Quality assessment of U.S. marketplace vancomycin for injection products using high-resolution liquid chromatography-mass spectrometry and potency assays.

abstract：:Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational an...

journal_title：Antimicrobial agents and chemotherapy

authors： Gutiérrez O,Juan C,Pérez JL,Oliver A

更新日期：2004-09-01 00:00:00

abstract：:The current voriconazole dosing recommendation in adolescents is based on limited efficacy and pharmacokinetic data. To confirm the appropriateness of dosing adolescents like adults, a pharmacokinetic study was conducted in 26 immunocompromised adolescents aged 12 to <17 years following intravenous (IV) voriconazole t...

journal_title：Antimicrobial agents and chemotherapy

authors： Driscoll TA,Frangoul H,Nemecek ER,Murphey DK,Yu LC,Blumer J,Krance RA,Baruch A,Liu P

更新日期：2011-12-01 00:00:00

abstract：:The effect of antichagasic benznidazole (BZL; 100 mg/kg body weight/day, 3 consecutive days, intraperitoneally) on biotransformation systems and ABC transporters was evaluated in rats. Expression of cytochrome P-450 (CYP3A), UDP-glucuronosyltransferase (UGT1A), glutathione S-transferases (alpha glutathione S-transfera...

journal_title：Antimicrobial agents and chemotherapy

authors： Perdomo VG,Rigalli JP,Villanueva SS,Ruiz ML,Luquita MG,Echenique CG,Catania VA

更新日期：2013-10-01 00:00:00

abstract：:A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of...

journal_title：Antimicrobial agents and chemotherapy

authors： Espuelas S,Legrand P,Loiseau PM,Bories C,Barratt G,Irache JM

更新日期：2000-08-01 00:00:00

abstract：:The gene coding for aminoglycoside 2'-N-acetyltransferase Ia [AAC(2')-Ia] from Providencia stuartii was amplified by PCR and cloned. The resulting construct, pACKF2, was transferred into Escherichia coli for overexpression of AAC(2')-Ia as a fusion protein with an N-terminal hexa-His tag. The fusion protein was isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Franklin K,Clarke AJ

更新日期：2001-08-01 00:00:00

abstract：:Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reactio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamaguchi M,Eda J,Kobayashi F,Mitsuhashi S

更新日期：1973-09-01 00:00:00

abstract：:Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Jacoby GA

更新日期：2010-03-01 00:00:00

abstract：:The effect of N-alkyl derivatives of saturated heterocyclic amine oxides on the growth and metabolism of microorganisms has been studied. 4-Dodecylmorpholine-N-oxide inhibited the differentiation and growth of Bacillus cereus, of different species of filamentous fungi, and of the yeast Saccharomyces cerevisiae. For ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Subík J,Takácsová G,Psenák M,Devínsky F

更新日期：1977-08-01 00:00:00

abstract：:We have used the endogenous reverse transcriptase reaction of viral core particles from duck liver to elucidate the mechanism of inhibition of duck hepatitis B virus (DHBV) replication by the nucleoside analog (-)-beta-L-2',3'-dideoxy-3'-thiacytidine (3TC). As is the case in human immunodeficiency virus replication, 3...

journal_title：Antimicrobial agents and chemotherapy

authors： Severini A,Liu XY,Wilson JS,Tyrrell DL

更新日期：1995-07-01 00:00:00

abstract：:Monensin is a polyether ionophore antibiotic that is widely used in the control of coccidia in animals. Despite its significance in veterinary medicine, little is known about its mode of action and potential mechanisms of resistance in coccidian parasites. Here we show that monensin causes accumulation of the coccidia...

journal_title：Antimicrobial agents and chemotherapy

authors： Lavine MD,Arrizabalaga G

更新日期：2011-02-01 00:00:00

abstract：:The efficacy of intravenous peramivir against influenza A (H1N1) 2009 virus infection was evaluated in mice in which the immune system was suppressed by cyclophosphamide (CP) treatment. The mortality rate of the vehicle control group was 100%, and the mice lost 20% of their body weight on average by day 13 postinfecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Kodama M,Itoh Y,Kanazu T,Kobayashi M,Yoshida R,Sato A

更新日期：2013-05-01 00:00:00

abstract：:Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. enterica serovar Typhi pil operon located in Salmonella pathogenicity island 7, are important in the pathogenic process. In this study, by using...

journal_title：Antimicrobial agents and chemotherapy

authors： Pan Q,Zhang XL,Wu HY,He PW,Wang F,Zhang MS,Hu JM,Xia B,Wu J

更新日期：2005-10-01 00:00:00

abstract：:We have evaluated the influence of age on the intracortical accumulation kinetics of gentamicin in conscious male rats by using a short-term infusion model. Animals were infused with gentamicin over a 6-h period and achieved individual steady-state levels in serum ranging from 0.5 to 12 micrograms/ml. Young rats were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Beauchamp D,Gourde P,Bergeron MG

更新日期：1989-11-01 00:00:00

abstract：:Mannopeptimycins alpha, beta, gamma, delta, and epsilon are new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98. Mannopeptimycins gamma, delta, and epsilon, which have an isovaleryl substitution at various positions on the terminal mannose of the disaccharide moiety, demonstrated moderat...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Janso JE,Luckman SW,Lenoy EB,Bradford PA,Testa RT,Greenstein M

更新日期：2003-01-01 00:00:00

abstract：:Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Beshir K,Sutherland CJ,Merinopoulos I,Durrani N,Leslie T,Rowland M,Hallett RL

更新日期：2010-09-01 00:00:00

abstract：:Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro;...

journal_title：Antimicrobial agents and chemotherapy

authors： Lopes SC,Blanco YC,Justo GZ,Nogueira PA,Rodrigues FL,Goelnitz U,Wunderlich G,Facchini G,Brocchi M,Duran N,Costa FT

更新日期：2009-05-01 00:00:00

abstract：:We compared the activity of delavirdine (DLV) plus zidovudine (AZT) (n = 300) with that of AZT (n = 297) against human immunodeficiency virus type 1 in a randomized, double-blind, placebo-controlled trial. DLV exerted a transient antiviral effect, and mutations for resistance to DLV were found in more than 90% of subj...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly V,Moroni M,Concia E,Lazzarin A,Hirschel B,Jost J,Chiodo F,Bentwich Z,Love WC,Hawkins DA,Wilkins EG,Gatell AJ,Vetter N,Greenwald C,Freimuth WW,de Cian W

更新日期：2000-11-01 00:00:00

abstract：:The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted significant scientific interest as models for targeting and management o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parisot J,Carey S,Breukink E,Chan WC,Narbad A,Bonev B

更新日期：2008-02-01 00:00:00

abstract：:The in vitro interaction between triclosan and fluconazole against 24 azole-resistant clinical isolates of Candida albicans was evaluated by the microdilution checkerboard technique. The synergisms were verified by time-killing curves and agar diffusion tests in selected strains. Antagonistic activity was not detected...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu L,Ling G,Deng X,Jin J,Jin Q,Guo N

更新日期：2011-07-01 00:00:00

abstract：:Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious top...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti S,Cevini C,Bruno A,Penso G,Rama P,Scaglia M

更新日期：1998-09-01 00:00:00

abstract：:Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus Candida albicans, which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN s...

journal_title：Antimicrobial agents and chemotherapy

authors： Willems HME,Stultz JS,Coltrane ME,Fortwendel JP,Peters BM

更新日期：2019-10-22 00:00:00

abstract：:Therapeutic treatment for systemic mycoses is severely hampered by the extremely limited number of antifungals. The difficulty of treatment of fungal infections in the central nervous system is further compounded by the poor central nervous system (CNS) penetration of most antifungals due to the blood-brain barrier. O...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhai B,Wu C,Wang L,Sachs MS,Lin X

更新日期：2012-07-01 00:00:00

abstract：:The inhibition of Saccharomyces cerevisiae growth by amphotericin B and rifampin was studied. Rifampin alone had no effect on growth or macromolecular syntheses. Lethal amounts of amphotericin B produced a late inhibition of ribonucleic acid (RNA) synthesis simultaneous with the arrest of growth and protein synthesis....

journal_title：Antimicrobial agents and chemotherapy

authors： Battaner E,Kumar BV

更新日期：1974-04-01 00:00:00

abstract：:Aspergillus fumigatus infections are associated with high mortality rates and high treatment costs. Limited available antifungals and increasing antifungal resistance highlight an urgent need for new antifungals. Thioredoxin reductase (TrxR) is essential for maintaining redox homeostasis and presents as a promising ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Marshall AC,Kidd SE,Lamont-Friedrich SJ,Arentz G,Hoffmann P,Coad BR,Bruning JB

更新日期：2019-02-26 00:00:00

abstract：:Aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (IA), a major cause of death among immunosuppressed patients. Echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for IA, but their activity is only fungistatic. Heat shock protein 90 (Hsp90) was previously shown ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Steinbach WJ

更新日期：2015-08-01 00:00:00

abstract：:It has recently become apparent that inflammatory reactions including nitric oxide (NO) release contribute to the outcome of pulmonary infections. To investigate the effect of N(G)-monomethyl-L-arginine (L-NMMA), a NO synthase inhibitor, on the pathogenesis of pneumococcal pneumonia, we inoculated CD(1) Swiss mice wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron Y,Ouellet N,Simard M,Olivier M,Bergeron MG

更新日期：1999-09-01 00:00:00

abstract：:We have studied the interference of roxithromycin with NADPH oxidase, the key enzymatic system for oxidant production by human neutrophils. Roxithromycin alters the reconstitution of an active enzyme and impairs the translocation to the outer membrane of the cytosolic components p47-phox and p67-phox. Interestingly, i...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelghaffar H,Babin-Chevaye C,Labro MT

更新日期：2005-07-01 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00

abstract：:GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, di...

journal_title：Antimicrobial agents and chemotherapy

authors： Delbrück H,Bogaerts P,Kupper MB,Rezende de Castro R,Bennink S,Glupczynski Y,Galleni M,Hoffmann KM,Bebrone C

更新日期：2012-11-01 00:00:00

abstract：:Morinidazole, a 5-nitroimidazole antimicrobial drug, has been approved for the treatment of amoebiasis, trichomoniasis, and anaerobic bacterial infections in China. It was reported that drug-drug interaction happened after the coadministration of ornidazole, an analog of morinidazole, and rifampin or ketoconazole. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Pang X,Zhang Y,Gao R,Zhong K,Zhong D,Chen X

更新日期：2014-10-01 00:00:00