Treatment with linezolid or vancomycin in combination with rifampin is effective in an animal model of methicillin-resistant Staphylococcus aureus foreign body osteomyelitis.

abstract：:The susceptibility of Saccharomyces cerevisiae JG436 multidrug transporter deletion mutant, Deltapdr5, to several antifungal agents was compared to that of JG436-derived JGCDR1 and JGCaMDR1 transformants, harboring the CDR1 and CaMDR1 genes, encoding the main drug-extruding membrane proteins of Candida albicans. The J...

journal_title：Antimicrobial agents and chemotherapy

authors： Milewski S,Mignini F,Prasad R,Borowski E

更新日期：2001-01-01 00:00:00

abstract：:Hyperbaric oxygen exposures were evaluated for treatment of progressive liver abscesses produced by intraperitoneal injection of combined cultures of Fusobacterium necrophorum plus either Bacteroides fragilis subsp. fragilis or Fusobacterium nucleatum in a mouse model. Infected control and hyperbaric oxygen-exposed mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hill GB

更新日期：1976-02-01 00:00:00

abstract：:Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. An in vitro Bacillus subtilis well-agar diffusion assay was employed to test the hypothesis that himastatin was enzymatically inactivated. The activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mamber SW,Brookshire KW,Dean BJ,Firestone RA,Leet JE,Matson JA,Forenza S

更新日期：1994-11-01 00:00:00

abstract：:The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodrigues M,McBride SW,Hullahalli K,Palmer KL,Duerkop BA

更新日期：2019-10-22 00:00:00

abstract：:Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoyle BD,Alcantara J,Costerton JW

更新日期：1992-09-01 00:00:00

abstract：:RU44790 belongs to a new class of synthetic monocyclic beta-lactam antibiotics which feature a bioisosteric tetrazole moiety instead of the more classical acidic functions at the N-1 position of the beta-lactam ring. Its antibacterial activity was evaluated against some 900 strains and was compared with those of other...

journal_title：Antimicrobial agents and chemotherapy

authors： Chantot JF,Klich M,Teutsch G,Bryskier A,Collette P,Markus A,Seibert G

更新日期：1992-08-01 00:00:00

abstract：:A comparison of the daclatasvir (DCV [BMS-790052]) resistance barrier on authentic or hybrid replicons containing NS5A from hepatitis C virus (HCV) genotypes 1 to 6 (GT-1 to -6) was completed using a replicon elimination assay. The data indicated that genotype 1b (GT-1b) has the highest relative resistance barrier and...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang C,Jia L,O'Boyle DR 2nd,Sun JH,Rigat K,Valera L,Nower P,Huang X,Kienzle B,Roberts S,Gao M,Fridell RA

更新日期：2014-09-01 00:00:00

abstract：:The potential of bacteriophage therapy to treat infections caused by antibiotic-resistant bacteria has now been well established using various animal models. While numerous newly isolated bacteriophages have been claimed to be potential therapeutic candidates on the basis of in vitro observations, the parameters used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Henry M,Lavigne R,Debarbieux L

更新日期：2013-12-01 00:00:00

abstract：:To date, the majority of pharmacokinetic/pharmacodynamic (PK/PD) discussions have focused on PK/PD relationships evaluated at steady-state drug concentrations. However, a concern with reliance upon steady-state drug concentrations is that it ignores events occurring while the pathogen is exposed to intermittent subopt...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez MN,Papich MG,Drusano GL

更新日期：2012-06-01 00:00:00

abstract：:We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures we...

journal_title：Antimicrobial agents and chemotherapy

authors： Mroczkowska JE,Barlow M

更新日期：2008-09-01 00:00:00

abstract：:The antibacterial drug nalidixic acid (Nal) can suppress the growth of Candida albicans at levels of the drug normally found in urine. Growth suppression increases as drug levels are increased, and Nal also causes a similar proportional inhibition of the synthesis of all cellular macromolecules. However, growth temper...

journal_title：Antimicrobial agents and chemotherapy

authors： Sobieski RJ,Brewer AR

更新日期：1976-03-01 00:00:00

abstract：:Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection. Novel di...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang S,Wenzler T,Miller PN,Wu H,Boykin DW,Brun R,Wang MZ

更新日期：2014-07-01 00:00:00

abstract：:There are currently few or no published data on the amount of cerebrospinal fluid (CSF) penetration of daptomycin in patients with suspected or documented neurosurgical infections. We conducted a prospective study, assessing the pharmacokinetics and CSF penetration of a single intravenous daptomycin dose administered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kullar R,Chin JN,Edwards DJ,Parker D,Coplin WM,Rybak MJ

更新日期：2011-07-01 00:00:00

abstract：:An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region w...

journal_title：Antimicrobial agents and chemotherapy

authors： Janvier F,Jeannot K,Tessé S,Robert-Nicoud M,Delacour H,Rapp C,Mérens A

更新日期：2013-07-01 00:00:00

abstract：:Conventional therapy for human cytomegalovirus (CMV) relies on inhibition of the viral DNA polymerase. Ganciclovir (GCV) is the first-line therapy, but when GCV-resistant strains emerge, alternative therapies are extremely limited and are associated with significant toxicities. Combination of anti-CMV agents that act ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai H,Kapoor A,He R,Venkatadri R,Forman M,Posner GH,Arav-Boger R

更新日期：2014-01-01 00:00:00

abstract：:Macrolide antibiotics are used as anti-inflammatory agents, e.g., for prevention of exacerbations in chronic obstructive pulmonary disease and cystic fibrosis. Several studies have shown improved outcomes after the addition of macrolides to β-lactam antibiotics for treatment of severe community-acquired pneumonia. How...

journal_title：Antimicrobial agents and chemotherapy

authors： Kasetty G,Bhongir RKV,Papareddy P,Herwald H,Egesten A

更新日期：2017-08-24 00:00:00

abstract：:There has been major interest by the scientific community in antivirulence approaches against bacterial infections. However, partly due to a lack of viable lead compounds, antivirulence therapeutics have yet to reach the clinic. Here we investigate the development of an antivirulence lead targeting quorum sensing sign...

journal_title：Antimicrobial agents and chemotherapy

authors： Todd DA,Parlet CP,Crosby HA,Malone CL,Heilmann KP,Horswill AR,Cech NB

更新日期：2017-07-25 00:00:00

abstract：:The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined. Cefoperazone showed the highest antibacterial activity, followed by ceftezole, cefazolin, cefamandole, and cephalothin. There were two groups of resistant strains: one group (ca. 15%), of which B. fra...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Mitsuyama J,Hori R,Yasuda T,Saikawa I,Inoue M,Mitsuhashi S

更新日期：1988-12-01 00:00:00

abstract：:Treatment of Escherichia coli K-10 with 100 mug of chloramphenicol per ml for periods greater than 30 min leads to progressive lysis and killing of cells. The bactericidal action of the antibiotic is dependent on cell growth and physiology; only rapidly dividing cells are susceptible to killing; resting or slowly grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Guota RS

更新日期：1975-06-01 00:00:00

abstract：:The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication in vitro and in animal models when administered parenterally or b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Hartline C,Harden E,Keith K,Rodriguez N,Beadle JR,Hostetler KY

更新日期：2002-04-01 00:00:00

abstract：:BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

journal_title：Antimicrobial agents and chemotherapy

authors： Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

更新日期：2019-05-24 00:00:00

abstract：:A survey of 1,203 Escherichia coli isolates from 44 hospitals in Taiwan revealed that 136 (11.3%) isolates were resistant to fluoroquinolones and that another 261 (21.7%) isolates had reduced susceptibility. Resistance was more common in isolates responsible for hospital-acquired (mostly in intensive care units) infec...

journal_title：Antimicrobial agents and chemotherapy

authors： McDonald LC,Chen FJ,Lo HJ,Yin HC,Lu PL,Huang CH,Chen P,Lauderdale TL,Ho M

更新日期：2001-11-01 00:00:00

abstract：:Seventy-two (54.5%) out of 132 fecal samples from a group of yellow-legged gulls in Barcelona, Spain, were positive for Escherichia coli producing either extended-spectrum β-lactamases (ESBL) (51.5%), carbapenemase (1.5%), or cephamycinase (1.5%). The isolation of two carbapenemase-producing E. coli strains is a matte...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Pitart C,Montalvo T,Roca I,Sabaté S,Hurtado JC,Planell R,Marco F,Ramírez B,Peracho V,de Simón M,Vila J

更新日期：2017-01-24 00:00:00

abstract：:As opposed to Enterococcus faecalis, which is intrinsically resistant to lincosamides, streptogramins A, and pleuromutilins (LSAP phenotype) by production of the ABC protein Lsa(A), Enterococcus faecium is naturally susceptible. Since this phenotype may be selected for in vivo by quinupristin-dalfopristin (Q-D), the a...

journal_title：Antimicrobial agents and chemotherapy

authors： Isnard C,Malbruny B,Leclercq R,Cattoir V

更新日期：2013-09-01 00:00:00

abstract：:The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson P,Guarro J,Mayayo E,Capilla J

更新日期：2015-12-01 00:00:00

abstract：:Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distin...

journal_title：Antimicrobial agents and chemotherapy

authors： Marwaha S,Uvell H,Salin O,Lindgren AE,Silver J,Elofsson M,Gylfe A

更新日期：2014-05-01 00:00:00

abstract：:The 47-kbp plasmid pGFT1 from Salmonella enterica subsp. enterica serovar Dublin mediated tetracycline resistance via a tet(A) gene located on an integrated copy of a Tn1721-analogous transposon. The integration site of the transposon was located within the reading frame of a fip gene. Plasmid pGFT1 was shown to be co...

journal_title：Antimicrobial agents and chemotherapy

authors： Frech G,Schwarz S

更新日期：1998-05-01 00:00:00

abstract：:Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinf...

journal_title：Antimicrobial agents and chemotherapy

authors： Quiroga MP,Orman B,Errecalde L,Kaufman S,Centrón D

更新日期：2015-05-01 00:00:00

abstract：:Eight healthy male volunteers received 1 g of either ceftazidime or cefamandole as an intravenous infection. Serial blood samples were taken over the next 8 h. Urine samples were collected over 24 h. Levels of these antibiotics were measured in the fluid of blisters resulting from application of cantharides. The conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Armstrong GC,Wise R,Brown RM,Hancox J

更新日期：1981-09-01 00:00:00

abstract：:The pharmacokinetics and tolerability of a new parenteral carbapenem antibiotic, biapenem (L-627), were studied in healthy elderly volunteers aged 65 to 74 years (71.6 +/- 2.7 years [mean +/- standard deviation], n = 5; group B) and > or = 75 years (77.8 +/- 1.9 years, n = 5; group C), following single intravenous dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Takiguchi Y,Matsumoto S,Minamoto M,Niida Y,Yokokawa M,Nagashima S,Kanamaru M

更新日期：1998-06-01 00:00:00