UK-18892, a new aminoglycoside: an in vitro study.

abstract：:Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which Acinetobacter-derived cephalosporinase-7 (ADC-7), a chromosomal AmpC enzyme, hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Curtis BN,Smolen KA,Barlow SJ,Caselli E,Prati F,Taracila MA,Bonomo RA,Wallar BJ,Powers RA

更新日期：2020-11-17 00:00:00

abstract：:Inter- and intralaboratory reproducibility of susceptibility testing requires stable control strains. The Food and Drug Administration diffusion procedure recommends the Seattle strains of Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) for this purpose. It was of interest to determine the present...

journal_title：Antimicrobial agents and chemotherapy

authors： Coyle MB,Lampe MF,Aitken CL,Feigl P,Sherris JC

更新日期：1976-09-01 00:00:00

abstract：:Pathogenic bacterial biofilms, such as those found in the lungs of patients with cystic fibrosis (CF), exhibit increased antimicrobial resistance, due in part to the inherent architecture of the biofilm community. The protection provided by the biofilm limits antimicrobial dispersion and penetration and reduces the ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Habash MB,Park AJ,Vis EC,Harris RJ,Khursigara CM

更新日期：2014-10-01 00:00:00

abstract：:Identifying and understanding potential drug-drug interactions (DDIs) are vital for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. This article discusses DDIs between doravirine, a nonnucleoside reverse transcriptase inhibitor (NNRTI), and cytochrome P450 3A (CYP3A) substrates and drugs that m...

journal_title：Antimicrobial agents and chemotherapy

authors： Khalilieh SG,Yee KL,Sanchez RI,Fan L,Anderson MS,Sura M,Laethem T,Rasmussen S,van Bortel L,van Lancker G,Iwamoto M

更新日期：2019-04-25 00:00:00

abstract：:DNA gyrase is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA. It is the accepted target of quinolones. The enzyme from Citrobacter freundii IID976 was purified by affinity chromatography on novobiocin-Sepharose and heparin-Sepharose. It had two subunits, designated A and B, which clo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoyama H,Sato K,Fujii T,Fujimaki K,Inoue M,Mitsuhashi S

更新日期：1988-01-01 00:00:00

abstract：:Caseinomacropeptide (CMP) is a heterogeneous C-terminal fragment (residues 106 to 169) of bovine milk kappa-casein composed of glycosylated and phosphorylated forms of different genetic variants. We have demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkoski M,Dashper SG,O'Brien-Simpson NM,Talbo GH,Macris M,Cross KJ,Reynolds EC

更新日期：2001-08-01 00:00:00

abstract：:Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis. MRSA was inoculated into the proximal tibia, and a titanium wire was implanted. Four weeks after infection...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergidis P,Rouse MS,Euba G,Karau MJ,Schmidt SM,Mandrekar JN,Steckelberg JM,Patel R

更新日期：2011-03-01 00:00:00

abstract：:The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Koup JR,Lau AH,Brodsky B,Slaughter RL

更新日期：1979-05-01 00:00:00

abstract：:A new commercial low-density microarray which identifies common extended-spectrum β-lactamase plasmid-mediated cephalosporinase genes, as well as carbapenemase (bla(KPC) and bla(NDM)) genes, was evaluated. We tested 207 clinical and reference/collection isolates of the Enterobacteriaceae possessing different bla genes...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Hujer AM,Naas T,de Castro RR,Endimiani A,Nordmann P,Glupczynski Y,Bonomo RA

更新日期：2011-09-01 00:00:00

abstract：:Fifty-seven cultures of Haemophilus influenzae were tested for production of beta-lactamase by use of a modified, 1-min test. Only the 24 cultures that were ampicillin resistant, whether type b or not, yielded positive results for the enzyme; all ampicillin-susceptible isolates were uniformly negative. The beta-lactam...

journal_title：Antimicrobial agents and chemotherapy

authors： Escamilla J

更新日期：1976-01-01 00:00:00

abstract：:In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based assay which uses Alamar blue reagent for determination of growth was evaluated. MICs of 30 antimicrobial agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis H37Ra, and Mycobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins L,Franzblau SG

更新日期：1997-05-01 00:00:00

abstract：:Disseminated infections caused by the Mycobacterium avium-M. intracellulare complex (MAC) are the most frequent opportunistic bacterial infections in patients with AIDS. MAC isolates are resistant to many of the standard antituberculous drugs. Failure to obtain significant activities of certain drugs is due to difficu...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehta RT

更新日期：1996-08-01 00:00:00

abstract：:Faldaprevir is a potent hepatitis C virus (HCV) NS3/4A protease inhibitor with negligible urinary excretion. We assessed the pharmacokinetics and safety of a single oral dose of faldaprevir (480 mg) in 32 HCV-negative subjects with renal impairment or normal renal function. Compared with subjects with normal renal fun...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang F,Moschetti V,Lang B,Halabi A,Petersen-Sylla M,Yong CL,Elgadi M

更新日期：2015-01-01 00:00:00

abstract：:Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. Adjusted conidium in...

journal_title：Antimicrobial agents and chemotherapy

authors： Escribano P,Recio S,Peláez T,González-Rivera M,Bouza E,Guinea J

更新日期：2012-01-01 00:00:00

abstract：:The in vitro susceptibilities of 12 strains of Chlamydia pneumoniae to a new quinolone, trovafloxacin, and ofloxacin, doxycycline, erythromycin, and azithromycin were determined. The activity of trovafloxacin was similar to that of ofloxacin, with a MIC at which 90% of the isolates are inhibited and a minimal concentr...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Kutlin A,Hammerschlag MR

更新日期：1997-09-01 00:00:00

abstract：:A clinical isolate of Bacteroides vulgatus was resistant to tetracycline, clindamycin, ampicillin, cephaloridine, cefoxitin, and other beta-lactam antibiotics except imipenem. beta-Lactam resistance was mediated by a membrane-associated, clavulanate-sensitive cephalosporinase capable of degrading cephalosporins and pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Parker AC,Smith CJ

更新日期：1993-05-01 00:00:00

abstract：:Mannopeptimycins alpha, beta, gamma, delta, and epsilon are new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98. Mannopeptimycins gamma, delta, and epsilon, which have an isovaleryl substitution at various positions on the terminal mannose of the disaccharide moiety, demonstrated moderat...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Janso JE,Luckman SW,Lenoy EB,Bradford PA,Testa RT,Greenstein M

更新日期：2003-01-01 00:00:00

abstract：:The in vitro activities of two investigational quinolones, sparfloxacin (previously designated AT 4140) and PD 127391, were determined for 30 strains each of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum and compared with those of ciprofloxacin, tetracycline, clindamycin, and erythromycin. Eryt...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Duffy LB,Schmid T,Crabb D,Pate MS,Cassell GH

更新日期：1991-06-01 00:00:00

abstract：:We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be conside...

journal_title：Antimicrobial agents and chemotherapy

authors： Clavel-Osorio C,Cazassus F,Stegmann S,Huc-Anaïs P,Lecam D,Peytavin G

更新日期：2013-12-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal subjects, pharmacokinetic data were calculated, using a two-compartment open body model. The mean distribution serum half...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroy A,Humbert G,Godin M,Fillastre JP

更新日期：1980-03-01 00:00:00

abstract：:Using measured free fraction and 50% inhibitory concentration (IC50) values for the human immunodeficiency virus protease inhibitors lopinavir (LPV) and ritonavir (RTV) in tissue culture media with various protein concentrations ranging from 5 to 50%, we estimated serum-free IC50 values for each drug. The range of ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Hickman D,Vasavanonda S,Nequist G,Colletti L,Kati WM,Bertz R,Hsu A,Kempf DJ

更新日期：2004-08-01 00:00:00

abstract：:Candida albicans, an opportunistic fungus, and Staphylococcus aureus, a bacterial pathogen, are two clinically relevant biofilm-forming microbes responsible for a majority of catheter-related infections, with such infections often resulting in catheter loss and removal. Not only do these pathogens cause a substantial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Peters BM,Ward RM,Rane HS,Lee SA,Noverr MC

更新日期：2013-01-01 00:00:00

abstract：:Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of current combination therapies for human immunodeficiency virus type 1 (HIV-1) infection. In screening of chemical libraries, we found 6-azido-1-benzyl-3-(3,5-dimethylbenzyl)uracil (AzBBU) and 6-amino-1-benzyl-3-(3,5-dimethylbenzyl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ordonez P,Hamasaki T,Isono Y,Sakakibara N,Ikejiri M,Maruyama T,Baba M

更新日期：2012-05-01 00:00:00

abstract：:(1,3)Beta-D-glucan synthase (EC 2.4.1.34. UDP-glucose: 1,3-beta-D-glucan 3-beta-glucosyltransferase) uses UDP-glucose as substrate and catalyzes the polymerization of glucose ([1,3]-beta-linkages) to form the major carbohydrate component of the fungal cell wall. We have optimized in vitro assay conditions for (1,3)bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Maligie MA,Selitrennikoff CP

更新日期：2005-07-01 00:00:00

abstract：:Bacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue is trans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes in the absence of suff...

journal_title：Antimicrobial agents and chemotherapy

authors： Goralski TD,Dewan KK,Alumasa JN,Avanzato V,Place DE,Markley RL,Katkere B,Rabadi SM,Bakshi CS,Keiler KC,Kirimanjeswara GS

更新日期：2016-05-23 00:00:00

abstract：:5-episisomicin (Sch 22591) is a novel semisynthetic aminoglycoside with a spectrum and potency similar to gentamicin in its activity against susceptible bacterial strains, but with increased potency against Pseudomonas, Providencia, and Proteus rettgeri. It is also more active than tobramycin and amikacin against thes...

journal_title：Antimicrobial agents and chemotherapy

authors： Waitz JA,Miller GH,Moss E Jr,Chiu PJ

更新日期：1978-01-01 00:00:00

abstract：:A collection of 2,278 isolates belonging to 86 different fungal species was tested with micafungin and eight other drugs using the EUCAST procedures. Micafungin was active against species of Candida and Aspergillus (even azole-resistant species) as well as Penicillium spp., Scedosporium apiospermum, and Acremonium spp...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Gomez-Lopez A,Mellado E,Monzon A,Buitrago MJ,Rodriguez-Tudela JL

更新日期：2009-05-01 00:00:00

abstract：:The entry of an antibiotic into phagocytes is a prerequisite for its intracellular bioactivity against susceptible facultative or obligatory intracellular microorganisms. Brodimoprim is a dimethoxybenzylpyrimidine that has recently entered into clinical use, and its uptake into and elimination from human polymorphonuc...

journal_title：Antimicrobial agents and chemotherapy

authors： Braga PC,Dal Sasso M,Maci S,Bondiolotti G,Fonti E,Reggio S

更新日期：1996-10-01 00:00:00

abstract：:Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lo...

journal_title：Antimicrobial agents and chemotherapy

authors： Chaturvedi V,Ramani R,Ghannoum MA,Killian SB,Holliday N,Knapp C,Ostrosky-Zeichner L,Messer SA,Pfaller MA,Iqbal NJ,Arthington-Skaggs BA,Vazquez JA,Sein T,Rex JH,Walsh TJ

更新日期：2008-04-01 00:00:00

abstract：:The two components of virginiamycin, virginiamycin M (VM) and virginiamycin S (VS), were used to explore the life cycle of symbiosis-dependent and -independent strains of Bdellovibrio bacteriovorus during multiplication in a two-membered system with either living or heat-inactivated Escherichia coli or in axenic cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Varon M,Cocito C,Seijffers J

更新日期：1976-01-01 00:00:00