Abstract:
:The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(-1) s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater extent, ranging from 10(3) M(-1) s(-1) for the cephamycin cefoxitin and the extended-spectrum cephalosporin ceftazidime to 10(5) to 10(6) M(-1) s(-1) for the narrow-spectrum and some of the extended-spectrum cephalosporins.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Lamoureaux TL,Frase H,Antunes NT,Vakulenko SBdoi
10.1128/AAC.01338-12subject
Has Abstractpub_date
2012-11-01 00:00:00pages
6006-8issue
11eissn
0066-4804issn
1098-6596pii
AAC.01338-12journal_volume
56pub_type
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