Natural occurrence of structures in oral streptococci and enterococci with DNA homology to Tn916.

abstract：:A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

journal_title：Antimicrobial agents and chemotherapy

authors： Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

更新日期：2000-06-01 00:00:00

abstract：:The generation rate constants for the steady-state growth of antibiotic-inhibited Escherichia coli have the same formal dependency on concentration for deoxylincomycin, lincomycin (phase I), erythromycin, clindamycin, and U24729A. They may be kinetically classified as a group A, in which the first three compounds comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Garrett ER,Heman-Ackah SM

更新日期：1973-11-01 00:00:00

abstract：:wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lentz CS,Sattler JM,Fendler M,Gottwalt S,Halls VS,Strassel S,Arriens S,Hannam JS,Specht S,Famulok M,Mueller AK,Hoerauf A,Pfarr KM

更新日期：2015-01-01 00:00:00

abstract：:During the second quarter each of 1988, 1989, and 1990, a French collaborative study group, including 12 university hospital laboratories, surveyed the resistance to beta-lactams of clinical isolates from hospitalized patients: consecutively, 10,641, 10,692, and 9,382 isolates were tested. The distribution of bacteria...

journal_title：Antimicrobial agents and chemotherapy

authors： Sirot DL,Goldstein FW,Soussy CJ,Courtieu AL,Husson MO,Lemozy J,Meyran M,Morel C,Perez R,Quentin-Noury C

更新日期：1992-08-01 00:00:00

abstract：:Pseudomonas putida is well known for its metabolic capabilities, but recently, it has been shown to exhibit resistance to a wide range of antibiotics. In P. putida DOT-T1E, the TtgABC efflux pump, which has a broad substrate specificity, extrudes antibiotics such as ampicillin, carbenicillin, tetracycline, nalidixic a...

journal_title：Antimicrobial agents and chemotherapy

authors： Terán W,Felipe A,Segura A,Rojas A,Ramos JL,Gallegos MT

更新日期：2003-10-01 00:00:00

abstract：:Optimal doses for antituberculosis (anti-TB) drugs in children have yet to be established. In 2010, the World Health Organization (WHO) recommended revised dosages of the first-line anti-TB drugs for children. Pharmacokinetic (PK) studies that investigated the adequacy of the WHO revised dosages to date have yielded c...

journal_title：Antimicrobial agents and chemotherapy

authors： Horita Y,Alsultan A,Kwara A,Antwi S,Enimil A,Ortsin A,Dompreh A,Yang H,Wiesner L,Peloquin CA

更新日期：2018-08-27 00:00:00

abstract：:The susceptibility of 53 clinical isolates of Bacteroides fragilis to cephamycins was examined. Judging from the MICs for 50% of the strains tested, moxalactam was the most active, however, judging from the MICs for 90% of the strains tested, cefbuperazone was more effective than moxalactam. A correlation was observed...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Minami S,Kakizawa H,Yasuda T,Takai A,Saikawa I,Inoue M,Mitsuhashi S

更新日期：1985-12-01 00:00:00

abstract：:Multidrug-resistant Enterobacteriaceae (MRE) colonize the intestine asymptomatically from where they can breach into the bloodstream and cause life-threatening infections, especially in heavily colonized patients. Despite the clinical relevance of MRE colonization levels, we know little about how they vary in hospital...

journal_title：Antimicrobial agents and chemotherapy

authors： Djukovic A,González-Barberá EM,Sanz J,Artacho A,Peñaranda I,Herrera B,Garzón MJ,Salavert M,López-Hontangas JL,Xavier KB,Kuster B,Debrauwer L,Rolain JM,Sanz MA,Xavier JB,Ubeda C

更新日期：2020-01-27 00:00:00

abstract：:There are no data comparing outcomes of patients treated with ceftazidime-avibactam versus comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shields RK,Nguyen MH,Chen L,Press EG,Potoski BA,Marini RV,Doi Y,Kreiswirth BN,Clancy CJ

更新日期：2017-07-25 00:00:00

abstract：:Atazanavir (Reyataz; ATV) is a well-tolerated protease inhibitor (PI) that is indicated as a once-daily treatment for HIV infections. These features of ATV, combined with its virologic potency, make it particularly desirable for the treatment of HIV-infected pediatric patients. The objective of this study was to use a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong Y,Kowalski KG,Zhang J,Zhu L,Horga M,Bertz R,Pfister M,Roy A

更新日期：2011-12-01 00:00:00

abstract：:Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of w...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Y,Creek D,Chollet J,Matile H,Charman SA,Wittlin S,Wood JK,Vennerstrom JL

更新日期：2007-08-01 00:00:00

abstract：:We have developed a new recombinant retroviral system in which a library of infectious molecular clones of human immunodeficiency virus type 1 (HIV-1) is constructed with reverse transcriptase (RT) genes derived from viral RNA sequences in plasma. HIV-1 RT is amplified from plasma HIV-1 RNA by nested RT-PCR and cloned...

journal_title：Antimicrobial agents and chemotherapy

authors： Shi C,Mellors JW

更新日期：1997-12-01 00:00:00

abstract：:The biological signal molecule nitric oxide (NO) was found to induce biofilm dispersal across a range of bacterial species, which led to its consideration for therapeutic strategies to treat biofilms and biofilm-related infections. However, biofilms are often not completely dispersed after exposure to NO. To better un...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhu X,Oh HS,Ng YCB,Tang PYP,Barraud N,Rice SA

更新日期：2018-02-23 00:00:00

abstract：:Actinobacillus actinomycetemcomitans, a pathogen associated with aggressive periodontitis, resists phagocytic killing by polymorphonuclear leukocytes (PMNs). It is susceptible to ciprofloxacin, which PMNs actively accumulate. This study tested the hypothesis that ciprofloxacin-loaded PMNs are more effective at killing...

journal_title：Antimicrobial agents and chemotherapy

authors： Cacchillo DA,Walters JD

更新日期：2002-06-01 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:We previously reported the isolation of a laboratory-derived Staphylococcus aureus mutant, 523k, that has constitutive low-level resistance to vancomycin (MIC = 5 micrograms/ml) and teicoplanin (MIC = 5 micrograms/ml) and elaborates a ca. 39-kDa cytoplasmic protein that was not detected in the parent strain 523 (MIC =...

journal_title：Antimicrobial agents and chemotherapy

authors： Milewski WM,Boyle-Vavra S,Moreira B,Ebert CC,Daum RS

更新日期：1996-01-01 00:00:00

abstract：:Isoprinosine has been reported to decrease progression to AIDS, primarily by preventing Pneumocystis carinii pneumonia (PCP), in human immunodeficiency virus-infected patients, but the mechanism of action is unknown. para-Acetamidobenzoic acid (PAcBA), one component of isoprinosine, is structurally related to para-ami...

journal_title：Antimicrobial agents and chemotherapy

authors： Kovacs JA,Powell F,Voeller D,Allegra CJ

更新日期：1993-06-01 00:00:00

abstract：:Respiratory infection with Burkholderia cenocepacia is associated with accelerated decline in lung function and increased mortality in cystic fibrosis (CF) patients (A. M. Jones, M. E. Dodd, J. R. W. Govan, V. Barcus, C. J. Doherty, J. Morris, and A. K. Webb, Thorax 59:948-951, 2004, http://dx.doi.org/10.1136/thx.2003...

journal_title：Antimicrobial agents and chemotherapy

authors： Balwan A,Nicolau DP,Wungwattana M,Zuckerman JB,Waters V

更新日期：2015-12-31 00:00:00

abstract：:Antimicrobial photodynamic inactivation (PDI) was shown to be a promising treatment modality for microbial infections. This study explores the effect of chitosan, a polycationic biopolymer, in increasing the PDI efficacy against Gram-positive bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Strep...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsai T,Chien HF,Wang TH,Huang CT,Ker YB,Chen CT

更新日期：2011-05-01 00:00:00

abstract：:We determined the antibiotic susceptibilities of 1,785 enterococcal bloodstream isolates collected over 25 years. Antibiotic resistance emerged at a greater rate in Enterococcus faecium than in other enterococcal species, and E. faecium isolates became proportionally more common over time. Our findings confirm the pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Murdoch DR,Mirrett S,Harrell LJ,Monahan JS,Reller LB

更新日期：2002-11-01 00:00:00

abstract：:In response to a published concern about the potency and quality of generic vancomycin products, the United States Food and Drug Administration investigated a small sampling of the vancomycin products available in North America with regard to purity, content, and potency. To facilitate identification of impurities, a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hadwiger ME,Sommers CD,Mans DJ,Patel V,Boyne MT 2nd

更新日期：2012-06-01 00:00:00

abstract：:MICs, time-kills, and postantibiotic effects (PAEs) of ABT-773 (a new ketolide) and 10 other agents were determined against 226 pneumococci. Against 78 ermB- and 44 mefE-containing strains, ABT-773 MICs at which 50% of the isolates tested were inhibited (MIC(50)s) and MIC(90)s were 0.016 to 0.03 and 0.125 microgram/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Ednie LM,Hoellman DM,Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：2000-07-01 00:00:00

abstract：:Seventy-one strains of 15 species of rapidly growing mycobacteria were studied for their susceptibilities to fatty acids with 2 to 20 carbons by the agar dilution method at pH 7.0. Most mycobacteria other than potential pathogens (Mycobacterium fortuitum and Mycobacterium chelonei) were resistant to saturated fatty ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Saito H,Tomioka H,Yoneyama T

更新日期：1984-08-01 00:00:00

abstract：:The iron-chelating drug deferoxamine (DFO) has been shown to be active in animal models of Pneumocystis carinii pneumonia (PCP), with effective daily intraperitoneal bolus dosages being 400 and 1,000 mg of DFO mesylate kg of body weight-1 in mouse and rat models, respectively. Continuous infusion produced a moderately...

journal_title：Antimicrobial agents and chemotherapy

authors： Merali S,Chin K,Del Angel L,Grady RW,Armstrong M,Clarkson AB Jr

更新日期：1995-09-01 00:00:00

abstract：:The role of Acinetobacter baumannii ATCC 17978 UmuDC homologs A1S_0636-A1S_0637, A1S_1174-A1S_1173, and A1S_1389 (UmuDAb) in antibiotic resistance acquired through UV-induced mutagenesis was evaluated. Neither the growth rate nor the UV-related survival of any of the three mutants was significantly different from that...

journal_title：Antimicrobial agents and chemotherapy

authors： Aranda J,López M,Leiva E,Magán A,Adler B,Bou G,Barbé J

更新日期：2014-01-01 00:00:00

abstract：:We reviewed data for almost 300,000 clinical Escherichia coli urinary isolates (collected in 2009 through 2013) from 127 inpatient and outpatient facilities, to assess antibiotic resistance among Veterans Affairs health care system patients using Clinical and Laboratory Standards Institute and Centers for Disease Cont...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrill HJ,Morton JB,Caffrey AR,Jiang L,Dosa D,Mermel LA,LaPlante KL

更新日期：2017-04-24 00:00:00

abstract：:A total of 6,991 unique patient isolates of Streptococcus pneumoniae were collected from October 1997 to June 2002 from 25 medical centers in 9 of the 10 Canadian provinces. Among these isolates, 20.2% were penicillin nonsusceptible, with 14.6% being penicillin intermediate (MIC, 0.12 to 1 microg/ml) and 5.6% being pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Palatnick L,Nichol KA,Bellyou T,Low DE,Hoban DJ

更新日期：2003-06-01 00:00:00

abstract：:Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prev...

journal_title：Antimicrobial agents and chemotherapy

authors： Coolen-Allou N,Touron T,Belmonte O,Gazaille V,Andre M,Allyn J,Picot S,Payet A,Veziris N

更新日期：2018-06-26 00:00:00

abstract：:Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison EM,Paterson GK,Holden MT,Morgan FJ,Larsen AR,Petersen A,Leroy S,De Vliegher S,Perreten V,Fox LK,Lam TJ,Sampimon OC,Zadoks RN,Peacock SJ,Parkhill J,Holmes MA

更新日期：2013-03-01 00:00:00

abstract：:Thirty-four infants and children ranging in age from 2.5 to 180 months (mean, 40 months) were treated with parenteral moxalactam (150 mg/kg per day) for suspected or proved bacterial infections outside the central nervous system. Six patients infected with Haemophilus influenzae b, nine infected with Staphylococcus au...

journal_title：Antimicrobial agents and chemotherapy

authors： Keyserling H,Feldman WE,Moffitt S,Manning N,Hollins M

更新日期：1982-06-01 00:00:00