Primary structure of OXA-3 and phylogeny of oxacillin-hydrolyzing class D beta-lactamases.

abstract：:Quadruple mutations in the Plasmodium falciparum dihydrofolate reductase (PFDHFR) enzyme give rise to the highest level of pyrimethamine resistance leading to treatment failures. We describe here the presence of these quadruple mutations in a majority of P. falciparum isolates from Car Nicobar (Andaman and Nicobar) Is...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahmed A,Das MK,Dev V,Saifi MA,Wajihullah,Sharma YD

更新日期：2006-04-01 00:00:00

abstract：:Sordarin and its derivatives are antifungal compounds of potential clinical interest. Despite the highly conserved nature of the fungal and mammalian protein synthesis machineries, sordarin is a selective inhibitor of protein synthesis in fungal organisms. In cells sensitive to sordarin, its mode of action is through ...

journal_title：Antimicrobial agents and chemotherapy

authors： Botet J,Rodríguez-Mateos M,Ballesta JP,Revuelta JL,Remacha M

更新日期：2008-05-01 00:00:00

abstract：:The pharmacodynamic properties of levofloxacin (an optically active isomer of ofloxacin), ofloxacin, and ciprofloxacin, alone and in combination with rifampin, were evaluated over 24 to 48 h against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA 1199 and MRSA 494, respectively)...

journal_title：Antimicrobial agents and chemotherapy

authors： Kang SL,Rybak MJ,McGrath BJ,Kaatz GW,Seo SM

更新日期：1994-12-01 00:00:00

abstract：:Ceftolozane-tazobactam, a combination of the novel antipseudomonal cephalosporin ceftolozane and the well-established extended-spectrum β-lactamase inhibitor tazobactam, is approved for treating complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults. To determine doses ...

journal_title：Antimicrobial agents and chemotherapy

authors： Larson KB,Patel YT,Willavize S,Bradley JS,Rhee EG,Caro L,Rizk ML

更新日期：2019-05-24 00:00:00

abstract：:Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC > or = 0.125 microg/ml) to ciprofloxacin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunell M,Webber MA,Kotilainen P,Lilly AJ,Caddick JM,Jalava J,Huovinen P,Siitonen A,Hakanen AJ,Piddock LJ

更新日期：2009-09-01 00:00:00

abstract：:A basic, random copolymer of l-ornithine and l-leucine (OL; molar ratios 1:1) was bactericidal to a sensitive (S) strain of Staphylococcus aureus at low concentration. Resistant cells (R) were selected from the culture medium and, after serial transfers to solutions containing increasing amounts of the polymer, grew w...

journal_title：Antimicrobial agents and chemotherapy

authors： Shenfeld A,Flowers HM,Katchalski E

更新日期：1974-02-01 00:00:00

abstract：:A total of 521 unique clinical isolates from cancer patients with primarily (>90%) bloodstream infections were tested for susceptibility to ceftazidime-avibactam and comparators using broth microdilution methods. Ceftazidime-avibactam inhibited 97.8% of all Enterobacteriaceae (n = 321) at the susceptibility breakpoint...

journal_title：Antimicrobial agents and chemotherapy

authors： Hachem R,Reitzel R,Rolston K,Chaftari AM,Raad I

更新日期：2017-03-24 00:00:00

abstract：:The pharmacokinetics of two prodrugs of zidovudine (AZT), 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester and isoleucinyl ester (DPAZT and IAZT, respectively), were investigated in a rabbit model to determine their potential utility as drugs against human immunodeficiency virus. Drugs were administered by intraven...

journal_title：Antimicrobial agents and chemotherapy

authors： Lupia RH,Ferencz N,Lertora JJ,Aggarwal SK,George WJ,Agrawal KC

更新日期：1993-04-01 00:00:00

abstract：:Escherichia coli sequence type 131 (ST131) is a pandemic clonal lineage that is responsible for the global increase in fluoroquinolone resistance and extended-spectrum-β-lactamase (ESBL) producers. The members of ST131 clade C, especially subclades C2 and C1-M27, are associated with ESBLs. We developed a multiplex con...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura Y,Pitout JDD,Peirano G,DeVinney R,Noguchi T,Yamamoto M,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2017-07-25 00:00:00

abstract：:During its intraerythrocytic phase, the most lethal human malarial parasite, Plasmodium falciparum, digests host cell hemoglobin as a source of some of the amino acids required for its own protein synthesis. A number of parasite endopeptidases (including plasmepsins and falcipains) process the globin into small peptid...

journal_title：Antimicrobial agents and chemotherapy

authors： Cunningham E,Drag M,Kafarski P,Bell A

更新日期：2008-09-01 00:00:00

abstract：:Peritonitis is a major complication of continuous ambulatory peritoneal dialysis. Relapsing peritonitis after the cessation of antimicrobial therapy is frequently reported and often involves Staphylococcus epidermidis. To investigate the potential role of catheter-associated biofilm in the pathogenesis of relapsing pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Evans RC,Holmes CJ

更新日期：1987-06-01 00:00:00

abstract：:Potential alternatives, including linezolid, adjunctive rifampin, and moxifloxacin, were evaluated against vancomycin-tolerant (P9802-020) and vancomycin-susceptible clinical isolates of Streptococcus pneumoniae in an in vitro pharmacodynamic model. Vancomycin exhibited maximal killing of 2-log(10) CFU/ml against P980...

journal_title：Antimicrobial agents and chemotherapy

authors： Cha R,Rybak MJ

更新日期：2003-06-01 00:00:00

abstract：:The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there have been increasing recommendations for self-initiated therapy and use of prophylactic drugs for TD. We last examined the in vitro susceptibilities of commonly used antibiotics against TD pathogens in 1997. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ouyang-Latimer J,Jafri S,VanTassel A,Jiang ZD,Gurleen K,Rodriguez S,Nandy RK,Ramamurthy T,Chatterjee S,McKenzie R,Steffen R,DuPont HL

更新日期：2011-02-01 00:00:00

abstract：:The frequencies of tetracycline resistance determinants of the classes A, B, C, and D were determined in 53 non-lactose-fermenting clinical isolates. The most frequent class of determinant in Salmonella typhimurium and Shigella flexneri strains was class B; however, the predominant determinant in Shigella sonnei strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Salazar JM,Alvarez G,Gómez-Eichelmann MC

更新日期：1986-10-01 00:00:00

abstract：:The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human volunteers. Serum levels of tetracycline were uniformly reduced by approximately 50% by all test meals, whereas serum level...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Koch PA,Lau CC,Craig WA

更新日期：1977-03-01 00:00:00

abstract：:The in vitro interaction between triclosan and fluconazole against 24 azole-resistant clinical isolates of Candida albicans was evaluated by the microdilution checkerboard technique. The synergisms were verified by time-killing curves and agar diffusion tests in selected strains. Antagonistic activity was not detected...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu L,Ling G,Deng X,Jin J,Jin Q,Guo N

更新日期：2011-07-01 00:00:00

abstract：:The trypanocidal action of green tea catechins against two different developmental stages of Trypanosoma cruzi is reported for the first time. This activity was assayed with the nonproliferative bloodstream trypomastigote and with the intracellular replicative amastigote parasite forms. An ethyl acetate fraction from ...

journal_title：Antimicrobial agents and chemotherapy

authors： Paveto C,Güida MC,Esteva MI,Martino V,Coussio J,Flawiá MM,Torres HN

更新日期：2004-01-01 00:00:00

abstract：:Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active t...

journal_title：Antimicrobial agents and chemotherapy

authors： Edelstein PH,Edelstein MA

更新日期：1993-04-01 00:00:00

abstract：:Sch 22591 (5-episisomicin), gentamicin, sisomicin, and tobramycin were compared for their ability to protect mice from lethal intraperitoneal challenge with 12 Pseudomonas strains, all susceptible to each of the aminoglycosides (minimal inhibitory concentrations and minimal bactericidal concentrations were

journal_title：Antimicrobial agents and chemotherapy

authors： Goering RV,Sanders CC,Sanders WE Jr

更新日期：1978-12-01 00:00:00

abstract：:Amoxicillin and ampicillin were compared at a dose of 250 mg twice daily for 4 weeks to treat Salmonella typhi or Salmonella paratyphi A chronic bacteriuria with intermittent bacteremia. Eleven patients received amoxicillin, and 15 received ampicillin. Concentrations of the two drugs were measured in the urine and ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Bassily SB,Kilpatrick ME,Farid Z,Mikhail IA,El-Masry NA

更新日期：1981-11-01 00:00:00

abstract：:Drug susceptibility tests (DSTs) for Mycobacterium tuberculosis require at least 7 days of incubation. Drugs that are unstable at 37°C, such as ertapenem, are likely to be degraded before killing or inhibiting slow-growing bacteria. This would alter the MICs of these drugs, including ertapenem, leading to falsely high...

journal_title：Antimicrobial agents and chemotherapy

authors： Srivastava S,van Rijn SP,Wessels AM,Alffenaar JW,Gumbo T

更新日期：2016-04-22 00:00:00

abstract：:Antiviral screens have proved useful for the identification of novel human immunodeficiency virus type 1 (HIV-1) inhibitors. In this study, we describe an HIV-1 full replication (HIV-1 Rep) assay that incorporates all of the targets required for replication in T-cell lines, including the HIV-1 Vif gene. The HIV-1 Rep ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao J,Isaacson J,Patick AK,Blair WS

更新日期：2005-09-01 00:00:00

abstract：:In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2.7.1.21) activity. Plaque-purified clones derived from the original clinical sample were heterogeneous with respect to plaque siz...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellis MN,Keller PM,Fyfe JA,Martin JL,Rooney JF,Straus SE,Lehrman SN,Barry DW

更新日期：1987-07-01 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:Quinazoline-2,4-diones, such as PD 0305970, are new DNA gyrase and topoisomerase IV (topo IV) inhibitors with potent activity against gram-positive pathogens, including quinolone-resistant isolates. The mechanistic basis of dione activity vis-à-vis quinolones is not understood. We present evidence for Streptococcus pn...

journal_title：Antimicrobial agents and chemotherapy

authors： Pan XS,Gould KA,Fisher LM

更新日期：2009-09-01 00:00:00

abstract：:We determined the complete nucleotide sequence of a self-transmissible IncL/M plasmid, pKOI-34, from a Klebsiella oxytoca isolate. pKOI-34 possessed the core structure of an IncL/M plasmid found in Erwinia amylovora, pEL60, with two mobile elements inserted, a transposon carrying the arsenic resistance operon and a Tn...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Kayama S,Shigemoto N,Hisatsune J,Kuwahara R,Nishio H,Yamasaki K,Wada Y,Sueda T,Ohge H,Sugai M

更新日期：2016-04-22 00:00:00

abstract：:Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be available for quite some time. Clinicians will need to find more effective ways to utilize available agents. Colistin is an older but no...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson BW,Ibrahim KH,Hovde LB,Fromm TL,Reed MD,Rotschafer JC

更新日期：2003-03-01 00:00:00

abstract：:Polymyxins are often the only option to treat acquired multidrug-resistant Pseudomonas aeruginosa. Polymyxin susceptibility in P. aeruginosa PAO1 is associated with the lipopolysaccharide structure that is determined by arnBCADTEF and modulated by phoPQ and pmrAB. We examined five clonally unrelated clinical isolates ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barrow K,Kwon DH

更新日期：2009-12-01 00:00:00

abstract：:The activity of cefbuperazone against 266 strains of anaerobic bacteria was determined by the agar dilution method and compared with cefoxitin, moxalactam, piperacillin, and clindamycin. All strains were recent clinical isolates from community hospitals. All agents tested showed good activity against Bacteroides fragi...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM

更新日期：1985-02-01 00:00:00

abstract：:Amphotericin B, the principal drug used for treating systemic mycoses, possesses undesirable toxic properties. The ability of this antibiotic to potentiate antifungal activity of other compounds suggests that lower doses of amphotericin B could be used in combination with a second drug without loss of therapeutic effi...

journal_title：Antimicrobial agents and chemotherapy

authors： Huppert M,Pappagianis D,Sun SH,Gleason-Jordan I,Collins MS,Vukovich KR

更新日期：1976-03-01 00:00:00