Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.

abstract：:Berberine sulfate is an alkaloid extracted from the roots and bark of various plants and possesses antibacterial, antifungal, and antiprotozoal activities. Most studies have focused on the bacteriostatic or bactericidal activities of this compound. In this study, we report that berberine sulfate is bacteriostatic for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Courtney HS,Beachey EH

更新日期：1988-09-01 00:00:00

abstract：:The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral do...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramon J,Dautrey S,Farinoti R,Carbon C,Rubinstein E

更新日期：1996-01-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:We report the sequence of a 630-bp fragment of a gene associated with resistance to high levels of vancomycin in a clinical isolate of Enterococcus faecalis which retained susceptibility to teicoplanin. This gene was similar to the recently sequenced vanB and partially homologous with vanA, but it showed less-marked s...

journal_title：Antimicrobial agents and chemotherapy

authors： Gold HS,Unal S,Cercenado E,Thauvin-Eliopoulos C,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1993-08-01 00:00:00

abstract：:Monensin is a polyether ionophore antibiotic that is widely used in the control of coccidia in animals. Despite its significance in veterinary medicine, little is known about its mode of action and potential mechanisms of resistance in coccidian parasites. Here we show that monensin causes accumulation of the coccidia...

journal_title：Antimicrobial agents and chemotherapy

authors： Lavine MD,Arrizabalaga G

更新日期：2011-02-01 00:00:00

abstract：:Tigemonam, a new monobactam with excellent activity against gram-negative bacteria, was evaluated for in vivo efficacy and absorption after oral administration to laboratory animals. Tigemonam is absorbed when administered orally to mice and dogs. In a variety of gram-negative systemic infections in mice, orally admin...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark JM,Olsen SJ,Weinberg DS,Dalvi M,Whitney RR,Bonner DP,Sykes RB

更新日期：1987-02-01 00:00:00

abstract：:Tigecycline is a glycylcycline with activity against Enterobacteriaceae, including multidrug-resistant isolates of Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta-lactamase (ESBL) and carbapenemases. Herein, we used an in vivo murine thigh model to characterize the pharmacodynamic profile o...

journal_title：Antimicrobial agents and chemotherapy

authors： Nicasio AM,Crandon JL,Nicolau DP

更新日期：2009-07-01 00:00:00

abstract：:Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Sidwell RW,Huffman JH,Call EW,Alaghamandan H,Cook PD,Robins RK

更新日期：1985-09-01 00:00:00

abstract：:Pyronaridine, a Mannich base antimalarial, has demonstrated high in vivo and in vitro efficacy against chloroquine-resistant Plasmodium falciparum. Although this drug has the potential to become a prominent artemisinin combination therapy, little is known about its efficacy against drug-resistant Plasmodium vivax. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Price RN,Marfurt J,Chalfein F,Kenangalem E,Piera KA,Tjitra E,Anstey NM,Russell B

更新日期：2010-12-01 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:We studied the effects of two N,N'-bis(benzyl)-substituted polyamine analogs on the capacities of Trypanosoma cruzi to invade and multiply within a mammalian host cell. At concentrations as low as 1 microM, these compounds reduced significantly the infectivity of the parasite for rat heart myoblasts in a time-dependen...

journal_title：Antimicrobial agents and chemotherapy

authors： Majumder S,Kierszenbaum F

更新日期：1993-10-01 00:00:00

abstract：:Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors. However, it is unknown if the pathway to inhibition by β-lactamase inhibitors for CTX-M ESBLs is similar to TEM an...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethel CR,Taracila M,Shyr T,Thomson JM,Distler AM,Hujer KM,Hujer AM,Endimiani A,Papp-Wallace K,Bonnet R,Bonomo RA

更新日期：2011-07-01 00:00:00

abstract：:The MICs and minimum bactericidal concentrations (MBCs) for the biocides benzalkonium chloride and chlorhexidine were determined against 1,602 clinical isolates of Staphylococcus aureus. Both compounds showed unimodal MIC and MBC distributions (2 and 4 or 8 mg/liter, respectively) with no apparent subpopulation with r...

journal_title：Antimicrobial agents and chemotherapy

authors： Furi L,Ciusa ML,Knight D,Di Lorenzo V,Tocci N,Cirasola D,Aragones L,Coelho JR,Freitas AT,Marchi E,Moce L,Visa P,Northwood JB,Viti C,Borghi E,Orefici G,BIOHYPO Consortium.,Morrissey I,Oggioni MR

更新日期：2013-08-01 00:00:00

abstract：:The antibiotic cerulenin markedly inhibits the growth of Escherichia coli. The effects of the antibiotic on cellular syntheses were studied by measuring the incorporation of labeled precursors into lipids and macromolecules. During the first 40 min after the addition of cerulenin to a culture of growing cells, lipid s...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldberg I,Walker JR,Bloch K

更新日期：1973-05-01 00:00:00

abstract：:In this study, two identical copies of a 23S-5S gene cluster, which are separately situated within the Helicobacter pylori UA802 chromosome, were cloned and sequenced. Comparison of the DNA sequence of the H. pylori 23S rRNA gene with known sequences of other bacterial 23S rRNA genes indicated that the H. pylori UA802...

journal_title：Antimicrobial agents and chemotherapy

authors： Taylor DE,Ge Z,Purych D,Lo T,Hiratsuka K

更新日期：1997-12-01 00:00:00

abstract：:Despite the availability of >30 effective drugs for managing HIV-1 infection, no current therapy is curative, and long-term management is challenging owing to the emergence and spread of drug-resistant mutants. Identification of drugs against novel HIV-1 targets would expand the current treatment options and help to c...

journal_title：Antimicrobial agents and chemotherapy

authors： Halambage UD,Wong JP,Melancon BJ,Lindsley CW,Aiken C

更新日期：2015-09-01 00:00:00

abstract：:The aim of this study was to investigate the influence of hypovolemia on the distribution of imipenem in muscle extracellular fluid determined by microdialysis in awake rats. Microdialysis probes were inserted into the jugular vein and hind leg muscle. Imipenem recoveries in muscle and blood were determined in each ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchand S,Dahyot C,Lamarche I,Plan E,Mimoz O,Couet W

更新日期：2005-12-01 00:00:00

abstract：:The mechanism(s) of daptomycin (DAP) resistance (DAPr) is incompletely defined. Thickened cell walls (CWs) acting as either a mechanical barrier or an affinity trap for DAP have been purported to be a major contributor to the DAPr phenotype. To this end, we studied an isogenic set of methicillin-resistant Staphylococc...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang SJ,Nast CC,Mishra NN,Yeaman MR,Fey PD,Bayer AS

更新日期：2010-08-01 00:00:00

abstract：:The novel triazole D0870 was tested for in vitro activity, as well as in vivo in a murine model of pulmonary blastomycosis. In vitro, D0870 had inhibitory and fungicidal activity against Blastomyces dermatitidis (MIC = 0.048 microgram/ml; minimal fungicidal concentration = 0.097 microgram/ml). In vivo, D0870 was appro...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Hanson LH,Stevens DA

更新日期：1993-05-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal subjects, pharmacokinetic data were calculated, using a two-compartment open body model. The mean distribution serum half...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroy A,Humbert G,Godin M,Fillastre JP

更新日期：1980-03-01 00:00:00

abstract：:Enterococcus faecium has emerged as a major opportunistic pathogen for 2 decades with the spread of hospital-adapted multidrug-resistant clones. As members of the intestinal microbiota, they are subjected to numerous bacterial stresses, including antibiotics at subinhibitory concentrations (SICs). Since fluoroquinolon...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinel C,Cacaci M,Meignen P,Guérin F,Davies BW,Sanguinetti M,Giard JC,Cattoir V

更新日期：2017-04-24 00:00:00

abstract：:"Shock and kill" therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect of HIV or an arm of the immune system. We have recently found several benzotri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sorensen ES,Macedo AB,Resop RS,Howard JN,Nell R,Sarabia I,Newman D,Ren Y,Jones RB,Planelles V,Spivak AM,Bosque A

更新日期：2020-07-22 00:00:00

abstract：:Ten strains each of 18 clinically important species of Clostridium were tested for susceptibility to clindamycin. Of the 180 strains tested, 56 (31%) were resistant to more than 1.6 mug/ml. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilkins TD,Thiel T

更新日期：1973-01-01 00:00:00

abstract：:We previously demonstrated that the biguanide-based compound NB325 inhibits human immunodeficiency virus type 1 (HIV-1) infection by interacting with the CXCR4 viral coreceptor. This interaction also appeared to be persistent, since HIV-1 infection was inhibited even when the virus was introduced subsequent to the rem...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Keogan S,Zhu W,Kholodovych V,Welsh W,Rando R,Labib M,Wigdahl B,Krebs FC

更新日期：2010-05-01 00:00:00

abstract：:2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demons...

journal_title：Antimicrobial agents and chemotherapy

authors： Stuyver LJ,McBrayer TR,Whitaker T,Tharnish PM,Ramesh M,Lostia S,Cartee L,Shi J,Hobbs A,Schinazi RF,Watanabe KA,Otto MJ

更新日期：2004-02-01 00:00:00

abstract：:The pharmacokinetics of gentamicin C(1), C(2), and C(1a) were studied in six beagles after administration of gentamicin at 4 mg/kg of body weight as a single intravenous bolus dose. Plasma concentrations of the gentamicin components were analyzed with a novel high-performance liquid chromatography method capable of id...

journal_title：Antimicrobial agents and chemotherapy

authors： Isoherranen N,Lavy E,Soback S

更新日期：2000-06-01 00:00:00

abstract：:Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitchel B,Sundin DR,Patel JB

更新日期：2009-10-01 00:00:00

abstract：:An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium clavulanate and oxacillin, distinguished type I chromosomally mediated enzymes from other beta-lactamases of gram-negative bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr,Moland ES

更新日期：1986-12-01 00:00:00

abstract：:The caspofungin clinical trial database offers an opportunity to assess susceptibility results for Candida pathogens obtained from patients with candidiasis and allows for correlations between efficacy outcomes and MICs. Candida isolates have been identified from patients enrolled in four studies of esophageal candidi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kartsonis N,Killar J,Mixson L,Hoe CM,Sable C,Bartizal K,Motyl M

更新日期：2005-09-01 00:00:00

abstract：:Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substituti...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Castanheira M,Carrër A,Rodriguez CP,Jones RN,Smayevsky J,Nordmann P

更新日期：2011-06-01 00:00:00