Effect of vancomycin hydrochloride on Staphylococcus epidermidis biofilm associated with silicone elastomer.

abstract：:Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches in...

journal_title：Antimicrobial agents and chemotherapy

authors： Townsend EM,Sherry L,Kean R,Hansom D,Mackay WG,Williams C,Butcher J,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:High-performance liquid chromatography was used to determine the penetration of 19 antimicrobial agents into human polymorphonuclear leukocytes. The ratios of the intracellular concentration to the extracellular concentration of ampicillin, piperacillin, cefazolin, ceftizoxime, cefpimizole, and ceftazidime were all le...

journal_title：Antimicrobial agents and chemotherapy

authors： Koga H

更新日期：1987-12-01 00:00:00

abstract：:Monotherapy with isoniazid or amikacin or clarithromycin or combinations of two of these drugs showed nil to modest therapeutic activity in beige mice infected with Mycobacterium avium. However, the combination of all three, isoniazid-amikacin-clarithromycin, markedly reduced CFUs in both spleens and lungs after 91 da...

journal_title：Antimicrobial agents and chemotherapy

authors： Fattorini L,Xiao Y,Mattei M,Li Y,Iona E,Ricci ML,Thoresen OF,Creti R,Orefici G

更新日期：1998-03-01 00:00:00

abstract：:Ten beta-lactamase-producing Enterococcus faecalis isolates were examined for the presence of the staphylococcal beta-lactamase repressor and antirepressor genes. Four isolates, previously shown to be unrelated to each other by pulsed-field gel electrophoresis analysis, were positive for both genes by PCR, although be...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomayko JF,Zscheck KK,Singh KV,Murray BE

更新日期：1996-05-01 00:00:00

abstract：:Plasmodium falciparum, the deadliest species of malaria parasites, is dependent on glycolysis for the generation of ATP during the pathogenic red blood cell stage. Hexokinase (HK) catalyzes the first step in glycolysis, transferring the γ-phosphoryl group of ATP to glucose to yield glucose-6-phosphate. Here, we descri...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis MI,Patrick SL,Blanding WM,Dwivedi V,Suryadi J,Golden JE,Coussens NP,Lee OW,Shen M,Boxer MB,Hall MD,Sharlow ER,Drew ME,Morris JC

更新日期：2016-09-23 00:00:00

abstract：:Pseudomonas aeruginosa AH, isolated in Ankara, Turkey, was highly resistant to ceftazidime (MIC, 128 microg/ml) and produced a beta-lactamase that gave a doublet of bands at pIs 8.7 and 8.9. beta-Lactamase production was transferable to P. aeruginosa PU21 by conjugation and was determined by a ca. 450-kb plasmid, pMLH...

journal_title：Antimicrobial agents and chemotherapy

authors： Danel F,Hall LM,Gur D,Livermore DM

更新日期：1997-04-01 00:00:00

abstract：:Occidiofungin is produced by the soil bacterium Burkolderia contaminans MS14 and is structurally similar or identical to the burkholdines, xylocandins, and cepacidines. This study identified the primary cellular target of occidiofungin, which was determined to be actin. The modification of occidiofungin with a functio...

journal_title：Antimicrobial agents and chemotherapy

authors： Ravichandran A,Geng M,Hull KG,Li J,Romo D,Lu SE,Albee A,Nutter C,Gordon DM,Ghannoum MA,Lockless SW,Smith L

更新日期：2018-12-21 00:00:00

abstract：:The effects of binding and the bactericidal action of vancomycin on the arrangement and mobilities of cell wall polymers in Bacillus licheniformis were investigated by (15)N nuclear magnetic resonance spectroscopy. The bactericidal action of vancomycin led to reduced mobilities of cell wall teichoic acid and teichuron...

journal_title：Antimicrobial agents and chemotherapy

authors： Irving CS,Lapidot A

更新日期：1978-11-01 00:00:00

abstract：:A novel stilbene glycoside [piceid-(1-->6)-beta-d-glucopyranoside; PBG] from Parthenocissus tricuspidata was tested in vivo against Plasmodium berghei. PBG exhibited significant blood schizontocidal activity in a 4-day early infection, a repository evaluation, and an established infection, with a significant mean surv...

journal_title：Antimicrobial agents and chemotherapy

authors： Park WH,Lee SJ,Moon HI

更新日期：2008-09-01 00:00:00

abstract：:MICs of a newly developed benzoxazinorifamycin derivative, KRM-1648, for Mycobacterium avium complex (MAC) were determined by the BACTEC 460 TB system and compared with those of other known antimicrobial agents. The radiometric method gave a fast, accurate, and reproducible MIC for each antimicrobial agent. MICs of KR...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Saito H,Fujii K,Sato K,Hidaka T

更新日期：1993-01-01 00:00:00

abstract：:We investigated the azole resistance mechanisms and clinical features of fluconazole-nonsusceptible (FNS) isolates of Candida tropicalis recovered from Korean surveillance cultures in comparison with fluconazole-less-susceptible (FLS) isolates. Thirty-five clinical isolates of C. tropicalis, comprising 9 FNS (fluconaz...

journal_title：Antimicrobial agents and chemotherapy

authors： Choi MJ,Won EJ,Shin JH,Kim SH,Lee WG,Kim MN,Lee K,Shin MG,Suh SP,Ryang DW,Im YJ

更新日期：2016-05-23 00:00:00

abstract：:The echinocandins are a class of semisynthetic natural products that target β-1,3-glucan synthase (GS). Their proven clinical efficacy combined with minimal safety issues has made the echinocandins an important asset in the management of fungal infection in a variety of patient populations. However, the echinocandins ...

journal_title：Antimicrobial agents and chemotherapy

authors： Walker SS,Xu Y,Triantafyllou I,Waldman MF,Mendrick C,Brown N,Mann P,Chau A,Patel R,Bauman N,Norris C,Antonacci B,Gurnani M,Cacciapuoti A,McNicholas PM,Wainhaus S,Herr RJ,Kuang R,Aslanian RG,Ting PC,Black TA

更新日期：2011-11-01 00:00:00

abstract：:PSI-352938 is a novel cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine 5'-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with other inhibitors of H...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam AM,Espiritu C,Murakami E,Zennou V,Bansal S,Micolochick Steuer HM,Niu C,Keilman M,Bao H,Bourne N,Veselenak RL,Reddy PG,Chang W,Du J,Nagarathnam D,Sofia MJ,Otto MJ,Furman PA

更新日期：2011-06-01 00:00:00

abstract：:P128 is an antistaphylococcal protein, comprising a cell wall-degrading enzymatic region and a Staphylococcus-specific binding region, which possesses specific and potent bactericidal activity against sensitive and drug-resistant strains of Staphylococcus aureus To explore P128's ability to kill S. aureus in a range o...

journal_title：Antimicrobial agents and chemotherapy

authors： Nair S,Desai S,Poonacha N,Vipra A,Sharma U

更新日期：2016-11-21 00:00:00

abstract：:A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eshaghi A,Zittermann S,Bharat A,Mulvey MR,Allen VG,Patel SN

更新日期：2020-04-21 00:00:00

abstract：:We report on the cloning of the gene smeT, which encodes the transcriptional regulator of the Stenotrophomonas maltophilia efflux pump SmeDEF. SmeT belongs to the TetR and AcrR family of transcriptional regulators. The smeT gene is located upstream from the structural operon of the pump genes smeDEF and is divergently...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez P,Alonso A,Martinez JL

更新日期：2002-11-01 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

journal_title：Antimicrobial agents and chemotherapy

authors： Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

更新日期：2003-12-01 00:00:00

abstract：:Establishing an effective empirical antifungal therapy requires that national surveillance studies be conducted. Herein, we report the clinical outcome of infections with and the microbiological features of Iranian isolates of Candidaglabrata derived from patients suffering from candidemia. C. glabrata isolates were r...

journal_title：Antimicrobial agents and chemotherapy

authors： Arastehfar A,Daneshnia F,Zomorodian K,Najafzadeh MJ,Khodavaisy S,Zarrinfar H,Hagen F,Zare Shahrabadi Z,Lackner M,Mirhendi H,Salehi M,Roudbary M,Pan W,Kostrzewa M,Boekhout T

更新日期：2019-06-24 00:00:00

abstract：:Pyronaridine, a Mannich base antimalarial, has demonstrated high in vivo and in vitro efficacy against chloroquine-resistant Plasmodium falciparum. Although this drug has the potential to become a prominent artemisinin combination therapy, little is known about its efficacy against drug-resistant Plasmodium vivax. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Price RN,Marfurt J,Chalfein F,Kenangalem E,Piera KA,Tjitra E,Anstey NM,Russell B

更新日期：2010-12-01 00:00:00

abstract：:Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic fungi such as Candida albicans, its effect on Aspergillus fumigatus is less well understood. We used the fluorescent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowman JC,Hicks PS,Kurtz MB,Rosen H,Schmatz DM,Liberator PA,Douglas CM

更新日期：2002-09-01 00:00:00

abstract：:The biosynthetic gene cluster of the aminocoumarin antibiotic coumermycin A(1) was cloned by screening of a cosmid library of Streptomyces rishiriensis DSM 40489 with heterologous probes from a dTDP-glucose 4,6-dehydratase gene, involved in deoxysugar biosynthesis, and from the aminocoumarin resistance gyrase gene gyr...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang ZX,Li SM,Heide L

更新日期：2000-11-01 00:00:00

abstract：:We showed in a previous study that associations of antimicrobial peptides (AMPs), which are key components of the innate immune systems of all living species, with the fluoroquinolone enrofloxacin can successfully cure HeLa cell cultures of Mycoplasma fermentans and M. hyorhinis contamination. In the present work, the...

journal_title：Antimicrobial agents and chemotherapy

authors： Fassi Fehri L,Wróblewski H,Blanchard A

更新日期：2007-02-01 00:00:00

abstract：:The emergence of resistance to last-resort antibiotics is a public health concern of global scale. Besides direct person-to-person propagation, environmental pathways might contribute to the dissemination of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Here, we describe the incidence of blaNDM...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantilla-Calderon D,Jumat MR,Wang T,Ganesan P,Al-Jassim N,Hong PY

更新日期：2016-08-22 00:00:00

abstract：:Gentamicin is a commonly used antibiotic for the treatment of gram-negative-bacterial infections. Bacterial endotoxin is liberated during antibiotic therapy, and we have shown that endotoxemic animals accumulate more aminoglycosides in their renal parenchyma than normal animals. Vasoactive mediators, such as prostagla...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron MG,Bergeron Y,Tardif M,Marchand S,Beauchamp D

更新日期：1989-08-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Levy L

更新日期：1976-04-01 00:00:00

abstract：:Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asculai SS,Weis MT,Rancourt MW,Kupferberg AB

更新日期：1978-04-01 00:00:00

abstract：:In addition to cholesterol-lowering capabilities, statins possess anti-inflammatory and immunomodulatory effects. We sought to quantify the real-world impact of different statin exposure patterns on clinical outcomes in Staphylococcus aureus bacteremia. We conducted a retrospective cohort study among hospitalized pati...

journal_title：Antimicrobial agents and chemotherapy

authors： Caffrey AR,Timbrook TT,Noh E,Sakoulas G,Opal SM,Nizet V,LaPlante KL

更新日期：2017-02-23 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:We describe the clinical outcome of 17 patients with secondary Acinetobacter bacteremia whose isolates had a tigecycline MIC of ≤2 mg/liter and who received tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the tigecycline cohort was 41.2% (7/17), which was significantly higher than that of t...

journal_title：Antimicrobial agents and chemotherapy

authors： Liou BH,Lee YT,Kuo SC,Liu PY,Fung CP

更新日期：2015-01-01 00:00:00