstract：:Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the pyrrolamide class which kill Mycobacterium tuberculosis through inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： P SH,Solapure S,Mukherjee K,Nandi V,Waterson D,Shandil R,Balganesh M,Sambandamurthy VK,Raichurkar AK,Deshpande A,Ghosh A,Awasthy D,Shanbhag G,Sheikh G,McMiken H,Puttur J,Reddy J,Werngren J,Read J,Kumar M,R M,Chi

更新日期：2014-01-01 00:00:00

abstract：:A clinical trial was designed to evaluate the efficacy and safety of cefotaxime, a new semisynthetic, broad-spectrum cephalosporin, in the therapy of community-and hospital-acquired pneumonias. Thirty-nine males (mean age, 65 years) were treated for 41 episodes of pneumonia. Only five patient did not have a serious un...

journal_title：Antimicrobial agents and chemotherapy

authors： Schleupner CJ,Engle JC

更新日期：1982-02-01 00:00:00

abstract：:Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic, and metabolic prope...

journal_title：Antimicrobial agents and chemotherapy

authors： Lake P,DeLeo J,Cerasoli F,Logdberg L,Weetall M,Handley D

更新日期：2004-08-01 00:00:00

abstract：:Using J774 macrophages, the intracellular activities of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) against Staphylococcus aureus (strain ATCC 25923) have been quantitatively assessed in a 24-h model. S. aureus was positively localized in phagolysosomes by confocal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Van Bambeke F,Tulkens PM

更新日期：2003-07-01 00:00:00

abstract：:The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(-1) s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoureaux TL,Frase H,Antunes NT,Vakulenko SB

更新日期：2012-11-01 00:00:00

abstract：:A PCR-based technique using new fluorescent probes, called molecular beacons, was developed to detect the antifolate resistance-associated S108N point mutation in Plasmodium falciparum. One hundred African clinical isolates were tested by the new method in comparison with the PCR-restriction fragment length polymorphi...

journal_title：Antimicrobial agents and chemotherapy

authors： Durand R,Eslahpazire J,Jafari S,Delabre JF,Marmorat-Khuong A,di Piazza JP,Le Bras J

更新日期：2000-12-01 00:00:00

abstract：:In 2016, we identified a new class A carbapenemase, VCC-1, in a nontoxigenic Vibrio cholerae strain that had been isolated from retail shrimp imported into Canada for human consumption. Shortly thereafter, seven additional VCC-1-producing V. cholerae isolates were recovered along the German coastline. These isolates a...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangat CS,Vadlamani G,Holicek V,Chu M,Larmour VLC,Vocadlo DJ,Mulvey MR,Mark BL

更新日期：2019-03-27 00:00:00

abstract：:We report the identification of a carbapenem-resistant, hypervirulent Klebsiella pneumoniae (hvKp) strain which produced the carbapenemase VIM-1. Genomic analysis showed that the strain belonged to sequence type ST23 and serotype K1, a major hvKp clone, and harbored three resistance-encoding plasmids. Among them, a bl...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong N,Sun Q,Huang Y,Shu L,Ye L,Zhang R,Chen S

更新日期：2019-08-23 00:00:00

abstract：:Many Pseudomonas aeruginosa isolates from the airways of patients with cystic fibrosis (CF) are sensitive to antibiotics in susceptibility testing, but eradication of the infection is difficult. The main reason is the biofilm formation in the airways of patients with CF. The pharmacokinetics (PKs) and pharmacodynamics...

journal_title：Antimicrobial agents and chemotherapy

authors： Hengzhuang W,Wu H,Ciofu O,Song Z,Høiby N

更新日期：2012-05-01 00:00:00

abstract：:Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kine...

journal_title：Antimicrobial agents and chemotherapy

authors： Rattie ES,Bernardo PD,Ravin JJ

更新日期：1976-08-01 00:00:00

abstract：:Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigated. Their potencies in inhibiting disease-associated protease-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Caughey WS,Priola SA,Kocisko DA,Raymond LD,Ward A,Caughey B

更新日期：2007-11-01 00:00:00

abstract：:The effect of liposomal encapsulation of ampicillin on the antibacterial activity against intracellular Listeria monocytogenes was studied by comparing survival of L. monocytogenes within peritoneal mouse macrophages in the presence of free ampicillin alone or in combination with liposome-entrapped ampicillin. In the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakker-Woudenberg IA,Lokerse AF,Vink-van den Berg JC,Roerdink FH,Michel MF

更新日期：1986-08-01 00:00:00

abstract：:Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

更新日期：2018-11-26 00:00:00

abstract：:The in vitro susceptibilities of 11 strains of Chlamydia pneumoniae to azithromycin, clarithromycin, erythromycin, L-oflaxacin, and doxycycline were determined. Clarithromycin was the most active agent tested, with an MIC for 90% of strains and minimal chlamydiacidal concentration for 90% of strains of 0.03 microns/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Hammerschlag MR,Qumei KK,Roblin PM

更新日期：1992-07-01 00:00:00

abstract：:We present a new strategy for predicting novel antibiotic mechanisms of action based on the analysis of whole-genome microarray data. We first built up a reference compendium of Bacillus subtilis expression profiles induced by 14 different antibiotics. This data set was expanded by adding expression profiles from muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Freiberg C,Fischer HP,Brunner NA

更新日期：2005-02-01 00:00:00

abstract：:The effects of ceftizoxime and gentamicin alone and in combination were determined against 100 Pseudomonas aeruginosa strains. Concentrations of 32 micrograms of ceftizoxime and 8 micrograms of gentamicin per ml inhibited 22 and 43% of the strains, respectively. At concentrations of ceftizoxime and gentamicin that are...

journal_title：Antimicrobial agents and chemotherapy

authors： King JW,Penn RL

更新日期：1984-06-01 00:00:00

abstract：:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakken JS,Cavalieri SJ,Gangeness D

更新日期：1990-06-01 00:00:00