Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents.

abstract：:Mycobacterium ulcerans causes Buruli ulcer, a potentially disabling ulcerative skin disease. Only recently was antimicrobial therapy proven effective. Treatment for 2 months with rifampin plus streptomycin was first proposed after experiments in the mouse footpad model demonstrated bactericidal activity. This treatmen...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang T,Li SY,Converse PJ,Almeida DV,Grosset JH,Nuermberger EL

更新日期：2011-01-01 00:00:00

abstract：:The chromosome-encoded class C β-lactamase CHE-1 produced by Enterobacter cloacae exhibits a lower sensitivity to avibactam than the P99 enzyme from which it is derived by a 6-residue deletion in the H-10 helix. In the present study, we investigated the sensitivity of CHE-1 to two other β-lactamase inhibitors: LK-157 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernea A,Galleni M,Frère JM

更新日期：2016-01-04 00:00:00

abstract：:TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the blaTEM gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G-->T transversion at position 1 of the -10 consensus sequence was identified to be the mechanism of TE...

journal_title：Antimicrobial agents and chemotherapy

authors： Siu LK,Ho PL,Yuen KY,Wong SS,Chau PY

更新日期：1997-02-01 00:00:00

abstract：:PER-1 extended-spectrum β-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla(PER-1) gene has never been reported in Klebsiella pneumoniae. Here, we studied interspecies dissemination of the bla(PER-1) gene by horizontal transfer of Tn1213 among Acinetobacter baumannii,...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae IK,Jang SJ,Kim J,Jeong SH,Cho B,Lee K

更新日期：2011-03-01 00:00:00

abstract：:BMS-207147, Sch 56592, and voriconazole are three new investigational triazoles with broad-spectrum antifungal activity. The in vitro activities of these three agents were compared with those of itraconazole and fluconazole against 1,300 bloodstream isolates of Candida species obtained from over 50 different medical c...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Messer SA,Hollis RJ,Jones RN,Doern GV,Brandt ME,Hajjeh RA

更新日期：1998-12-01 00:00:00

abstract：:Selective decontamination of the digestive tract (SDD) has been evaluated as a method to prevent colonization and infection in ventilated patients in 40 trials. On the basis of an assumption that cross-infection would be reduced as a consequence of SDD and that this would distort the results of SDD studies that used c...

journal_title：Antimicrobial agents and chemotherapy

authors： Hurley JC

更新日期：1995-04-01 00:00:00

abstract：:We describe here the in vitro activities of azithromycin, clarithromycin, minocycline, or tigecycline alone and in combination with amphotericin B, itraconazole, terbinafine, voriconazole, anidulafungin, caspofungin, or micafungin against 30 isolates of the oomycete Pythium insidiosum. The assays were based on the CLS...

journal_title：Antimicrobial agents and chemotherapy

authors： Jesus FP,Ferreiro L,Loreto ÉS,Pilotto MB,Ludwig A,Bizzi K,Tondolo JS,Zanette RA,Alves SH,Santurio JM

更新日期：2014-09-01 00:00:00

abstract：:Thirty-nine patients with uncomplicated gonorrhea were randomized to receive single, oral 50-, 100-, or 200-mg doses of trovafloxacin (CP-99,219), a new quinolone antibiotic. All 31 evaluable patients were cured of infection. Trovafloxacin was well tolerated. The trovafloxacin MICs at which 50 and 90% of 36 Neisseria ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hook EW 3rd,Pinson GB,Blalock CJ,Johnson RB

更新日期：1996-07-01 00:00:00

abstract：:Accumulating data have brought the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) into the forefront of antiretroviral therapy. Among the emerging compounds in this class, a particularly attractive one is efavirenz (Sustiva), recently approved for clinical use by the U.S. Food and Drug Administration. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Maga G,Ubiali D,Salvetti R,Pregnolato M,Spadari S

更新日期：2000-05-01 00:00:00

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:Ceftibuten (CFB), a new broad-spectrum cephalosporin for oral administration, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens frequently encountered in pediatric patients. Its antimicrobial spectrum and dosage formulation suggest a use for CFB in the treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Kearns GL,Reed MD,Jacobs RF,Ardite M,Yogev RD,Blumer JL

更新日期：1991-10-01 00:00:00

abstract：:Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wingard JR,Bender WJ,Saral R,Burns WH

更新日期：1981-08-01 00:00:00

abstract：:Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show here that the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Arita-Morioka K,Yamanaka K,Mizunoe Y,Ogura T,Sugimoto S

更新日期：2015-01-01 00:00:00

abstract：:The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity against both gram-positive and gram-negative bacteria. We studied the ability of several fragments of LL-37, exhibiting different antimicrobial activities, to interact with membranes whose compositions mimic the cytoplasmic memb...

journal_title：Antimicrobial agents and chemotherapy

authors： Epand RF,Wang G,Berno B,Epand RM

更新日期：2009-09-01 00:00:00

abstract：:The determination of antibiotic potency against bacterial strains by assessment of their minimum inhibitory concentration normally uses a standardized broth microdilution assay procedure developed more than 50 years ago. However, certain antibiotics require modified assay conditions in order to observe optimal activit...

journal_title：Antimicrobial agents and chemotherapy

authors： Kavanagh A,Ramu S,Gong Y,Cooper MA,Blaskovich MAT

更新日期：2018-12-21 00:00:00

abstract：:Macrolide antibiotics like erythromycin can prevent the formation of the 50S ribosomal subunit in growing bacterial cells, in addition to their inhibitory effect on translation. The significance of this novel finding has been further investigated. The 50% inhibitory doses of erythromycin for the inhibition of translat...

journal_title：Antimicrobial agents and chemotherapy

authors： Champney WS,Burdine R

更新日期：1996-05-01 00:00:00

abstract：:We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC(90)) was 4.0 mg/liter. For the Etest method, the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spanjaard L,Vandenbroucke-Grauls CM

更新日期：2008-05-01 00:00:00

abstract：:Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Covering only first-line antituberculosis drugs, this review addresses whether and how...

journal_title：Antimicrobial agents and chemotherapy

authors： Yew WW,Chang KC,Chan DP

更新日期：2018-07-27 00:00:00

abstract：:Efavirenz-based antiretroviral regimen is preferred during rifampin-containing tuberculosis therapy. However, current pharmacokinetic data are insufficient to guide optimized concurrent dosing. This study aimed to better characterize the effects of rifampin on efavirenz pharmacokinetics. Subjects were randomized to re...

journal_title：Antimicrobial agents and chemotherapy

authors： Kwara A,Tashima KT,Dumond JB,Poethke P,Kurpewski J,Kashuba AD,Court MH,Greenblatt DJ

更新日期：2011-07-01 00:00:00

abstract：:In this study, our objective was to determine whether a synergistic antimicrobial combination in vitro would be beneficial in the downregulation of pneumococcal virulence genes and whether the associated inflammation of the lung tissue induced by multidrug-resistant Streptococcus pneumoniae infection in vivo needs to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Majhi A,Adhikary R,Bhattacharyya A,Mahanti S,Bishayi B

更新日期：2014-09-01 00:00:00

abstract：:Statins are inhibitors of cholesterol synthesis, but other biological properties, such as antimicrobial effects, have also been assigned to them, leading to their designation as pleiotropic agents. Our goal was to investigate the activity and selectivity of atorvastatin (AVA) against Trypanosoma cruzi by using in vitr...

journal_title：Antimicrobial agents and chemotherapy

authors： Araujo-Lima CF,Peres RB,Silva PB,Batista MM,Aiub CAF,Felzenszwalb I,Soeiro MNC

更新日期：2018-08-27 00:00:00

abstract：:Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the synthesis of both DHBV DNA and DHBV core antigen. Several nucleoside analogs which were previously shown to inhibit the replication of DNA viruses (i.e., herpesviruses) and retroviruses were examined for their inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Yokota T,Konno K,Chonan E,Mochizuki S,Kojima K,Shigeta S,de Clercq E

更新日期：1990-07-01 00:00:00

abstract：:Daptomycin-nonsusceptible (DAP-NS) Staphylococcus aureus often exhibits gain-in-function mutations in the mprF gene (involved in positive surface charge maintenance). Standard β-lactams, although relatively inactive against methicillin-resistant S. aureus (MRSA), may prevent the emergence of mprF mutations and DAP-NS....

journal_title：Antimicrobial agents and chemotherapy

authors： Jenson RE,Baines SL,Howden BP,Mishra NN,Farah S,Lew C,Berti AD,Shukla SK,Bayer AS,Rose WE

更新日期：2020-08-20 00:00:00

abstract：:An in vitro tissue culture system consisting of reaggregated embryonic brain cells was used to evaluate the inhibition of herpes simplex type 1 (HSV-1) by several antiviral compounds. The efficacy of acyclovir, vidarabine, bromovinyldeoxyuridine, and 9-(1,3-dihydroxy-2-propoxymethyl) guanine in HSV-1-infected Vero cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Pulliam L,Panitch HS,Baringer JR,Dix RD

更新日期：1986-12-01 00:00:00

abstract：:Sixty-seven patients were treated with moxalactam in a noncomparative trial of hospitalized patients; 32 had endometritis or chorioamnionitis, 12 had skin and soft tissue infections, 5 had osteomyelitis, 5 had pneumonia, 5 had urinary tract infections, 4 had arthritis, 2 had sepsis from an unknown source, 1 had endoca...

journal_title：Antimicrobial agents and chemotherapy

authors： Marier RL,Faro S,Sanders CV,Williams W,Derks F,Janney A,Aldridge K

更新日期：1982-04-01 00:00:00

abstract：:The molecular mechanisms of resistance to fluoroquinolones, tetracyclines, an aminocyclitol, macrolides, a lincosamide, a phenicol, and pleuromutilins were investigated in Mycoplasma bovis For the identification of mutations responsible for the high MICs of certain antibiotics, whole-genome sequencing of 35 M. bovis f...

journal_title：Antimicrobial agents and chemotherapy

authors： Sulyok KM,Kreizinger Z,Wehmann E,Lysnyansky I,Bányai K,Marton S,Jerzsele Á,Rónai Z,Turcsányi I,Makrai L,Jánosi S,Nagy SÁ,Gyuranecz M

更新日期：2017-01-24 00:00:00

abstract：:Group B beta-hemolytic streptococci (GB-BHS) frequently cause severe infection in newborns. Previous in vitro studies showed accelerated killing of GB-BHS by ampicillin plus gentamicin as compared with ampicillin alone. To extend the in vitro observations, mice were infected experimentally with GB-BHS and treated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Deveikis A,Schauf V,Mizen M,Riff L

更新日期：1977-05-01 00:00:00

abstract：:The bla(OXA-51)-like gene with an upstream ISAba1 (ISAba1-bla(OXA-51)-like gene) was originally found on the chromosomes of carbapenem-resistant or -susceptible Acinetobacter baumannii isolates. However, a plasmid-borne ISAba1-bla(OXA-51)-like gene has recently been identified in Acinetobacter genomic species 13TU and...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen TL,Lee YT,Kuo SC,Hsueh PR,Chang FY,Siu LK,Ko WC,Fung CP

更新日期：2010-11-01 00:00:00

abstract：:A hemoglobin-supplemented medium composed of Columbia agar base supplemented with 1% hemoglobin and 1% Polyvitex was used to investigate the in vitro activity of 29 antimicrobial agents against Capnocytophaga species. Clindamycin was the most active agent, with all strains being inhibited by 0.06 microgram/ml or less....

journal_title：Antimicrobial agents and chemotherapy

authors： Rummens JL,Gordts B,Van Landuyt HW

更新日期：1986-11-01 00:00:00

abstract：:According to recommendations of the 6th WHO Advisory Committee on Buruli ulcer, directly observed treatment with the combination of rifampin and streptomycin, administered daily for 8 weeks, was recommended to 310 patients diagnosed with Buruli ulcer in Pobè, Bénin. Among the 224 (72%) eligible patients for whom treat...

journal_title：Antimicrobial agents and chemotherapy

authors： Chauty A,Ardant MF,Adeye A,Euverte H,Guédénon A,Johnson C,Aubry J,Nuermberger E,Grosset J

更新日期：2007-11-01 00:00:00