Cephamycin inactivation due to enzymatic hydrolysis by beta-lactamase from Bacteroides fragilis.

abstract：:Olorofim is a novel antifungal drug in phase 2 trials. It has shown promising in vitro activity against various molds, except for Mucorales. Initially, we observed a broad range of EUCAST MICs for Aspergillus fumigatus Here, we explored the MIC variability in more detail and prospectively investigated the susceptibili...

journal_title：Antimicrobial agents and chemotherapy

authors： Astvad KMT,Jørgensen KM,Hare RK,Datcu R,Arendrup MC

更新日期：2020-12-16 00:00:00

abstract：:We have analyzed the contribution of different efflux components to glutathione-mediated abrogation of ciprofloxacin's activity in Escherichia coli and the underlying potential mechanism(s) behind this phenomenon. The results indicated that glutathione increased the total active efflux, thereby partially contributing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goswami M,Subramanian M,Kumar R,Jass J,Jawali N

更新日期：2016-06-20 00:00:00

abstract：:Lipids in fresh human milk do not inactivate viruses but become antiviral after storage of the milk for a few days at 4 or 23 degrees C. The appearance of antiviral activity depends on active milk lipases and correlates with the release of free fatty acids in the milk. A number of fatty acids which are normal componen...

journal_title：Antimicrobial agents and chemotherapy

authors： Thormar H,Isaacs CE,Brown HR,Barshatzky MR,Pessolano T

更新日期：1987-01-01 00:00:00

abstract：:Here, we report the first detection of carbapenemase-producing Escherichia coli in Alaska and in wildlife in the United States. Wild bird (gull) feces sampled at three locations in Southcentral Alaska yielded isolates that harbored plasmid-encoded blaKPC-2 or chromosomally encoded blaOXA-48 and genes associated with a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlstrom CA,Ramey AM,Woksepp H,Bonnedahl J

更新日期：2019-07-25 00:00:00

abstract：:Community-onset (CO) candidemia, defined as a positive blood culture taken at or within 2 days of hospital admission, represents a distinct clinical entity associated with substantial morbidity and mortality. Reference MIC results from the SENTRY Antimicrobial Surveillance Program (2008-2009) were analyzed to compare ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Moet GJ,Messer SA,Jones RN,Castanheira M

更新日期：2011-02-01 00:00:00

abstract：:The serum pharmacokinetic profile of intravenous (i.v.) tobramycin administration was characterized for a sample of nine adult patients with cystic fibrosis (CF) who were hospitalized for an acute pulmonary exacerbation. Current recommended i.v. tobramycin dosing protocols are predicted through modeling and simulation...

journal_title：Antimicrobial agents and chemotherapy

authors： Butterfield JM,Lodise TP,Beegle S,Rosen J,Farkas J,Pai MP

更新日期：2013-10-01 00:00:00

abstract：:Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 and Pdr11 in fluconazole susceptibility. Using biolistic transformatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang ML,Uhrig J,Vu K,Singapuri A,Dennis M,Gelli A,Thompson GR 3rd

更新日期：2015-12-07 00:00:00

abstract：:Resistance-nodulation-division (RND) efflux pumps are important contributors to bacterial antibiotic resistance. In this study, we combined evolutionary sequence analyses, computational structural modeling, and ligand docking to develop a framework that can explain the known antibiotic substrate selectivity difference...

journal_title：Antimicrobial agents and chemotherapy

authors： Dey D,Kavanaugh LG,Conn GL

更新日期：2020-07-22 00:00:00

abstract：:Pefloxacin mesylate is well absorbed by the oral route. The antimicrobial activity in dog, cynomolgus monkey, and human plasma was essentially due to unchanged drug which respectively accounted for 64, 94, and 84% of the total activity (ratios derived from relative area under the curve [AUC] values). Half-lives ranged...

journal_title：Antimicrobial agents and chemotherapy

authors： Montay G,Goueffon Y,Roquet F

更新日期：1984-04-01 00:00:00

abstract：:Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five...

journal_title：Antimicrobial agents and chemotherapy

authors： Pak TR,Altman DR,Attie O,Sebra R,Hamula CL,Lewis M,Deikus G,Newman LC,Fang G,Hand J,Patel G,Wallach F,Schadt EE,Huprikar S,van Bakel H,Kasarskis A,Bashir A

更新日期：2015-11-01 00:00:00

abstract：:Ceftobiprole (formerly BAL9141), the active component of the prodrug BAL5788 (ceftobiprole medocaril), is a novel cephalosporin with expanded activity against gram-positive bacteria. Among 152 Staphylococcus aureus isolates, including 5 vancomycin-intermediate and 2 vancomycin-resistant strains, MIC(50) and MIC(90) va...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogdanovich T,Ednie LM,Shapiro S,Appelbaum PC

更新日期：2005-10-01 00:00:00

abstract：:Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 μg/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and pos...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellis D,Gosai J,Emrick C,Heintz R,Romans L,Gordon D,Lu SE,Austin F,Smith L

更新日期：2012-02-01 00:00:00

abstract：:Pseudomonas aeruginosa infections represent a serious threat to worldwide health. Proline-rich antimicrobial peptides (PR-AMPs), a particular group of peptide antibiotics, have demonstrated in vitro activity against P. aeruginosa strains. Here we show that the mammalian PR-AMP Bac7(1-35) is active against some multidr...

journal_title：Antimicrobial agents and chemotherapy

authors： Runti G,Benincasa M,Giuffrida G,Devescovi G,Venturi V,Gennaro R,Scocchi M

更新日期：2017-03-24 00:00:00

abstract：:Mycobacterium abscessus is intrinsically resistant to many antimycobacterial antibiotics, which presents serious problems in therapy. Here, we describe the development of a novel phenotype-based microscopic and computerized imaging drug screening approach. A pilot screen of 568 compounds from two libraries identified ...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter A,Strauch A,Chao J,Ko M,Av-Gay Y

更新日期：2018-08-27 00:00:00

abstract：:Activity against the coccidial pathogen Eimeria tenella in chickens has been discovered among alpha 2 adrenergic agonists. The clonidine analog 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine was active in feed at 7.5 ppm, a concentration similar to the use levels of potent commercial agents, e.g., maduramicin. A...

journal_title：Antimicrobial agents and chemotherapy

authors： McFarland JW,Ricketts AP,Newcomb DM,Shively JE,Glazer EA

更新日期：1992-02-01 00:00:00

abstract：:Filibuvir and VX-222 are nonnucleoside inhibitors (NNIs) that bind to the thumb II allosteric pocket of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. Both compounds have shown significant promise in clinical trials and, therefore, it is relevant to better understand their mechanisms of inhibition. In our s...

journal_title：Antimicrobial agents and chemotherapy

authors： Yi G,Deval J,Fan B,Cai H,Soulard C,Ranjith-Kumar CT,Smith DB,Blatt L,Beigelman L,Kao CC

更新日期：2012-02-01 00:00:00

abstract：:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakken JS,Cavalieri SJ,Gangeness D

更新日期：1990-06-01 00:00:00

abstract：:Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are an important cause of morbidity and mortality in hospital patients. Moreover, increased incidences of outpatient MRSA have been recently reported. This study investigated the bactericidal activity of dalbavancin, a novel, semisynthetic glycopepti...

journal_title：Antimicrobial agents and chemotherapy

authors： Jabés D,Candiani G,Romanó G,Brunati C,Riva S,Cavaleri M

更新日期：2004-04-01 00:00:00

abstract：:The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak co...

journal_title：Antimicrobial agents and chemotherapy

authors： Pradines B,Tall A,Fusai T,Spiegel A,Hienne R,Rogier C,Trape JF,Le Bras J,Parzy D

更新日期：1999-02-01 00:00:00

abstract：:The activity of the pradimicin derivative BMS 181184 was evaluated in a model of invasive pulmonary aspergillosis in persistently neutropenic rabbits and compared with that of amphotericin B deoxycholate. BMS 181184 at total daily doses of 50 and 150 mg/kg of body weight was at least as effective as amphotericin B at ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gonzalez CE,Groll AH,Giri N,Shetty D,Al-Mohsen I,Sein T,Feuerstein E,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-09-01 00:00:00

abstract：:The accumulation of quinolones by Escherichia coli JF568, Pseudomonas aeruginosa PAO1, and Staphylococcus aureus ATCC 29213 was measured by a modified fluorometric assay (J. S. Chapman and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:27-29, 1989). The quinolones examined were fleroxacin, pefloxacin, norflox...

journal_title：Antimicrobial agents and chemotherapy

authors： McCaffrey C,Bertasso A,Pace J,Georgopapadakou NH

更新日期：1992-08-01 00:00:00

abstract：:Acyclovir, known as an antiherpetic agent, showed an inhibitory effect on the propagation of pseudorabies virus in BHK-21 cells. The antiviral effect of acyclovir was observed by plaque reduction, as well as by the inhibition of the virus-stimulated uptake of thymidine by BHK-21 cells. Amphotericin B potentiated the a...

journal_title：Antimicrobial agents and chemotherapy

authors： Malewicz B,Momsen M,Jenkin HM

更新日期：1983-01-01 00:00:00

abstract：:Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Prunier AL,Malbruny B,Tandé D,Picard B,Leclercq R

更新日期：2002-09-01 00:00:00

abstract：:Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hatfaludi T,Al-Hasani K,Dunstone M,Boyce J,Adler B

更新日期：2008-11-01 00:00:00

abstract：:The aim of this study was to determine the penetration of doripenem administered intravenously into the rabbit aqueous and vitreous humors. Nineteen New Zealand White rabbits received a 20-mg dose of doripenem intravenously over 60 min. Specimens of aqueous humor, vitreous humor, and blood were obtained 30 min (n = 5)...

journal_title：Antimicrobial agents and chemotherapy

authors： Semoun O,Marchand S,Grégoire N,Lamarche I,Adier C,Laroche L,Goldschmidt P,Couet W

更新日期：2012-07-01 00:00:00

abstract：:Mycoplasma hominis was highly susceptible to two new quinolones, with MICs for 90% of isolates tested of 0.004 micrograms/ml for WIN 57273 and 0.063 micrograms/ml for sparfloxacin, which were activities much greater than the 1 microgram/ml found for ofloxacin and tetracycline. Although Ureaplasma urealyticum was less ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kenny GE,Cartwright FD

更新日期：1991-07-01 00:00:00

abstract：:The production of Klebsiella pneumoniae carbapenemases (KPCs) by Enterobacteriaceae has become a significant problem in recent years. To identify factors that could predict isolation of KPC-producing K. pneumoniae (KPCKP) in clinical samples from hospitalized patients, we conducted a retrospective, matched (1:2) case-...

journal_title：Antimicrobial agents and chemotherapy

authors： Tumbarello M,Trecarichi EM,Tumietto F,Del Bono V,De Rosa FG,Bassetti M,Losito AR,Tedeschi S,Saffioti C,Corcione S,Giannella M,Raffaelli F,Pagani N,Bartoletti M,Spanu T,Marchese A,Cauda R,Viscoli C,Viale P

更新日期：2014-06-01 00:00:00

abstract：:Implant-associated infections (IAIs) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium-aluminum-niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuehl R,Brunetto PS,Woischnig AK,Varisco M,Rajacic Z,Vosbeck J,Terracciano L,Fromm KM,Khanna N

更新日期：2016-03-25 00:00:00

abstract：:N(2)-(3,4-Dichlorobenzyl)-7-(2-[1-morpholinyl]ethyl)guanine (MorE-DCBG, 362E) is a synthetic purine that selectively inhibits the replication-specific DNA polymerase of Clostridium difficile. MorE-DCBG and its analogs strongly inhibited the growth of a wide variety of C. difficile strains. When administered orally in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dvoskin S,Xu WC,Brown NC,Yanachkov IB,Yanachkova M,Wright GE

更新日期：2012-03-01 00:00:00

abstract：:A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luque S,Hope W,Campillo N,Muñoz-Bermúdez R,Sorli L,Barceló-Vidal J,González-Colominas E,Alvarez-Lerma F,Masclans JR,Montero M,Horcajada JP,Grau S

更新日期：2019-06-24 00:00:00