Occidiofungin's chemical stability and in vitro potency against Candida species.

abstract：:Multiresistant enterococci were tested for susceptibility to trimethoprim (TMP). Although most enterococci are inhibited by less than or equal to 1.0 microgram/ml, the MICs for 7 of 29 selected multiresistant isolates were greater than or equal to 8 micrograms/ml, including for two beta-lactamase positive (Bla+) strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Frosolono M,Hodel-Christian SL,Murray BE

更新日期：1991-09-01 00:00:00

abstract：:The JAK-STAT pathway is activated in both macrophages and lymphocytes upon human immunodeficiency virus type 1 (HIV-1) infection and thus represents an attractive cellular target to achieve HIV suppression and reduced inflammation, which may impact virus sanctuaries. Ruxolitinib and tofacitinib are JAK1/2 inhibitors t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavegnano C,Detorio M,Montero C,Bosque A,Planelles V,Schinazi RF

更新日期：2014-01-01 00:00:00

abstract：:Invasive and allergic infections by Aspergillus flavus are more common in tropical and subtropical countries. The emergence of voriconazole (VRC) resistance in A. flavus impacts the management of aspergillosis, as azoles are used as the first-line and empirical therapy. We screened 120 molecularly confirmed A. flavus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sharma C,Kumar R,Kumar N,Masih A,Gupta D,Chowdhary A

更新日期：2018-02-23 00:00:00

abstract：:In a dose-ranging study of amprenavir (formerly 141W94), an inhibitor of the protease enzyme of human immunodeficiency virus (HIV) type 1, single-dose and steady-state pharmacokinetic parameters were estimated from plasma samples collected on day 1 and during week 3, respectively. Amprenavir was administered on either...

journal_title：Antimicrobial agents and chemotherapy

authors： Sadler BM,Gillotin C,Lou Y,Stein DS

更新日期：2001-01-01 00:00:00

abstract：:The indinavir dosage regimen currently used for human immunodeficiency virus (HIV)-infected children is not based on pharmacokinetic data obtained in the target patient population. The purpose of our study was to characterize indinavir pharmacokinetics and pharmacodynamics in HIV-infected children. Eleven children (ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Vigano' A,Sala N,Vella S,Bassetti M,Bassetti D,Principi N

更新日期：2000-03-01 00:00:00

abstract：:Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracyclin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lynch C,Courvalin P,Nikaido H

更新日期：1997-04-01 00:00:00

abstract：:The design of novel integrase (IN) inhibitors has been aided by recent crystal structures revealing the binding mode of these compounds with a full-length prototype foamy virus (PFV) IN and synthetic viral DNA ends. Earlier docking studies relied on incomplete structures and did not include the contribution of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson BC,Métifiot M,Pommier Y,Hughes SH

更新日期：2012-01-01 00:00:00

abstract：:The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 microCi) of [(3)H]caspofungin to healthy men, plasma, urine, and feces were collected over 27 days in study A (n = 6) and plasma was collected over 26 weeks in study B (n = 7). Su...

journal_title：Antimicrobial agents and chemotherapy

authors： Stone JA,Xu X,Winchell GA,Deutsch PJ,Pearson PG,Migoya EM,Mistry GC,Xi L,Miller A,Sandhu P,Singh R,deLuna F,Dilzer SC,Lasseter KC

更新日期：2004-03-01 00:00:00

abstract：:Caspofungin (CAS) is approved for second-line management of proven or probable invasive aspergillosis at a dose of 50 mg once daily (QD). Preclinical and limited clinical data support the concept of the dose-dependent antifungal efficacy of CAS with preservation of its favorable safety profile. Little is known, howeve...

journal_title：Antimicrobial agents and chemotherapy

authors： Würthwein G,Cornely OA,Trame MN,Vehreschild JJ,Vehreschild MJ,Farowski F,Müller C,Boos J,Hempel G,Hallek M,Groll AH

更新日期：2013-04-01 00:00:00

abstract：:Hypermutable Pseudomonas aeruginosa strains are prevalent in patients with cystic fibrosis and rapidly become resistant to antibiotic monotherapies. Combination dosage regimens have not been optimized against such strains using mechanism-based modeling (MBM) and the hollow-fiber infection model (HFIM). The PAO1 wild-t...

journal_title：Antimicrobial agents and chemotherapy

authors： Landersdorfer CB,Rees VE,Yadav R,Rogers KE,Kim TH,Bergen PJ,Cheah SE,Boyce JD,Peleg AY,Oliver A,Shin BS,Nation RL,Bulitta JB

更新日期：2018-03-27 00:00:00

abstract：:We evaluated the effect of repeated oral doses (5 days of treatment) on the kinetics of lomefloxacin in volunteers and compared the kinetics after two different regimens, i.e., 400 mg once daily and 200 mg twice daily. After 400 mg of lomefloxacin was given once daily, no significant modification in the pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Gros I,Carbon C

更新日期：1990-01-01 00:00:00

abstract：:Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Ou...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai AD,Komorowski AS,Lo CKL,Tandon P,Li XX,Mokashi V,Cvetkovic A,Findlater A,Liang L,Loeb M,Mertz D

更新日期：2020-10-20 00:00:00

abstract：:In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine treatment (200 mg/day for 5 days) was associated with significant reductions in nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayden FG,Monto AS

更新日期：1986-02-01 00:00:00

abstract：:Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Slifer T,Araujo FG,Polzer RJ,Remington JS

更新日期：1997-05-01 00:00:00

abstract：:Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculosis strains from divers...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Stockbauer KE,Pan X,Kreiswirth BN,Moghazeh SL,Jacobs WR Jr,Telenti A,Musser JM

更新日期：1997-08-01 00:00:00

abstract：:This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzitko K,Paneth A,Plech T,Pawełczyk J,Węglińska L,Paneth P

更新日期：2014-12-01 00:00:00

abstract：:The in vitro susceptibility of Brucella melitensis was examined vis-a-vis the clinical outcome in 75 patients with brucellosis. The initial MICs for Brucella isolates from patients who relapsed and from those who did not were similar. Furthermore, the MICs for isolates from patients whose infections relapsed were no d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza J,Bosch J,Gudiol F,Liñares J,Viladrich PF,Martín R

更新日期：1986-12-01 00:00:00

abstract：:A sensitive, precise microbiological assay was developed for the determination of tissue distribution of dl-alanosine, a new antitumor agent. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1973-06-01 00:00:00

abstract：:A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

journal_title：Antimicrobial agents and chemotherapy

authors： Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

更新日期：2000-06-01 00:00:00

abstract：:The determination of antibiotic potency against bacterial strains by assessment of their minimum inhibitory concentration normally uses a standardized broth microdilution assay procedure developed more than 50 years ago. However, certain antibiotics require modified assay conditions in order to observe optimal activit...

journal_title：Antimicrobial agents and chemotherapy

authors： Kavanagh A,Ramu S,Gong Y,Cooper MA,Blaskovich MAT

更新日期：2018-12-21 00:00:00

abstract：:We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-...

journal_title：Antimicrobial agents and chemotherapy

authors： Di Luca MC,D'Ercole S,Petrelli D,Prenna M,Ripa S,Vitali LA

更新日期：2010-10-01 00:00:00

abstract：:The anilinouracils (AUs) such as 6-(3-ethyl-4-methylanilino)uracil (EMAU) are a novel class of gram-positive, selective, bactericidal antibacterials which inhibit pol IIIC, the gram-positive-specific replicative DNA polymerase. We have linked various fluoroquinolones (FQs) to the N-3 position of EMAU to generate a var...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler MM,Lamarr WA,Foster KA,Barnes MH,Skow DJ,Lyden PT,Kustigian LM,Zhi C,Brown NC,Wright GE,Bowlin TL

更新日期：2007-01-01 00:00:00

abstract：:The effects of ceftizoxime and gentamicin alone and in combination were determined against 100 Pseudomonas aeruginosa strains. Concentrations of 32 micrograms of ceftizoxime and 8 micrograms of gentamicin per ml inhibited 22 and 43% of the strains, respectively. At concentrations of ceftizoxime and gentamicin that are...

journal_title：Antimicrobial agents and chemotherapy

authors： King JW,Penn RL

更新日期：1984-06-01 00:00:00

abstract：:R plasmids from chloramphenicol-resistant salmonella from Ontario are shown to belong to the H(2) incompatibility subgroup and to mediate a broad-spectrum, phage inhibition function. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor DE,Grant RB

更新日期：1976-10-01 00:00:00

abstract：:Treatment of mucocutaneous and cutaneous Candida albicans infections with photosensitizing agents and light, termed photodynamic therapy (PDT), offers an alternative to conventional treatments. Initial studies using the clinically approved photosensitizer Photofrin demonstrated the susceptibility of C. albicans to its...

journal_title：Antimicrobial agents and chemotherapy

authors： Chabrier-Roselló Y,Foster TH,Pérez-Nazario N,Mitra S,Haidaris CG

更新日期：2005-10-01 00:00:00

abstract：:Minimal inhibitory concentrations of carbenicillin, chloramphenicol, tetracycline, gentamicin, tobramycin, and trimethoprim-sulfamethoxazole were determined for rough, smooth, and mucoid Pseudomonas sp. isolates from sputa collected from 40 cystic fibrosis patients. Ninety-four percent of the minimal inhibitory concen...

journal_title：Antimicrobial agents and chemotherapy

authors： Maybury BA,Blessing-Moore J,deWit SA,Lewiston NJ,Yeager AS

更新日期：1979-03-01 00:00:00

abstract：:The presence and characterization of plasmid-mediated fosfomycin resistance determinants among Escherichia coli isolates collected from pets in China between 2006 and 2010 were investigated. Twenty-nine isolates (9.0%) were positive for fosA3, and all of them were CTX-M producers. The fosA3 genes were flanked by IS26 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hou J,Huang X,Deng Y,He L,Yang T,Zeng Z,Chen Z,Liu JH

更新日期：2012-04-01 00:00:00

abstract：:Cyclacillin, a new aminosalicylic semisynthetic penicillin, was compared with amoxicillin for the therapy of acute bacterial maxillary sinusitis in 80 patients (ages, 12 to 70 years) in a prospective, double-blind, randomized clinical trial. Direct sinus aspirations for quantitative culture were done for all patients ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scheld WM,Sydnor A Jr,Farr B,Gratz JC,Gwaltney JM Jr

更新日期：1986-09-01 00:00:00

abstract：:Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the pyrrolamide class which kill Mycobacterium tuberculosis through inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： P SH,Solapure S,Mukherjee K,Nandi V,Waterson D,Shandil R,Balganesh M,Sambandamurthy VK,Raichurkar AK,Deshpande A,Ghosh A,Awasthy D,Shanbhag G,Sheikh G,McMiken H,Puttur J,Reddy J,Werngren J,Read J,Kumar M,R M,Chi

更新日期：2014-01-01 00:00:00

abstract：:Neisseria meningitidis has been relatively slow to acquire resistance to penicillin. We previously reported an increase in the incidence of invasive meningococcal disease (IMD) strains with decreased susceptibility to penicillin (DSP) in Ontario. Our objectives were to evaluate trends in IMD with DSP, to identify case...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown EM,Fisman DN,Drews SJ,Dolman S,Rawte P,Brown S,Jamieson F

更新日期：2010-03-01 00:00:00