Stability of peroxide antimalarials in the presence of human hemoglobin.

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, express a single polar flagellum powered by sodium motive force and require motility to colonize and spread along the small intestine. In a previous study, we described a high-throughput assay for screening for sm...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Zhang L,Silva AJ,Benitez JA

更新日期：2013-08-01 00:00:00

abstract：:In this study, concentrations of amikacin in blood and bronchial secretions of 10 patients with mechanical ventilation for acute respiratory failure due to pneumonia were measured. One-half of the patients received amikacin twice daily, and the others received once-daily administration. Concentrations in bronchial sec...

journal_title：Antimicrobial agents and chemotherapy

authors： Santré C,Georges H,Jacquier JM,Leroy O,Beuscart C,Buguin D,Beaucaire G

更新日期：1995-01-01 00:00:00

abstract：:The in vitro activities of two new carboxyquinolones, A-56619 (difloxacin) and A-56620, were compared with those of ciprofloxacin, norfloxacin, and ofloxacin against genital tract pathogens. All the quinolones were highly active against Neisseria gonorrhoeae. A-56619 had the lowest MICs against Chlamydia trachomatis (...

journal_title：Antimicrobial agents and chemotherapy

authors： Liebowitz LD,Saunders J,Fehler G,Ballard RC,Koornhof HJ

更新日期：1986-12-01 00:00:00

abstract：:Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetra...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1986-07-01 00:00:00

abstract：:The efficacy of atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, and minocycline was examined in vitro and in a murine model of acute toxoplasmosis. In vitro studies were performed with MRC5 fibroblast tissue cultures, with quantification of Toxoplasma growth by an enzyme-linked immunosor...

journal_title：Antimicrobial agents and chemotherapy

authors： Romand S,Pudney M,Derouin F

更新日期：1993-11-01 00:00:00

abstract：:We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at positi...

journal_title：Antimicrobial agents and chemotherapy

authors： Welsh KJ,Barlow M,Tenover FC,Biddle JW,Rasheed JK,Clark LA,McGowan JE Jr

更新日期：2005-03-01 00:00:00

abstract：:The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both species. In dogs, c...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller WM

更新日期：1977-07-01 00:00:00

abstract：:The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：1998-11-01 00:00:00

abstract：:Enterococci are intrinsically resistant to low levels of aminoglycosides. We previously selected in vitro and in vivo Enterococcus faecalis with intermediate-level resistance to gentamicin that did not abolish synergism with a cell-wall-active agent (E. Aslangul et al., Antimicrob. Agents Chemother. 49:4144-4148, 2005...

journal_title：Antimicrobial agents and chemotherapy

authors： Aslangul E,Massias L,Meulemans A,Chau F,Andremont A,Courvalin P,Fantin B,Ruimy R

更新日期：2006-11-01 00:00:00

abstract：:Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

journal_title：Antimicrobial agents and chemotherapy

authors： Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

更新日期：2003-12-01 00:00:00

abstract：:A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jung H,Medina R,Castro N,Corona T,Sotelo J

更新日期：1997-06-01 00:00:00

abstract：:We determined the nucleotide sequence of the blaOXA-3(pMG25) gene from Pseudomonas aeruginosa. The bla structural gene encoded a protein of 275 amino acids representing one monomer of 31,879 Da for the OXA-3 enzyme. Comparisons between the OXA-3 nucleotide and amino acid sequences and those of class A, B, C, and D bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanschagrin F,Couture F,Levesque RC

更新日期：1995-04-01 00:00:00

abstract：:Berberine sulfate is an alkaloid extracted from the roots and bark of various plants and possesses antibacterial, antifungal, and antiprotozoal activities. Most studies have focused on the bacteriostatic or bactericidal activities of this compound. In this study, we report that berberine sulfate is bacteriostatic for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Courtney HS,Beachey EH

更新日期：1988-09-01 00:00:00

abstract：:Imipenem-cilastatin concentrations in bile were measured in 12 cholecystectomy patients (group 1) and 12 patients with common duct drainage (group 2). Six patients in each group received 0.5 g, and six received 1.0 g intravenously over 30 to 60 min. In group 1, bile was collected a mean of 85 min postinfusion. The mea...

journal_title：Antimicrobial agents and chemotherapy

authors： Graziani AL,Gibson GA,MacGregor RR

更新日期：1987-11-01 00:00:00

abstract：:The rate of occurrence of the extended-spectrum beta-lactamase (ESBL)-producing phenotype among Escherichia coli isolates in Tel Aviv is 12% (22). The aim of this study was to understand the molecular epidemiology of E. coli ESBL producers and to identify the ESBL genes carried by them. We studied 20 single-patient ES...

journal_title：Antimicrobial agents and chemotherapy

authors： Chmelnitsky I,Carmeli Y,Leavitt A,Schwaber MJ,Navon-Venezia S

更新日期：2005-11-01 00:00:00

abstract：:Ceftaroline is a new cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae, as well as common Gram-negative organisms. This study tested the prodrug, ceftaroline fosamil, against...

journal_title：Antimicrobial agents and chemotherapy

authors： Cottagnoud P,Cottagnoud M,Acosta F,Stucki A

更新日期：2013-10-01 00:00:00

abstract：:We describe here the in vitro activities of azithromycin, clarithromycin, minocycline, or tigecycline alone and in combination with amphotericin B, itraconazole, terbinafine, voriconazole, anidulafungin, caspofungin, or micafungin against 30 isolates of the oomycete Pythium insidiosum. The assays were based on the CLS...

journal_title：Antimicrobial agents and chemotherapy

authors： Jesus FP,Ferreiro L,Loreto ÉS,Pilotto MB,Ludwig A,Bizzi K,Tondolo JS,Zanette RA,Alves SH,Santurio JM

更新日期：2014-09-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal subjects, pharmacokinetic data were calculated, using a two-compartment open body model. The mean distribution serum half...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroy A,Humbert G,Godin M,Fillastre JP

更新日期：1980-03-01 00:00:00

abstract：:Peritonitis is a major complication of continuous ambulatory peritoneal dialysis. Relapsing peritonitis after the cessation of antimicrobial therapy is frequently reported and often involves Staphylococcus epidermidis. To investigate the potential role of catheter-associated biofilm in the pathogenesis of relapsing pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Evans RC,Holmes CJ

更新日期：1987-06-01 00:00:00

abstract：:Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under sel...

journal_title：Antimicrobial agents and chemotherapy

authors： Orlén H,Hughes D

更新日期：2006-10-01 00:00:00

abstract：:Four pre-exposure prophylaxis (PrEP) users with gastro-intestinal disorders (sleeve gastrectomy, terminal ileitis, celiac disease or chronic diarrhea) and receiving oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) were included. Despite a self-reported high adherence, trough plasma tenofovir concentrations (...

journal_title：Antimicrobial agents and chemotherapy

authors： Calcagno A,Dal Conte I,Cattaneo D,Testi R,Mistrangelo M,Gervasoni C,de Nicolò A,Bonora S,D'Avolio A,Di Perri G

更新日期：2020-10-26 00:00:00

abstract：:This study investigates the role of active efflux system MexXY in the emergence of aminoglycoside (AG) resistance among cystic fibrosis (CF) isolates of Pseudomonas aeruginosa. Three genotypically related susceptible and resistant (S/R) bacterial pairs and three other AG-resistant CF strains were compared to four non-...

journal_title：Antimicrobial agents and chemotherapy

authors： Vogne C,Aires JR,Bailly C,Hocquet D,Plésiat P

更新日期：2004-05-01 00:00:00

abstract：:A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had hig...

journal_title：Antimicrobial agents and chemotherapy

authors： Brimacombe M,Hazbon M,Motiwala AS,Alland D

更新日期：2007-11-01 00:00:00

abstract：:Real-time quantitative PCR was used to measure expression levels of genes encoding efflux pumps, ERG11 and two control genes, ACT1 and PMA1, in a collection of 14 fluconazole-susceptible Candida albicans isolates. For each gene, average expression levels and variations within the population were determined. These valu...

journal_title：Antimicrobial agents and chemotherapy

authors： Chau AS,Mendrick CA,Sabatelli FJ,Loebenberg D,McNicholas PM

更新日期：2004-06-01 00:00:00

abstract：:An important determinant of nephrotoxicity, which is the major complication of long-term amphotericin B treatment, is dysfunction of distal tubular epithelial cells. The underlying cause for this rather selective damage to the cells is unknown. In the present investigation, it was shown that kidney epithelial cells we...

journal_title：Antimicrobial agents and chemotherapy

authors： Walev I,Bhakdi S

更新日期：1996-05-01 00:00:00

abstract：:Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, and disinfectants in members of the Enterobacteriaceae. The AcrAB-TolC efflux pump is involved in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pérez A,Poza M,Aranda J,Latasa C,Medrano FJ,Tomás M,Romero A,Lasa I,Bou G

更新日期：2012-12-01 00:00:00

abstract：:The use of dialysis fermentation with the continuous extraction of the dialysate has resulted in a twofold increase in the cycloheximide titer due to relief from product inhibition. Continuous extraction of the dialysate has eliminated the necessity for large reservoir volumes of fermentation medium normally used in d...

journal_title：Antimicrobial agents and chemotherapy

authors： Kominek LA

更新日期：1975-06-01 00:00:00

abstract：:The response of tolerant Streptococcus sanguis and nontolerant Streptococcus mitis infections to penicillin therapy was compared in the rabbit model of endocarditis. The minimal inhibitory and bactericidal concentrations of penicillin were 0.1 and 0.1 mug/ml, respectively, for S. mitis and 0.05 and 6.2 mug/ml, respect...

journal_title：Antimicrobial agents and chemotherapy

authors： Lowy FD,Neuhaus EG,Chang DS,Steigbigel NH

更新日期：1983-01-01 00:00:00

abstract：:More than 250 Providencia strains isolated from the urine of institutionalized elderly patients were tested against cefaclor, cefuroxime, cefetamet, cefpodoxime, ciprofloxacin, and amoxicillin-clavulanic acid. Our results confirm the strong activities of expanded-spectrum oral cephalosporins against Providencia isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Cornaglia G,Frugoni S,Mazzariol A,Piacentini E,Berlusconi A,Fontana R

更新日期：1995-12-01 00:00:00