Inhibition of bacteriophage lambda, T1, and T7 development by R plasmids of the H incompatibility group.

abstract：:Early studies of immobilized peptides mainly focused upon the relationship between structural properties and the activity of soluble and surface-tethered sequences. The intention of this study was to analyze the influence of immobilization parameters upon the activity profile of peptides. Resin beads (TentaGel S NH(2)...

journal_title：Antimicrobial agents and chemotherapy

authors： Bagheri M,Beyermann M,Dathe M

更新日期：2009-03-01 00:00:00

abstract：:Aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (IA), a major cause of death among immunosuppressed patients. Echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for IA, but their activity is only fungistatic. Heat shock protein 90 (Hsp90) was previously shown ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Steinbach WJ

更新日期：2015-08-01 00:00:00

abstract：:The use of dialysis fermentation with the continuous extraction of the dialysate has resulted in a twofold increase in the cycloheximide titer due to relief from product inhibition. Continuous extraction of the dialysate has eliminated the necessity for large reservoir volumes of fermentation medium normally used in d...

journal_title：Antimicrobial agents and chemotherapy

authors： Kominek LA

更新日期：1975-06-01 00:00:00

abstract：:Twenty strains of Staphylococcus aureus isolated from patients with endocarditis were examined in vitro for susceptibility to rifampin, nafcillin, and vancomycin and to combinations of rifampin with nafcillin or vancomycin. Minimum bactericidal concentrations of rifampin ranged from 0.0031 to 0.0125 mug/ml, of nafcill...

journal_title：Antimicrobial agents and chemotherapy

authors： Tuazon CU,Lin MY,Sheagren JN

更新日期：1978-05-01 00:00:00

abstract：:The morphology of cells of the H37Ra strain of Mycobacterium tuberculosis exposed to 0.5 mug of isonicotinic acid hydrazide (isoniazid) per ml was examined by scanning electron microscopy (SEM). Cells that were exposed to isoniazid for 3 h showed no detectable change, whereas cells exposed to the drug for 24 h exhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Takayama K,Wang L,Merkal RS

更新日期：1973-07-01 00:00:00

abstract：:Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation, and an increased risk of resistance emergence. We evaluated the impact of ciprofloxacin and meropenem as monotherapy and in combination in the d...

journal_title：Antimicrobial agents and chemotherapy

authors： Bilal H,Bergen PJ,Tait JR,Wallis SC,Peleg AY,Roberts JA,Oliver A,Nation RL,Landersdorfer CB

更新日期：2020-06-23 00:00:00

abstract：:The accumulation of quinolones by Escherichia coli JF568, Pseudomonas aeruginosa PAO1, and Staphylococcus aureus ATCC 29213 was measured by a modified fluorometric assay (J. S. Chapman and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:27-29, 1989). The quinolones examined were fleroxacin, pefloxacin, norflox...

journal_title：Antimicrobial agents and chemotherapy

authors： McCaffrey C,Bertasso A,Pace J,Georgopapadakou NH

更新日期：1992-08-01 00:00:00

abstract：:The effect of the cephalosporin precursors and amino acids of the aspartic acid family on antibiotic production by Streptomyces clavuligerus was investigated DL-meso-Diaminopimelate and L-lysine each stimulated specific antibiotic production by 75%. A fourfold increase in specific production was obtained by simultaneo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendelovitz S,Aharonowitz Y

更新日期：1982-01-01 00:00:00

abstract：:Amoxycillin was significantly more active than ampicillin in the treatment of intraperitoneal mouse infections when administered by oral and parenteral routes, although the causal bacteria were equally susceptible in vitro to the two penicillins. Amoxycillin produced higher antibiotic blood concentrations in mice than...

journal_title：Antimicrobial agents and chemotherapy

authors： Comber KR,Osborne CD,Sutherland R

更新日期：1975-02-01 00:00:00

abstract：:The most widely used drug for treatment of candidiasis is fluconazole (FCZ). Recently, a new derivative of 1,4-benzothiazine, compound FS5, was developed. FS5 had an appreciable protective effect against murine candidiasis. The present study was designed to dissect the antifungal mechanisms triggered by FS5 and to est...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitzurra L,Fringuelli R,Perito S,Schiaffella F,Barluzzi R,Bistoni F,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:The antimicrobial treatment of multidrug-resistant (MDR) Acinetobacter baumannii infections has become a great challenge for medical staff all over the world. Increasing numbers of MDR A. baumannii infections have been identified and reported, but effective clinical treatments for them are decreasing. The objective of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai Y,Liu B,Wang T,Cai Y,Liang B,Wang R,Liu Y,Wang J

更新日期：2015-03-01 00:00:00

abstract：:Past studies conducted in Australian and American families have demonstrated that alpha 2b interferon (IFN) is effective in preventing rhinovirus-associated illnesses in exposed family members. IFN had been used by intranasal application for 7 days after exposure (5 x 10(6) IU/day). We used the same approach but with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Monto AS,Schwartz SA,Albrecht JK

更新日期：1989-03-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:Few studies have estimated the excess inpatient costs due to nosocomial cultures of Gram-negative bacteria (GNB), and those that do are often subject to time-dependent bias. Our objective was to generate estimates of the attributable costs of the underlying infections associated with nosocomial cultures by using a uni...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson RE,Stevens VW,Jones M,Khader K,Schweizer ML,Perencevich EN,Rubin MA,Samore MH

更新日期：2018-10-24 00:00:00

abstract：:A clinical isolate of Enterobacter cloacae, strain NOR-1, exhibited resistance to imipenem and remained susceptible to extended-spectrum cephalosporins. Clavulanic acid partially restored the susceptibility of the strain to imipenem. Two beta-lactamases with isoelectric points (pI) of 6.9 and > 9.2 were detected in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Nordmann P,Mariotte S,Naas T,Labia R,Nicolas MH

更新日期：1993-05-01 00:00:00

abstract：:Acanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Contact lens wearers are most at risk and account for some 95% of cases. Hydrogen peroxide is used for contact lens disinfection due to its broad antimicrobial activity. Lenses must be neutralized before use to avoid pronounce...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes R,Kilvington S

更新日期：2001-07-01 00:00:00

abstract：:Rabbits with nutritionally variant viridans group streptococcal experimental endocarditis were treated three times daily for 3 days with procaine penicillin (1.2 X 10(6) U) alone or together with low-dose streptomycin (2 mg/kg), high-dose streptomycin (8 mg/kg), low-dose gentamicin (0.32 mg/kg), or high-dose gentamici...

journal_title：Antimicrobial agents and chemotherapy

authors： Henry NK,Wilson WR,Roberts RB,Acar JF,Geraci JE

更新日期：1986-09-01 00:00:00

abstract：:Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (W...

journal_title：Antimicrobial agents and chemotherapy

authors： Yui Eto K,Firth N,Davis AM,Kwong SM,Krysiak M,Lee YT,O'Brien FG,Grubb WB,Coombs GW,Bond CS,Ramsay JP

更新日期：2019-10-22 00:00:00

abstract：:We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This r...

journal_title：Antimicrobial agents and chemotherapy

authors： Gollapudi SV,Chuah SK,Harvey T,Thadepalli HD,Thadepalli H

更新日期：1993-08-01 00:00:00

abstract：:We studied the susceptibilities of 77 strains of Neisseria gonorrhoeae to four antibiotics: cefpodoxime, ceftriaxone, penicillin, and tetracycline. All strains were susceptible to ceftriaxone. Cefpodoxime MICs (range, 0.001 to 0.125 micrograms/ml) were parallel to and approximately four times those of ceftriaxone, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Fekete T,Woodwell J,Cundy KR

更新日期：1991-03-01 00:00:00

abstract：:The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality, and economic hardship. Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options. We designed methyltriazenyl pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodenko B,Wanner MJ,Alkhaldi AA,Ebiloma GU,Barnes RL,Kaiser M,Brun R,McCulloch R,Koomen GJ,de Koning HP

更新日期：2015-11-01 00:00:00

abstract：:Peroxide antimalarials, including artemisinin, are important for the treatment of multidrug-resistant malaria. These peroxides are known to react with iron or heme to produce reactive intermediates that are thought to be responsible for their antimalarial activities. This study investigated the potential interaction o...

journal_title：Antimicrobial agents and chemotherapy

authors： Creek DJ,Ryan E,Charman WN,Chiu FC,Prankerd RJ,Vennerstrom JL,Charman SA

更新日期：2009-08-01 00:00:00

abstract：:Patients (n = 409) with severe skin and soft tissue infections (SSTIs) were randomized to receive clinafloxacin or piperacillin-tazobactam (plus optional vancomycin for methicillin-resistant cocci), administered intravenously, with the option to switch to oral medication. Most patients had cellulitis, wound infections...

journal_title：Antimicrobial agents and chemotherapy

authors： Siami G,Christou N,Eiseman I,Tack KJ,Severe Skin and Soft Tissue Infections Study Group.

更新日期：2001-02-01 00:00:00

abstract：:Two types of polycations with pendant active groups were synthesized: one is polymethacrylate containing pendant biguanide units, and the other is poly(vinylbenzyl ammonium chloride). The two polycations were found to exhibit higher bactericidal activity against Staphylococcus aureus than the corresponding monomers. F...

journal_title：Antimicrobial agents and chemotherapy

authors： Ikeda T,Hirayama H,Yamaguchi H,Tazuke S,Watanabe M

更新日期：1986-07-01 00:00:00

abstract：:A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity of this resistance at the farm level. Strains were examined for resistance against beta-lactam antibiotics and other antimicrobial...

journal_title：Antimicrobial agents and chemotherapy

authors： Smet A,Martel A,Persoons D,Dewulf J,Heyndrickx M,Catry B,Herman L,Haesebrouck F,Butaye P

更新日期：2008-04-01 00:00:00

abstract：:The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC beta-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these ...

journal_title：Antimicrobial agents and chemotherapy

authors： Padilla E,Alonso D,Doménech-Sánchez A,Gomez C,Pérez JL,Albertí S,Borrell N

更新日期：2006-06-01 00:00:00

abstract：:Minocycline and valproic acid are potential adjuvant therapies for the treatment of human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine whether minocycline alone or in combination with valproic acid affected atazanavir plasma concentrations. Twelve adult HIV-i...

journal_title：Antimicrobial agents and chemotherapy

authors： DiCenzo R,Peterson DR,Cruttenden K,Mariuz P,Rezk NL,Hochreiter J,Gelbard H,Schifitto G

更新日期：2008-09-01 00:00:00

abstract：:We have analyzed the contribution of different efflux components to glutathione-mediated abrogation of ciprofloxacin's activity in Escherichia coli and the underlying potential mechanism(s) behind this phenomenon. The results indicated that glutathione increased the total active efflux, thereby partially contributing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goswami M,Subramanian M,Kumar R,Jass J,Jawali N

更新日期：2016-06-20 00:00:00

abstract：:The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity against both gram-positive and gram-negative bacteria. We studied the ability of several fragments of LL-37, exhibiting different antimicrobial activities, to interact with membranes whose compositions mimic the cytoplasmic memb...

journal_title：Antimicrobial agents and chemotherapy

authors： Epand RF,Wang G,Berno B,Epand RM

更新日期：2009-09-01 00:00:00

abstract：:The resistance mechanisms of methicillin-resistant strains of Staphylococcus saprophyticus were characterized. Penicillin-binding protein (PBP) studies demonstrated an inducible PBP identical to PBP 2a in the membranes of these isolates. The amount of beta-lactamase produced was minimal. PBP 2a is responsible for the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Gelfand MS,Gerberding JL,Chambers HF

更新日期：1990-09-01 00:00:00